3.4.23.5: cathepsin D
This is an abbreviated version!
For detailed information about cathepsin D, go to the full flat file.
Word Map on EC 3.4.23.5
-
3.4.23.5
-
lysosomal
-
pepstatin
-
estrogen
-
metastasis
-
alzheimer
-
proteinases
-
aspartyl
-
node
-
vacuole
-
lymph
-
renin
-
pepsin
-
endosomes
-
progesterone
-
hydrolases
-
endocytic
-
phagosomes
-
amyloid
-
beta-glucuronidase
-
plasminogen
-
mannose
-
6-phosphate
-
axillary
-
autophagosomes
-
saposins
-
lysosomal-associated
-
leupeptin
-
plasmepsins
-
beta-hexosaminidase
-
missorting
-
mannose-6-phosphate
-
chymosin
-
lysotracker
-
lipofuscinosis
-
lc3-ii
-
autophagy-lysosomal
-
rab7
-
ceroid
-
estrogen-regulated
-
immunoradiometric
-
medicine
-
lc3
-
lamp-1
-
node-negative
-
trans-golgi
-
upa
-
endocytosed
-
node-positive
-
c-erbb-2
-
autolysosomes
-
cation-independent
-
molecular biology
- 3.4.23.5
- lysosomal
- pepstatin
- estrogen
- metastasis
- alzheimer
- proteinases
-
aspartyl
- node
- vacuole
- lymph
- renin
- pepsin
- endosomes
- progesterone
- hydrolases
-
endocytic
-
phagosomes
-
amyloid
- beta-glucuronidase
- plasminogen
- mannose
- 6-phosphate
-
axillary
-
autophagosomes
-
saposins
-
lysosomal-associated
- leupeptin
-
plasmepsins
- beta-hexosaminidase
-
missorting
- mannose-6-phosphate
- chymosin
-
lysotracker
- lipofuscinosis
-
lc3-ii
-
autophagy-lysosomal
- rab7
-
ceroid
-
estrogen-regulated
-
immunoradiometric
- medicine
- lc3
- lamp-1
-
node-negative
-
trans-golgi
- upa
-
endocytosed
-
node-positive
-
c-erbb-2
-
autolysosomes
-
cation-independent
- molecular biology
Reaction
Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His bond in B chain of insulin =
Synonyms
BmCatD, CAD 1, CAD 2, CAD 3, CapD, Cat D, CAT-D, CatD, Cath D, cath-D, cathD, cathepsin D, cathepsin D-like proteinase, cathepsin D1, cathepsin D2, CD1, CTSD, EC 3.4.4.23, matCTSD, PCD, Pep4p, preproCatD, pro-cathepsin, pro-cathepsin D, pro-CD, pro-CtsD, proCat, proCDrec, proCTSD, Proteinase A
ECTree
3.4.23.5 cathepsin DAdvanced search results
results (
results (KM Value
KM Value on EC 3.4.23.5 - cathepsin D
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.0037
(7-methoxycoumarin-4-yl)acetyl-Gly-Lys-Pro-Ile-Ile-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2
-
40°C, pH 4.0, gastric cathepsin D
0.0022 - 0.00265
(7-methoxycoumarin-4-yl)acetyl-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(Dnp)-D-Arg-NH2
0.00212
(7-methoxycoumarin-4-yl)acetyl-Gly-Ser-Ser-Ala-Phe-Leu-Ala-Phe-Lys(Dnp)-D-Arg-NH2
-
40°C, pH 4.0, gastric cathepsin D
0.00045
2-aminobenzoyl-AAKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00031
2-aminobenzoyl-AEKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00027
2-aminobenzoyl-AIAFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00017
2-aminobenzoyl-AIEFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00007
2-aminobenzoyl-AIFFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00005
2-aminobenzoyl-AIIFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00028
2-aminobenzoyl-AIKFFARQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00034
2-aminobenzoyl-AIKFFERQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00021
2-aminobenzoyl-AIKFFIRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.0003
2-aminobenzoyl-AIKFFKRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.0001
2-aminobenzoyl-AIKFFLRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00009
2-aminobenzoyl-AIKFFNRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00009
2-aminobenzoyl-AIKFFORQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00034
2-aminobenzoyl-AIKFFRRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00037
2-aminobenzoyl-AIKFFSA-(N-(2,4-dinitrophenyl)ethylenediamine)
-
37°C, pH 4.0
-
0.0008
2-aminobenzoyl-AIKFFSAQTNR-(N-(2,4-dinitrophenyl)ethylenediamine)
-
37°C, pH 4.0
-
0.00008
2-aminobenzoyl-AIKFFSAQTNRHILRFNR-(N-(2,4-dinitrophenyl)ethylenediamine)
-
37°C, pH 4.0
-
0.0008
2-aminobenzoyl-AIKFFSAQTNRHILRFNRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.0008
2-aminobenzoyl-AIKFFSAQTNRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00066
2-aminobenzoyl-AIKFFSEQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00007
2-aminobenzoyl-AIKFFSIQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00055
2-aminobenzoyl-AIKFFSKQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00011
2-aminobenzoyl-AIKFFSLQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.0005
2-aminobenzoyl-AIKFFSNQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00066
2-aminobenzoyl-AIKFFSOQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00057
2-aminobenzoyl-AIKFFSPQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.0012
2-aminobenzoyl-AIKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00021
2-aminobenzoyl-AIKFFSSQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00043
2-aminobenzoyl-AIKFFSTQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.0001
2-aminobenzoyl-AIKFFSVQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00023
2-aminobenzoyl-AIKFFTRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00007
2-aminobenzoyl-AIKFFVRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00031
2-aminobenzoyl-AIKFMSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00041
2-aminobenzoyl-AIKLFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00028
2-aminobenzoyl-AIKLLSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00017
2-aminobenzoyl-AIKLMSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00016
2-aminobenzoyl-AIKMFLRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.001
2-aminobenzoyl-AIKMFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00076
2-aminobenzoyl-AIKMMSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00009
2-aminobenzoyl-AIKYYSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00019
2-aminobenzoyl-AILFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00037
2-aminobenzoyl-AIMFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00081
2-aminobenzoyl-AINFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00085
2-aminobenzoyl-AIPFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00043
2-aminobenzoyl-AIQFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00032
2-aminobenzoyl-AISFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00086
2-aminobenzoyl-AITFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00017
2-aminobenzoyl-AIVFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00016
2-aminobenzoyl-AKKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00054
2-aminobenzoyl-ALKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00076
2-aminobenzoyl-ANKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00052
2-aminobenzoyl-APKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00082
2-aminobenzoyl-AQKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00096
2-aminobenzoyl-ASKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.0007
2-aminobenzoyl-ATKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00039
2-aminobenzoyl-AVKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00016
2-aminobenzoyl-KITLLSALVETRIVRFNRQ-(N-(2,4-dinitrophenyl)ethylenediamine)
-
37°C, pH 4.0
0.00074
2-aminobenzoyl-KITLLSALVETRQ-(N-(2,4-dinitrophenyl)ethylenediamine)
-
37°C, pH 4.0
3.2
7-methoxycoumarin-4-yl-GKPILFFRLK(2,4-dinitrophenyl)-D-Arg
-
pH 2.2, 30°C
1.7
7-methoxycoumarin-4-yl-SEVNLDAEFRK(2,4-dinitrophenyl)RR
-
pH 2.2, 30°C
0.0211
R[K-2,4-dinitrophenyl]LRFFLIPK[G-7-amido-4-methylcoumarin]
-
at pH 3.7 and 37°C
0.0022
(7-methoxycoumarin-4-yl)acetyl-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(Dnp)-D-Arg-NH2
-
40°C, pH 4.0, spleen cathepsin D
0.00265
(7-methoxycoumarin-4-yl)acetyl-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(Dnp)-D-Arg-NH2
-
40°C, pH 4.0, gastric cathepsin D
0.00046
2-aminobenzoyl-AIKFFSAQ-N-(2,4-dinitrophenyl)ethylenediamine
-
37°C, pH 4.0
0.00046
2-aminobenzoyl-AIKFFSAQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.00051
2-aminobenzoyl-KITLLSAQ-(N-(2,4-dinitrophenyl)ethylenediamine)
-
37°C, pH 4.0
0.00094
2-aminobenzoyl-KITLLSAQ-(N-(2,4-dinitrophenyl)ethylenediamine)
-
37°C, pH 4.0
0.0293
hemoglobin
-
enzyme from animals with experimental neurofibrillary changes
-
0.05
Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu
-
enzyme from AH-130 hepatoma cells
0.07
Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu
-
enzyme from liver of AH-130 hepatoma-bearing rats
0.015
Pro-Pro-Thr-Ile-Phe-(4-nitro)Phe-Arg-Leu
-
enzyme from liver of AH-130 hepatoma-bearing rats
0.04
Pro-Pro-Thr-Ile-Phe-(4-nitro)Phe-Arg-Leu
-
enzyme from cells from AH-130 hepatoma
