Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 3.4.23.5 - cathepsin D

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
The expression of cathepsin D, oestrogen receptor and progestogen receptor in hydatidiform mole--an immunohistochemical study.
Acquired Immunodeficiency Syndrome
Aspartic peptidase inhibitors: implications in drug development.
Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block.
Acromegaly
Human nasal septal cartilage: local distribution of different enzyme activities in healthy adults and acromegalic patients.
Acute Coronary Syndrome
Anaphylactic cardiovascular collapse and Kounis syndrome: systemic vasodilation or coronary vasoconstriction?
Quest for novel cardiovascular biomarkers by proteomic analysis.
Acute Kidney Injury
Lack of Cathepsin D in the Renal Proximal Tubular Cells Resulted in Increased Sensitivity against Renal Ischemia/Reperfusion Injury.
Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury.
Adenocarcinoma
Activation of cathepsin B, secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D.
Adenosquamous carcinoma of the gall-bladder with gastric foveolar-type epithelium.
Cathepsin D activity in colorectal cancer.
Cathepsin D activity in human ovarian tissues and ovarian carcinoma.
Cathepsin D as a potential prognostic marker for lung adenocarcinoma.
Cathepsin D expression in colorectal adenocarcinomas and adenomas.
Cathepsin D expression in normal, hyperplastic and malignant endometrial tissue: an immunohistochemical analysis.
CD44 expression in colorectal cancer. An immunohistochemical study including correlation with cathepsin D immunoreactivity and some tumour clinicopathological features.
Cellular localisation by in situ hybridisation of cathepsin D, stromelysin 3, and urokinase plasminogen activator RNAs in breast cancer.
Clinicopathological significance of cathepsin D expression in gastric adenocarcinoma.
Comparative quantitative immunohistochemical and immunoradiometric determinations of cathepsin D in endometrial adenocarcinoma: predictors of tumor aggressiveness.
Correlation of tumor cytosol cathepsin D with differentiation and invasiveness of endometrial adenocarcinoma.
DNA and protein content as cellular biochemical parameters. A discussion with two examples: acid phosphatase and cathepsin D in rat liver and hepatoma and acid phosphatase in human breast normal tissue and adenocarcinoma.
Endometrial adenocarcinoma of endometrioid subtype with squamous differentiation: an immunohistochemical study of MIB-1 (ki-67 paraffin), cathepsin D, and C-erbB-2 protein (p185).
Evaluation of cathepsin D immunostaining in colorectal adenocarcinoma.
Expression of cathepsin D and galectin 3 in tubular carcinomas of the breast.
Expression of cathepsin D in colorectal adenocarcinomas: Correlation with clinicopathologic features.
Immuno-histochemical evaluation of Cathepsin D in malignant salivary gland carcinomas.
Immunohistochemical evaluation of cathepsin D expression in colorectal cancer.
Immunohistochemical evaluation of cathepsin D expression in colorectal tumours: a correlation with extracellular matrix components, p53, pRb, bcl-2, c-erbB-2, EGFR and proliferation indices.
Immunohistochemical evaluation of tissue-specific proteolytic enzymes in adenomas containing foci of early carcinoma: correlations with cathepsin D expression and other malignant features.
Intracytoplasmic localization of cathepsin D reflects the invasive potential of gastric carcinoma.
Ki-67 staining in benign, borderline, malignant primary and metastatic ovarian tumors: correlation with steroid receptors, epidermal-growth-factor receptor and cathepsin D.
Lipofuscin pigment can be used as a prognostic marker in prostatic adenocarcinoma.
Low levels of cathepsin D are associated with a poor prognosis in endometrial cancer.
Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.
Proteomic screening of a cell line model of esophageal carcinogenesis identifies cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barrett's esophagus and esophageal adenocarcinoma.
Serum CA19-9, cathepsin D, and matrix metalloproteinase-7 as a diagnostic panel for pancreatic ductal adenocarcinoma.
Significance of estrogen receptors and cathepsin D tissue detection in gastric adenocarcinoma.
[Prognostic value of molecular biologogy and immunologic parameters in human pancreatic carcinoma]
Adenocarcinoma of Lung
Cathepsin D as a potential prognostic marker for lung adenocarcinoma.
Influence of cathepsin D expression in lung adenocarcinoma on prognosis: possible importance of its expression in tumor cells and stromal cells, and its intracellular polarization in tumor cells.
Proteomic study of malignant pleural mesothelioma by laser microdissection and two-dimensional difference gel electrophoresis identified cathepsin D as a novel candidate for a differential diagnosis biomarker.
[CYFRA 21.1 cytosol levels in lung adenocarcinomas. Correlation with other clinico-biological parameters]
Adenoma
Cathepsin B and Cathepsin D Expression in Follicular Adenomas and Carcinomas of the Thyroid Gland.
Cathepsin B and cathepsin D expression in the progression of colorectal adenoma to carcinoma.
Cathepsin D expression in colorectal adenocarcinomas and adenomas.
DNA measurement, proliferation markers, and other factors in pituitary adenomas.
Estrogen receptors and cathepsin D in human thyroid tissue.
Expression of hypoxia-inducible factor 1alpha and cathepsin D in pituitary adenomas.
Expression, localization, and thyrotropin regulation of cathepsin D in human thyroid tissues.
Glycoprotein CD44 expression in colorectal neoplasms. An immuno-histochemical study including correlation with cathepsin D, extracellular matrix components, p53, Rb, bcl-2, c-erbB-2, EGFR and proliferation indices.
Immunohistochemical evaluation of cathepsin D expression in colorectal tumours: a correlation with extracellular matrix components, p53, pRb, bcl-2, c-erbB-2, EGFR and proliferation indices.
Immunohistochemical evaluation of tissue-specific proteolytic enzymes in adenomas containing foci of early carcinoma: correlations with cathepsin D expression and other malignant features.
Intracytoplasmic localization of cathepsin D reflects the invasive potential of gastric carcinoma.
Proliferation Markers and EGF in ACTH-Secreting Adenomas and Carcinomas of the Pituitary.
Aggressive Periodontitis
Amplified crevicular leukocyte activity in aggressive periodontal disease.
Alzheimer Disease
A beta-amyloid peptide variant related with familial Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis is poorly eliminated by cathepsin D.
A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease.
A high-resolution linkage map for comparative genome analysis and QTL fine mapping in Asian seabass, Lates calcarifer.
A Novel Approach for Characterization of Cathepsin D Protease and Its Effect on Tau and ?-Amyloid Proteins.
A Novel Dual Fluorochrome Near-Infrared Imaging Probe for Potential Alzheimer's Enzyme Biomarkers-BACE1 and Cathepsin D.
A paramagnetic chemical exchange-based MRI probe metabolized by cathepsin D: design, synthesis and cellular uptake studies.
Abnormal distribution of cathepsins in the brain of patients with Alzheimer's disease.
ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease.
Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D.
An Alzheimer's Disease-Linked Loss-of-Function CLN5 Variant Impairs Cathepsin D Maturation, Consistent with a Retromer Trafficking Defect.
Aspartic peptidase inhibitors: implications in drug development.
Association between cathepsin D polymorphism and Alzheimer's disease in a Chinese Han population.
Association Study of Cathepsin D Gene Polymorphism in Iranian Patients with Sporadic Late-Onset Alzheimer's Disease.
Candidate gamma-secretases in the generation of the carboxyl terminus of the Alzheimer's disease beta A4 amyloid: possible involvement of cathepsin D.
Cathepsin D as a therapeutic target in Alzheimer's disease.
Cathepsin D displays in vitro beta-secretase-like specificity.
Cathepsin D expression is decreased in Alzheimer's disease fibroblasts.
Cathepsin D from Alzheimer's-diseased and normal brains.
Cathepsin D gene and the risk of Alzheimer's disease: A population-based study and meta-analysis.
Cathepsin D gene exon 2 polymorphism and sporadic Alzheimer's disease.
Cathepsin D polymorphism in Italian elderly subjects with sporadic late-onset Alzheimer's disease.
Cathepsin D polymorphism in Italian sporadic and familial Alzheimer's disease.
Cathepsin D polymorphism not associated with Alzheimer's disease in Japanese.
Cathepsin D regulates cerebral A?42/40 ratios via differential degradation of A?42 and A?40.
Cathepsin D SNP associated with increased risk of variant Creutzfeldt-Jakob disease.
Cathepsin D: A Candidate Link between Amyloid ?-protein and Tauopathy in Alzheimer Disease.
Cathepsin D: screening for new polymorphisms using single-strand conformation polymorphism analysis.
Cerebellar dysfunction in a family harboring the PSEN1 mutation co-segregating with a Cathepsin D variant p.A58V.
Cerebrospinal fluid levels of beta-amyloid(42) in patients with Alzheimer's disease are related to the exon 2 polymorphism of the cathepsin D gene.
Colocalization of lysosomal hydrolase and beta-amyloid in diffuse plaques of the cerebellum and striatum in Alzheimer's disease and Down's syndrome.
Comparison of cathepsin protease activities in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease.
Comprehensive Exploration of Target-specific Ligands Using a Graph Convolution Neural Network.
Contribution of apolipoprotein E and cathepsin D genotypes to the familial aggregation of Alzheimer's disease.
Cortical cathepsin D activity and immunolocalization in Alzheimer disease, critical coronary artery disease, and aging.
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Decreased Expression of Cathepsin D in Monocytes is Related to the Defective Degradation of Amyloid-? in Alzheimer's Disease.
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, ?-site amyloid precursor protein cleaving enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.
Design of sensitive fluorogenic substrates for human cathepsin D.
Effect of Temperature and pH on the Secondary Structure and Denaturation Process of Jumbo Squid Hepatopancreas Cathepsin D.
Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB).
Elevated levels of the endosomal-lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease.
Evaluation of cathepsins D and G and EC 3.4.24.15 as candidate beta-secretase proteases using peptide and amyloid precursor protein substrates.
Expression and characterization of human beta-secretase candidates metalloendopeptidase MP78 and cathepsin D in beta APP-overexpressing cells.
Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system.
Genetic associations between cathepsin D exon 2 C-->T polymorphism and Alzheimer's disease, and pathological correlations with genotype.
Genetic polymorphism in exon 2 of cathepsin D is not associated with vascular dementia.
Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease.
Identification of Cathepsin D as a Plasma Biomarker for Alzheimer's Disease.
In vitro processing of amyloid precursor protein by cathepsin D.
Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities.
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Lack of association between cathepsin D C224T polymorphism and Alzheimer's disease risk: an update meta-analysis.
Lack of association between cathepsin D genetic polymorphism and Alzheimer disease in a Spanish sample.
Lack of association of cathepsin D genetic polymorphism with Alzheimer's disease in Koreans.
Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration.
Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin.
Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease.
Meta-analysis of the association of the cathepsin D Ala224Val gene polymorphism with the risk of Alzheimer's disease: a HuGE gene-disease association review.
Modulation of disease risk according to a cathepsin D / apolipoprotein E genotype in Parkinson's disease.
Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes.
New cathepsin d inhibitors with hydroxyethylamine isosteres: preparation and characterization.
New insights into the roles of endolysosomal cathepsins in the pathogenesis of Alzheimer's disease: cathepsin inhibitors as potential therapeutics.
No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease.
Non-replication of association between cathepsin D genotype and late onset Alzheimer disease.
Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus.
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Oxidative imbalance and cathepsin D changes as peripheral blood biomarkers of Alzheimer disease: a pilot study.
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.
Positive Association of the Cathepsin D Ala224Val Gene Polymorphism With the Risk of Alzheimer's Disease.
Processing of the pre-beta-amyloid protein by cathepsin D is enhanced by a familial Alzheimer's disease mutation.
Prolonged In Vivo Retention of a Cathepsin D Targeted Optical Contrast Agent in a Mouse Model of Alzheimer's Disease.
Putative association of polymorphism in the mannose 6-phosphate receptor gene with major depression and Alzheimer's disease.
Quantitative decrease in synaptophysin message expression and increase in cathepsin D message expression in Alzheimer disease neurons containing neurofibrillary tangles.
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Short arm of chromosome 11 and sporadic Alzheimer's disease: catalase and cathepsin D gene polymorphisms.
Significance of cytosolic cathepsin D in Alzheimer's disease pathology: Protective cellular effects of PLGA nanoparticles against ?-amyloid-toxicity.
Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease.
Structure-based subsite specificity mapping of human cathepsin D using statine-based inhibitors.
Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors.
The cathepsin D (224C/T) polymorphism confers an increased risk to develop Alzheimer's disease in men.
The cathepsin D gene exon 2 (C224T) polymorphism and sporadic Alzheimer's disease in European populations.
The cathepsin D rs17571 polymorphism: effects on CSF tau concentrations in Alzheimer disease.
The genetic association between Cathepsin D and Alzheimer's disease.
Uptake and pathogenic effects of amyloid beta peptide 1-42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists.
[The C224T polymorphism in the cathepsin D gene is not associated with sporadic Alzheimer's disease in Chinese]
Amyloidosis
A beta-amyloid peptide variant related with familial Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis is poorly eliminated by cathepsin D.
Activities of lysosomal enzymes and levels of serum amyloid A (SAA) in blood plasma of hamsters during casein induction of AA-amyloidosis.
Haplodeficiency of Cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice.
Hereditary cerebral hemorrhage with amyloidosis (Dutch): a model for congophilic plaque formation without neurofibrillary pathology.
In vitro degradation of serum amyloid A by cathepsin D and other acid proteases: possible protection against amyloid fibril formation.
Proteome analysis of cerebrospinal fluid in Guillain-Barré syndrome (GBS).
The effect of beta aminoproprionitrile (BAPN) on experimental amyloidosis.
Amyotrophic Lateral Sclerosis
Lysosomal and nonlysosomal hydrolases of skeletal muscle in neuromuscular diseases.
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43.
Anaphylaxis
Anaphylactic cardiovascular collapse and Kounis syndrome: systemic vasodilation or coronary vasoconstriction?
Anaplasia
Association between high concentrations of Mr 52,000 cathepsin D and poor prognosis in primary human breast cancer.
Expression of cathepsin D in human astrocytic neoplasias.
Anemia
Antianaemic properties of ayurvedic drugs, raktavardhak, punarnavasav and navayas louh in albino rats during phenylhydrazine induced haemolytic anaemia.
Aneurysm
Activity of enzymes with different subcellular localization in the blood plasma of patients with aortic aneurysm.
Cathepsin D and cathepsin L activities in aortic aneurysm wall and parietal thrombus.
Angina Pectoris
Beneficial effects of ibuprofen in pacing-induced myocardial ischemia.
Aortic Aneurysm
Activity of enzymes with different subcellular localization in the blood plasma of patients with aortic aneurysm.
Cathepsin D and cathepsin L activities in aortic aneurysm wall and parietal thrombus.
[Concentration and activity of cathepsin D in the blood plasma and serum of patients with abdominal aortic aneurysm]
Aortic Aneurysm, Abdominal
[Concentration and activity of cathepsin D in the blood plasma and serum of patients with abdominal aortic aneurysm]
Arthritis
Effect of bioflavonoids on lysosomal acid hydrolases and lysosomal stability in adjuvant-induced arthritis.
Experimental arthritis of rabbits caused by intra-articular injection of autologous Fab2 produced by digestion of IgG with cathepsin D.
Experimental arthritis of rabbits caused by intra-articular injection of autologous Fab2 produced by digestion of IgG with cathepsin D. II. Microscopical and immunohistochemical findings in long-term experiments.
The secretion of enzymes into the pericellular environment.
[Role of cathepsin D of synovial fluid of the knee joint in the pathogenesis of traumatic arthritis]
Arthritis, Reactive
[Role of cathepsin D of synovial fluid of the knee joint in the pathogenesis of traumatic arthritis]
Arthritis, Rheumatoid
Anti-inflammatory activity of Jasminum grandiflorum L. subsp. floribundum (Oleaceae) in inflammatory bowel disease and arthritis models.
Cathepsin D agglutinators and neutral protease agglutinators in rheumatoid arthritis. II. Production of CDA and NPA by rheumatoid synovium and phagocytosis of CDA by synovial phagocytic cells.
Cathepsin D agglutinators in rheumatoid arthritis. I. Increased CDA titers in serum and synovial fluid of patients with seropositive RA.
Comparative analysis of cathepsin L, cathepsin D, and collagenase messenger RNA expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization.
Comparative analysis of hexosaminidase and cathepsin D expression in synovial fluid of patients with rheumatoid arthritis and traumatized joints.
Lysosomal peptidases and glycosidases in rheumatoid arthritis.
Arthus Reaction
Failure of complete in vivo inhibition of cathepsin D to mitigate the pulmonary arthus reaction.
arylsulfatase (type i) deficiency
Enhanced breakdown of arylsulfatase A in multiple sulfatase deficiency.
Astrocytoma
Cathepsin D is a potential serum marker for poor prognosis in glioma patients.
Distribution of Lysosome-associated Membrane Proteins-1 and -2, and Cathepsin D in Eosinophilic Granular Bodies: Possible Relationship to Cyst Development in Pilocytic Astrocytomas.
Expression of cathepsin D during the progression of human gliomas.
Matrix metalloproteinase-9 interplays with the IGFBP2-IGFII complex to promote cell growth and motility in astrocytomas.
Ataxia
Cathepsin D deficiency causes juvenile-onset ataxia and distinctive muscle pathology.
Atherosclerosis
Cancer biomarkers in atherosclerotic plaque: Evidenced from structural and proteomic analyses.
Correlation between cathepsin D serum concentration and carotid intima-media thickness in hemodialysis patients.
Evaluation of serum cathepsin D concentrations in coronary artery disease.
Relation between serum cathepsin D levels and endothelial dysfunction in patients with chronic kidney disease.
Significances of viable synergistic autophagy-associated cathepsin B and cathepsin D (CTSB/CTSD) as potential biomarkers for sudden cardiac death.
Autoimmune Diseases
Cathepsin D-like activity in serum of patients with systemic lupus erythematosus.
Azoospermia
TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation.
Bacterial Infections
Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation.
Cloning and expression analysis of cathepsin D in the olive flounder Paralichthys olivaceus.
Molecular characterization and expression analysis of the channel catfish cathepsin D genes.
Molecular cloning, characterization and expression of cathepsin D from grass carp (Ctenopharyngodon idella).
Barrett Esophagus
Proteomic screening of a cell line model of esophageal carcinogenesis identifies cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barrett's esophagus and esophageal adenocarcinoma.
Bone Cysts
The role of lysosomes in the pathogenesis of unicameral bone cysts.
Bone Resorption
Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status.
Giant-cell tumors of bone and progesterone receptors.
Immunocytochemical localization of cathepsin D in the rat osteoclast.
Bowen's Disease
Cathepsin B and D expression in squamous cell carcinoma.
Brain Edema
Changes of perivascular macrophages in the process of brain edema induced by cold injury.
Brain Injuries
Autophagic neuron death.
Brain Injuries, Traumatic
Immunoblot analyses of the relative contributions of cysteine and aspartic proteases to neurofilament breakdown products following experimental brain injury in rats.
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.
Brain Neoplasms
Cathepsin D and its prognostic value in neuroepithelial brain tumors.
Breast Cyst
Cathepsin D and epidermal growth factor in human breast cyst fluid.
Quantification and molecular analysis of cathepsin D in breast cyst fluids.
[Levels of Cathepsin D in breast cyst fluid]
Breast Diseases
A two-site immunoenzymometric assay of 52-kDa pro-cathepsin D, and its use in human breast diseases.
Analysis of breast-tissue cathepsin-d isoforms from patients with breast-cancer, benign breast disease and from normal controls.
Analysis of cathepsin D in human breast cancer: usefulness of the processed 31 kDa active form of the enzyme as a prognostic indicator in node-negative and node-positive patients.
Cathepsin D in breast secretions from women with breast cancer.
Cathepsin-D expression in breast lesion: an immunohistochemical study.
Dissociated overexpression of cathepsin D and estrogen receptor alpha in preinvasive mammary tumors.
Progestin treatment depresses estrogen receptor but not cathepsin D levels in needle aspirates of benign breast disease.
Receiver-operating characteristic (ROC) curve analysis of cathepsin D and pS2 in breast disease; results from a prospective study.
Western blotting and enzymatic activity analysis of cathepsin D in breast tissue and sera of patients with breast cancer and benign breast disease and of normal controls.
Breast Neoplasms
3,3'4,4'-Tetrachlorobiphenyl exhibits antiestrogenic and antitumorigenic activity in the rodent uterus and mammary cells and in human breast cancer cells.
A hormone-regulated pro-cathepsin D secreted by human mammary cancer cells.
A lysosomal pepstatin-insensitive proteinase as a novel biomarker for breast carcinoma.
A multiparametric study on the prognostic value of epidermal growth factor receptor in operable breast carcinoma.
A novel aspartic protease gene, ALP56, is up-regulated in human breast cancer independently from the cathepsin D gene.
A prospective study of the prognostic value of cathepsin D levels in breast cancer cytosol.
A two-site immunoenzymometric assay of 52-kDa pro-cathepsin D, and its use in human breast diseases.
Abnormal expression of four novel molecular markers represents a highly aggressive phenotype in breast cancer. Immunohistochemical assay of p53, nm23, erbB-2, and cathepsin D protein.
Activation of peripheral blood neutrophils and lymphocytes by human procathepsin D and insulin-like growth factor II.
Activity of cathepsin D and alpha(1)-antitrypsin in the blood serum of patients with mammary carcinoma.
Age-dependent changes in breast cancer hormone receptors and oxidant stress markers.
Alteration of cathepsin D trafficking induced by hypoxia and extracellular acidification in MCF-7 breast cancer cells.
Alterations and role of human cathepsin D in cancer metastasis.
An immunohistochemical assessment of cathepsin D in gastric carcinoma: its impact on clinical prognosis.
Analysis of breast-tissue cathepsin-d isoforms from patients with breast-cancer, benign breast disease and from normal controls.
Analysis of cathepsin D in human breast cancer: usefulness of the processed 31 kDa active form of the enzyme as a prognostic indicator in node-negative and node-positive patients.
Analysis of the interaction of procathepsin D activation peptide with breast cancer cells.
Aspartic peptidase inhibitors: implications in drug development.
Aspects of breast cancers.
Association between high concentrations of Mr 52,000 cathepsin D and poor prognosis in primary human breast cancer.
Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study.
Association of the 323/A3 surface glycoprotein with tumor characteristics and behavior in human breast cancer.
Autoantibodies to tumor-associated antigens in breast carcinoma.
Benzophenone-1 and nonylphenol stimulated MCF-7 breast cancer growth by regulating cell cycle and metastasis-related genes via an estrogen receptor ?-dependent pathway.
Biochemical parameters for prognostic evaluation in patients with breast cancer.
Biological and clinical relevance of the urokinase-type plasminogen activator (uPA) in breast cancer.
Biological and clinical significance of cathepsin D in breast cancer metastasis.
Biological and clinical significance of cathepsin D in breast cancer.
Biological heterogeneity of ER-positive breast cancers in the post-menopausal population.
Bisphenol AF-Induced Endogenous Transcription Is Mediated by ER? and ERK1/2 Activation in Human Breast Cancer Cells.
c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis.
Capillary electrophoretic determination of cathepsin D activity using Oregon Green-labeled hemoglobin.
Catalytically inactive human cathepsin D triggers fibroblast invasive growth.
Cathepsin B, a prognostic indicator in lymph node-negative breast carcinoma patients: comparison with cathepsin D, cathepsin L, and other clinical indicators.
Cathepsin D and breast cancer.
Cathepsin D and breast cancer: useful?
Cathepsin D and epidermal growth factor in human breast cyst fluid.
Cathepsin D and prognosis in breast cancer.
Cathepsin D and prognosis in breast cancer: one piece of a larger puzzle?
Cathepsin D as a prognostic indicator for node-negative breast cancer patients using both immunoassays and enzymatic assays.
Cathepsin D as an indicator of clinical outcome in early breast carcinoma during the first 3 years of follow-up.
Cathepsin D assay in primary breast cancer and lymph nodes: relationship with c-myc, c-erb-B-2 and int-2 oncogene amplification and node invasiveness.
Cathepsin D by western blotting and immunohistochemistry: failure to confirm correlations with prognosis in node-negative breast cancer.
Cathepsin D concentration in breast cancer cytosols: correlation with biochemical, histological, and clinical findings.
Cathepsin D concentration in breast cancer cytosols: correlation with disease-free interval and overall survival.
Cathepsin D concentration in tumor cytosols improves the accuracy of prognostic evaluation of primary breast cancer.
Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling.
Cathepsin D detected by automated and quantitative immunohistochemistry in breast carcinomas: correlation with overall and disease free survival.
Cathepsin D enhances breast cancer invasion and metastasis through promoting hepsin ubiquitin-proteasome degradation.
Cathepsin D expression by cancer and stromal cells in breast cancer: an immunohistochemical study of 1348 cases.
Cathepsin D expression detected by immunohistochemistry has independent prognostic value in axillary node-negative breast cancer.
Cathepsin D expression in skin metastasis of breast cancer.
Cathepsin D expression levels in nongynecological solid tumors: clinical and therapeutic implications.
Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells.
Cathepsin D gene of human MCF7 cells contains estrogen-responsive sequences in its 5' proximal flanking region.
Cathepsin D immunocytochemical assays in breast carcinomas: image analysis and correlation to prognostic factors.
Cathepsin D immunostaining in paraffin-embedded breast cancer cells and macrophages: correlation with cytosolic assay.
Cathepsin D in breast cancer cells can digest extracellular matrix in large acidic vesicles.
Cathepsin D in breast cancer tissue.
Cathepsin D in breast cancer.
Cathepsin D in breast cancer: a tissue marker associated with metastasis.
Cathepsin D in breast cancer: from molecular and cellular biology to clinical applications.
Cathepsin D in breast cancer: mechanisms and clinical applications, a 1999 overview.
Cathepsin D in breast secretions from women with breast cancer.
Cathepsin D in cancer metastasis: a protease and a ligand.
Cathepsin D in host stromal cells is associated with more highly vascular and aggressive invasive breast carcinoma.
Cathepsin D in host stromal cells, but not in tumor cells, is associated with aggressive behavior in node-negative breast cancer.
Cathepsin D in invasive ductal NOS breast carcinoma as defined by immunohistochemistry. No correlation with survival at 5 years.
Cathepsin D in invasive ductal NOS, medullary, lobular and mucinous breast carcinoma. An immunohistochemical study.
Cathepsin D in primary breast carcinoma: adverse prognosis is associated with expression of cathepsin D in stromal cells.
Cathepsin D inhibitors as potential therapeutics for breast cancer treatment: Molecular docking and bioevaluation against triple-negative and triple-positive breast cancers.
Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis.
Cathepsin D levels in primary breast cancers: relationship with epidermal growth factor receptor, oestrogen receptor and axillary nodal status.
Cathepsin D may help in discriminating node-negative breast cancer patients at risk for local-regional recurrence.
Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer.
Cathepsin D stimulates the activities of secreted plasminogen activators in the breast cancer acidic environment.
Cathepsin D versus other prognostic factors in breast cancer. Results and controversies of a multicenter study on 2575 cases.
Cathepsin D, both a prognostic factor and a predictive factor for the effect of adjuvant tamoxifen in breast cancer. South Sweden Breast Cancer Group.
Cathepsin D-related disease-free interval in pT1 primary breast carcinomas: a pilot study.
Cathepsin D: a protease involved in breast cancer metastasis.
Cathepsin D: an independent prognostic factor for metastasis of breast cancer.
Cathepsin D: association between TN-stage and steroid receptor status of breast carcinoma.
Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis.
Cathepsin D: Regulation in mammary gland remodeling, misregulation in breast cancer.
Cathepsin D: screening for new polymorphisms using single-strand conformation polymorphism analysis.
Cathepsin-D and c-erb-B 2 have an additive prognostic value for breast cancer patients.
Cathepsin-D expression in breast lesion: an immunohistochemical study.
Cathepsin-d in breast carcinomas - the role of the stromal cell component.
Cathepsin-D, urokinase plasminogen activator and type-1 plasminogen activator inhibitor in early breast cancer: an immunohistochemical study of prognostic value and relations to tenascin-C and other factors.
Cellular and molecular biology of aryl hydrocarbon (Ah) receptor-mediated gene expression.
Cellular localisation by in situ hybridisation of cathepsin D, stromelysin 3, and urokinase plasminogen activator RNAs in breast cancer.
Characterization and enumeration of cells secreting tumor markers in the peripheral blood of breast cancer patients.
Characterization and properties of two monoclonal antibodies specific for the Mr 52,000 precursor of cathepsin D in human breast cancer cells.
Characterization of purified cathepsin D from malignant human breast tissue.
Characterization of the estrogen receptor transfected MCF10A breast cell line 139B6.
Characterization of the proximal estrogen-responsive element of human cathepsin D gene.
Characterization of very acidic phagosomes in breast cancer cells and their association with invasion.
Characterizing the Relapse Potential in Different Luminal Subtypes of Breast Cancers with Functional Proteomics.
Chromatin structure of the regulatory regions of pS2 and cathepsin D genes in hormone-dependent and -independent breast cancer cell lines.
Clinical and Biological Significance of Cathepsin D Levels in Breast Cancer Cytosol in Women Over 70 years.
Clinical relevance of biologic factors in male breast cancer.
Clinical significance of cathepsin D assay in breast cancer tissues.
Clinical significance of cathepsin D concentration in tumor cytosol of primary breast cancer.
Clinicopathological study of the expression of hsp27, pS2, cathepsin D and metallothionein in primary invasive breast cancer.
Cloning and sequencing of the 52K cathepsin D complementary deoxyribonucleic acid of MCF7 breast cancer cells and mapping on chromosome 11.
Cloning of a major human retinal pigment epithelial lysosomal aspartic protease and mapping its transcriptional start sites.
Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells.
Co-Expression of Androgen Receptor and Cathepsin D Defines a Triple-Negative Breast Cancer Subgroup with Poorer Overall Survival.
Co-expression of thymidine kinase and cathepsin D in 200 primary breast carcinomas.
Comparative biochemical and immunohistochemical studies on the cathepsin D content of human breast cancer.
Comparative prognostic value of Cathepsin D and urokinase plasminogen activator, detected by immunohistochemistry, in primary breast carcinoma.
Comparative proteome analysis of breast cancer and adjacent normal breast tissues in human.
Comparative quantitative immunohistochemical and immunoradiometric determinations of cathepsin D in endometrial adenocarcinoma: predictors of tumor aggressiveness.
Comparison of Functional Proteomic Analyses of Human Breast Cancer Cell Lines T47D and MCF7.
Comparison of hyaluronidase expression, invasiveness and tubule formation promotion in ER (-) and ER (+) breast cancer cell lines in vitro.
Comparison of the tumor associated proteases cathepsin D (CATH D) and urokinase-type plasminogen activator (uPA) in cytosols of human breast cancer patients.
Confocal fluorescence microscopy of urokinase plasminogen activator receptor and cathepsin D in human MDA-MB-231 breast cancer cells migrating in reconstituted basement membrane.
Correlated expression of BCL-2 protein, estrogen receptor, cathepsin D and low growth fraction (PCNA) in intracystic papillary breast carcinoma.
Correlation between cathepsin D expression and p53 protein nuclear accumulation in oesophageal squamous cell carcinoma.
Correlation between laminin and cathepsin D expressions in breast carcinoma.
Correlation between mannose-6-phosphate/IGFII receptor and cathepsin D RNA levels by in situ hybridization in benign and malignant mammary tumors.
Correlation of cytosolic concentrations of ER, PS2, Cath-D, TPS, TK and cAMP in primary breast carcinomas.
Correlation of tumor cytosol cathepsin D with differentiation and invasiveness of endometrial adenocarcinoma.
Correlation of two methods for determination of cathepsin D in breast carcinoma (immunohistochemistry and ELISA in cytosol).
Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.
Cyclosporin A potentiates estradiol-induced expression of the cathepsin D gene in MCF7 breast cancer cells.
Cytosol cathepsin D in Thai women with breast cancer.
Cytosol cathepsin-D content and proliferative activity of human breast cancer. The Comitato Italiano per il Controllo di Qualita del Laboratorio in Oncologia.
Decreased secretion of Cathepsin D in breast cancer in vivo by tamoxifen: mediated by the mannose-6-phosphate/IGF-II receptor?
Depletion of Procathepsin D Gene Expression by RNA Interference: A Potential Therapeutic Target for Breast Cancer.
Design of sensitive fluorogenic substrates for human cathepsin D.
Development and characterization of a tamoxifen-resistant breast carcinoma xenograft.
Development of gel staining techniques for detecting the secretion of procathepsin D (52-kDa protein) in MCF-7 human breast cancer cells.
Differential effect of forms A and B of human progesterone receptor on estradiol-dependent transcription.
Differential expression of the mannose 6-phosphate/ insulin-like growth factor-II receptor in human breast cancer cell lines of different invasive potential.
Differential quantitative proteomics reveals key proteins related to phenotypic changes of breast cancer cells expressing progesterone receptor A.
Differential regulation of cathepsin D by sex steroids in mammary cancer and uterine cells.
Dissociated overexpression of cathepsin D and estrogen receptor alpha in preinvasive mammary tumors.
Effect of cathepsin D and prostate specific antigen on latent transforming growth factor-beta in breast cancer cell lines.
Effect of steroid receptors, pS2 and cathepsin D on the outcome of elderly breast cancer patients: an exploratory investigation.
Effects of cathepsin D inhibitor from Vicia sativa L. seed hulls on human skin fibroblasts and breast cancer cells (in vitro studies).
Effects of Cu/Zn superoxide dismutase on estrogen responsiveness and oxidative stress in human breast cancer cells.
Elevated levels of pro-cathepsin-d in the plasma of breast-cancer patients.
Endocytosis of pro-cathepsin D into breast cancer cells is mostly independent of mannose-6-phosphate receptors.
Enhanced Expression of Rab27A Gene by Breast Cancer Cells Promoting Invasiveness and the Metastasis Potential by Secretion of Insulin-Like Growth Factor-II.
Enzymatically active cathepsin D sensitizes breast carcinoma cells to TRAIL.
Enzyme-linked immunosorbent assay of HER-2/neu gene product (p185) in breast cancer: its correlation with sex steroid receptors, cathepsin D and histologic grades.
Enzymes as prognostic markers and therapeutic indicators in patients with cancer.
Estradiol stimulates cell growth and secretion of procathepsin D and a 120-kilodalton protein in the human ovarian cancer cell line BG-1.
Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells.
Estrogen-regulated cut-off values of pS2 and cathepsin D expression in breast carcinomas.
Estrogens and growth factors induce the mRNA of the 52K-pro-cathepsin-D secreted by breast cancer cells.
Evaluation of cathepsin D as a prognostic factor in breast cancer.
Evaluation of cathepsin D as prognostic predictor in breast cancer.
Exploration of subsite binding specificity of human cathepsin D through kinetics and rule-based molecular modeling.
Exposure to xenobiotic compounds: looking for new biomarkers.
Expression of cathepsin D and galectin 3 in tubular carcinomas of the breast.
Expression of cathepsin D and pS2 in imprint smears of breast carcinoma.
Expression of cathepsin D in head and neck cancer.
Expression of cathepsin D in primary and metastatic human melanoma and dysplastic nevi.
Expression of cathepsin D, stromelysin-3, and urokinase by reactive stromal cells on breast carcinoma prognosis.
Expression of E-cadherin, beta-catenin, cathepsin D, gelatinases and their inhibitors in invasive ductal breast carcinomas.
Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients.
Expression of ps2 and cathepsin-d in breast-cancer.
Expression of pS2, c-erbB-2, and cathepsin D during the menstrual cycle in human breast cancers.
Fibroblasts capture cathepsin D secreted by breast cancer cells: possible role in the regulation of the invasive process.
Fluctuation of HER2 expression in breast carcinomas during the menstrual cycle.
Functional and physical interactions between the estrogen receptor Sp1 and nuclear aryl hydrocarbon receptor complexes.
Heat shock cognate 70 protein secretion as a new growth arrest signal for cancer cells.
Heterologous expression and characterization of the aspartic endoprotease Pep4um from Ustilago maydis, a homolog of the human Chatepsin D, an important breast cancer therapeutic target.
High levels of cathepsin B predict poor outcome in patients with breast cancer.
Hormonal regulation of cathepsin D following transfection of the estrogen or progesterone receptor into three sex steroid hormone resistant cancer cell lines.
How to target estrogen receptor-negative breast cancer?
Human breast cancer: prognostic significance of DNA ploidy compared with c-erbB2 expression, Cathepsin D and silver-binding nucleolar organizer regions (AgNORs).
Human breast milk contains procathepsin D--detection by specific antibodies.
Hybrid 2D/3D-quantitative structure-activity relationship and modeling studies perspectives of pepstatin A analogs as cathepsin D inhibitors.
Identification of a functional imperfect estrogen-responsive element in the 5'-promoter region of the human cathepsin D gene.
Identification of Sulfamoylbenzamide derivatives as selective Cathepsin D inhibitors.
IGFs and human cancer: implications regarding the risk of growth hormone therapy.
Immunoelectron microscopy of the receptor for urokinase plasminogen activator and cathepsin D in the human breast cancer cell line MDA-MB-231.
Immunoenzymatic assay of Mr 52,000 cathepsin D in 182 breast cancer cytosols: low correlation with other prognostic parameters.
Immunofluorometric analysis of p53 protein and prostate-specific antigen in breast tumours and their association with other prognostic indicators.
Immunohistochemical analysis of cathepsins D, B, and L in human breast cancer.
Immunohistochemical detection of cathepsin D in low grade breast invasive cancer.
Immunohistochemical detection of cathepsin D in T2N0M0 breast carcinoma.
Immunohistochemical detection of cathepsin-d expression in prostate-cancer.
Immunohistochemical evaluation of cathepsin D expression in colorectal cancer.
Immunohistochemical expression of cathepsin D in correlation with extracellular matrix component, steroid receptor status and proliferative indices in breast cancer.
Immunohistochemical localization of cathepsin D, proliferating cell nuclear antigen and epidermal growth factor receptor in human breast carcinoma analysed by computer image analyser: correlation with histological grade and metastatic behaviour.
Immunohistochemical localization of metallothionein in human breast cancer in comparison with cathepsin D, stromelysin-1, CD44, extracellular matrix components, P53, Rb, C-erbB-2, EGFR, steroid receptor content and proliferation.
Immunohistochemical profile of invasive lobular carcinoma of the breast: predominantly vimentin and p53 protein negative, cathepsin D and oestrogen receptor positive.
Immunohistochemical visualisation of cathepsin-D expression in breast cancer.
Immunohistologic analysis of invasive phenotype in breast carcinoma. A clinicopathologic study.
Immunohistologic evaluation of invasion-associated proteases in breast carcinoma.
Immunoradiometric assay of pro-cathepsin D in breast cancer cytosol: relative prognostic value versus total cathepsin D.
Immunoradiometric detection of pS2 and total cathepsin D in primary breast cancer biopsies: their correlation with steroid receptors.
Immunostaining of cathepsin D in breast cancer: quantification by computerised image analysis and correlation with cytosolic assay.
Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies.
Impact of steroid receptors, pS2 and cathepsin D on the outcome of N+ postmenopausal breast cancer patients treated with tamoxifen.
In Vitro and In Vivo Imaging of Peptide-Encapsulated Polymer Nanoparticles for Cancer Biomarker Activated Drug Delivery.
In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells.
In vivo stimulation by tamoxifen of cathepsin D RNA level in breast cancer.
Increased cathepsin D level in the serum of patients with metastatic breast carcinoma detected with a specific pro-cathepsin D immunoassay.
Increased plasma cathepsin D concentration in hepatic carcinoma and cirrhosis but not in breast cancer.
Increased secretion, altered processing, and glycosylation of pro-cathepsin D in human mammary cancer cells.
Inhibiting proteasomal proteolysis sustains estrogen receptor-alpha activation.
Inhibition of breast cancer growth by suramin.
Insulin-like growth factor II mediates resveratrol stimulatory effect on cathepsin D in breast cancer cells.
Insulin-like growth factor II modulates the routing of cathepsin D in MCF-7 breast cancer cells.
Insulin-like growth factors (IGFs) stimulate the release of alpha 1-antichymotrypsin and soluble IGF-II/mannose 6-phosphate receptor from MCF7 breast cancer cells.
Interaction of the Tumor Metastasis Suppressor Nonmetastatic Protein 23 Homologue H1 and Estrogen Receptor {alpha} Alters Estrogen-Responsive Gene Expression.
Is the mannose-6-phosphate/insulin-like growth factor 2 receptor coded by a breast cancer suppressor gene?
Keeping data continuous when analyzing the prognostic impact of a tumor marker: an example with cathepsin D in breast cancer.
Lack of prognostic value of cathepsin D levels for predicting short term outcomes of breast cancer patients.
Long-term follow-up confirms prognostic impact of PAI-1 and cathepsin D and L in primary breast cancer.
Low cathepsin D and low plasminogen activator type 1 inhibitor in tumor cytosols defines a group of node negative breast cancer patients with low risk of recurrence.
Low levels of basic fibroblast growth factor (bFGF) are associated with a poor prognosis in human breast carcinoma.
Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis.
Mass spectrometry (LC-MS/MS) identified proteomic biosignatures of breast cancer in proximal fluid.
Matrix metalloproteinase expression in human breast cancer: an immunohistochemical study including correlation with cathepsin D, type IV collagen, laminin, fibronectin, EGFR, c-erbB-2 oncoprotein, p53, steroid receptors status and proliferative indices.
MCF7 mammary cancer cells respond to bFGF and internalize it following its release from extracellular matrix: a permissive role of cathepsin D.
Mitogenic activity toward human breast cancer cell line MCF-7 of two bFGFs purified from sera of breast cancer patients: co-operative role of cathepsin D.
Modulation of cathepsin D routing by IGF-II involves IGF-II binding to IGF-II/M6P receptor in MCF-7 breast cancer cells.
Modulation of the estrogen-regulated proteins cathepsin D and pS2 by opioid agonists in hormone-sensitive breast cancer cell lines (MCF7 and T47D): evidence for an interaction between the two systems.
Molecular biomarkers for breast cancer prognosis: coexpression of c-erbB-2 and p53.
Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells.
Multiparametric prognostic evaluation of biological factors in primary breast cancer.
Multivariable difference gel electrophoresis and mass spectrometry: a case study on transforming growth factor-beta and ERBB2 signaling.
Mutual predictive value of c-erbB-2 overexpression and various prognostic factors in ductal invasive breast carcinoma.
New functional aspects of cathepsin D and cathepsin E.
Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells.
Oestrogen receptor, progesterone receptor, pS2, ERD5, HSP27 and cathepsin D in invasive ductal breast carcinomas.
Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells.
Oestrogen- and anti-oestrogen-regulated genes in human breast cancer.
Overexpression and hormonal regulation of pro-cathepsin D in mammary and endometrial cancer.
Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency.
Overview on human breast cancer with focus on prognostic and predictive factors with special attention on the tumour suppressor gene p53.
p53 associated with cathepsin D in primary breast cancer.
p53, cathepsin D, Bcl-2 are joint prognostic indicators of breast cancer metastatic spreading.
Pathophysiological functions of cathepsin D: Targeting its catalytic activity versus its protein binding activity?
Plasminogen activator inhibitor-1 and prognosis in primary breast cancer.
Potential markers predicting distant metastasis in axillary node-negative breast carcinoma.
Prediction of axillary lymph node status of breast cancer patients by tumorbiological factors of the primary tumor.
Pro-cathepsin D interacts with the extracellular domain of the beta chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth.
Progesterone receptor synthesis in human meningiomas: relation to the estrogen-induced proteins pS2 and cathepsin-D and influence of epidermal growth factor, Forskolin and phorbol ester in vitro.
Prognostic evaluation of oestrogen-regulated protein immunoreactivity in ductal invasive (NOS) breast cancer.
Prognostic impact of cathepsin D and c-erbB-2 oncoprotein in a subgroup of node-negative breast cancer patients with low histological grade tumors.
Prognostic impact of tumor biological factors on survival in node-negative breast cancer.
Prognostic indicators for early-stage breast-carcinoma .2. Value of cathepsin-d expression, detected by immunocytochemistry - a multiparametric study.
Prognostic indicators in node-negative early stage breast cancer.
Prognostic relevance of cathepsin D detection in micrometastatic cells in the bone marrow of patients with primary breast cancer.
Prognostic relevance of cathepsin D versus oestrogen receptors in node negative breast cancers.
Prognostic role of high cathepsin D expression in breast cancer: a systematic review and meta-analysis.
Prognostic significance of immunohistochemical analysis of cathepsin D in low-stage breast cancer.
Prognostic significance of the estrogen-regulated protein, cathepsin D, in breast cancer. An immunohistochemical study.
Prognostic significance of the estrogen-regulated proteins, cathepsin-D and pS2, in breast cancer.
Prognostic significance of tumor-related proteases as a function of the estrogen receptor status.
Prognostic value of cathepsin D expression and association with histomorphological subtypes in breast cancer.
Prognostic value of Cathepsin D expression in breast cancer: immunohistochemical assessment and correlation with radiometric assay.
Prognostic value of cathepsin D in breast cancer.
Prognostic value of cathepsin D in breast cancer: comparison of immunohistochemical and immunoradiometric detection methods.
Prognostic value of PS2 and cathepsin D in 710 human primary breast tumors: multivariate analysis.
Prognostic value of the quantitative measurement of the oncoprotein p185(Her-2/neu) in a group of patients with breast cancer and positive node involvement.
Prognostic value of total cathepsin D in breast tumors. A possible role in selection of chemoresistant patients.
Prospective evaluation of prognostic factors in operable breast cancer.
Protease levels in breast, ovary, and other gynecological tumor tissues: prognostic importance in breast cancer.
Proteases as prognostic markers in cancer.
Proteases associated with gynecological tumors.
Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment.
Proteolysis of human prolactin: resistance to cathepsin D and formation of a nonangiostatic, C-terminal 16K fragment by thrombin.
Proteomic analysis of MCF-7 breast cancer cell line exposed to leptin.
Proteomic characterization of nipple aspirate fluid: identification of potential biomarkers of breast cancer.
PS2 in breast cancer--alternative or complementary tool to steroid receptor status? Evaluation of 446 cases.
Quantification and molecular analysis of cathepsin D in breast cyst fluids.
Quantitative immunohistochemistry using the CAS 200/486 image analysis system in invasive breast carcinoma: a reproducibility study.
Receiver-operating characteristic (ROC) curve analysis of cathepsin D and pS2 in breast disease; results from a prospective study.
Reduced levels of cathepsin D associated with tamoxifen resistance and estrogen independence in the ZR-75-1 human breast cancer cell line.
Reevaluating cathepsin D as a biomarker for breast cancer: serum activity levels versus histopathology.
Regulation, clinical and biological significance of cathepsin D in breast cancer.
Relation between cathepsin D expression and other prognostic factors in breast carcinomas.
Relation of cathepsin D level to the estrogen receptor in human breast cancer.
Relationship between cathepsin D and other pathological and biological parameters in 1752 patients with primary breast cancer.
Relationship between cathepsin D, urokinase, and plasminogen activator inhibitors in malignant vs benign breast tumours.
Relationship between cathepsin-D and other prognostic factors in human breast cancer.
Relationship between the expression of various markers and prognostic factors in breast cancer.
Relationships between oestrogen-inducible proteins, oestradiol and electrolyte ratio in breast cyst fluid.
Release of the aspartyl protease cathepsin D is associated with and facilitates human breast cancer cell invasion.
Retinoid regulation of human cathepsin D gene expression.
Reversal of cathepsin D routing modulation in MCF-7 breast cancer cells expressing antisense insulin-like growth factor II (IGF-II).
Ribozyme-targeting procathepsin D and its effect on invasion and growth of breast cancer cells: an implication in breast cancer therapy.
Role of direct interaction in BRCA1 inhibition of estrogen receptor activity.
Salivary duct carcinoma. Part II. Immunohistochemical evaluation of 13 cases for estrogen and progesterone receptors, cathepsin D, and c-erbB-2 protein.
Significance of estrogen receptors and cathepsin D tissue detection in gastric adenocarcinoma.
Significance of the tumor protease Cathepsin D for the biology of breast cancer.
Simultaneous quantitative analyses of c-erbB-2 protein, epidermal growth factor receptor, cathepsin D, and hormone receptors in breast cancer.
Specific mannose-6-phosphate receptor-independent sorting of pro-cathepsin D in breast cancer cells.
Specific oncological contribution of cathepsin D and pS2 in human breast cancer: their relationship with TNM status, estradiol receptors, epidermal growth factor receptor and neu amplification.
Stable transfection of the estrogen receptor cDNA into Hela cells induces estrogen responsiveness of endogenous cathepsin D gene but not of cell growth.
Stefins and lysosomal cathepsins B, L and D in human breast carcinoma.
Steroid receptors, pS2 and cathepsin D in early clinically node-negative breast cancer.
Stromal cell cathepsin D expression and long-term survival in breast cancer.
Structure, function, regulation and clinical significance of the 52K pro-cathepsin D secreted by breast cancer cells.
Structure-based subsite specificity mapping of human cathepsin D using statine-based inhibitors.
Tamoxifen treatment increases the concentration of 52K-cathepsin D and its precursor in breast cancer tissue.
The immunohistochemical expression of cathepsin D in colorectal cancer.
The influence of antiestrogens on pS2 and cathepsin D mRNA induction in MCF-7 breast cancer cells.
The p160 family coactivators regulate breast cancer cell proliferation and invasion through autocrine/paracrine activity of SDF-1alpha/CXCL12.
The prognostic importance of cathepsin D and E-cadherin in early breast cancer: A single-institution experience.
The prognostic value of cathepsin D in breast cancer. A long road to the clinic.
The prognostic-significance of cathepsin-d in breast carcinomas - an immunohistochemical study.
The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells.
The relative prognostic significance of total cathepsin D and HER-2/neu oncogene amplification in breast cancer. The South Australian Breast Cancer Study Group.
The role of cathepsin D and PAI-1 in primary invasive breast cancer as prognosticators and predictors of treatment benefit with adjuvant tamoxifen.
The role of cathepsin D in the invasiveness of human breast cancer cells.
Three-dimensional chitosan scaffold-based MCF-7 cell culture for the determination of the cytotoxicity of tamoxifen.
Thrombospondin-1 and -2 in node-negative breast cancer: correlation with angiogenic factors, p53, cathepsin D, hormone receptors and prognosis.
Time at surgery during menstrual cycle and menopause affects pS2 but not cathepsin D levels in breast cancer.
Tissue cathepsins as tumor markers.
Tissue polypeptide antigen in breast cancer cytosol: a new effective prognostic indicator.
Tocotrienols Modulate Breast Cancer Secretomes and Affect Cancer-Signaling Pathways in MDA-MB-231 Cells: A Label-Free Quantitative Proteomic Analysis.
Transcriptional activation of cathepsin D gene expression by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition.
Transcriptional activation of cathepsin D gene expression by growth factors.
Transfected cathepsin D stimulates high density cancer cell growth by inactivating secreted growth inhibitors.
Tumor growth fraction, expression of estrogen and progesterone receptors, p53, bcl-2 and cathepsin D activity in primary ductal invasive breast carcinoma and their axillary lymph node metastases.
Tumour epidermal growth factor receptor, erbB-2 and cathepsin D in node-negative invasive breast cancer: their impact on the selection of patients for systemic adjuvant therapy.
Tumour-associated fibrinolysis: the prognostic relevance of plasminogen activators uPA and tPA in human breast cancer.
Two-site immunoenzymometric assay for the 52-kDa cathepsin D in cytosols of breast cancer tissues.
Upstream stimulatory factors mediate estrogen receptor activation of the cathepsin D promoter.
Western blotting and enzymatic activity analysis of cathepsin D in breast tissue and sera of patients with breast cancer and benign breast disease and of normal controls.
Western immunoblotting and enzymatic activity analysis of cathepsin D in human breast cancer cell lines of different invasive potential. Regulation by 17beta-estradiol, tamoxifen and ICI 182,780.
[Cathepsin D as a prognostic marker in breast cancer]
[Cathepsin D expression in primary breast cancer. Comparison of immunohistochemical and biochemical results]
[Cathepsin D in diagnosis of neoplastic diseases]
[Cathepsin D in primary breast cancer in correlation with various prognostic factors]
[Cathepsin D: an independent prognostic factor in cancer of the breast]
[Cytosolic concentrations of cathepsin D in 88 infiltrating ductal breast carcinomas having negative estrogen and progesterone receptors. Correlation with other clinical and biological parameters]
[Estrogen-induced genes in breast cancer, and their medical importance]
[Estrogens, cathepsin D and metastasis in cancers of the breast and ovary: invasion or proliferation?]
[Evaluation of several biological markers in the prognosis of patients with node-negative breast cancer]
[Expression of cathepsin D in breast cancer and its clinical and histopathological correlations]
[Mechanism of the overexpression of the cathepsin D gene in breast cancer and consequences in the metastatic process]
[Molecular markers in breast cancer: practical aspects and morphologic evaluation]
[New factors of possible prognostic value in breast cancer]
[Pro-cathepsin D can activate in vitro pro-cathepsin B secreted by ovarian cancers]
[Prognostic parameters in localized breast cancer]
[Prognostic value of a continuous variable and an optimal cutoff point]
[Proteases and prostatic disease: cytosolic cathepsin D]
[Significance of cathepsin D in breast cancer]
[Study of G2M cell fraction by flow cytometry in 200 infiltrating ductal breast carcinomas. Correlation with receptor positivity of the epidermal growth factor, cathepsin D and histological grade 3]
[The expression of Cath-D, c-erbB-2 and EGFR in breast cancer and its correlation to lymphatic metastasis]
[The prognostic significance of cathepsin D in primary breast cancer]
[The prognostic value of cathepsin D concentration in cytosol of primary breast carcinoma]
[The relationship between prognosis, metastasis and microvessel quantity in invasive breast carcinoma]
[Value of immunohistochemical determination of receptors, tissue proteases, tumor suppressor proteins and proliferation markers as prognostic indicators in primary breast carcinoma]
Breast Neoplasms, Male
Clinical relevance of biologic factors in male breast cancer.
Expression of cathepsin D and estrogen receptor in male breast carcinoma.
Carcinogenesis
Aspartic proteinases in disease: a structural perspective.
Cathepsin D acts as an essential mediator to promote malignancy of benign prostatic epithelium.
Cathepsin D serum mass concentrations in patients with hepatocellular carcinoma and/or liver cirrhosis.
Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells.
Dissociated overexpression of cathepsin D and estrogen receptor alpha in preinvasive mammary tumors.
Growth and differentiation of the normal mammary gland and its tumours.
Induction of cathepsin D protein during estrogen carcinogenesis: possible role in estrogen-mediated kidney tubular cell damage.
Lowering endogenous cathepsin D abundance results in ROS accumulation and cell senescence.
Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells.
Overexpression and hormonal regulation of pro-cathepsin D in mammary and endometrial cancer.
Progestin treatment depresses estrogen receptor but not cathepsin D levels in needle aspirates of benign breast disease.
Proteomic identification of differentially-expressed proteins in esophageal cancer in three ethnic groups in Xinjiang.
Proteomic screening of a cell line model of esophageal carcinogenesis identifies cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barrett's esophagus and esophageal adenocarcinoma.
Carcinoma
A xenograft mouse model coupled with in-depth plasma proteome analysis facilitates identification of novel serum biomarkers for human ovarian cancer.
Activity of cathepsin D and alpha(1)-antitrypsin in the blood serum of patients with mammary carcinoma.
An immunohistochemical and prognostic evaluation of cathepsin D expression in 105 bladder carcinomas.
An immunohistochemical assessment of cathepsin D in gastric carcinoma: its impact on clinical prognosis.
Angiostatin generation by cathepsin D secreted by human prostate carcinoma cells.
Antimetastatic activity of adriamycin in combinations with proteinase inhibitors in mice.
Autoantibodies to tumor-associated antigens in epithelial ovarian carcinoma.
bcl-2 protein in invasive ductal breast carcinomas.
Carcinoma of the breast arising in microglandular adenosis.
Cathepsin B and Cathepsin D Expression in Follicular Adenomas and Carcinomas of the Thyroid Gland.
Cathepsin B and cathepsin D expression in the progression of colorectal adenoma to carcinoma.
Cathepsin B and D expression in squamous cell carcinoma.
Cathepsin D activity in human ovarian tissues and ovarian carcinoma.
Cathepsin D and chromogranin A as predictors of long term disease specific survival after radical prostatectomy for localized carcinoma of the prostate.
Cathepsin D and dynamic magnetic resonance imaging gadolinium enhancement in malignant and benign breast lesions.
Cathepsin D and PAI-1 expression in human head and neck cancer.
Cathepsin D cytosolic assay and immunohistochemical quantification in human prostate tumors.
Cathepsin D expression in colorectal adenocarcinomas and adenomas.
Cathepsin D expression in normal, hyperplastic and malignant endometrial tissue: an immunohistochemical analysis.
Cathepsin D expression in renal cell cancer-clinical implications.
Cathepsin D immunoreactivity in ovarian cancer: correlation with prognostic factors.
Cathepsin D in laryngeal carcinoma. preliminary report.
Cathepsin D in normal and neoplastic thyroid tissues.
Cathepsin D in tissue and serum of patients with squamous cell carcinoma of the head and neck.
Cathepsin D is secreted from M-BE cells: its potential role as a biomarker of lung cancer.
Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging.
Cathepsin D serum levels are not a valid serum marker in renal cell carcinoma.
Cathepsin expression in oral squamous cell carcinoma: relationship with clinicopathologic factors.
Cathepsin-D, urokinase plasminogen activator and type-1 plasminogen activator inhibitor in early breast cancer: an immunohistochemical study of prognostic value and relations to tenascin-C and other factors.
CD44 expression in colorectal cancer. An immunohistochemical study including correlation with cathepsin D immunoreactivity and some tumour clinicopathological features.
Clinical significance of cathepsin D in primary ovarian cancer.
Clinicopathological significance of cathepsin D expression in gastric adenocarcinoma.
Combination of new biologic parameters as a prognostic index in epithelial ovarian carcinoma.
Comparison of cathepsin D determinations in human carcinomas by enzyme immunoassay and immunoradiometric assay.
Correlation between cathepsin D expression and p53 protein nuclear accumulation in oesophageal squamous cell carcinoma.
Correlation between laminin and cathepsin D expressions in breast carcinoma.
Correlation of mammographic appearance and molecular prognostic factors in high-grade breast carcinomas.
Correlation of tumor cytosol cathepsin D with differentiation and invasiveness of endometrial adenocarcinoma.
CORRELATIONSHIP OF CATHEPSIN D AND TOPOISOMERASE II ALPHA WITH NUCLEAR GRADING IN BREAST CANCERS.
Corrigendum: Overexpression Cathepsin D Contributes to Perineural Invasion of Salivary Adenoid Cystic Carcinoma.
Detection of oral squamous cell carcinoma metastasis with cathepsin D: An immunohistochemical approach.
Differential expression levels of urokinase-type plasminogen activator and cathepsin D in locally advanced laryngeal squamous cell carcinoma: clinical implications.
Dissociated overexpression of cathepsin D and estrogen receptor alpha in preinvasive mammary tumors.
Drug resistant tumor cells have increased levels of tumor markers for invasion and metastasis.
Effect of Temperature and pH on the Secondary Structure and Denaturation Process of Jumbo Squid Hepatopancreas Cathepsin D.
Effect of tumor size on the association between ps2 and cathepsin-d in primary breast-cancer.
Endogenous cathepsin D-mediated hydrolysis of insulin-like growth factor-binding proteins in cultured human prostatic carcinoma cells.
Enzyme-linked immunosorbent assay of HER-2/neu gene product (p185) in breast cancer: its correlation with sex steroid receptors, cathepsin D and histologic grades.
Estrogen receptors and cathepsin D in human thyroid tissue.
Evaluation of cathepsin D and epidermal growth factor receptor in prostate carcinoma.
Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study.
Evaluation of the prognostic significance of nm23/NDP kinase and cathepsin D in anal carcinomas. An immunohistochemical study.
Expression and posttranslational fate of cathepsin D in HT-29 tumor cells depend on their enterocytic differentiation state.
Expression of cathepsin D and B in invasion and metastasis of squamous cell carcinoma.
Expression of cathepsin D in bladder carcinoma: correlation with pathological features and serum cystatin C levels.
Expression of cathepsin D in malignant and in the corresponding non-malignant node-negative laryngeal samples: correlation with receptors for androgen, glucocorticoid, oestrogen and progesterone.
Expression of cathepsin D in transitional cell bladder tumours.
Expression of cathepsin D in urothelial carcinoma of the urinary bladder: an immunohistochemical study including correlations with extracellular matrix components, CD44, p53, Rb, c-erbB-2 and the proliferation indices.
Expression of cathepsins B, D and K in thymic epithelial tumours.
Expression of oestrogen and progesterone receptors, Ki-67, p53 and BCL-2 proteins, cathepsin D, urokinase plasminogen activator and urokinase plasminogen activator-receptors in carcinomas of the female breast in an African population.
Expression profiling of supraglottic carcinoma: PTEN and thrombospondin 2 are associated with inhibition of lymphatic metastasis.
Expression, localization, and thyrotropin regulation of cathepsin D in human thyroid tissues.
Gastric carcinoma: expression of c-erbB-2/neu oncoprotein, epidermal growth factor receptor, cathepsin D, progesterone receptor and tumor associated glycoprotein-72 in different histological types.
Glycoprotein CD44 expression in colorectal neoplasms. An immuno-histochemical study including correlation with cathepsin D, extracellular matrix components, p53, Rb, bcl-2, c-erbB-2, EGFR and proliferation indices.
Immuno-histochemical evaluation of Cathepsin D in malignant salivary gland carcinomas.
Immunocytochemical localization of Cathepsin D and CA 125 in ovarian cancer.
Immunohistochemical analysis and prognostic value of cathepsin D determination in laryngeal squamous cell carcinoma.
Immunohistochemical analysis of cathepsin D in prostate carcinoma.
Immunohistochemical evaluation of tissue-specific proteolytic enzymes in adenomas containing foci of early carcinoma: correlations with cathepsin D expression and other malignant features.
Immunohistochemical expression of cathepsin D in laryngeal epithelial lesions: correlation with CD44 expression, p53 and Rb status and proliferation associated indices.
Immunohistochemical Expression of Cathepsin D in Primary and Recurrent Squamous Cell Carcinoma.
Immunohistochemical markers of prolonged survival in small cell carcinoma of the lung. An immunohistochemical study.
Immunohistochemical studies of proliferating cell nuclear antigen and cathepsin D in transitional cell carcinoma of the urinary bladder.
Immunolocalisation of aspartic proteinases in the developing human stomach.
Immunolocalization of cathepsin D in normal and neoplastic human tissues.
In vitro activation of pro-cathepsin B by three serine proteinases: leucocyte elastase, cathepsin G, and the urokinase-type plasminogen activator.
Inactivation of cathepsin D from human gastric mucosa and from stomach carcinoma by diazoacetyl-DL-norleucine methyl ester.
Increased plasma cathepsin D concentration in hepatic carcinoma and cirrhosis but not in breast cancer.
Intracytoplasmic localization of cathepsin D reflects the invasive potential of gastric carcinoma.
MIB1 proliferation index in breast infiltrating carcinoma: comparison with other proliferative markers and association with new biological prognostic factors.
New functional aspects of cathepsin D and cathepsin E.
Nm23 and cathepsin D expression in laryngeal carcinomas.
Overexpression Cathepsin D Contributes to Perineural Invasion of Salivary Adenoid Cystic Carcinoma.
Pathological and biological features of mammographically detected invasive breast carcinomas.
Pre-operative urinary cathepsin D is associated with survival in patients with renal cell carcinoma.
Prognostic significance of angiogenesis and immunoreactivity of cathepsin D and type IV collagen in high-grade stage T1 primary bladder cancer.
Prognostic significance of the metastasis-inducing protein S100A4 (p9Ka) in human breast cancer.
Prognostic value of cytosolyc cathepsin D content in resectable gastric cancer.
Prognostic value of p53 expression in early-stage breast-carcinoma compared with tumor angiogenesis, epidermal growth-factor receptor, C-erbb-2, cathepsin-d, DNA-ploidy, parameters of cell-kinetics and conventional features.
Proliferation Markers and EGF in ACTH-Secreting Adenomas and Carcinomas of the Pituitary.
Protease levels in breast, ovary, and other gynecological tumor tissues: prognostic importance in breast cancer.
Proteases associated with gynecological tumors.
Quantitative immunohistochemical determination of cathepsin D levels in prostatic carcinoma biopsies. Correlation with tumor grade, stage, PSA level, and DNA ploidy status.
Regulation of cathepsin D dependent on the phenotype of colon carcinoma cells.
Relationship of tumoral hyaluronic acid and cathepsin D contents with histological type of gastric carcinoma.
Salivary duct carcinoma. Part II. Immunohistochemical evaluation of 13 cases for estrogen and progesterone receptors, cathepsin D, and c-erbB-2 protein.
Significance of estrogen receptors and cathepsin D tissue detection in gastric adenocarcinoma.
Significance of the tumor protease Cathepsin D for the biology of breast cancer.
Steroid receptors, pS2 and cathepsin D in early clinically node-negative breast cancer.
Studies of the activities of lysosomal enzymes in serum and buccal pouch tissue of hamsters during 7,12-dimethylbenz[a]anthracene-induced carcinogenesis.
Tenascin C and cathepsin d expression in adipocytic tumors: an immunohistochemical investigation of 43 cases.
The diagnostic value of lysosomal enzyme patterns in bronchial aspirates of patients with suspected bronchial carcinoma.
The effect of combined therapy on activity of cathepsin D and alpha-1-antitrypsin in the blood serum of women with cervical cancer.
The pathology of low-grade adenosquamous carcinoma of the breast. An immunohistochemical study.
The potential prognostic value of cathepsin D protein in serous ovarian cancer.
The prognostic value of the expression of collagenase IV, cathepsin D and metallothionein in squamous cell carcinomas of the skin determined by immunohistochemistry.
The state of differentiation of HT-29 colon carcinoma cells alters the secretion of cathepsin D and of plasminogen activator.
The value of the lysosomal protease cathepsin-d in egyptian bladder-cancer.
Urokinase-type plasminogen activator, plasminogen activator inhibitor type 1 and cathepsin D: analysis of their prognostic significance in squamous cell carcinoma of the head and neck.
[A comparism between lysosomal enzyme activity in normal ectocervical squamous epithelium and squamous carcinoma of the ectocervix]
[Axillary lymph node involvement in hormone-independent breast carcinomas]
[Cathepsin D activity in human ovarian carcinoma]
[CYFRA 21.1 cytosol levels in lung adenocarcinomas. Correlation with other clinico-biological parameters]
[Cytosolic cathepsin D levels in squamous carcinomas of the lung]
[Expression of Cath-D, P-gp and Her-2 in carcinoma of the cardia]
[Immunohistochemical study of Cath-D and CD44 in laryngeal squamous cell carcinomas]
[Study of the cytosolic concentrations of the tissue poly-peptide specific (TPS) antigen in infiltrating ductal carcinomas of the breast. Positive relationship with hormone dependency and negative with cellular proliferation]
[The function of lymphangiogenesis and the expression of Cathepsin D in laryngeal carcinoma metabasis].
Carcinoma, Adenoid Cystic
Corrigendum: Overexpression Cathepsin D Contributes to Perineural Invasion of Salivary Adenoid Cystic Carcinoma.
Immuno-histochemical evaluation of Cathepsin D in malignant salivary gland carcinomas.
Overexpression Cathepsin D Contributes to Perineural Invasion of Salivary Adenoid Cystic Carcinoma.
Carcinoma, Ductal
Analysis of cathepsin D in human breast cancer: usefulness of the processed 31 kDa active form of the enzyme as a prognostic indicator in node-negative and node-positive patients.
Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study.
Cathepsin D in host stromal cells, but not in tumor cells, is associated with aggressive behavior in node-negative breast cancer.
Clinical and Biological Significance of Cathepsin D Levels in Breast Cancer Cytosol in Women Over 70 years.
Correlation between laminin and cathepsin D expressions in breast carcinoma.
Effect of tumor size on the association between ps2 and cathepsin-d in primary breast-cancer.
Enzyme-linked immunosorbent assay of HER-2/neu gene product (p185) in breast cancer: its correlation with sex steroid receptors, cathepsin D and histologic grades.
Expression of cathepsin D and galectin 3 in tubular carcinomas of the breast.
Histological grade in breast cancer: association with clinical and biological features in a series of 229 patients.
Immunohistochemical expression of uPA, PAI-1, cathepsin D and apoptotic cells in ductal carcinoma in situ of the breast.
Prognostic significance of immunohistochemical analysis of cathepsin D in low-stage breast cancer.
Prognostic value of cathepsin D expression and association with histomorphological subtypes in breast cancer.
Reduced clinicopathological influence of hormone-dependence on breast carcinomas in women older than 70 years.
Significance of the tumor protease Cathepsin D for the biology of breast cancer.
Carcinoma, Endometrioid
Clinical prognostic factors and expression of cathepsin D in endometrioid adenocarcinoma.
Carcinoma, Hepatocellular
Altered intracellular processing and enhanced secretion of procathepsin D in a highly deviated rat hepatoma.
Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum.
Cathepsin D associates with lysosomal membranous protein.
Cathepsin D serum mass concentrations in patients with hepatocellular carcinoma and/or liver cirrhosis.
Cloning and sequence analysis of cDNA for human cathepsin D.
DNA and protein content as cellular biochemical parameters. A discussion with two examples: acid phosphatase and cathepsin D in rat liver and hepatoma and acid phosphatase in human breast normal tissue and adenocarcinoma.
Elevated activity and increased mannose-6-phosphate in the carbohydrate moiety of cathepsin D from human hepatoma.
Elevated carbohydrate phosphotransferase activity in human hepatoma and phosphorylation of cathepsin D.
Excision of foreign gene product with cathepsin D in chicken hepatoma cell line.
Expressions of chromogranin A and cathepsin D in human primary hepatocellular carcinoma.
Increased plasma cathepsin D concentration in hepatic carcinoma and cirrhosis but not in breast cancer.
Influence of Ukrain and cyclophosphamide administration on HA-1 murine hepatoma and LS lymphoma on aspartic proteinase cathepsin D.
Mannose 6-phosphate-independent targeting of cathepsin D to lysosomes in HepG2 cells.
Proteolytic activation of internalized cholera toxin within hepatic endosomes by cathepsin D.
Proteomic analysis of differential protein expression in a human hepatoma revertant cell line by using an improved two-dimensional electrophoresis procedure combined with matrix assisted laser desorption/ionization-time of flight-mass spectrometry.
Purification and properties of cathepsin D from rat Yoshida ascites hepatoma AH-130.
Small guanosine triphosphatase Rho/Rho-associated kinase as a novel regulator of intracellular redistribution of lysosomes in invasive tumor cells.
Sphingomyelins suppress the targeted disruption of lysosomes/endosomes by the photosensitizer NPe6 during photodynamic therapy.
[Carbohydrate phosphotransferase in human hepatoma and phosphorylation of cathepsin D]
[Cysteine proteinases and their inhibitors in the development of mouse HA-1 hepatoma and antineoplastic therapy]
[Tumor-associated impairment of the processing of hepatoma cathepsin D]
Carcinoma, Intraductal, Noninfiltrating
Analysis of cathepsin D in human breast cancer: usefulness of the processed 31 kDa active form of the enzyme as a prognostic indicator in node-negative and node-positive patients.
Dissociated overexpression of cathepsin D and estrogen receptor alpha in preinvasive mammary tumors.
Immunohistochemical expression of uPA, PAI-1, cathepsin D and apoptotic cells in ductal carcinoma in situ of the breast.
Carcinoma, Lewis Lung
Antimetastatic activity of adriamycin in combinations with proteinase inhibitors in mice.
Carcinoma, Lobular
Immunohistochemical profile of invasive lobular carcinoma of the breast: predominantly vimentin and p53 protein negative, cathepsin D and oestrogen receptor positive.
Significance of the tumor protease Cathepsin D for the biology of breast cancer.
Carcinoma, Medullary
Immunohistochemical detection of nm23/NDP kinase and cathepsin D in medullary carcinomas of the thyroid gland.
Carcinoma, Mucoepidermoid
Immuno-histochemical evaluation of Cathepsin D in malignant salivary gland carcinomas.
Carcinoma, Non-Small-Cell Lung
Clinicopathological significance of cathepsin D expression in non-small cell lung cancer is conditional on apoptosis-associated protein phenotype: an immunohistochemistry study.
Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer.
Immunostaining of cathepsin-d in nonsmall cell lung-cancer - correlations with morphological and biological parameters.
Secretion of a latent, acid activatable cathepsin L precursor by human non-small cell lung cancer cell lines.
[Expression and prognostic relation of cathepsin D in non-small cell lung cancer tissues and lymph nodes]
Carcinoma, Ovarian Epithelial
Autoantibodies to tumor-associated antigens in epithelial ovarian carcinoma.
Combination of new biologic parameters as a prognostic index in epithelial ovarian carcinoma.
The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer.
Carcinoma, Papillary
Expression, localization, and thyrotropin regulation of cathepsin D in human thyroid tissues.
Carcinoma, Renal Cell
Cathepsin D expression in renal cell cancer-clinical implications.
Cathepsin D serum levels are not a valid serum marker in renal cell carcinoma.
Pre-operative urinary cathepsin D is associated with survival in patients with renal cell carcinoma.
Carcinoma, Small Cell
Immunohistochemical markers of prolonged survival in small cell carcinoma of the lung. An immunohistochemical study.
Carcinoma, Squamous Cell
Cathepsin B and D expression in squamous cell carcinoma.
Cathepsin D and PAI-1 expression in human head and neck cancer.
Cathepsin D in tissue and serum of patients with squamous cell carcinoma of the head and neck.
Cathepsin D is secreted from M-BE cells: its potential role as a biomarker of lung cancer.
Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study.
Evaluation of the prognostic significance of nm23/NDP kinase and cathepsin D in anal carcinomas. An immunohistochemical study.
Expression of cathepsin D and B in invasion and metastasis of squamous cell carcinoma.
Expression of cathepsins B, D and K in thymic epithelial tumours.
Immunohistochemical expression of cathepsin D in laryngeal epithelial lesions: correlation with CD44 expression, p53 and Rb status and proliferation associated indices.
Immunohistochemical Expression of Cathepsin D in Primary and Recurrent Squamous Cell Carcinoma.
The prognostic value of the expression of collagenase IV, cathepsin D and metallothionein in squamous cell carcinomas of the skin determined by immunohistochemistry.
Urokinase-type plasminogen activator, plasminogen activator inhibitor type 1 and cathepsin D: analysis of their prognostic significance in squamous cell carcinoma of the head and neck.
[Cytosolic cathepsin D levels in squamous carcinomas of the lung]
[Immunohistochemical study of Cath-D and CD44 in laryngeal squamous cell carcinomas]
Carcinoma, Transitional Cell
Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging.
Immunohistochemical studies of proliferating cell nuclear antigen and cathepsin D in transitional cell carcinoma of the urinary bladder.
Prognostic significance of angiogenesis and immunoreactivity of cathepsin D and type IV collagen in high-grade stage T1 primary bladder cancer.
Cardiac Tamponade
Pericardial tamponade-induced myocardial ischemic injury.
Cardiomegaly
Increased myocardial cathepsin D activity during regression of thyrotoxic cardiac hypertrophy.
The pathways of protein synthesis and degradation in normal heart and during development and regression of cardiac hypertrophy.
Cardiomyopathies
Biomarkers and Their Relation to Cardiac Function Late After Peripartum Cardiomyopathy.
Inhibition of the Notch1 pathway induces peripartum cardiomyopathy.
Is there cardiac risk in panic disorder? An updated systematic review.
Cardiomyopathy, Dilated
Autophagic degeneration and death of cardiomyocytes in heart failure.
Cardiotoxicity
Lysosomal alterations in heart and liver of mice treated with doxorubicin.
Cardiovascular Diseases
High levels of cathepsin D and cystatin B are associated with increased risk of coronary events.
Increased Cathepsin D Correlates with Clinical Parameters in Newly Diagnosed Type 2 Diabetes.
Relation between serum cathepsin D levels and endothelial dysfunction in patients with chronic kidney disease.
[Analysis of Urine Proteome in Patients With Postinfarction Cardiosclerosis Combined With Hypertensive Disease for Assessing Endothelial Dysfunction].
Cataract
Link between neurodegeneration and trabecular meshwork injury in glaucomatous patients.
TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation.
cathepsin d deficiency
Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation.
Cathepsin D deficiency and NCL/Batten disease: there's more to death than apoptosis.
Cathepsin D Deficiency and NCL/Batten Disease: There's More to Death than Apoptosis.
Cathepsin D deficiency causes juvenile-onset ataxia and distinctive muscle pathology.
Cathepsin D deficiency delays central nervous system myelination by inhibiting proteolipid protein trafficking from late endosome/lysosome to plasma membrane.
Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling.
Cathepsin D deficiency induces cytoskeletal changes and affects cell migration pathways in the brain.
Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons.
Cathepsin D deficiency induces oxidative damage in brain pericytes and impairs the blood-brain barrier.
Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis.
Cathepsin D deficiency is associated with a human neurodegenerative disorder.
Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis.
Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.
Congenital ovine neuronal ceroid lipofuscinosis--a cathepsin D deficiency with increased levels of the inactive enzyme.
Genetic modifiers of degeneration in the cathepsin D deficient Drosophila model for neuronal ceroid lipofuscinosis.
Haematopoietic development and immunological function in the absence of cathepsin D.
Metabolic epilepsies: approaches to a diagnostic challenge.
Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.
Murine cathepsin D deficiency is associated with dysmyelination/myelin disruption and accumulation of cholesteryl esters in the brain.
Novel mutation and the first prenatal screening of cathepsin D deficiency (CLN10).
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway.
Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice-An Animal Model of CLN10 Disease.
Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking.
Synaptic changes in the thalamocortical system of cathepsin D-deficient mice: a model of human congenital neuronal ceroid-lipofuscinosis.
cathepsin l deficiency
Epidermal differentiation: the role of proteases and their inhibitors.
Central Nervous System Neoplasms
Immunolocalization of cathepsin D in the human central nervous system and central nervous system neoplasms.
Cerebellar Diseases
Cerebellar dysfunction in a family harboring the PSEN1 mutation co-segregating with a Cathepsin D variant p.A58V.
Cerebral Amyloid Angiopathy, Familial
A beta-amyloid peptide variant related with familial Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis is poorly eliminated by cathepsin D.
Hereditary cerebral hemorrhage with amyloidosis (Dutch): a model for congophilic plaque formation without neurofibrillary pathology.
Cerebral Hemorrhage
A beta-amyloid peptide variant related with familial Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis is poorly eliminated by cathepsin D.
Hereditary cerebral hemorrhage with amyloidosis (Dutch): a model for congophilic plaque formation without neurofibrillary pathology.
Chemical and Drug Induced Liver Injury
[Structuro-functional changes in dog liver and regional lymph node lysosomes in toxic hepatitis]
Cholera
Comparative responsiveness of HL-60, HL-60R, and HL-60R+ (LRARSN) cells to retinoic acid, calcitriol, 9 cis-retinoic acid, and sodium butyrate.
Proteolytic activation of internalized cholera toxin within hepatic endosomes by cathepsin D.
Role of receptor-mediated endocytosis, endosomal acidification and cathepsin D in cholera toxin cytotoxicity.
Cholesteatoma
Gene expression analysis of human middle ear cholesteatoma using complementary DNA arrays.
Immunohistochemical investigations of cathepsin D activity in the structures of cholesteatoma.
Chondrosarcoma
Implication of granulocyte-macrophage colony-stimulating factor induced neutrophil gelatinase-associated lipocalin in pathogenesis of rheumatoid arthritis revealed by proteome analysis.
[Indices of proteolysis in evaluation of resorption in bone tumors]
Choroid Plexus Neoplasms
Immunolocalization of cathepsin D in the human central nervous system and central nervous system neoplasms.
Chronic Periodontitis
Amplified crevicular leukocyte activity in aggressive periodontal disease.
Colitis
Cathepsin D is up-regulated in inflammatory bowel disease macrophages.
Sphingomyelin and phosphatidylcholine contrarily affect the induction of apoptosis in intestinal epithelial cells.
Colonic Diseases
Expression of hormone receptors, cathepsin D, and HER-2/neu oncoprotein in normal colon and colonic disease.
Colonic Neoplasms
Cathepsin D and carcino-embryonic antigen in serum, urine and tissues of colon adenocarcinoma patients.
Cigarette smoke extracts induced the colon cancer migration via regulating epithelial mesenchymal transition and metastatic genes in human colon cancer cells.
Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis.
Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells.
Increased expression of cathepsin D is required for L1-mediated colon cancer progression.
Lysosomal exoglycosidases and cathepsin D in colon adenocarcinoma.
New cathepsin d inhibitors with hydroxyethylamine isosteres: preparation and characterization.
[Activity of cathepsin D in some neoplasms of the gastrointestinal tract]
Colorectal Neoplasms
Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D release.
Activation of cathepsin B, secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D.
Activity of cathepsin B and D in colorectal cancer: relationships with tumour budding.
Cancer with low cathepsin D levels is susceptible to V-ATPase inhibition.
Cathepsin D activity in colorectal cancer.
Cathepsin D content in colorectal cancer. Correlation with cathepsin D activity and other biological parameters: a preliminary report.
Cathepsin D cytosol content in colorectal cancer.
Cathepsin D expression as a possible predictor of lymph node metastasis in submucosal colorectal cancer.
Cathepsin D expression in colorectal adenocarcinomas and adenomas.
Cathepsin D Expression in Colorectal Cancer: From Proteomic Discovery through Validation Using Western Blotting, Immunohistochemistry, and Tissue Microarrays.
Cathepsin D expression in human colorectal cancer: relationship with tumour type and tissue differentiation grade.
Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria.
Cathepsin D protein levels in colorectal tumors: divergent expression patterns suggest complex regulation and function.
Cathepsin-d activity levels in colorectal-cancer - correlation with cathepsin-B and cathepsin-L and other biological and clinical-parameters.
CD44 expression in colorectal cancer. An immunohistochemical study including correlation with cathepsin D immunoreactivity and some tumour clinicopathological features.
Direct-S: a directed mass spectrometry method for biomarker verification in native serum.
Evaluation of serum cathepsin B and D in relation to clinicopathological staging of colorectal cancer.
Glycoprotein CD44 expression in colorectal neoplasms. An immuno-histochemical study including correlation with cathepsin D, extracellular matrix components, p53, Rb, bcl-2, c-erbB-2, EGFR and proliferation indices.
Hyperplex-MRM: A Hybrid Multiple Reaction Monitoring Method Using mTRAQ/iTRAQ Labeling for Multiplex Absolute Quantification of Human Colorectal Cancer Biomarker.
Immunohistochemical analysis and prognostic value of cathepsin D determination in laryngeal squamous cell carcinoma.
Immunohistochemical evaluation of cathepsin D expression in colorectal cancer.
Immunohistochemical evaluation of cathepsin D expression in colorectal tumours: a correlation with extracellular matrix components, p53, pRb, bcl-2, c-erbB-2, EGFR and proliferation indices.
Immunohistochemical localization of cathepsin D in colorectal tumors.
Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer.
Immunohistochemical p53 overexpression correlated to c-erbB-2 and cathepsin D proteins in colorectal cancer.
Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells.
MUC1 and cathepsin D expression in early colorectal carcinoma showing V type pit pattern.
Mutational and expressional analysis of cathepsin D in gastric and colorectal cancers with microsatellite instability.
Novel proteomic strategy reveal combined alpha1 antitrypsin and cathepsin D as biomarkers for colorectal cancer early screening.
Prognostic evaluation of metallothionein expression in human colorectal neoplasms.
Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenascin-C expression in colorectal carcinoma.
Relationship between cathepsin B, cathepsin D expression and biological behaviour in mucinous colorectal carcinoma.
Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D.
Serum proteolytic activities and antiproteases in human colorectal carcinoma.
The expression of multiple proteins as prognostic factors in colorectal cancer: cathepsin D, p53, COX-2, epidermal growth factor receptor, C-erbB-2, and Ki-67.
The immunohistochemical expression of cathepsin D in colorectal cancer.
Tumour budding intensity in relation to cathepsin D expression and some clinicopathological features of colorectal cancer.
Coronary Artery Disease
Beneficial effects of ibuprofen in pacing-induced myocardial ischemia.
Cardiac allograft rejection late after transplantation is a risk factor for graft coronary artery disease.
Cortical cathepsin D activity and immunolocalization in Alzheimer disease, critical coronary artery disease, and aging.
Early recurrent arrhythmias after out-of-hospital cardiac arrest associated with obstructive coronary artery disease: Analysis of the PROCAT registry.
Evaluation of serum cathepsin D concentrations in coronary artery disease.
Prevalence of Subclinical Coronary Artery Disease in Middle-Aged, Male Marathon Runners Detected by Cardiac CT.
Craniopharyngioma
Cathepsin B, D and K expression in adamantinomatous craniopharyngiomas relates to their levels of differentiation as determined by the patterns of retinoic acid receptor expression.
Creutzfeldt-Jakob Syndrome
Cathepsin D (C224T) Polymorphism in Sporadic and Genetic Creutzfeldt-Jakob Disease.
Cathepsin D SNP associated with increased risk of variant Creutzfeldt-Jakob disease.
Genetic Association of a Cathepsin D Polymorphism and Sporadic Creutzfeldt-Jakob Disease.
Involvement of the endosomal-lysosomal system correlates with regional pathology in Creutzfeldt-Jakob disease.
Crohn Disease
Cathepsin D is up-regulated in inflammatory bowel disease macrophages.
Cryptorchidism
The effect of cryptorchidism on the quantitative histology, histochemistry and hydrolytic enzyme activity of the rat testis.
Cystadenoma
Ki-67 staining in benign, borderline, malignant primary and metastatic ovarian tumors: correlation with steroid receptors, epidermal-growth-factor receptor and cathepsin D.
Cystic Fibrosis
The activity of cathepsin D in saliva of cystic fibrosis patients.
Cystinosis
Lysosomal enzymuria is a feature of hereditary Fanconi syndrome and is related to elevated CI-mannose-6-P-receptor excretion.
Cysts
Cathepsin D and epidermal growth factor in human breast cyst fluid.
Distribution of Lysosome-associated Membrane Proteins-1 and -2, and Cathepsin D in Eosinophilic Granular Bodies: Possible Relationship to Cyst Development in Pilocytic Astrocytomas.
Quantification and molecular analysis of cathepsin D in breast cyst fluids.
Relationships between oestrogen-inducible proteins, oestradiol and electrolyte ratio in breast cyst fluid.
Cytomegalovirus Infections
[Effects of HCMV on phenotypes of parotid duct epithelial cells and its mechanisms]
Death, Sudden, Cardiac
Myocardial cathepsin D is downregulated in sudden cardiac death.
Significances of viable synergistic autophagy-associated cathepsin B and cathepsin D (CTSB/CTSD) as potential biomarkers for sudden cardiac death.
Dementia
Cathepsin D Polymorphism C224T in Childhood-Onset Neurodegenerative Disorders: No Impact for Childhood Dementia.
Identification of Cathepsin D as a Plasma Biomarker for Alzheimer's Disease.
Immunodetection of cathepsin D in neuritic plaques found in brains of patients with dementia of Alzheimer type.
Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration.
New insights into the roles of endolysosomal cathepsins in the pathogenesis of Alzheimer's disease: cathepsin inhibitors as potential therapeutics.
Dementia, Vascular
Genetic polymorphism in exon 2 of cathepsin D is not associated with vascular dementia.
Demyelinating Diseases
Changes induced in astrocyte cathepsin D by cytokines and leupeptin.
The use of protease inhibitors in experimental allergic neuritis.
Dent Disease
Lysosomal enzymuria is a feature of hereditary Fanconi syndrome and is related to elevated CI-mannose-6-P-receptor excretion.
Dermatitis, Phototoxic
Lysosome-associated miniSOG as a photosensitizer for mammalian cells.
Diabetes Mellitus
The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach.
Diabetes Mellitus, Type 1
Urine RAS components in mice and people with type 1 diabetes and chronic kidney disease.
Diabetes Mellitus, Type 2
Exendin-4 stimulates autophagy in pancreatic ?-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis.
Increased Cathepsin D Correlates with Clinical Parameters in Newly Diagnosed Type 2 Diabetes.
Plasma Cathepsin D Activity Rather Than Levels Correlates With Metabolic Parameters of Type 2 Diabetes in Male Individuals.
Diabetic Cardiomyopathies
Lysosomal and nonlysosomal proteolytic activities in experimental diabetic cardiomyopathy.
Diabetic Foot
Cathepsin-D, Adiponectin, TNF-?, IL-6 and hsCRP plasma levels in subjects with diabetic foot and possible correlation with clinical variables: A multicentric study.
Meta-analysis for assessing the healing process of ulcers among diabetic patients: Cases of HbA1c, lipid, S. Creatinine, Adiponectin, Cat D, HSP70, HSP47, 25-hydroxy vitamin D.
Diabetic Nephropathies
Urinary cathepsin L is predictive of changes in albuminuria and correlates with glucosepane in patients with type 2 diabetes in a closed-cohort study.
Diabetic Retinopathy
Cathepsin D plays a role in endothelial-pericyte interactions during alteration of the blood-retinal barrier in diabetic retinopathy.
Cathepsin D: an M?-derived factor mediating increased endothelial cell permeability with implications for alteration of the blood-retinal barrier in diabetic retinopathy.
Diffuse Cerebral Sclerosis of Schilder
Metabolic epilepsies: approaches to a diagnostic challenge.
Disorders of Sex Development
Sex differences in autophagy-mediated diseases: toward precision medicine.
Down Syndrome
Colocalization of lysosomal hydrolase and beta-amyloid in diffuse plaques of the cerebellum and striatum in Alzheimer's disease and Down's syndrome.
Drug-Related Side Effects and Adverse Reactions
CHEMOTHERAPY DRUG RESPONSE IN OVARIAN CANCER CELLS STRICTLY DEPENDS ON A CATHEPSIN D - BAX ACTIVATION LOOP.
Dyslipidemias
Evaluation of serum cathepsin D concentrations in coronary artery disease.
Dysplastic Nevus Syndrome
Activity, expression, and transcription rate of the cathepsins B, D, H, and L in cutaneous malignant melanoma.
Expression of cathepsin D in primary and metastatic human melanoma and dysplastic nevi.
Encephalomyelitis
Astrocytosis and cathepsin D activity in experimental measles encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Mitigation of experimental allergic encephalomyelitis by cathepsin D inhibition.
Treatment of experimental allergic encephalomyelitis with an inhibitor of cathepsin D (pepstatin).
Endometrial Neoplasms
Cathepsin D expression in normal, hyperplastic and malignant endometrial tissue: an immunohistochemical analysis.
Cathepsin D expression levels in nongynecological solid tumors: clinical and therapeutic implications.
Differential regulation of cathepsin D by sex steroids in mammary cancer and uterine cells.
Epitope recognition by anti-cathepsin D autoantibodies in endometrial cancer patients.
Estrogen and aryl hydrocarbon responsiveness of ECC-1 endometrial cancer cells.
Hormonal regulation of cathepsin D following transfection of the estrogen or progesterone receptor into three sex steroid hormone resistant cancer cell lines.
Immunohistochemical evaluation of cathepsin D in normal, hyperplastic and malignant endometrium: correlation with hormone receptor status c-erbB-2, p53, Rb proteins and proliferation associated indices.
Immunohistochemical studies concerning cathepsin D in endometrial carcinomas.
Insensitivity of cathepsin D gene to estradiol in endometrial cells is determined by the sequence of its estrogen responsive element.
Low levels of cathepsin D are associated with a poor prognosis in endometrial cancer.
Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.
May cathepsin D immunoreactivity be used as a prognostic factor in endometrial carcinomas? A comparative immunohistochemical study.
Overexpression and hormonal regulation of pro-cathepsin D in mammary and endometrial cancer.
Quantitative analyses of epidermal growth factor receptors, HER-2/neu oncoprotein and cathepsin D in nonmalignant and malignant uteri.
Significance of cathepsin-D expression in uterine tumours.
[The prognostic value of cathepsin D in endometrial carcinoma]
Endometriosis
Increased concentrations of cathepsin D in peritoneal fluid from women with endometriosis.
Endotoxemia
Plasma lysosomal enzymes in experimental and clinical endotoxemia.
Enterocolitis, Necrotizing
Cathepsin D in intestinal ganglion cells. A potential aid to diagnosis in suspected Hirschsprung's disease.
Epilepsy
Metabolic epilepsies: approaches to a diagnostic challenge.
Esophageal Squamous Cell Carcinoma
Correlation between cathepsin D expression and p53 protein nuclear accumulation in oesophageal squamous cell carcinoma.
Fatty Liver
Cathepsin D regulates lipid metabolism in murine steatohepatitis.
Increased plasma cathepsin D concentration in hepatic carcinoma and cirrhosis but not in breast cancer.
Inhibiting Extracellular Cathepsin D Reduces Hepatic Steatosis in Sprague?Dawley Rats †.
Inhibition of Extracellular Cathepsin D Reduces Hepatic Lipid Accumulation and Leads to Mild Changes in Inflammationin NASH Mice.
Limited applicability of cathepsin D for the diagnosis and monitoring of non-alcoholic steatohepatitis.
Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention.
Fibroadenoma
Correlation between laminin and cathepsin D expressions in breast carcinoma.
Fibrocystic Breast Disease
Cytosol cathepsin D in Thai women with breast cancer.
Western blotting and enzymatic activity analysis of cathepsin D in breast tissue and sera of patients with breast cancer and benign breast disease and of normal controls.
Fibromatosis, Aggressive
Immunohistochemical analysis of desmoid tumours.
Fibrosarcoma
Endosomal-lysosomal proteolysis mediates death signalling by TNFalpha, not by etoposide, in L929 fibrosarcoma cells: evidence for an active role of cathepsin D.
Foot Ulcer
Cathepsin-D, Adiponectin, TNF-?, IL-6 and hsCRP plasma levels in subjects with diabetic foot and possible correlation with clinical variables: A multicentric study.
Foot-and-Mouth Disease
T cell-stimulatory fragments of foot-and-mouth disease virus released by mild treatment with cathepsin D.
Frontotemporal Dementia
Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease.
Cathepsin d in a murine model of frontotemporal dementia with parkinsonism-linked to chromosome 17.
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43.
Frontotemporal Lobar Degeneration
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Regulation of cathepsin D activity by the FTLD protein progranulin.
The role of lysosomes and autophagosomes in frontotemporal lobar degeneration.
Ganglioneuroma
Cathepsin D in intestinal ganglion cells. A potential aid to diagnosis in suspected Hirschsprung's disease.
Gaucher Disease
Aberrant progranulin, YKL-40, cathepsin D and cathepsin S in Gaucher disease.
Geographic Atrophy
Progressive age-related changes similar to age-related macular degeneration in a transgenic mouse model.
Gingivitis
Increase of extracellular cathepsin D activity in gingival washings during experimental gingivitis in man.
Glioblastoma
Adhesive and invasive features in gliomas.
Autophagy and lysosomal related protein expression patterns in human glioblastoma.
Cathepsin D is a potential serum marker for poor prognosis in glioma patients.
Expression of adhesion factors and degrading proteins in primary and secondary glioblastomas and their precursor tumors.
Expression of cathepsin D during the progression of human gliomas.
Inhibition of Cathepsin D (CTSD) enhances radiosensitivity of glioblastoma cells by attenuating autophagy.
Overexpression of Lipocalin-2 Inhibits Proliferation and Invasiveness of Human Glioblastoma Multiforme Cells by Activating ERK Targeting Cathepsin D Expression.
Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma.
WIN55,212-2 induces caspase-independent apoptosis on human glioblastoma cells by regulating HSP70, p53 and Cathepsin D.
Glioma
Adhesive and invasive features in gliomas.
Alterations of the posttranslational processing of a lysosomal enzyme in C6 glioma cells.
Cathepsin D and its prognostic value in neuroepithelial brain tumors.
Cathepsin D is a potential serum marker for poor prognosis in glioma patients.
Expression of cathepsin D during the progression of human gliomas.
Inhibition of Cathepsin D (CTSD) enhances radiosensitivity of glioblastoma cells by attenuating autophagy.
Inhibition of glioma cell lysosome exocytosis inhibits glioma invasion.
Lysosomal ceramide mediates gemcitabine-induced death of glioma cells.
Protein alterations associated with temozolomide resistance in subclones of human glioblastoma cell lines.
Glomerulonephritis
Changes in lysosome populations in the rat kidney cortex induced by passive Heymann glomerulonephritis.
The role of cathepsin D in pathogenesis of acute post-streptococcal glomerulonephritis.
glucan 1,4-alpha-glucosidase deficiency
Immunocytochemical studies of cathepsin D in human skeletal muscle.
Glycogen Storage Disease Type II
Biosynthesis of acid alpha-glucosidase in late-onset forms of glycogenosis type II (Pompe's disease).
Immunocytochemical studies of cathepsin D in human skeletal muscle.
Granuloma
A Comparative Study of Cathepsin D Expression in Peripheral and Central Giant Cell Granuloma of the Jaws by Immunohistochemistry Technique.
Effects of phenylbutazone on the activities of cathepsin D, collagenolytic cathepsin and collagen peptidase in turpentine-induced granuloma.
High gene expression of inflammatory markers and IL-17A correlates with severity of injection site reactions of Atlantic salmon vaccinated with oil-adjuvanted vaccines.
[Lysosomal enzymes of phagocytizing cells in the pathogenesis of inflammation]
Granuloma, Giant Cell
A Comparative Study of Cathepsin D Expression in Peripheral and Central Giant Cell Granuloma of the Jaws by Immunohistochemistry Technique.
Graves Disease
Estrogen receptors and cathepsin D in human thyroid tissue.
Expression, localization, and thyrotropin regulation of cathepsin D in human thyroid tissues.
Head and Neck Neoplasms
Cathepsin D and PAI-1 expression in human head and neck cancer.
Expression of cathepsin D in head and neck cancer.
Heart Arrest
Benefit of an early and systematic imaging procedure after cardiac arrest: Insights from the PROCAT (Parisian Region Out of Hospital Cardiac Arrest) registry.
Gender differences in early invasive strategy after cardiac arrest: Insights from the PROCAT registry.
[Cathepsin D activity and myocardial protein degradation in controlled cardiac arrest during operations with extracorporeal circulation]
[Characteristics of the activation of lysosomal enzymes in the rat liver after death and during resuscitation]
Heart Failure
Multidisciplinary rounds (MDR): an implementation system for sustained improvement in the American Heart Association's Get With The Guidelines program.
Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure.
Proteomic exploration of common pathophysiological pathways in diabetes and cardiovascular disease.
Role of cathepsin D activation in major adverse cardiovascular events and new-onset heart failure after STEMI.
The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach.
Heart Neoplasms
[Expression of Cath-D, P-gp and Her-2 in carcinoma of the cardia]
Hemangioendothelioma
Bone hemangioendothelioma: an immunohistochemical study related to histological malignancy and proliferative activity (NORs).
Hemangioma
Splenic littoral cell haemangioendothelioma: a new low-grade variant of malignant littoral cell tumour.
Hepatitis
Lysosomal enzyme activities in normals and in patients with chronic liver diseases.
Molecular forms of beta-hexosaminidase and cathepsin D in serum and urine of healthy subjects and patients with elevated activity of lysosomal enzymes.
[Change in the state of liver lysosomes and lymphocytes during development of secondary immunodeficiency and in chronic toxic hepatitis]
Hepatitis B
Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling.
Immunohistological investigations of PAS-negative globular intracisternal hyalin in human liver biopsy specimens.
Hepatitis, Chronic
Lysosomal enzyme activities in normals and in patients with chronic liver diseases.
Herpes Simplex
Functional activity of peritoneal macrophages from sensitive and resistant mouse strains during intravaginal infection with herpes simplex virus type 2 and mucosal vaccination.
Intraoral squamous cell carcinoma in human immunodeficiency virus infection. A clinicopathologic study.
Local and Systemic Functional Responses of Mouse Macrophages to Intravaginal Infection with Type 2 Herpes Simplex Virus and Vaccination.
Herpes Zoster
Vitellogenin transport and yolk formation in the quail ovary.
Vitellogenin, zona radiata protein, cathepsin D and heat shock protein 70 as biomarkers of exposure to xenobiotics.
Hirschsprung Disease
Cathepsin D in intestinal ganglion cells. A potential aid to diagnosis in suspected Hirschsprung's disease.
Histiocytic Sarcoma
Immunophenotypic analysis of extranodal non-Hodgkin's lymphomas in the oral cavity.
Histiocytosis
Cathepsin D and E co-expression in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) and Langerhans' cell histiocytosis: further evidences of a phenotypic overlap between these histiocytic disorders.
Histiocytosis, Sinus
Cathepsin D and E co-expression in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) and Langerhans' cell histiocytosis: further evidences of a phenotypic overlap between these histiocytic disorders.
Huntington Disease
Comparison of cathepsin protease activities in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease.
Elevated levels of the endosomal-lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease.
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Hydatidiform Mole
The expression of cathepsin D, oestrogen receptor and progestogen receptor in hydatidiform mole--an immunohistochemical study.
Use of a novel system for defining a gene imprinting region.
Hyperinsulinism
Euglycemic hyperinsulinemia and hyperaminoacidemia decrease skeletal muscle ubiquitin mRNA in goats.
Hyperlipidemias
The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats.
Hypersensitivity
Chromatin structure of the regulatory regions of pS2 and cathepsin D genes in hormone-dependent and -independent breast cancer cell lines.
Hypertension
Aspartic peptidase inhibitors: implications in drug development.
Expression of antiangiogenic prolactin fragments in the placentas of women with pregnancy induced hypertension.
High levels of cathepsin D and cystatin B are associated with increased risk of coronary events.
Proteolytic activities in hypertensive cardiomyopathy of rats.
The relation between serum cathepsin D level and carotid intima-media thickness in nondiabetic hypertensive patients.
Hypertension, Pregnancy-Induced
Expression of antiangiogenic prolactin fragments in the placentas of women with pregnancy induced hypertension.
Hypertension, Pulmonary
Pulmonary pressure reduction attenuates expression of proteins identified by lung proteomic profiling in pulmonary hypertensive rats.
Hyperthyroidism
Effect of altered thyroid status on lysosomal enzymes and thymidylate synthetase activity in tumors and livers of host animals.
[Effect of somatotropin on cathepsin D in the liver of hypo- and hyperthyroid rats]
Hypertriglyceridemia
Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking.
Hypokinesia
Effect of motor activity on cathepsin D activity in rat muscles.
[Influence of delta-sleep-inducing peptide on the activity of proteolytic enzymes in the rat brain under hypokinesia]
Hypoproteinemia
The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats.
Hypotension
Beneficial actions of BN 50739, a new PAF receptor antagonist, in murine traumatic shock.
Plasma lysosomal enzymes in experimental and clinical endotoxemia.
Potentiation of the protective effects of a converting enzyme inhibitor and a thromboxane synthetase inhibitor in hemorrhagic shock.
Protective effects of CG-4203, a novel stable prostacyclin analog, in traumatic shock.
Protective effects of KW-3635, a novel thromboxane A2 antagonist, in murine traumatic shock.
Hypothyroidism
Effect of altered thyroid status on lysosomal enzymes and thymidylate synthetase activity in tumors and livers of host animals.
Infarction, Middle Cerebral Artery
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia.
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Infections
Acid Sphingomyelinase Contributes to the Control of Mycobacterial Infection via a Signaling Cascade Leading from Reactive Oxygen Species to Cathepsin D.
Antiviral and metabolic gene expression responses to viral infection in Atlantic salmon (Salmo salar).
Are tryptase and cathepsin D related to Helicobacter pylori infection and mucosal gastrin in peptic ulcer?
Aspartic peptidase inhibitors: implications in drug development.
Birc1e/Naip5 rapidly antagonizes modulation of phagosome maturation by Legionella pneumophila.
Characterization of cathepsin D from Eriocheir sinensis involved in Spiroplasma eriocheiris infection.
Cutting Edge: A Novel Nonoxidative Phagosomal Mechanism Exerted by Cathepsin-D Controls Listeria monocytogenes Intracellular Growth.
Differential expression profiles in the midgut of Triatoma infestans infected with Trypanosoma cruzi.
Direct delivery of procathepsin D to phagosomes: implications for phagosome biogenesis and parasitism by Mycobacterium.
Effect of enterotoxigenic Escherichia coli heat stable toxin on intestinal lysosomal enzymes in the suckling rat.
Elevated levels of activities of beta-hexosaminidase and alpha-mannosidase in human immunodeficiency virus-infected patients.
Evidence that Dot-dependent and -independent factors isolate the Legionella pneumophila phagosome from the endocytic network in mouse macrophages.
Expression profiles of seven channel catfish antimicrobial peptides in response to Edwardsiella ictaluri infection.
Francisella tularensis strain LVS resides in MHC II-positive autophagic vacuoles in macrophages.
Functional activity of peritoneal macrophages from sensitive and resistant mouse strains during intravaginal infection with herpes simplex virus type 2 and mucosal vaccination.
Immunocytochemical evaluation of gastric mucosal cathepsin D in peptic ulcer.
In-vitro anti-inflammatory and immunomodulatory effects of grepafloxacin in zymogen A- or Staphylococcus aureus-stimulated human THP-1 monocytes.
Infectivity of Trichomonas vaginalis pseudocysts inoculated intra-vaginally in mice.
Influence of Helicobacter pylori on tryptase and cathepsin D in peptic ulcer.
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Local and Systemic Functional Responses of Mouse Macrophages to Intravaginal Infection with Type 2 Herpes Simplex Virus and Vaccination.
Molecular characterization and expression analysis of the channel catfish cathepsin D genes.
Muscovy duck reovirus promotes virus replication by inhibiting autophagy-lysosomal degradation pathway.
Protein regulation strategies of the mouse spleen in response to Babesia microti infection.
Proteomic analysis of murine macrophages mitochondria and lysosomes reveal Cathepsin D as a potential broad-spectrum antimicrobial protein.
Proteotoxic stress induced by Autographa californica nucleopolyhedrovirus infection of Spodoptera frugiperda Sf9 cells.
Sequential metabolic alterations in the myocardium during influenza and tularemia in mice.
The autophagic pathway is actively modulated by phase II Coxiella burnetii to efficiently replicate in the host cell.
The effect of intracellular Chlamydia psittaci on lysosomal enzyme activities in mouse peritoneal macrophages.
Trypanosoma cruzi: effects of infection on cathepsin D activity in the midgut of Rhodnius prolixus.
Virulent and avirulent strains of Francisella tularensis prevent acidification and maturation of their phagosomes and escape into the cytoplasm in human macrophages.
Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells.
[Cathepsin D activity in splenocytes in relation to Shigella virulence in an experiment]
Inflammatory Bowel Diseases
Cathepsin D is up-regulated in inflammatory bowel disease macrophages.
Influenza, Human
Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling.
Sequential metabolic alterations in the myocardium during influenza and tularemia in mice.
[Role of cathepsin D in the appearance of micronuclei in lung cells of mice immunized with influenza vaccine]
Insulin Resistance
Increased Cathepsin D Correlates with Clinical Parameters in Newly Diagnosed Type 2 Diabetes.
Insulin resistance is positively associated with plasma cathepsin D activity in NAFLD patients.
Plasma cathepsin D activity is negatively associated with hepatic insulin sensitivity in overweight and obese humans.
Plasma Cathepsin D Activity Rather Than Levels Correlates With Metabolic Parameters of Type 2 Diabetes in Male Individuals.
Keloid
Expression of Cathepsins B, D and G by the Embryonic Stem Cell-like Population within Human Keloid Tissues and keloid-derived Primary Cell Lines.
Keratosis
Cathepsin B and D expression in squamous cell carcinoma.
Immunohistochemical expression of cathepsin D in laryngeal epithelial lesions: correlation with CD44 expression, p53 and Rb status and proliferation associated indices.
Kidney Neoplasms
Characteristic [3H]glucosamine-labeled glycoproteins in two-dimensional electrophoretograms of human renal cancer cells: identification as cathepsin D.
Kounis Syndrome
Anaphylactic cardiovascular collapse and Kounis syndrome: systemic vasodilation or coronary vasoconstriction?
Laryngeal Neoplasms
Cathepsin D concentration in primary laryngeal cancer: correlation with clinico-pathological parameters, EGFR status and prognosis.
Cathepsin D in laryngeal carcinoma. preliminary report.
Cathepsin D in primary squamous laryngeal tumors: correlation with clinico-pathological parameters and receptor status.
Expression of cathepsin D and E-cadherin in primary laryngeal cancers correlation with neck lymph node involvement.
Expression of cathepsin D in malignant and in the corresponding non-malignant node-negative laryngeal samples: correlation with receptors for androgen, glucocorticoid, oestrogen and progesterone.
Immunohistochemical analysis and prognostic value of cathepsin D determination in laryngeal squamous cell carcinoma.
Immunohistochemical and immunoradiometric evaluations of total cathepsin D in human larynx.
Leiomyoma
Lipid-rich residual bodies and cathepsin D in the human uterus: ultrastructural and quantitative comparison between normal myometrium and leiomyoma.
Leishmaniasis, Cutaneous
P 53 suppressor gene and cathepsin D expression in correlation with cellular and humoral immunity in cutaneous leishmaniasis.
Leukemia
Antimetastatic activity of adriamycin in combinations with proteinase inhibitors in mice.
Involvement of cathepsin D in chemotherapy-induced cytochrome c release, caspase activation, and cell death.
Resveratrol induces autophagic apoptosis via the lysosomal cathepsin D pathway in human drug-resistant K562/ADM leukemia cells.
Leukemia L1210
Cathepsin D of mouse leukemia L1210 cells. Unusual intracellular localization and biochemical properties.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cold agglutinin disease following allogeneic bone marrow transplantation.
Glucosamine sulfate-induced apoptosis in chronic myelogenous leukemia K562 cells is associated with translocation of cathepsin D and downregulation of Bcl-xL.
Leukemia, Myeloid
Leukotoxin kills rodent WBC by targeting leukocyte function associated antigen 1.
Lewy Body Disease
Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration.
Liver Cirrhosis
Cathepsin D serum mass concentrations in patients with hepatocellular carcinoma and/or liver cirrhosis.
Changes in the catalytic activities of proteoglycan-degrading lysosomal enzymes in parenchymal and non-parenchymal liver cells and in serum during the development of experimental liver fibrosis.
Increased plasma cathepsin D concentration in hepatic carcinoma and cirrhosis but not in breast cancer.
Liver Diseases
Increased plasma cathepsin D concentration in hepatic carcinoma and cirrhosis but not in breast cancer.
Myosteatosis in NAFLD patients correlates with plasma Cathepsin D.
Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention.
Liver Failure
Hepatic retinopathy: morphological features of retinal glial (Müller) cells accompanying hepatic failure.
Liver Failure, Acute
Characterization of the molecular forms of fibronectin in fulminant hepatic failure.
Liver Neoplasms
[Activity of cathepsin D in the blood serum and urine of patients with cancer of the stomach, pancreas and liver]
Liver Neoplasms, Experimental
Altered intracellular processing and enhanced secretion of procathepsin D in a highly deviated rat hepatoma.
Lung Diseases
The expression and activity of cathepsins d, h and k in asthmatic airways.
Lung Diseases, Interstitial
Changes in collagen metabolism and proteinolysis after repeated inhalation exposure to ozone.
Lung Injury
Cathepsins in bleomycin-induced lung injury in rat.
Lung Neoplasms
Activity and tissue localization of cathepsin D in non small cell lung cancer.
Cathepsin D expression in skin metastasis of breast cancer.
Cathepsin D is secreted from M-BE cells: its potential role as a biomarker of lung cancer.
Cathepsin D messenger RNA is downregulated in human lung cancer.
Clinicopathological significance of cathepsin D expression in non-small cell lung cancer is conditional on apoptosis-associated protein phenotype: an immunohistochemistry study.
Comparative autoantibody profiling before and after appearance of malignance: Identification of anti-cathepsin D autoantibody as a promising diagnostic marker for lung cancer.
Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer.
Immunostaining of cathepsin-d in nonsmall cell lung-cancer - correlations with morphological and biological parameters.
Proteomic study of malignant pleural mesothelioma by laser microdissection and two-dimensional difference gel electrophoresis identified cathepsin D as a novel candidate for a differential diagnosis biomarker.
Secretion of a latent, acid activatable cathepsin L precursor by human non-small cell lung cancer cell lines.
Skeletal muscle mRNA levels for cathepsin B, but not components of the ubiquitin-proteasome pathway, are increased in patients with lung cancer referred for thoracotomy.
[Expression and prognostic relation of cathepsin D in non-small cell lung cancer tissues and lymph nodes]
Lymphadenitis
Cathepsin D and E co-expression in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) and Langerhans' cell histiocytosis: further evidences of a phenotypic overlap between these histiocytic disorders.
Lymphadenopathy
Cathepsin D and E co-expression in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) and Langerhans' cell histiocytosis: further evidences of a phenotypic overlap between these histiocytic disorders.
Plasma coenzyme Q10 concentrations in breast cancer: prognosis and therapeutic consequences.
Lymphatic Metastasis
Activity and tissue localization of cathepsin D in non small cell lung cancer.
Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study.
Cathepsin D and PAI-1 expression in human head and neck cancer.
Cathepsin D concentration in primary laryngeal cancer: correlation with clinico-pathological parameters, EGFR status and prognosis.
Cathepsin D expression as a possible predictor of lymph node metastasis in submucosal colorectal cancer.
Correlation of tumor cytosol cathepsin D with differentiation and invasiveness of endometrial adenocarcinoma.
Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study.
Expression of cathepsin D and E-cadherin in primary laryngeal cancers correlation with neck lymph node involvement.
Expression of cathepsin D and pS2 in imprint smears of breast carcinoma.
Expression of cathepsin D in head and neck cancer.
Identificating cathepsin D as a biomarker for differentiation and prognosis of nasopharyngeal carcinoma by laser capture microdissection and proteomic analysis.
Immunohistochemical detection of nm23/NDP kinase and cathepsin D in medullary carcinomas of the thyroid gland.
Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer.
Predictive value of cathepsin D and Ki-67 expression at the deepest penetration site for lymph node metastases in gastric cancer.
Prognostic significance of the estrogen-regulated protein, cathepsin D, in breast cancer. An immunohistochemical study.
Significance of the tumor protease Cathepsin D for the biology of breast cancer.
The prognostic significance of p53, mdm2, c-erbB-2, cathepsin D, and thrombocytosis in stage IB cervical cancer treated by primary radical hysterectomy.
The prognostic-significance of cathepsin-d in breast carcinomas - an immunohistochemical study.
The value of the lysosomal protease cathepsin-d in egyptian bladder-cancer.
Tumor growth fraction, expression of estrogen and progesterone receptors, p53, bcl-2 and cathepsin D activity in primary ductal invasive breast carcinoma and their axillary lymph node metastases.
Tumour budding intensity in relation to cathepsin D expression and some clinicopathological features of colorectal cancer.
[A histopathologic and immunohistochemical study of prognostic factors in esophageal squamous cell carcinoma]
[Expression of Cath-D, P-gp and Her-2 in carcinoma of the cardia]
[Immunohistochemical study of Cath-D and CD44 in laryngeal squamous cell carcinomas]
[Study of cathepsin D levels in invasive bladder cancer and its stroma. Correlation with tumor stage, cytological grade, lymph node metastasis and survival]
[The expression of Cath-D, c-erbB-2 and EGFR in breast cancer and its correlation to lymphatic metastasis]
Lymphoma
Enhanced Autophagy and Reduced Expression of Cathepsin D Are Related to Autophagic Cell Death in Epstein-Barr Virus-Associated Nasal Natural Killer/T-Cell Lymphomas: An Immunohistochemical Analysis of Beclin-1, LC3, Mitochondria (AE-1), and Cathepsin D in Nasopharyngeal Lymphomas.
High expression of cathepsin D in non-Hodgkin's lymphomas negatively impacts on clinical outcome.
HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.
Human herpesvirus 8 interleukin-6 contributes to primary effusion lymphoma cell viability via suppression of proapoptotic cathepsin D, a cointeraction partner of vitamin K epoxide reductase complex subunit 1 variant 2.
Influence of Ukrain and cyclophosphamide administration on HA-1 murine hepatoma and LS lymphoma on aspartic proteinase cathepsin D.
Insulin-Like Growth Factor 2 Receptor Expression Is Promoted by Human Herpesvirus 8-Encoded Interleukin-6 and Contributes to Viral Latency and Productive Replication.
Promotion of Endoplasmic Reticulum-Associated Degradation of Procathepsin D by Human Herpesvirus 8-Encoded Viral Interleukin-6.
Lymphoma, B-Cell
Enhanced Autophagy and Reduced Expression of Cathepsin D Are Related to Autophagic Cell Death in Epstein-Barr Virus-Associated Nasal Natural Killer/T-Cell Lymphomas: An Immunohistochemical Analysis of Beclin-1, LC3, Mitochondria (AE-1), and Cathepsin D in Nasopharyngeal Lymphomas.
Glucosamine sulfate-induced apoptosis in chronic myelogenous leukemia K562 cells is associated with translocation of cathepsin D and downregulation of Bcl-xL.
Immunophenotypic analysis of extranodal non-Hodgkin's lymphomas in the oral cavity.
Lymphoma, Non-Hodgkin
Influence of Ukrain and cyclophosphamide administration on HA-1 murine hepatoma and LS lymphoma on aspartic proteinase cathepsin D.
Lymphoma, Primary Effusion
HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.
Human herpesvirus 8 interleukin-6 contributes to primary effusion lymphoma cell viability via suppression of proapoptotic cathepsin D, a cointeraction partner of vitamin K epoxide reductase complex subunit 1 variant 2.
Insulin-Like Growth Factor 2 Receptor Expression Is Promoted by Human Herpesvirus 8-Encoded Interleukin-6 and Contributes to Viral Latency and Productive Replication.
Promotion of Endoplasmic Reticulum-Associated Degradation of Procathepsin D by Human Herpesvirus 8-Encoded Viral Interleukin-6.
Lymphoma, T-Cell
Enhanced Autophagy and Reduced Expression of Cathepsin D Are Related to Autophagic Cell Death in Epstein-Barr Virus-Associated Nasal Natural Killer/T-Cell Lymphomas: An Immunohistochemical Analysis of Beclin-1, LC3, Mitochondria (AE-1), and Cathepsin D in Nasopharyngeal Lymphomas.
Immunophenotypic analysis of extranodal non-Hodgkin's lymphomas in the oral cavity.
Lymphopenia
CNS-expressed cathepsin D prevents lymphopenia in a murine model of congenital neuronal ceroid lipofuscinosis.
Lysosomal Storage Diseases
A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration.
Haematopoietic development and immunological function in the absence of cathepsin D.
Neuronal and microglial cathepsins in aging and age-related diseases.
Presynaptic Endosomal Cathepsin D Regulates the Biogenesis of GABAergic Synaptic Vesicles.
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Macular Degeneration
Distribution of cathepsin D in human eyes with or without age-related maculopathy.
Malaria
Aspartic peptidase inhibitors: implications in drug development.
Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1.
Enzymatic Characterization of Recombinant Food Vacuole Plasmepsin 4 from the Rodent Malaria Parasite Plasmodium berghei.
Identification of Sulfamoylbenzamide derivatives as selective Cathepsin D inhibitors.
Purification of Plasmodium lophurae cathepsin D and its effects on erythrocyte membrane proteins.
Malnutrition
Lack of evidence for elevated breakdown rate of skeletal muscles in weight-losing, tumor-bearing mice.
Mastitis
Peptidomic analysis of healthy and subclinically mastitic bovine milk.
Mastocytoma
[Activity of proteolytic enzymes and their inhibitors during proliferation of P-815 mastocytoma cell proliferation in vitro]
Measles
Astrocytosis and cathepsin D activity in experimental measles encephalomyelitis.
Melanoma
Activity of cathepsin D and ?1-antitrypsin in blood of men with malignant melanoma.
Activity, expression, and transcription rate of the cathepsins B, D, H, and L in cutaneous malignant melanoma.
B16 melanoma secretomes and in vitro invasiveness: syntenin as an invasion modulator.
Biomarker discovery from uveal melanoma secretomes: identification of gp100 and cathepsin D in patient serum.
Cathepsin D expression in early cutaneous malignant melanoma.
Effect of trypan blue on the activity of lysosomal enzymes, tumor growth and cell ultrastructure in B16 melanotic melanoma in mice.
Expression of cathepsin D in primary and metastatic human melanoma and dysplastic nevi.
Function of liver activation-regulated chemokine/CC chemokine ligand 20 is differently affected by cathepsin B and cathepsin D processing.
Gamma-IFN-inducible-lysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma.
Influence of quercetin on B16 melanotic melanoma growth in C57BL/6 mice and on activity of some acid hydrolases in melanoma tissue.
Interaction of cationic ultrasmall superparamagnetic iron oxide nanoparticles with human melanoma cells.
Overexpression of cathepsin D in malignant melanoma.
Quantification of cathepsin D in plasma of patients with malignant melanoma.
Targeted Multiple Reaction Monitoring Analysis of CSF Identifies UCHL1 and GPNMB as Candidate Biomarkers for ALS.
Transparent polyamide: a promising new material for microscopic slides.
Melanoma, Amelanotic
Activity of some lysosomal hydrolases in the homogenates of transplantable melanotic and amelanotic melanoma in golden hamster (Mesocricetus auratus, Waterhouse).
Meningioma
Expression of extracellular matrix-degrading proteins in classic, atypical, and anaplastic meningiomas.
Immunohistochemical characterization of brain-invasive meningiomas.
Immunohistochemical expression of cathepsin D in meningiomas.
Influence of preoperative dexamethasone therapy on proliferating cell nuclear antigen (PCNA) expression in comparison to other parameters in meningiomas.
Progesterone receptor synthesis in human meningiomas: relation to the estrogen-induced proteins pS2 and cathepsin-D and influence of epidermal growth factor, Forskolin and phorbol ester in vitro.
Mesothelioma
Proteomic study of malignant pleural mesothelioma by laser microdissection and two-dimensional difference gel electrophoresis identified cathepsin D as a novel candidate for a differential diagnosis biomarker.
Mesothelioma, Malignant
Proteomic study of malignant pleural mesothelioma by laser microdissection and two-dimensional difference gel electrophoresis identified cathepsin D as a novel candidate for a differential diagnosis biomarker.
Metabolic Syndrome
Effect of Curcumin on Serum Cathepsin D in Patients with Metabolic Syndrome.
Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.
Metrorrhagia
Immunohistochemical detection of cathepsin D in endometrium from long-term subdermal levonorgestrel users and during the normal menstrual cycle.
Mouth Neoplasms
Immunohistochemical Expression of Cathepsin D in Primary and Recurrent Squamous Cell Carcinoma.
Mucolipidoses
Impaired phosphorylation of lysosomal enzymes in fibroblasts of patients with mucolipidosis III.
Molecular forms of beta-hexosaminidase and cathepsin D in serum and urine of healthy subjects and patients with elevated activity of lysosomal enzymes.
Mucositis
Beneficial effects of cathepsin inhibition to prevent chemotherapy-induced intestinal mucositis.
Chemotherapy-induced mucositis is associated with changes in proteolytic pathways.
Multiple Sclerosis
Acidic lipids enhance cathepsin D cleavage of the myelin basic protein.
Multiple Sulfatase Deficiency Disease
Enhanced breakdown of arylsulfatase A in multiple sulfatase deficiency.
Muscular Diseases
Immunohistochemical evidence for amyloid beta in rat soleus muscle in chloroquine-induced myopathy.
Knock-down of Cathepsin D in zebrafish fertilized eggs determines congenital myopathy.
The role of proteases in experimental glucocorticoid myopathy.
Muscular Dystrophies
Immunocytochemical studies of cathepsin D in human skeletal muscle.
Lysosomal and nonlysosomal hydrolases of skeletal muscle in neuromuscular diseases.
Mycoses
[The histamine-serotonin-monoamine oxidase system in patients with foot mycosis during treatment]
Myocardial Infarction
Admission Value of Serum Cathepsin D Level Can be Useful for Predicting In-Hospital Mortality in Patients with NSTEMI.
Cathepsin D improves the prediction of undetected diabetes in patients with myocardial infarction.
Influence of isoproterenol-induced myocardial infarction on certain glycohydrolases and cathepsins in rats.
Mild hyperhomocysteinemia is associated with a decreased fibrinolytic activity in patients after ST-elevation myocardial infarction.
Plasma cathepsin D isoforms and their active metabolites increase after myocardial infarction and contribute to plasma renin activity.
Role of cathepsin D activation in major adverse cardiovascular events and new-onset heart failure after STEMI.
Myocardial Ischemia
An increase of cathepsin D activity in cardiac lymph and pericadial fluid induced by experimental myocardial ischemia in the dog.
Biochemical and immunological studies of lysosomal and related proteinases in health and disease.
Influence of methylprednisolone of the sequential redistribution of cathepsin D and other lysosomal enzymes during myocardial ischemia in rabbits.
Lysosomal hypothesis in evolution of myocardial infarction. Subcellular fractionation and electron microscopic cytochemical study.
Myocardial ischemia and reperfusion injury in rats: lysosomal hydrolases and matrix metalloproteinases mediated cellular damage.
Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure.
Myositis
Immunocytochemical studies of cathepsin D in human skeletal muscle.
Ubiquitinated inclusions in inclusion-body myositis patients are immunoreactive for cathepsin D but not beta-amyloid.
Nasal Polyps
Cathepsin D activity in nasal polyps.
SPR Imaging Biosensor for Aspartyl Cathepsins: Sensor Development and Application for Biological Material.
Nasopharyngeal Carcinoma
Identificating cathepsin D as a biomarker for differentiation and prognosis of nasopharyngeal carcinoma by laser capture microdissection and proteomic analysis.
Neoplasm Metastasis
A novel aspartic protease gene, ALP56, is up-regulated in human breast cancer independently from the cathepsin D gene.
Activity and tissue localization of cathepsin D in non small cell lung cancer.
Alterations and role of human cathepsin D in cancer metastasis.
Altered gene expression profiles of NIH3T3 cells regulated by human lung cancer associated gene CT120.
Angiostatin generation by cathepsin D secreted by human prostate carcinoma cells.
Aspartic peptidase inhibitors: implications in drug development.
Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study.
Benzophenone-1 and nonylphenol stimulated MCF-7 breast cancer growth by regulating cell cycle and metastasis-related genes via an estrogen receptor ?-dependent pathway.
Biological and clinical significance of cathepsin D in breast cancer metastasis.
Biological and clinical significance of cathepsin D in breast cancer.
Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure-Activity Relationship and Binding Mode Analysis.
Breast-conserving therapy: proteases as risk factors in relation to survival after local relapse.
Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: The role of hypoxia inducible factor 1 pathway.
c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis.
CA 15-3 serum levels in patients with ductal breast carcinoma: relationship with clinicopathological parameters and tumor markers.
Calcium-binding protein S100P and cancer: mechanisms and clinical relevance.
Capillary electrophoretic determination of cathepsin D activity using Oregon Green-labeled hemoglobin.
Cathepsin D and PAI-1 expression in human head and neck cancer.
Cathepsin D concentration in breast cancer cytosols: correlation with disease-free interval and overall survival.
Cathepsin D concentration in primary laryngeal cancer: correlation with clinico-pathological parameters, EGFR status and prognosis.
Cathepsin D enhances breast cancer invasion and metastasis through promoting hepsin ubiquitin-proteasome degradation.
Cathepsin D expression as a possible predictor of lymph node metastasis in submucosal colorectal cancer.
Cathepsin D Expression in Colorectal Cancer: From Proteomic Discovery through Validation Using Western Blotting, Immunohistochemistry, and Tissue Microarrays.
Cathepsin D expression in renal cell cancer-clinical implications.
Cathepsin D expression in skin metastasis of breast cancer.
Cathepsin D immunostaining in paraffin-embedded breast cancer cells and macrophages: correlation with cytosolic assay.
Cathepsin D in breast cancer cells can digest extracellular matrix in large acidic vesicles.
Cathepsin D in breast cancer.
Cathepsin D in breast cancer: a tissue marker associated with metastasis.
Cathepsin D in breast cancer: from molecular and cellular biology to clinical applications.
Cathepsin D in breast cancer: mechanisms and clinical applications, a 1999 overview.
Cathepsin D in cancer metastasis: a protease and a ligand.
Cathepsin D in the malignant progression of neoplastic diseases (review).
Cathepsin D maturation and its stimulatory effect on metastasis are prevented by addition of KDEL retention signal.
Cathepsin D non-proteolytically induces proliferation and migration in human omental microvascular endothelial cells via activation of the ERK1/2 and PI3K/AKT pathways.
Cathepsin D serum levels are not a valid serum marker in renal cell carcinoma.
Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer.
Cathepsin D stimulates the activities of secreted plasminogen activators in the breast cancer acidic environment.
Cathepsin D, both a prognostic factor and a predictive factor for the effect of adjuvant tamoxifen in breast cancer. South Sweden Breast Cancer Group.
Cathepsin D-related disease-free interval in pT1 primary breast carcinomas: a pilot study.
Cathepsin D: a protease involved in breast cancer metastasis.
Cathepsin D: an independent prognostic factor for metastasis of breast cancer.
Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis.
Cathepsin-D and c-erb-B 2 have an additive prognostic value for breast cancer patients.
Cathepsin-D, urokinase plasminogen activator and type-1 plasminogen activator inhibitor in early breast cancer: an immunohistochemical study of prognostic value and relations to tenascin-C and other factors.
CD44 expression in colorectal cancer. An immunohistochemical study including correlation with cathepsin D immunoreactivity and some tumour clinicopathological features.
Cervical lymph node status and survival in laryngeal carcinoma: prognostic factors.
Characterization and enumeration of cells secreting tumor markers in the peripheral blood of breast cancer patients.
Characterization of protease expression in human prostate-cancer cell-lines.
Characterization of the proximal estrogen-responsive element of human cathepsin D gene.
Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells.
Comparative biochemical and immunohistochemical studies on the cathepsin D content of human breast cancer.
Correlation of tumor cytosol cathepsin D with differentiation and invasiveness of endometrial adenocarcinoma.
CORRELATIONSHIP OF CATHEPSIN D AND TOPOISOMERASE II ALPHA WITH NUCLEAR GRADING IN BREAST CANCERS.
Cyanobacterial peptides as a prototype for the design of cathepsin D inhibitors.
Decreased secretion of Cathepsin D in breast cancer in vivo by tamoxifen: mediated by the mannose-6-phosphate/IGF-II receptor?
Design, synthesis, and bioactivities of tasiamide B derivatives as cathepsin D inhibitors.
Detection of oral squamous cell carcinoma metastasis with cathepsin D: An immunohistochemical approach.
Detection of protein alterations in male breast cancer using two dimensional gel electrophoresis and mass spectrometry: the involvement of several pathways in tumorigenesis.
Differentiation and cathepsin D expression in human oral tumors.
Distribution of cathepsin D granules in normal and pathologic conditions in human prostate.
Effects of cathepsin D inhibitor from Vicia sativa L. seed hulls on human skin fibroblasts and breast cancer cells (in vitro studies).
Effects of cigarette smoke extracts on cell cycle, cell migration and endocrine activity in human placental cells.
Elevated levels of pro-cathepsin-d in the plasma of breast-cancer patients.
Elucidating the function of secreted maspin: inhibiting cathepsin D-mediated matrix degradation.
Evaluation of cathepsin D and epidermal growth factor receptor in prostate carcinoma.
Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study.
Exploring targeted therapy of osteosarcoma using proteomics data.
Expression of cathepsin D and B in invasion and metastasis of squamous cell carcinoma.
Expression of cathepsin D and E-cadherin in primary laryngeal cancers correlation with neck lymph node involvement.
Expression of cathepsin D and galectin 3 in tubular carcinomas of the breast.
Expression of cathepsin D and pS2 in imprint smears of breast carcinoma.
Expression of cathepsin D during the progression of human gliomas.
Expression of cathepsin D in head and neck cancer.
Expression of syndecan-1 and cathepsins D and K in advanced esophageal squamous cell carcinoma.
Expression, localization, and thyrotropin regulation of cathepsin D in human thyroid tissues.
Factors associated with bone metastasis in breast cancer: a preliminary study in an indonesian population.
Glycoprotein CD44 expression in colorectal neoplasms. An immuno-histochemical study including correlation with cathepsin D, extracellular matrix components, p53, Rb, bcl-2, c-erbB-2, EGFR and proliferation indices.
Graphene Oxide-Based Targeting of Extracellular Cathepsin D and Cathepsin L As A Novel Anti-Metastatic Enzyme Cancer Therapy.
Growth and differentiation of the normal mammary gland and its tumours.
Identificating cathepsin D as a biomarker for differentiation and prognosis of nasopharyngeal carcinoma by laser capture microdissection and proteomic analysis.
Immunohistochemical analysis and prognostic value of cathepsin D determination in laryngeal squamous cell carcinoma.
Immunohistochemical detection of cathepsin D in low grade breast invasive cancer.
Immunohistochemical detection of nm23/NDP kinase and cathepsin D in medullary carcinomas of the thyroid gland.
Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression.
Immunohistochemical localization of cathepsin D in colorectal tumors.
Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer.
Immunohistochemical visualisation of cathepsin-D expression in breast cancer.
Immunoradiometric assay of pro-cathepsin D in breast cancer cytosol: relative prognostic value versus total cathepsin D.
Increased cathepsin D protein expression is a biomarker for osteosarcomas, pulmonary metastases and other bone malignancies.
Increased plasma cathepsin D concentration in hepatic carcinoma and cirrhosis but not in breast cancer.
Induction of cathepsin D protein during estrogen carcinogenesis: possible role in estrogen-mediated kidney tubular cell damage.
Inhibition of breast cancer growth by suramin.
Micro-lymph node metastasis and its correlation with cathepsin D expression in early gastric cancer.
Missense polymorphism (C/T224) in the human cathepsin D pro-fragment determined by polymerase chain reaction--single strand conformational polymorphism analysis and possible consequences in cancer cells.
Nm23 and cathepsin D expression in laryngeal carcinomas.
Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells.
Oestrogens, proteases and breast cancer. From cell lines to clinical applications.
Olfactomedin 4 Suppresses Prostate Cancer Cell Growth and Metastasis via Negative Interaction with Cathepsin D and SDF-1.
Osteoprotegerin expression in triple-negative breast cancer cells promotes metastasis.
Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency.
Pathophysiological functions of cathepsin D: Targeting its catalytic activity versus its protein binding activity?
Potential markers predicting distant metastasis in axillary node-negative breast carcinoma.
Predictive value of cathepsin D and Ki-67 expression at the deepest penetration site for lymph node metastases in gastric cancer.
Prognostic indicators for early-stage breast-carcinoma .2. Value of cathepsin-d expression, detected by immunocytochemistry - a multiparametric study.
Prognostic significance of the estrogen-regulated protein, cathepsin D, in breast cancer. An immunohistochemical study.
Prognostic value of Cathepsin D expression in breast cancer: immunohistochemical assessment and correlation with radiometric assay.
Prognostic value of plasminogen activator inhibitor-1 in head and neck squamous cell carcinoma.
Proliferation Markers and EGF in ACTH-Secreting Adenomas and Carcinomas of the Pituitary.
Quantification of cathepsin D in plasma of patients with malignant melanoma.
Quantitative immunohistochemical determination of cathepsin D levels in prostatic carcinoma biopsies. Correlation with tumor grade, stage, PSA level, and DNA ploidy status.
Regulation, clinical and biological significance of cathepsin D in breast cancer.
Relationship between cathepsin D and other pathological and biological parameters in 1752 patients with primary breast cancer.
Serum levels of Hemorphin-7 peptides in patients with breast cancer.
Significance of the tumor protease Cathepsin D for the biology of breast cancer.
Structure-based subsite specificity mapping of human cathepsin D using statine-based inhibitors.
Tenascin C and cathepsin d expression in adipocytic tumors: an immunohistochemical investigation of 43 cases.
The effect of combined therapy on activity of cathepsin D and alpha-1-antitrypsin in the blood serum of women with cervical cancer.
The immunohistochemical expression of cathepsin D in colorectal cancer.
The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer.
The prognostic significance of p53, mdm2, c-erbB-2, cathepsin D, and thrombocytosis in stage IB cervical cancer treated by primary radical hysterectomy.
The prognostic-significance of cathepsin-d in breast carcinomas - an immunohistochemical study.
The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells.
The role of cathepsin D in the invasiveness of human breast cancer cells.
The role of proteolytic enzymes in cancer invasion and metastasis.
The value of the lysosomal protease cathepsin-d in egyptian bladder-cancer.
Thrombin up-regulates cathepsin D which enhances angiogenesis, growth, and metastasis.
Transfected cathepsin D stimulates high density cancer cell growth by inactivating secreted growth inhibitors.
Tumor growth fraction, expression of estrogen and progesterone receptors, p53, bcl-2 and cathepsin D activity in primary ductal invasive breast carcinoma and their axillary lymph node metastases.
Tumour budding intensity in relation to cathepsin D expression and some clinicopathological features of colorectal cancer.
Tumour-associated fibrinolysis: the prognostic relevance of plasminogen activators uPA and tPA in human breast cancer.
Variable expression of cathepsin B and D correlates with highly invasive and metastatic phenotype of oral cancer.
Western blotting and enzymatic activity analysis of cathepsin D in breast tissue and sera of patients with breast cancer and benign breast disease and of normal controls.
Western immunoblotting and enzymatic activity analysis of cathepsin D in human breast cancer cell lines of different invasive potential. Regulation by 17beta-estradiol, tamoxifen and ICI 182,780.
[A histopathologic and immunohistochemical study of prognostic factors in esophageal squamous cell carcinoma]
[Activity of cathepsin D in the blood serum and urine of patients with cancer of the stomach, pancreas and liver]
[Cathepsin D in diagnosis of neoplastic diseases]
[Cathepsin D in primary breast cancer in correlation with various prognostic factors]
[Estrogens, cathepsin D and metastasis in cancers of the breast and ovary: invasion or proliferation?]
[Expression of Cath-D, P-gp and Her-2 in carcinoma of the cardia]
[Hormonal regulation in breast cancer from cell lines to patients]
[Immunohistochemical study of Cath-D and CD44 in laryngeal squamous cell carcinomas]
[Involvement of cathepsin D and cathepsin E in the inhibition of tumor growth and metastasis through the production of angiogenetic inhibitors]
[Mechanism of the overexpression of the cathepsin D gene in breast cancer and consequences in the metastatic process]
[Proteolytic enzyme activity in stomach cancer patients with various prognoses]
[Study of cathepsin D levels in invasive bladder cancer and its stroma. Correlation with tumor stage, cytological grade, lymph node metastasis and survival]
[Study of the cytosolic concentrations of the tissue poly-peptide specific (TPS) antigen in infiltrating ductal carcinomas of the breast. Positive relationship with hormone dependency and negative with cellular proliferation]
[The expression of Cath-D, c-erbB-2 and EGFR in breast cancer and its correlation to lymphatic metastasis]
[The expression of cathepsin-D in salivary adenoid cystic carcinoma]
[The prognostic value of cathepsin D concentration in cytosol of primary breast carcinoma]
[The relationship between prognosis, metastasis and microvessel quantity in invasive breast carcinoma]
Neoplasm Micrometastasis
American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer.
Neoplasms
A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment.
A high-resolution linkage map for comparative genome analysis and QTL fine mapping in Asian seabass, Lates calcarifer.
A lysosomal pepstatin-insensitive proteinase as a novel biomarker for breast carcinoma.
A novel aspartic protease gene, ALP56, is up-regulated in human breast cancer independently from the cathepsin D gene.
A novel bis-aryl urea compound inhibits tumor proliferation via cathepsin D-associated apoptosis.
A paramagnetic chemical exchange-based MRI probe metabolized by cathepsin D: design, synthesis and cellular uptake studies.
A prognostic model to predict outcome of patients failing to achieve pathological complete response after anthracycline-containing neoadjuvant chemotherapy for breast cancer.
A prospective prognostic study of the hormonal milieu at the time of surgery in premenopausal breast carcinoma.
A two-site immunoenzymometric assay of 52-kDa pro-cathepsin D, and its use in human breast diseases.
Aberrant cystatin-C expression in blood from patients with breast cancer is a suitable marker for monitoring tumor burden.
Action of endogenous proteases on the distribution of tyrosinase isozymes in Harding-Passey mouse melanoma.
Activity and tissue localization of cathepsin D in non small cell lung cancer.
Activity of cathepsin B and D in colorectal cancer: relationships with tumour budding.
Activity of some lysosomal enzymes in serum and in tumors of patients with squamous cell lung carcinoma.
Activity of some lysosomal hydrolases in the homogenates of transplantable melanotic and amelanotic melanoma in golden hamster (Mesocricetus auratus, Waterhouse).
Adenosquamous carcinoma of the gall-bladder with gastric foveolar-type epithelium.
Adhesive and invasive features in gliomas.
Adjuvant therapy of node-negative breast cancer.
Age-associated biomarker profiles of human breast cancer.
Age-dependent changes in breast cancer hormone receptors and oxidant stress markers.
AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D.
Allylic structures in cancer drugs and body metabolites that control cell life and death.
Aloe vera and Honey Solution and Their Ethanolic Extraction Solution Could Act on Metastasis-Regulating Processes in Walker 256 Tumor Tissues In Vivo?
Alpha1-antichymotrypsin and kallistatin hydrolysis by human cathepsin D.
Alterations and role of human cathepsin D in cancer metastasis.
Altered gene expression profiles of NIH3T3 cells regulated by human lung cancer associated gene CT120.
American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer.
An aggressive desmoid tumor in a patient with familial adenomatous polyposis: immunohistochemical findings.
An immunohistochemical and prognostic evaluation of cathepsin D expression in 105 bladder carcinomas.
An immunohistochemical assessment of cathepsin D in gastric carcinoma: its impact on clinical prognosis.
Analysis of C-myc amplification by the differential polymerase chain-reaction (d-PCR), study in breast-cancer.
Angiostatin generation by cathepsin D secreted by human prostate carcinoma cells.
Anti-cathepsin D chicken IgY antibodies: characterisation, cross-species reactivity and application in immunogold labelling of human splenic neutrophils and fibroblasts.
Association between high concentrations of Mr 52,000 cathepsin D and poor prognosis in primary human breast cancer.
Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study.
Association of the 323/A3 surface glycoprotein with tumor characteristics and behavior in human breast cancer.
Atypical teratoid/rhabdoid tumor of the CNS: cytopathology and immunohistochemistry of insulin-like growth factor-II, insulin-like growth factor receptor type 1, cathepsin D, and Ki-67.
Basement membrane derived fibulin-1 and fibulin-5 function as angiogenesis inhibitors and suppress tumor growth.
Bcl-2 protein expression and long-term survival in breast cancer.
Benzophenone-1 and nonylphenol stimulated MCF-7 breast cancer growth by regulating cell cycle and metastasis-related genes via an estrogen receptor ?-dependent pathway.
Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process in the rat: Underlying mechanisms.
Biological and clinical relevance of the urokinase-type plasminogen activator (uPA) in breast cancer.
Biological and clinical significance of cathepsin D in breast cancer metastasis.
Biological and clinical significance of cathepsin D in breast cancer.
Biological heterogeneity of ER-positive breast cancers in the post-menopausal population.
Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure-Activity Relationship and Binding Mode Analysis.
Bone hemangioendothelioma: an immunohistochemical study related to histological malignancy and proliferative activity (NORs).
Breast-conserving therapy: proteases as risk factors in relation to survival after local relapse.
CA 15-3 serum levels in patients with ductal breast carcinoma: relationship with clinicopathological parameters and tumor markers.
Calcium-binding protein S100P and cancer: mechanisms and clinical relevance.
Cancer biomarkers in atherosclerotic plaque: Evidenced from structural and proteomic analyses.
Cancer with low cathepsin D levels is susceptible to V-ATPase inhibition.
Capillary electrophoretic determination of cathepsin D activity using Oregon Green-labeled hemoglobin.
Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes.
Catalytically inactive human cathepsin D triggers fibroblast invasive growth.
Cathepsin B activity in B16 melanoma cells: a possible marker for metastatic potential.
Cathepsin B and Cathepsin D Expression in Follicular Adenomas and Carcinomas of the Thyroid Gland.
Cathepsin B and cathepsin D expression in the progression of colorectal adenoma to carcinoma.
Cathepsin B and D expression in squamous cell carcinoma.
Cathepsin D activity and selectivity in the acidic conditions of a tumor microenvironment: Utilization in the development of a novel Cathepsin D substrate for simultaneous cancer diagnosis and therapy.
Cathepsin D activity in colorectal cancer.
Cathepsin D activity in human ovarian tissues and ovarian carcinoma.
Cathepsin D acts as an essential mediator to promote malignancy of benign prostatic epithelium.
Cathepsin D and chromogranin A as predictors of long term disease specific survival after radical prostatectomy for localized carcinoma of the prostate.
Cathepsin D and epidermal growth factor receptor immunohistochemistry does not predict recurrence of prostate cancer in patients undergoing radical prostatectomy.
Cathepsin D and its prognostic value in neuroepithelial brain tumors.
Cathepsin D and PAI-1 expression in human head and neck cancer.
Cathepsin D and prognosis in breast cancer.
Cathepsin D as a potential prognostic marker for lung adenocarcinoma.
Cathepsin D as a promising target for the discovery of novel anticancer agents.
Cathepsin D assay in ovarian cancer: correlation with pathological features and receptors for oestrogen, progesterone and epidermal growth factor.
Cathepsin D assay in primary breast cancer and lymph nodes: relationship with c-myc, c-erb-B-2 and int-2 oncogene amplification and node invasiveness.
Cathepsin D concentration in breast cancer cytosols: correlation with disease-free interval and overall survival.
Cathepsin D concentration in primary laryngeal cancer: correlation with clinico-pathological parameters, EGFR status and prognosis.
Cathepsin D concentration in tumor cytosols improves the accuracy of prognostic evaluation of primary breast cancer.
Cathepsin D content in colorectal cancer. Correlation with cathepsin D activity and other biological parameters: a preliminary report.
Cathepsin D content in malignant tumours of corpus uteri.
Cathepsin D cytosolic assay and immunohistochemical quantification in human prostate tumors.
Cathepsin D detected by automated and quantitative immunohistochemistry in breast carcinomas: correlation with overall and disease free survival.
Cathepsin D expression as a possible predictor of lymph node metastasis in submucosal colorectal cancer.
Cathepsin D expression by cancer and stromal cells in breast cancer: an immunohistochemical study of 1348 cases.
Cathepsin D expression in colorectal adenocarcinomas and adenomas.
Cathepsin D Expression in Colorectal Cancer: From Proteomic Discovery through Validation Using Western Blotting, Immunohistochemistry, and Tissue Microarrays.
Cathepsin D expression in early cutaneous malignant melanoma.
Cathepsin D expression in human colorectal cancer: relationship with tumour type and tissue differentiation grade.
Cathepsin D expression in renal cell cancer-clinical implications.
Cathepsin D expression in skin metastasis of breast cancer.
Cathepsin D expression levels in nongynecological solid tumors: clinical and therapeutic implications.
Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells.
Cathepsin D immobilized capillary reactors for on-flow screening assays.
Cathepsin D immunocytochemical assays in breast carcinomas: image analysis and correlation to prognostic factors.
Cathepsin D immunoreactivity in ovarian cancer: correlation with prognostic factors.
Cathepsin D immunostaining in paraffin-embedded breast cancer cells and macrophages: correlation with cytosolic assay.
Cathepsin D in breast cancer tissue.
Cathepsin D in breast cancer: from molecular and cellular biology to clinical applications.
Cathepsin D in breast cancer: mechanisms and clinical applications, a 1999 overview.
Cathepsin D in breast secretions from women with breast cancer.
Cathepsin D in cancer metastasis: a protease and a ligand.
Cathepsin D in host stromal cells is associated with more highly vascular and aggressive invasive breast carcinoma.
Cathepsin D in host stromal cells, but not in tumor cells, is associated with aggressive behavior in node-negative breast cancer.
Cathepsin D in invasive ductal NOS breast carcinoma as defined by immunohistochemistry. No correlation with survival at 5 years.
Cathepsin D in invasive ductal NOS, medullary, lobular and mucinous breast carcinoma. An immunohistochemical study.
Cathepsin D in laryngeal carcinoma. preliminary report.
Cathepsin D in normal and neoplastic thyroid tissues.
Cathepsin D in ovarian cancer: prognostic value and correlation with p53 expression and microvessel density.
Cathepsin D in primary breast carcinoma: adverse prognosis is associated with expression of cathepsin D in stromal cells.
Cathepsin D in primary squamous laryngeal tumors: correlation with clinico-pathological parameters and receptor status.
Cathepsin D in the malignant progression of neoplastic diseases (review).
Cathepsin D in the Tumor Microenvironment of Breast and Ovarian Cancers.
Cathepsin D in tissue and serum of patients with squamous cell carcinoma of the head and neck.
Cathepsin D inhibitors as potential therapeutics for breast cancer treatment: Molecular docking and bioevaluation against triple-negative and triple-positive breast cancers.
Cathepsin D inhibits oxidative stress-induced cell death via activation of autophagy in cancer cells.
Cathepsin D is a potential serum marker for poor prognosis in glioma patients.
Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation.
Cathepsin D levels in primary breast cancers: relationship with epidermal growth factor receptor, oestrogen receptor and axillary nodal status.
Cathepsin D maturation and its stimulatory effect on metastasis are prevented by addition of KDEL retention signal.
Cathepsin D non-proteolytically induces proliferation and migration in human omental microvascular endothelial cells via activation of the ERK1/2 and PI3K/AKT pathways.
Cathepsin D overexpressed by cancer cells can enhance apoptosis-dependent chemo-sensitivity independently of its catalytic activity.
Cathepsin D protein levels in colorectal tumors: divergent expression patterns suggest complex regulation and function.
Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging.
Cathepsin D serum levels are not a valid serum marker in renal cell carcinoma.
Cathepsin D serum mass concentrations in patients with hepatocellular carcinoma and/or liver cirrhosis.
Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer.
Cathepsin D test helps identify breast cancers likely to recur.
Cathepsin D versus other prognostic factors in breast cancer. Results and controversies of a multicenter study on 2575 cases.
Cathepsin D, both a prognostic factor and a predictive factor for the effect of adjuvant tamoxifen in breast cancer. South Sweden Breast Cancer Group.
Cathepsin D-related disease-free interval in pT1 primary breast carcinomas: a pilot study.
Cathepsin D: an independent prognostic factor for metastasis of breast cancer.
Cathepsin D: association between TN-stage and steroid receptor status of breast carcinoma.
Cathepsin D: Autoantibody profiling as a diagnostic marker for cancers.
Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis.
Cathepsin-d activity levels in colorectal-cancer - correlation with cathepsin-B and cathepsin-L and other biological and clinical-parameters.
Cathepsin-D and c-erb-B 2 have an additive prognostic value for breast cancer patients.
Cathepsin-d in breast carcinomas - the role of the stromal cell component.
Cathepsin-D, urokinase plasminogen activator and type-1 plasminogen activator inhibitor in early breast cancer: an immunohistochemical study of prognostic value and relations to tenascin-C and other factors.
Cathepsins D, B, and L in malignant human lung tissue.
Cathepsins in basal cell carcinomas: activity, immunoreactivity and mRNA staining of cathepsins B, D, H and L.
CD31 quantitative immunocytochemical assays in breast carcinomas. Correlation with current prognostic factors.
CD44 expression in colorectal cancer. An immunohistochemical study including correlation with cathepsin D immunoreactivity and some tumour clinicopathological features.
Cells producing cathepsins D, B, and L in human breast carcinoma and their association with prognosis.
Cellular distribution of cathepsin D in childhood tumors.
Cellular localisation by in situ hybridisation of cathepsin D, stromelysin 3, and urokinase plasminogen activator RNAs in breast cancer.
Cervical lymph node status and survival in laryngeal carcinoma: prognostic factors.
Changes induced in astrocyte cathepsin D by cytokines and leupeptin.
Characterization of purified cathepsin D from malignant human breast tissue.
Characterization of very acidic phagosomes in breast cancer cells and their association with invasion.
Clinical prognostic factors and expression of cathepsin D in endometrioid adenocarcinoma.
Clinical relevance of biologic factors in male breast cancer.
Clinical relevance of urokinase-type plasminogen activator, its receptor and inhibitor type 1 in ovarian cancer.
Clinical significance of cathepsin D assay in breast cancer tissues.
Clinical significance of cathepsin D concentration in tumor cytosol of primary breast cancer.
Clinical significance of cathepsin D in primary ovarian cancer.
Clinicopathological correlation between expression of PTHrP receptor and various prognostic factors in breast cancer without axillary lymph node metastasis.
Clinicopathological significance of cathepsin D expression in gastric adenocarcinoma.
Clinicopathological significance of cathepsin D expression in non-small cell lung cancer is conditional on apoptosis-associated protein phenotype: an immunohistochemistry study.
Clinicopathological study of the expression of hsp27, pS2, cathepsin D and metallothionein in primary invasive breast cancer.
Co-expression of thymidine kinase and cathepsin D in 200 primary breast carcinomas.
Collagen-based co-culture for invasive study on cancer cells-fibroblasts interaction.
Comparative autoantibody profiling before and after appearance of malignance: Identification of anti-cathepsin D autoantibody as a promising diagnostic marker for lung cancer.
Comparative biochemical and immunohistochemical studies on the cathepsin D content of human breast cancer.
Comparative quantitative immunohistochemical and immunoradiometric determinations of cathepsin D in endometrial adenocarcinoma: predictors of tumor aggressiveness.
Comparative transcriptional analysis reveals distinct expression patterns of channel catfish genes after the first infection and re-infection with Aeromonas hydrophila.
Comparison of hepatic cathepsin D activity in response to tumor growth and to caloric restriction in mice.
Comparison of proteinase activities in squamous cell carcinoma, basal cell epithelioma, and seborrheic keratosis.
Comparison of the metastasis-inducing protein S100A4 (p9ka) with other prognostic markers in human breast cancer.
Comparison of the tumor associated proteases cathepsin D (CATH D) and urokinase-type plasminogen activator (uPA) in cytosols of human breast cancer patients.
Complex modulation of peptidolytic activity of cathepsin D by sphingolipids.
Controversies in the treatment of ductal carcinoma in situ.
Correlation between cathepsin D expression and p53 protein nuclear accumulation in oesophageal squamous cell carcinoma.
Correlation between laminin and cathepsin D expressions in breast carcinoma.
Correlation between mannose-6-phosphate/IGFII receptor and cathepsin D RNA levels by in situ hybridization in benign and malignant mammary tumors.
Correlation between pS2 protein positivity, steroid receptor status and other prognostic factors in breast cancer.
Correlation of cytosolic concentrations of ER, PS2, Cath-D, TPS, TK and cAMP in primary breast carcinomas.
Correlation of tumor cytosol cathepsin D with differentiation and invasiveness of endometrial adenocarcinoma.
CORRELATIONSHIP OF CATHEPSIN D AND TOPOISOMERASE II ALPHA WITH NUCLEAR GRADING IN BREAST CANCERS.
Cyanobacterial peptides as a prototype for the design of cathepsin D inhibitors.
Cyclin D1 in human neuroblastic tumors recapitulates its developmental expression: An immunohistochemical study.
Cytosol cathepsin D in Thai women with breast cancer.
Cytosol cathepsin-D content and proliferative activity of human breast cancer. The Comitato Italiano per il Controllo di Qualita del Laboratorio in Oncologia.
Decreased secretion of Cathepsin D in breast cancer in vivo by tamoxifen: mediated by the mannose-6-phosphate/IGF-II receptor?
Defective acidification of intracellular organelles results in aberrant secretion of cathepsin D in cancer cells.
Depletion of Procathepsin D Gene Expression by RNA Interference: A Potential Therapeutic Target for Breast Cancer.
Design, synthesis, and bioactivities of tasiamide B derivatives as cathepsin D inhibitors.
Detection of isolated tumor cells in bone marrow is an independent prognostic factor in breast cancer.
Detection of oral squamous cell carcinoma metastasis with cathepsin D: An immunohistochemical approach.
Development and characterization of a tamoxifen-resistant breast carcinoma xenograft.
Diagnostic values of serum cathepsin B and D in patients with nasopharyngeal carcinoma.
Differential expression levels of urokinase-type plasminogen activator and cathepsin D in locally advanced laryngeal squamous cell carcinoma: clinical implications.
Differentiation and cathepsin D expression in human oral tumors.
Digital image-analysis of nuclear morphometry, DNA-ploidy and AgNORs in breast-carcinoma cell imprints.
Dipeptide mimic oligomer transporter mediates intracellular delivery of Cathepsin D inhibitors: A potential target for cancer therapy.
Dissociated overexpression of cathepsin D and estrogen receptor alpha in preinvasive mammary tumors.
Distant metastasis after radical treatment of breast cancer: risk factors and their prognostic relevance in 378 consecutive patients.
Do American oncologists know how to use prognostic variables for patients with newly diagnosed primary breast cancer?
Down-regulation of LAPTM5 in human cancer cells.
Effect of altered thyroid status on lysosomal enzymes and thymidylate synthetase activity in tumors and livers of host animals.
Effect of fenhexamid and cyprodinil on the expression of cell cycle- and metastasis-related genes via an estrogen receptor-dependent pathway in cellular and xenografted ovarian cancer models.
Effect of procathepsin D and its activation peptide on prostate cancer cells.
Effect of tumor size on the association between ps2 and cathepsin-d in primary breast-cancer.
Effects of cathepsin D inhibitor from Vicia sativa L. seed hulls on human skin fibroblasts and breast cancer cells (in vitro studies).
Elevated activity and increased mannose-6-phosphate in the carbohydrate moiety of cathepsin D from human hepatoma.
Elevated levels of pro-cathepsin-d in the plasma of breast-cancer patients.
Elucidating the function of secreted maspin: inhibiting cathepsin D-mediated matrix degradation.
Endocytosis of pro-cathepsin D into breast cancer cells is mostly independent of mannose-6-phosphate receptors.
Endometrial adenocarcinoma of endometrioid subtype with squamous differentiation: an immunohistochemical study of MIB-1 (ki-67 paraffin), cathepsin D, and C-erbB-2 protein (p185).
Endosomal proteolysis of insulin-like growth factor-I at its C-terminal D-domain by cathepsin B.
Enzymatically active cathepsin D sensitizes breast carcinoma cells to TRAIL.
Enzyme-linked immunosorbent assay of HER-2/neu gene product (p185) in breast cancer: its correlation with sex steroid receptors, cathepsin D and histologic grades.
Estrogen receptors and cathepsin D in human thyroid tissue.
Estrogen regulated proteases and antiproteases in ovarian and breast cancer cells.
Evaluation of cathepsin D and epidermal growth factor receptor in prostate carcinoma.
Evaluation of cathepsin D as prognostic predictor in breast cancer.
Evaluation of prognostic factors in male breast cancer.
Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study.
Evaluation of the prognostic significance of nm23/NDP kinase and cathepsin D in anal carcinomas. An immunohistochemical study.
Expression and Localization of Cathepsins B, D and G in Cancer Stem Cells in Liver Metastasis From Colon Adenocarcinoma.
Expression and posttranslational fate of cathepsin D in HT-29 tumor cells depend on their enterocytic differentiation state.
Expression and prognostic significance of apolipoprotein D in breast cancer.
Expression of adhesion factors and degrading proteins in primary and secondary glioblastomas and their precursor tumors.
Expression of cathepsin D and B in invasion and metastasis of squamous cell carcinoma.
Expression of cathepsin D and E-cadherin in primary laryngeal cancers correlation with neck lymph node involvement.
Expression of cathepsin D and pS2 in imprint smears of breast carcinoma.
Expression of cathepsin D during the progression of human gliomas.
Expression of cathepsin D in bladder carcinoma: correlation with pathological features and serum cystatin C levels.
Expression of cathepsin D in head and neck cancer.
Expression of cathepsin D in human astrocytic neoplasias.
Expression of cathepsin D in malignant and in the corresponding non-malignant node-negative laryngeal samples: correlation with receptors for androgen, glucocorticoid, oestrogen and progesterone.
Expression of cathepsin D in primary and metastatic human melanoma and dysplastic nevi.
Expression of cathepsin D in transitional cell bladder tumours.
Expression of cathepsin D in urothelial carcinoma of the urinary bladder: an immunohistochemical study including correlations with extracellular matrix components, CD44, p53, Rb, c-erbB-2 and the proliferation indices.
Expression of E-cadherin, beta-catenin, cathepsin D, gelatinases and their inhibitors in invasive ductal breast carcinomas.
Expression of extracellular matrix-degrading proteins in classic, atypical, and anaplastic meningiomas.
Expression of genes that contribute to proliferative and metastatic ability in breast cancer resected during various menstrual phases.
Expression of human mammaglobin as a marker of bone marrow micrometastasis in breast cancer.
Expression of hypoxia-inducible factor 1alpha and cathepsin D in pituitary adenomas.
Expression of ps2 and cathepsin-d in breast-cancer.
Expression of pS2, c-erbB-2, and cathepsin D during the menstrual cycle in human breast cancers.
Expression of syndecan-1 and cathepsins D and K in advanced esophageal squamous cell carcinoma.
Expression, localization, and thyrotropin regulation of cathepsin D in human thyroid tissues.
Expressions of chromogranin A and cathepsin D in human primary hepatocellular carcinoma.
Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas.
Fibroblasts capture cathepsin D secreted by breast cancer cells: possible role in the regulation of the invasive process.
Flow cytometry analysis of apoptotic progression and expression analysis of four apoptosis-related genes in Penaeus vannamei in response to white spot syndrome virus infection.
Fluctuation of HER2 expression in breast carcinomas during the menstrual cycle.
Gastric carcinoma: expression of c-erbB-2/neu oncoprotein, epidermal growth factor receptor, cathepsin D, progesterone receptor and tumor associated glycoprotein-72 in different histological types.
Genes associated with the tumour microenvironment are differentially expressed in cured versus primary chemotherapy-refractory diffuse large B-cell lymphoma.
Giant-cell tumors of bone and progesterone receptors.
Glycoprotein CD44 expression in colorectal neoplasms. An immuno-histochemical study including correlation with cathepsin D, extracellular matrix components, p53, Rb, bcl-2, c-erbB-2, EGFR and proliferation indices.
Glycoproteomic analysis of bronchoalveolar lavage (BAL) fluid identifies tumor-associated glycoproteins from lung adenocarcinoma.
Graphene Oxide-Based Targeting of Extracellular Cathepsin D and Cathepsin L As A Novel Anti-Metastatic Enzyme Cancer Therapy.
Heat shock cognate 70 protein secretion as a new growth arrest signal for cancer cells.
High expression of the trefoil protein TFF1 in interval breast cancers.
High levels of cathepsin B predict poor outcome in patients with breast cancer.
High levels of cathepsin D and cystatin B are associated with increased risk of coronary events.
High throughput screening of meningioma biomarkers using a tissue microarray.
High yield synthesis and characterization of phosphorylated recombinant human procathepsin D expressed in mammalian cells.
Histologic grade and p53 immunoreaction as indicators of early recurrence of node-negative breast cancer.
Hormonal regulation of cathepsin D following transfection of the estrogen or progesterone receptor into three sex steroid hormone resistant cancer cell lines.
Host cathepsin D response to tumor in the normal and pepstatin-treated mouse.
How to target estrogen receptor-negative breast cancer?
Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells.
Human telomerase reverse transcriptase (hTERT) promotes cancer invasion by modulating cathepsin D via early growth response (EGR)-1.
Identification and structure-activity relationship studies of small molecule inhibitors of the human cathepsin D.
Identification of a novel aspartic-like protease differentially expressed in human breast cancer cell lines.
Identification of a novel estrogen receptor-alpha variant and its upstream splicing regulator.
Identification of breast cancer metastasis-associated proteins in an isogenic tumor metastasis model using two-dimensional gel electrophoresis and liquid chromatography-ion trap-mass spectrometry.
Immuno-histochemical evaluation of Cathepsin D in malignant salivary gland carcinomas.
Immunocytochemical localization of Cathepsin D and CA 125 in ovarian cancer.
Immunohistochemical analysis and prognostic value of cathepsin D determination in laryngeal squamous cell carcinoma.
Immunohistochemical analysis of cathepsin D in prostate carcinoma.
Immunohistochemical analysis of cathepsins D, B, and L in human breast cancer.
Immunohistochemical analysis of desmoid tumours.
Immunohistochemical and immunoradiometric evaluations of total cathepsin D in human larynx.
Immunohistochemical and other features of breast carcinomas presenting clinically compared with those detected by cancer screening.
Immunohistochemical detection of cathepsin D in low grade breast invasive cancer.
Immunohistochemical detection of cathepsin D in T2N0M0 breast carcinoma.
Immunohistochemical detection of cathepsin-d expression in prostate-cancer.
Immunohistochemical detection of nm23/NDP kinase and cathepsin D in medullary carcinomas of the thyroid gland.
Immunohistochemical evaluation of cathepsin D expression in colorectal cancer.
Immunohistochemical evaluation of cathepsin D expression in colorectal tumours: a correlation with extracellular matrix components, p53, pRb, bcl-2, c-erbB-2, EGFR and proliferation indices.
Immunohistochemical evaluation of tissue-specific proteolytic enzymes in adenomas containing foci of early carcinoma: correlations with cathepsin D expression and other malignant features.
Immunohistochemical expression of cathepsin D in laryngeal epithelial lesions: correlation with CD44 expression, p53 and Rb status and proliferation associated indices.
Immunohistochemical expression of cathepsin D in meningiomas.
Immunohistochemical Expression of Cathepsin D in Primary and Recurrent Squamous Cell Carcinoma.
Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression.
Immunohistochemical localization of cathepsin D in colorectal tumors.
Immunohistochemical markers of prolonged survival in small cell carcinoma of the lung. An immunohistochemical study.
Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer.
Immunohistochemical p53 overexpression correlated to c-erbB-2 and cathepsin D proteins in colorectal cancer.
Immunohistochemical studies of proliferating cell nuclear antigen and cathepsin D in transitional cell carcinoma of the urinary bladder.
Immunohistochemical visualisation of cathepsin-D expression in breast cancer.
Immunolocalization of cathepsin D in normal and neoplastic human tissues.
Immunolocalization of cathepsin D in the human central nervous system and central nervous system neoplasms.
Immunoradiometric and immunohistochemical analysis of Cathepsin D in ovarian cancer: lack of association with clinical outcome.
Immunoradiometric assay of pro-cathepsin D in breast cancer cytosol: relative prognostic value versus total cathepsin D.
Immunoradiometric detection of pS2 and total cathepsin D in primary breast cancer biopsies: their correlation with steroid receptors.
Immunostaining of cathepsin D in breast cancer: quantification by computerised image analysis and correlation with cytosolic assay.
Immunostaining of cathepsin-d in nonsmall cell lung-cancer - correlations with morphological and biological parameters.
Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies.
In vivo stimulation by tamoxifen of cathepsin D RNA level in breast cancer.
Incorporation of histone derived recombinant protein for enhanced disassembly of core-membrane structured liposomal nanoparticles for efficient siRNA delivery.
Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells.
Increased apoptosis in cancer cells in vitro and in vivo by ceramides in transferrin-modified liposomes.
Increased cathepsin D protein expression is a biomarker for osteosarcomas, pulmonary metastases and other bone malignancies.
Increased secretion, altered processing, and glycosylation of pro-cathepsin D in human mammary cancer cells.
Induction of cathepsin D protein during estrogen carcinogenesis: possible role in estrogen-mediated kidney tubular cell damage.
Inflammatory cytokines increase extracellular procathepsin D in permanent and primary endothelial cell cultures.
Influence of cathepsin D expression in lung adenocarcinoma on prognosis: possible importance of its expression in tumor cells and stromal cells, and its intracellular polarization in tumor cells.
Influence of quercetin on B16 melanotic melanoma growth in C57BL/6 mice and on activity of some acid hydrolases in melanoma tissue.
Influence of Ukrain and cyclophosphamide administration on HA-1 murine hepatoma and LS lymphoma on aspartic proteinase cathepsin D.
Inhibition of breast cancer growth by suramin.
Inhibition of Cathepsin D (CTSD) enhances radiosensitivity of glioblastoma cells by attenuating autophagy.
Inhibitors of proteases as anticancer drugs.
Inhibitory Effects of ?- and ?-Tocopherols on Estrogen-Stimulated Breast Cancer In Vitro and In Vivo.
Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth.
Invasion marker PAI-1 remains a strong prognostic factor after long-term follow-up both for primary breast cancer and following first relapse.
Invasion of ras-transformed breast epithelial cells depends on the proteolytic activity of cysteine and aspartic proteinases.
Involvement of cathepsin D in chemotherapy-induced cytochrome c release, caspase activation, and cell death.
Keeping data continuous when analyzing the prognostic impact of a tumor marker: an example with cathepsin D in breast cancer.
Ki-67 staining in benign, borderline, malignant primary and metastatic ovarian tumors: correlation with steroid receptors, epidermal-growth-factor receptor and cathepsin D.
Lack of prognostic value of cathepsin D levels for predicting short term outcomes of breast cancer patients.
Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease.
Localization of nuclear cathepsin L and its association with disease progression and poor outcome in colorectal cancer.
Long-term follow-up confirms prognostic impact of PAI-1 and cathepsin D and L in primary breast cancer.
Low cathepsin D and low plasminogen activator type 1 inhibitor in tumor cytosols defines a group of node negative breast cancer patients with low risk of recurrence.
Low levels of basic fibroblast growth factor (bFGF) are associated with a poor prognosis in human breast carcinoma.
Lowering endogenous cathepsin D abundance results in ROS accumulation and cell senescence.
Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis.
Lysosome-mitochondria-mediated apoptosis specifically evoked in cancer cells induced by gold nanorods.
Male breast cancer: clinico-pathological features, immunocytochemical characteristics and prognosis.
Mammary serum antigen (MSA), Ca 549, CA 15-3 and CEA in breast cancer preoperative sensitivity and correlation to prognostic factors.
Markers of function and proliferation in non-invasive and invasive bi- and plurihormonal adenomas of patients with acromegaly: an immunohistochemical study.
Matrix metalloproteinase expression in human breast cancer: an immunohistochemical study including correlation with cathepsin D, type IV collagen, laminin, fibronectin, EGFR, c-erbB-2 oncoprotein, p53, steroid receptors status and proliferative indices.
Matrix metalloproteinase-9 interplays with the IGFBP2-IGFII complex to promote cell growth and motility in astrocytomas.
May cathepsin D immunoreactivity be used as a prognostic factor in endometrial carcinomas? A comparative immunohistochemical study.
Mechanisms and kinetics of procathepsin D activation.
Melatonin improves periodontitis-induced kidney damages by decreasing inflammatory stress and apoptosis in rats.
Mesenchymal stem cell homing towards cancer cells is increased by enzyme activity of cathepsin D.
Micro-lymph node metastasis and its correlation with cathepsin D expression in early gastric cancer.
Mis-sorting of procathepsin D in metastogenic tumor cells is not due to impaired synthesis of the phosphomannosyl signal.
Missense polymorphism (C/T224) in the human cathepsin D pro-fragment determined by polymerase chain reaction--single strand conformational polymorphism analysis and possible consequences in cancer cells.
Mitogenic function of human procathepsin D: the role of the propeptide.
Modulation of inflammatory markers by the ethanolic extract of Leucas aspera in adjuvant arthritis.
Modulation of proliferation and chemosensitivity by procathepsin D and its peptides in ovarian cancer.
MUC1 and cathepsin D expression in early colorectal carcinoma showing V type pit pattern.
Multiparametric prognostic evaluation of biological factors in primary breast cancer.
Mutual predictive value of c-erbB-2 overexpression and various prognostic factors in ductal invasive breast carcinoma.
Neither creatinine nor cystatin C-estimated glomerular filtration rate is optimal in oncology patients treated with targeted agents.
New cathepsin d inhibitors with hydroxyethylamine isosteres: preparation and characterization.
Nm23 and cathepsin D expression in laryngeal carcinomas.
nm23--relationship to the metastatic potential of breast carcinoma cell lines, primary human xenografts, and lymph node negative breast carcinoma patients.
Node negative breast carcinoma: hyperprolactinemia and/or overexpression of p53 as an independent predictor of poor prognosis compared to newer and established prognosticators.
Novel blood biomarkers of human urinary bladder cancer.
Novel proteomic strategy reveal combined alpha1 antitrypsin and cathepsin D as biomarkers for colorectal cancer early screening.
Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells.
Oestrogens, proteases and breast cancer. From cell lines to clinical applications.
Olfactomedin 4 Suppresses Prostate Cancer Cell Growth and Metastasis via Negative Interaction with Cathepsin D and SDF-1.
Oral granular cell myoblastoma: an immunohistochemical study.
Overexpression and hormonal regulation of pro-cathepsin D in mammary and endometrial cancer.
Overexpression Cathepsin D Contributes to Perineural Invasion of Salivary Adenoid Cystic Carcinoma.
Overexpression in colorectal carcinoma of two lysosomal enzymes, CLN2 and CLN1, involved in neuronal ceroid lipofuscinosis.
Overexpression of both catalytically active and -inactive cathepsin D by cancer cells enhances apoptosis-dependent chemo-sensitivity.
Overexpression of cathepsin D in malignant melanoma.
Overview on human breast cancer with focus on prognostic and predictive factors with special attention on the tumour suppressor gene p53.
P53 and cathepsin-d are independent of established prognostic factors in breast-cancer.
p53 associated with cathepsin D in primary breast cancer.
p53 quantitative immunocytochemical analysis in breast carcinomas.
Pathophysiological functions of cathepsin D: Targeting its catalytic activity versus its protein binding activity?
Pepstatin, an inhibitor of acid kininogenases and ascites retardant in neoplastic disease.
Periodontitis exacerbates the renal degenerative effects of obesity in rats.
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.
Predicting response to neoadjuvant chemotherapy in patients with cervical carcinoma: can we do without any longer?
Prediction of the extent of prostate cancer by the combined use of systematic biopsy and serum level of cathepsin D.
Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imaging.
Probing the cathepsin D using a BODIPY FL-pepstatin A: applications in fluorescence polarization and microscopy.
Procathepsin d as a tumor marker, anti-cancer drug or screening agent.
Prognostic evaluation of metallothionein expression in human colorectal neoplasms.
Prognostic evaluation of oestrogen-regulated protein immunoreactivity in ductal invasive (NOS) breast cancer.
Prognostic impact of cathepsin D and c-erbB-2 oncoprotein in a subgroup of node-negative breast cancer patients with low histological grade tumors.
Prognostic impact of tumor biological factors on survival in node-negative breast cancer.
Prognostic indicators for early-stage breast-carcinoma .2. Value of cathepsin-d expression, detected by immunocytochemistry - a multiparametric study.
Prognostic indicators in node-negative early stage breast cancer.
Prognostic markers in pheochromocytoma.
Prognostic molecular markers in early breast cancer.
Prognostic relevance of cathepsin D detection in micrometastatic cells in the bone marrow of patients with primary breast cancer.
Prognostic relevance of cathepsin D versus oestrogen receptors in node negative breast cancers.
Prognostic significance of angiogenesis and immunoreactivity of cathepsin D and type IV collagen in high-grade stage T1 primary bladder cancer.
Prognostic significance of immunohistochemical analysis of cathepsin D in low-stage breast cancer.
Prognostic significance of the estrogen-regulated protein, cathepsin D, in breast cancer. An immunohistochemical study.
Prognostic significance of the metastasis-inducing protein S100A4 (p9Ka) in human breast cancer.
Prognostic value of cathepsin D expression and association with histomorphological subtypes in breast cancer.
Prognostic value of Cathepsin D expression in breast cancer: immunohistochemical assessment and correlation with radiometric assay.
Prognostic value of cathepsin D in breast cancer: comparison of immunohistochemical and immunoradiometric detection methods.
Prognostic value of cytosolyc cathepsin D content in resectable gastric cancer.
Prognostic value of p53 expression in early-stage breast-carcinoma compared with tumor angiogenesis, epidermal growth-factor receptor, C-erbb-2, cathepsin-d, DNA-ploidy, parameters of cell-kinetics and conventional features.
Prognostic value of plasminogen activator inhibitor-1 in head and neck squamous cell carcinoma.
Prognostic value of PS2 and cathepsin D in 710 human primary breast tumors: multivariate analysis.
Prognostic value of the quantitative measurement of the oncoprotein p185(Her-2/neu) in a group of patients with breast cancer and positive node involvement.
Prognostic value of total cathepsin D in breast tumors. A possible role in selection of chemoresistant patients.
Prospective evaluation of prognostic factors in operable breast cancer.
Proteases associated with gynecological tumors.
Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry.
Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment.
Proteomic analysis of differential protein expression in a human hepatoma revertant cell line by using an improved two-dimensional electrophoresis procedure combined with matrix assisted laser desorption/ionization-time of flight-mass spectrometry.
Proteomic approach toward molecular backgrounds of drug resistance of osteosarcoma cells in spheroid culture system.
Proteomic characterization of nipple aspirate fluid: identification of potential biomarkers of breast cancer.
Proteomic profiling of cancer of the gingivo-buccal complex: Identification of new differentially expressed markers.
Proteomic study of malignant pleural mesothelioma by laser microdissection and two-dimensional difference gel electrophoresis identified cathepsin D as a novel candidate for a differential diagnosis biomarker.
Proteomic-based biosignatures in breast cancer classification and prediction of therapeutic response.
Proteomics-based Strategy to Delineate the Molecular Mechanisms of RhoGDI2-induced Metastasis and Drug Resistance in Gastric Cancer.
Purification and properties of cathepsin D from rat Yoshida ascites hepatoma AH-130.
Quantification of cathepsin D in plasma of patients with malignant melanoma.
Quantitative analyses of epidermal growth factor receptors, HER-2/neu oncoprotein and cathepsin D in nonmalignant and malignant uteri.
Quantitative analysis of p185(HER-2/neu) protein in breast cancer and its association with other prognostic factors.
Quantitative immunocytochemical assays of P-glycoprotein in breast carcinomas: correlation to messenger RNA expression and to immunohistochemical prognostic indicators.
Quantitative immunohistochemical determination of cathepsin D levels in prostatic carcinoma biopsies. Correlation with tumor grade, stage, PSA level, and DNA ploidy status.
Quantitative immunohistochemical determination of cathepsin-D and its relation with other variables.
Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor.
Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma.
Reevaluating cathepsin D as a biomarker for breast cancer: serum activity levels versus histopathology.
Regulation of metastasis-related gene expression by p53: a potential clinical implication.
Regulation, clinical and biological significance of cathepsin D in breast cancer.
Relation between cathepsin D expression and other prognostic factors in breast carcinomas.
Relation of cathepsin D level to the estrogen receptor in human breast cancer.
Relationship between cathepsin D and other pathological and biological parameters in 1752 patients with primary breast cancer.
Relationship between cathepsin D, urokinase, and plasminogen activator inhibitors in malignant vs benign breast tumours.
Relationship between cathepsin-D and other prognostic factors in human breast cancer.
Relationship of tumoral hyaluronic acid and cathepsin D contents with histological type of gastric carcinoma.
Release of the aspartyl protease cathepsin D is associated with and facilitates human breast cancer cell invasion.
Ribozyme-targeting procathepsin D and its effect on invasion and growth of breast cancer cells: an implication in breast cancer therapy.
Risk-group discrimination in node-negative breast cancer using invasion and proliferation markers: 6-year median follow-up.
Role for HER2/neu and HER3 in fulvestrant-resistant breast cancer.
Secretion of a latent, acid activatable cathepsin L precursor by human non-small cell lung cancer cell lines.
Serum levels of Hemorphin-7 peptides in patients with breast cancer.
Significance of cathepsin-D expression in uterine tumours.
Significance of estrogen receptors and cathepsin D tissue detection in gastric adenocarcinoma.
Significance of the tumor protease Cathepsin D for the biology of breast cancer.
Similarities and differences in the biogenesis, processing and lysosomal targeting between zebrafish and human pro-Cathepsin D: functional implications.
Single- and double-headed chemical probes for detection of active cathepsin D in a cancer cell proteome.
Skeletal muscle mRNA levels for cathepsin B, but not components of the ubiquitin-proteasome pathway, are increased in patients with lung cancer referred for thoracotomy.
Specific oncological contribution of cathepsin D and pS2 in human breast cancer: their relationship with TNM status, estradiol receptors, epidermal growth factor receptor and neu amplification.
Splenic littoral cell haemangioendothelioma: a new low-grade variant of malignant littoral cell tumour.
Squamous cell carcinoma of the vulva. Expression of tumor proteases cathepsin-D and pro-cathepsin-L.
Stefins and lysosomal cathepsins B, L and D in human breast carcinoma.
Steroid receptors, pS2 and cathepsin D in early clinically node-negative breast cancer.
Stromal cell cathepsin D expression and long-term survival in breast cancer.
Structural differences in the cell binding region of human fibronectin molecules isolated from cultured normal and tumor-derived human cells.
Structure-Activity Relationships of JMV4463, a Vectorized Cathepsin?D Inhibitor with Antiproliferative Properties: The Unique Role of the AMPA-Based Vector.
Study of the frequencies of CYP1A1 gene polymorphisms and glutathione S-transferase mu1 gene in primary breast cancers: an update with an additional 114 cases.
Tamoxifen treatment increases the concentration of 52K-cathepsin D and its precursor in breast cancer tissue.
Telmisartan prevents aneurysm progression in the rat by inhibiting proteolysis, apoptosis and inflammation.
Tenascin C and cathepsin d expression in adipocytic tumors: an immunohistochemical investigation of 43 cases.
The clinical value of cathepsin-D and TNF-alpha in bladder cancer patients.
The diagnostic value of lysosomal enzyme patterns in bronchial aspirates of patients with suspected bronchial carcinoma.
The dilemma: Does tissue expression of cathepsin D reflect tumor malignancy? The question: Does the assay truly mirror cathepsin D mis-function in the tumor?
The effect of hormone replacement therapy on prognostic indices in women with breast cancer.
The Expression of Lysosomal Proteinases and Their Inhibitors in Breast Cancer: Possible Relationship to Prognosis of the Disease.
The fibrinolytic system in neoplasia.
The human breast cancer cell line IIB-BR-G has amplified c-myc and c-fos oncogenes in vitro and is spontaneously metastatic in vivo.
The immunohistochemical expression of cathepsin D in colorectal cancer.
The pathological and biological nature of screen-detected breast carcinomas: a morphological and immunohistochemical study.
The pathology of low-grade adenosquamous carcinoma of the breast. An immunohistochemical study.
The potential prognostic value of cathepsin D protein in serous ovarian cancer.
The prognostic value of the expression of collagenase IV, cathepsin D and metallothionein in squamous cell carcinomas of the skin determined by immunohistochemistry.
The prognostic-significance of cathepsin-d in breast carcinomas - an immunohistochemical study.
The relative prognostic significance of total cathepsin D and HER-2/neu oncogene amplification in breast cancer. The South Australian Breast Cancer Study Group.
The role of cathepsin D in the invasiveness of human breast cancer cells.
The value of the lysosomal protease cathepsin-d in egyptian bladder-cancer.
Three-dimensional chitosan scaffold-based MCF-7 cell culture for the determination of the cytotoxicity of tamoxifen.
Three-dimensional type I collagen gel system containing MG-63 osteoblasts-like cells as a model for studying local bone reaction caused by metastatic cancer cells.
Thrombin up-regulates cathepsin D which enhances angiogenesis, growth, and metastasis.
Thrombospondin 1 and cathepsin D improve prostate cancer diagnosis by avoiding potentially unneeded prostate biopsies.
Thrombospondin-1 and -2 in node-negative breast cancer: correlation with angiogenic factors, p53, cathepsin D, hormone receptors and prognosis.
Thymidine phoshorylase expression in breast cancer: the prognostic significance and its association with other angiogenesis related proteins and extracellular matrix components.
Time at surgery during menstrual cycle and menopause affects pS2 but not cathepsin D levels in breast cancer.
Tissue cathepsins as tumor markers.
Tissue polypeptide antigen in breast cancer cytosol: a new effective prognostic indicator.
Transcriptionally active non-ligand binding oestrogen receptors in breast cancer.
Transfected cathepsin D stimulates high density cancer cell growth by inactivating secreted growth inhibitors.
Transformation by oncogenic ras-p21 alters the processing and subcellular localization of the lysosomal protease cathepsin D.
Tumor characteristics involved in the metastatic behaviour as an improvement in primary cutaneous melanoma prognostics.
Tumor growth fraction, expression of estrogen and progesterone receptors, p53, bcl-2 and cathepsin D activity in primary ductal invasive breast carcinoma and their axillary lymph node metastases.
Tumor oxygenation correlates with molecular growth determinants in breast cancer.
Tumor-associated proteases and inhibitors in gastric cancer: analysis of prognostic impact and individual risk protease patterns.
Tumour budding intensity in relation to cathepsin D expression and some clinicopathological features of colorectal cancer.
Tumour epidermal growth factor receptor, erbB-2 and cathepsin D in node-negative invasive breast cancer: their impact on the selection of patients for systemic adjuvant therapy.
Tumour-associated fibrinolysis: the prognostic relevance of plasminogen activators uPA and tPA in human breast cancer.
Two-dimensional gel electrophoresis of Caenorhabditis elegans homogenates and identification of protein spots by microsequencing.
Urokinase-type plasminogen activator, plasminogen activator inhibitor type 1 and cathepsin D: analysis of their prognostic significance in squamous cell carcinoma of the head and neck.
Variable expression of cathepsin B and D correlates with highly invasive and metastatic phenotype of oral cancer.
Vorinostat and hydroxychloroquine improve immunity and inhibit autophagy in metastatic colorectal cancer.
Well-differentiated adenocarcinoma, gastric foveolar type, of the extrahepatic bile ducts: A previously unrecognized and distinctive morphologic variant of bile duct carcinoma.
Western blotting and isoform analysis of cathepsin D from normal and malignant human breast cell lines.
Yeast as a tool to explore cathepsin D function.
Zn-alpha 2-glycoprotein levels in breast cancer cytosols and correlation with clinical, histological and biochemical parameters.
[A histopathologic and immunohistochemical study of prognostic factors in esophageal squamous cell carcinoma]
[Activity of cathepsin D in some neoplasms of the gastrointestinal tract]
[Activity of cathepsin D in the blood serum and urine of patients with cancer of the stomach, pancreas and liver]
[Axillary lymph node involvement in hormone-independent breast carcinomas]
[Cancer procoagulant and cathepsin D activity in blood serum in patients with bladder cancer]
[Cathepsin D activity in gastric cancer]
[Cathepsin D activity in human ovarian carcinoma]
[Cathepsin D and B activity in the serum of patients with urothelial bladder cancer].
[Cathepsin D expression in primary breast cancer. Comparison of immunohistochemical and biochemical results]
[Cathepsin D in diagnosis of neoplastic diseases]
[Cathepsin D in primary breast cancer in correlation with various prognostic factors]
[Cathepsin D: an independent prognostic factor in cancer of the breast]
[Clinical and prognostic significance of tumor-associated proteases in gynecologic oncology]
[Clinico-pathological features of ER+/PR+ and ER+/PR- breast tumors: a comparative study of 5211 cases]
[Cytosolic cathepsin D levels in squamous carcinomas of the lung]
[Cytosolic pS2 levels and cellular proliferation in ER-positive and PgR-positive infiltrating ductal carcinomas of the breast]
[Estrogens, cathepsin D and metastasis in cancers of the breast and ovary: invasion or proliferation?]
[Expression of cathepsin D in breast cancer and its clinical and histopathological correlations]
[Glutathione S-transferase mu 1 (GSTM1): susceptibility gene of breast cancer]
[Granular cell tumor of the breast]
[Immunohistochemical study of Cath-D and CD44 in laryngeal squamous cell carcinomas]
[Indices of proteolysis in evaluation of resorption in bone tumors]
[Involvement of cathepsin D and cathepsin E in the inhibition of tumor growth and metastasis through the production of angiogenetic inhibitors]
[Mechanism of the overexpression of the cathepsin D gene in breast cancer and consequences in the metastatic process]
[Modern prospects for molecular-biochemical methods for evaluating biological "behavior" of breast neoplasms]
[Neoadjuvant chemotherapy, with mitoxantrone, cyclophosphamide and fluorouracil, in operable breast cancer of intermediate stage: first results of a phase II study in 40 patients]
[Over-expression of Hypoxia-inducible factor 1alpha increases invasive potency of LNCaP cells in vitro]
[Prognostic factors in breast cancer with contralateral supraclavicular or axillary lymphatic metastases]
[Prognostic implications of biologic markers in intracranial meningiomas: 120 cases]
[Prognostic significance of determining cathepsin B activity in malignant ovarian tumors]
[Proteolytic enzyme activity in stomach cancer patients with various prognoses]
[Proteolytic lysosomal enzymes in ovarian cancer]
[Study of cathepsin D levels in invasive bladder cancer and its stroma. Correlation with tumor stage, cytological grade, lymph node metastasis and survival]
[Study of the cytosolic concentrations of the tissue poly-peptide specific (TPS) antigen in infiltrating ductal carcinomas of the breast. Positive relationship with hormone dependency and negative with cellular proliferation]
[The expression of cathepsin-D in salivary adenoid cystic carcinoma]
[The lysosomal cathepsins B, L and D in development of murine experimental leukemias]
[The prognostic significance of cathepsin D in primary breast cancer]
[The prognostic value of cathepsin D concentration in cytosol of primary breast carcinoma]
[The prognostic value of cathepsin D in endometrial carcinoma]
[The role of cathepsin D in progression of neoplasms]
[Value of immunohistochemical determination of receptors, tissue proteases, tumor suppressor proteins and proliferation markers as prognostic indicators in primary breast carcinoma]
Neoplasms, Connective Tissue
Immunolocalization of cathepsin D in normal and neoplastic human tissues.
Neoplastic Cells, Circulating
American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer.
Nephritis
Role of monocytes in cryoglobulinemia-associated nephritis.
[Pathogenetic significance of lipid peroxidation in damage of the proximal segment of the nephron in acute Masugi's nephritis]
Nephrotic Syndrome
Increased cathepsin D-like activity in cortex, tubules, and glomeruli isolated from rats with experimental nephrotic syndrome.
Molecular forms of beta-hexosaminidase and cathepsin D in serum and urine of healthy subjects and patients with elevated activity of lysosomal enzymes.
Nervous System Diseases
In vivo MRI reveals the dynamics of pathological changes in the brains of cathepsin D-deficient mice and correlates changes in manganese-enhanced MRI with microglial activation.
New insights into the roles of endolysosomal cathepsins in the pathogenesis of Alzheimer's disease: cathepsin inhibitors as potential therapeutics.
Netherton Syndrome
Epidermal differentiation: the role of proteases and their inhibitors.
Neurilemmoma
Immunohistochemical localization of lysosomal cathepsin D in schwannomas.
Neuroblastoma
Cathepsin D and its newly identified transport receptor SEZ6L2 can modulate neurite outgrowth.
Cathepsin D protects human neuroblastoma cells from doxorubicin-induced cell death.
Cellular distribution of cathepsin D in childhood tumors.
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Down-regulation of natural resistance-associated macrophage protein-1 (Nramp1) is associated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)/1-methyl-4-phenylpyridinium (MPP+ )-induced ?-synuclein accumulation and neurotoxicity.
Limited proteolytic processing of the mature form of cathepsin D in human and mouse brain: postmortem stability of enzyme structure and activity.
Neurotoxicity of microglial cathepsin D revealed by secretome analysis.
The pro-survival role of autophagy depends on Bcl-2 under nutrition stress conditions.
Neurodegenerative Diseases
Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain.
Cathepsin D deficiency and NCL/Batten disease: there's more to death than apoptosis.
Cathepsin D Deficiency and NCL/Batten Disease: There's More to Death than Apoptosis.
Cathepsin D deficiency induces cytoskeletal changes and affects cell migration pathways in the brain.
Cathepsin D deficiency is associated with a human neurodegenerative disorder.
Cathepsin D Polymorphism C224T in Childhood-Onset Neurodegenerative Disorders: No Impact for Childhood Dementia.
Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified ?-Synuclein Degradation Properties.
Cathepsin D-Managing the Delicate Balance.
Corrigendum: Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified ?-Synuclein Degradation Properties.
Elevated levels of the endosomal-lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease.
Knockdown of cathepsin D protects dopaminergic neurons against neuroinflammation-mediated neurotoxicity through inhibition of NF-?B signalling pathway in Parkinson's disease model.
Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.
Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis.
Multi-Granulin Domain Peptides Bind to Pro-Cathepsin D and Stimulate Its Enzymatic Activity More Effectively Than Progranulin in Vitro.
Neurotoxicity of microglial cathepsin D revealed by secretome analysis.
Role of Apolipoprotein E, Cathepsin D, and Brain-Derived Neurotrophic Factor in Parkinson's Disease: A Study from Eastern India.
Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis.
Similarities and differences in the biogenesis, processing and lysosomal targeting between zebrafish and human pro-Cathepsin D: functional implications.
The Role of Cathepsin D in the Pathogenesis of Human Neurodegenerative Disorders.
Neuroinflammatory Diseases
Knockdown of cathepsin D protects dopaminergic neurons against neuroinflammation-mediated neurotoxicity through inhibition of NF-?B signalling pathway in Parkinson's disease model.
Neuromuscular Diseases
Lysosomal and nonlysosomal hydrolases of skeletal muscle in neuromuscular diseases.
Neuronal Ceroid-Lipofuscinoses
A mutation in the cathepsin D gene (CTSD) in American Bulldogs with neuronal ceroid lipofuscinosis.
A novel cathepsin D mutation in 2 siblings with late infantile neuronal ceroid lipofuscinosis.
A replacement of the active-site aspartic acid residue 293 in mouse cathepsin D affects its intracellular stability, processing and transport in HEK-293 cells.
Accumulation of bis(monoacylglycero)phosphate and gangliosides in mouse models of neuronal ceroid lipofuscinosis.
An Alzheimer's Disease-Linked Loss-of-Function CLN5 Variant Impairs Cathepsin D Maturation, Consistent with a Retromer Trafficking Defect.
Cathepsin D deficiency and NCL/Batten disease: there's more to death than apoptosis.
Cathepsin D Deficiency and NCL/Batten Disease: There's More to Death than Apoptosis.
Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis.
Cathepsin D-Managing the Delicate Balance.
CNS-expressed cathepsin D prevents lymphopenia in a murine model of congenital neuronal ceroid lipofuscinosis.
Congenital ovine neuronal ceroid lipofuscinosis--a cathepsin D deficiency with increased levels of the inactive enzyme.
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis.
Genetic modifiers of degeneration in the cathepsin D deficient Drosophila model for neuronal ceroid lipofuscinosis.
Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of ?-synuclein aggregates.
Metabolic epilepsies: approaches to a diagnostic challenge.
Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.
Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis.
Neuroectoderm-specific deletion of cathepsin D in mice models human inherited neuronal ceroid lipofuscinosis type 10.
Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7.
Synaptic changes in the thalamocortical system of cathepsin D-deficient mice: a model of human congenital neuronal ceroid-lipofuscinosis.
Nevus
Expression of cathepsin D in primary and metastatic human melanoma and dysplastic nevi.
Overexpression of cathepsin D in malignant melanoma.
Newcastle Disease
Autophagy in farm animals: current knowledge and future challenges.
Niemann-Pick Disease, Type C
Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis.
Non-alcoholic Fatty Liver Disease
Insulin resistance is positively associated with plasma cathepsin D activity in NAFLD patients.
Limited applicability of cathepsin D for the diagnosis and monitoring of non-alcoholic steatohepatitis.
Myosteatosis in NAFLD patients correlates with plasma Cathepsin D.
Plasma cathepsin d levels: a novel tool to predict pediatric hepatic inflammation.
Severity of coronary artery disease is associated with non-alcoholic fatty liver dis-ease: A single-blinded prospective mono-center study.
Non-ST Elevated Myocardial Infarction
Admission Value of Serum Cathepsin D Level Can be Useful for Predicting In-Hospital Mortality in Patients with NSTEMI.
Obesity
Cathepsin-D, a key protease in breast cancer, is up-regulated in obese mouse and human adipose tissue, and controls adipogenesis.
Clinical prognostic factors and expression of cathepsin D in endometrioid adenocarcinoma.
Oculocerebrorenal Syndrome
Lysosomal enzymuria is a feature of hereditary Fanconi syndrome and is related to elevated CI-mannose-6-P-receptor excretion.
Oligodendroglioma
Adhesive and invasive features in gliomas.
Oligospermia
Identification and purification of an aspartic proteinase from human semen.
Osteoarthritis
Biochemical and histological changes in osteoarthritic synovial membrane.
Comparative analysis of cathepsin L, cathepsin D, and collagenase messenger RNA expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization.
Identification and structure-activity relationship studies of small molecule inhibitors of the human cathepsin D.
Structure-based optimization of non-peptidic Cathepsin D inhibitors.
Sustained and distinctive patterns of gene activation in synovial fibroblasts and whole synovial tissue obtained from inflammatory synovitis.
The activity of cathepsin D and alpha-1 antitrypsin in hip and knee osteoarthritis.
Osteoarthritis, Knee
Lysosomal enzymes in serum and synovial fluid in patients with osteoarthritis.
The activity of cathepsin D and alpha-1 antitrypsin in hip and knee osteoarthritis.
[Activity of cathepsin D and alpha-1 antitrypsin in patients with hip or knee osteoarthritis].
Osteochondritis Dissecans
Autophagy in farm animals: current knowledge and future challenges.
Osteosarcoma
Effects of Cu/Zn superoxide dismutase on estrogen responsiveness and oxidative stress in human breast cancer cells.
Increased cathepsin D protein expression is a biomarker for osteosarcomas, pulmonary metastases and other bone malignancies.
Proteomic approach toward molecular backgrounds of drug resistance of osteosarcoma cells in spheroid culture system.
Out-of-Hospital Cardiac Arrest
Early recurrent arrhythmias after out-of-hospital cardiac arrest associated with obstructive coronary artery disease: Analysis of the PROCAT registry.
Immediate percutaneous coronary intervention is associated with better survival after out-of-hospital cardiac arrest: insights from the PROCAT (Parisian Region Out of hospital Cardiac ArresT) registry.
Ovarian Diseases
Patient-derived tumor-reactive antibodies as diagnostic markers for ovarian cancer.
Ovarian Neoplasms
Analysis of potential prognostic factors in 111 patients with ovarian cancer.
Cathepsin D antigenic epitopes identified by the humoral responses of ovarian cancer patients.
Cathepsin D assay in ovarian cancer: correlation with pathological features and receptors for oestrogen, progesterone and epidermal growth factor.
Cathepsin D immunoreactivity in ovarian cancer: correlation with prognostic factors.
Cathepsin D in ovarian cancer: prognostic value and correlation with p53 expression and microvessel density.
Cathepsin D in the Tumor Microenvironment of Breast and Ovarian Cancers.
Cathepsin D non-proteolytically induces proliferation and migration in human omental microvascular endothelial cells via activation of the ERK1/2 and PI3K/AKT pathways.
CHEMOTHERAPY DRUG RESPONSE IN OVARIAN CANCER CELLS STRICTLY DEPENDS ON A CATHEPSIN D - BAX ACTIVATION LOOP.
Clinical significance of cathepsin D in primary ovarian cancer.
Effect of fenhexamid and cyprodinil on the expression of cell cycle- and metastasis-related genes via an estrogen receptor-dependent pathway in cellular and xenografted ovarian cancer models.
Estradiol stimulates cell growth and secretion of procathepsin D and a 120-kilodalton protein in the human ovarian cancer cell line BG-1.
Expression of high molecular weight cysteine proteinase inhibitor in ovarian cancer tissues: regulation of cathepsin B expression by placental CPI.
Humoral immune responses to cathepsin D and glucose-regulated protein 78 in ovarian cancer patients.
Immunocytochemical localization of Cathepsin D and CA 125 in ovarian cancer.
Immunoradiometric and immunohistochemical analysis of Cathepsin D in ovarian cancer: lack of association with clinical outcome.
In vitro invasion assays.
Interactions of a low molecular weight inhibitor from Streptomyces sp. MBR04 with human cathepsin D: implications in mechanism of inactivation.
Modulation of proliferation and chemosensitivity by procathepsin D and its peptides in ovarian cancer.
New cathepsin d inhibitors with hydroxyethylamine isosteres: preparation and characterization.
Patient-derived tumor-reactive antibodies as diagnostic markers for ovarian cancer.
Protease levels in breast, ovary, and other gynecological tumor tissues: prognostic importance in breast cancer.
Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors.
The potential prognostic value of cathepsin D protein in serous ovarian cancer.
[Estrogens, cathepsin D and metastasis in cancers of the breast and ovary: invasion or proliferation?]
[Pro-cathepsin D can activate in vitro pro-cathepsin B secreted by ovarian cancers]
Overweight
Insulin resistance is positively associated with plasma cathepsin D activity in NAFLD patients.
Plasma cathepsin D activity is negatively associated with hepatic insulin sensitivity in overweight and obese humans.
Pancreatic Neoplasms
Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach.
Cathepsin D Expression and Gemcitabine Resistance in Pancreatic Cancer.
Quantitative proteomics analysis reveals that proteins differentially expressed in chronic pancreatitis are also frequently involved in pancreatic cancer.
The role of S100P in the invasion of pancreatic cancer cells is mediated through cytoskeletal changes and regulation of cathepsin D.
[Activity of cathepsin D in the blood serum and urine of patients with cancer of the stomach, pancreas and liver]
Pancreatitis
Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis.
Hormonal and cholinergic effects on amylase and lysosomal enzyme activities in pancreatic tissue and ascites of rats with acute experimental pancreatitis.
Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis.
Protective effects of PGE2 on diet-induced acute pancreatitis in mice.
Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry.
Transgenic expression of GFP-LC3 perturbs autophagy in exocrine pancreas and acute pancreatitis responses in mice.
Pancreatitis, Chronic
Quantitative proteomics analysis reveals that proteins differentially expressed in chronic pancreatitis are also frequently involved in pancreatic cancer.
Papilloma
Immunohistochemical expression of cathepsin D in laryngeal epithelial lesions: correlation with CD44 expression, p53 and Rb status and proliferation associated indices.
Papillon-Lefevre Disease
Epidermal differentiation: the role of proteases and their inhibitors.
Paralysis
Proteolytic enzymes in ordinary, hyperacute, monocytic and passive transfer forms of experimental allergic encephalomyelitis.
Parkinson Disease
Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis.
Effect of Temperature and pH on the Secondary Structure and Denaturation Process of Jumbo Squid Hepatopancreas Cathepsin D.
Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson's Disease.
Knockdown of cathepsin D protects dopaminergic neurons against neuroinflammation-mediated neurotoxicity through inhibition of NF-?B signalling pathway in Parkinson's disease model.
Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease.
Modulation of disease risk according to a cathepsin D / apolipoprotein E genotype in Parkinson's disease.
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Role of Apolipoprotein E, Cathepsin D, and Brain-Derived Neurotrophic Factor in Parkinson's Disease: A Study from Eastern India.
Parkinsonian Disorders
Pro-cathepsin D, Prosaposin, and Progranulin: Lysosomal Networks in Parkinsonism.
Sex differences in autophagy-mediated diseases: toward precision medicine.
Upregulation of cathepsin D in the caudate nucleus of primates with experimental parkinsonism.
Peptic Ulcer
Are tryptase and cathepsin D related to Helicobacter pylori infection and mucosal gastrin in peptic ulcer?
Aspartic proteinases in disease: a structural perspective.
Immunocytochemical evaluation of gastric mucosal cathepsin D in peptic ulcer.
Influence of Helicobacter pylori on tryptase and cathepsin D in peptic ulcer.
Periodontal Diseases
[Collagenase, dipeptidylpeptidase IV, and cathepsin D activities in gingival fluid and whole saliva from patients with periodontal disease (author's transl)]
Periodontitis
Possible role of lysosomal enzymes in the pathogenesis of periodontitis: a study on cathepsin D in human gingival fluid.
[The proteinase inhibitors of mixed saliva in periodontitis]
Peripheral Arterial Disease
Activity of cathepsin D and alpha-glucosidase in muscle from patients with peripheral arterial disease.
Peritonitis
[Blood proteinase inhibitors and cathepsin D in diffuse peritonitis]
Peste-des-Petits-Ruminants
Autophagy in farm animals: current knowledge and future challenges.
Pheochromocytoma
Prognostic markers in pheochromocytoma.
Pituitary Neoplasms
DNA measurement, proliferation markers, and other factors in pituitary adenomas.
Expression of hypoxia-inducible factor 1alpha and cathepsin D in pituitary adenomas.
Proliferation Markers and EGF in ACTH-Secreting Adenomas and Carcinomas of the Pituitary.
Pleural Effusion
Pro-cathepsin D as a diagnostic marker in differentiating malignant from benign pleural effusion: a retrospective cohort study.
Pneumococcal Infections
A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.
Poliomyelitis
[Action of human leukocyte interferon on poliomyelitis virus reproduction in resistant MIO(r) cells]
[Cathepsin D activity in cells differing in their sensitivity to the poliomyelitis virus]
Polycystic Kidney, Autosomal Dominant
Functional defects in lysosomal enzymes in autosomal dominant polycystic kidney disease (ADPKD): abnormalities in synthesis, molecular processing, polarity, and secretion.
Polycystic Ovary Syndrome
[Cathepsin D expression in ovaries from polycystic ovarian syndrome patients]
Pre-Eclampsia
Cathepsin D levels are reduced in patients with preeclampsia in Korean population.
Elevated vasoinhibin derived from prolactin and cathepsin D activities in sera of patients with preeclampsia.
Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia.
Preeclampsia-associated reduction of cathepsin D activity in the umbilical cord.
Pregnancy, Ectopic
Proteinase and proteinase inhibitor localization in the human placenta.
Prion Diseases
Genetic Association of a Cathepsin D Polymorphism and Sporadic Creutzfeldt-Jakob Disease.
Prostatic Diseases
[Proteases and prostatic disease: cytosolic cathepsin D]
Prostatic Hyperplasia
Cathepsin D cytosolic assay and immunohistochemical quantification in human prostate tumors.
Potential biomarkers for differentiation of benign prostatic hyperplasia and prostate cancer.
Prostatic Neoplasms
Analysis of cathepsin D forms and their clinical implications in human prostate cancer.
Analytical performance of thrombospondin-1 and cathepsin D immunoassays part of a novel CE-IVD marked test as an aid in the diagnosis of prostate cancer.
Camalexin-induced apoptosis in prostate cancer cells involves alterations of expression and activity of lysosomal protease cathepsin d.
Cathepsin D and epidermal growth factor receptor immunohistochemistry does not predict recurrence of prostate cancer in patients undergoing radical prostatectomy.
Cathepsin D cytosolic assay and immunohistochemical quantification in human prostate tumors.
Characterization of protease expression in human prostate-cancer cell-lines.
Distribution of cathepsin D granules in normal and pathologic conditions in human prostate.
Endogenous cathepsin D-mediated hydrolysis of insulin-like growth factor-binding proteins in cultured human prostatic carcinoma cells.
High-throughput detection of low abundance sialylated glycoproteins in human serum by TiO2 enrichment and targeted LC-MS/MS analysis: application to a prostate cancer sample set.
Hydrolysis of androgen receptor by cathepsin D: its biological significance in human prostate cancer.
Immunohistochemical analysis of cathepsin D in prostate carcinoma.
Immunohistochemical detection of cathepsin-d expression in prostate-cancer.
New cathepsin d inhibitors with hydroxyethylamine isosteres: preparation and characterization.
Olfactomedin 4 Suppresses Prostate Cancer Cell Growth and Metastasis via Negative Interaction with Cathepsin D and SDF-1.
Over-expression of hypoxia-inducible factor-1alpha increases the invasive potency of LNCaP cells in vitro.
Potential biomarkers for differentiation of benign prostatic hyperplasia and prostate cancer.
Prediction of the extent of prostate cancer by the combined use of systematic biopsy and serum level of cathepsin D.
Quantitative immunohistochemical determination of cathepsin D levels in prostatic carcinoma biopsies. Correlation with tumor grade, stage, PSA level, and DNA ploidy status.
Role of cathepsin D in prostatic cancer cell growth and its regulation by brefeldin A.
Serum cathepsin D and its density in men with prostate cancer as new predictors of disease progression.
Thrombospondin 1 and cathepsin D improve prostate cancer diagnosis by avoiding potentially unneeded prostate biopsies.
[Over-expression of Hypoxia-inducible factor 1alpha increases invasive potency of LNCaP cells in vitro]
[Proteases and prostatic disease: cytosolic cathepsin D]
Protein Deficiency
Activation of protease activity in rat peritoneal macrophages in protein deficiency: characterization of cathepsin D.
Dietary control of cardiac lysosomal enzyme activities.
Proteinuria
Cathepsin D in Podocytes Is Important in the Pathogenesis of Proteinuria and CKD.
Changes in lysosome populations in the rat kidney cortex induced by experimental proteinuria.
The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats.
Psoriasis
Cathepsin D expression in chronic plaque psoriasis: an immunohistochemical study.
Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation.
Pulmonary Disease, Chronic Obstructive
Activity of ?1-antitrypsin and some lysosomal enzymes in the blood serum of patients with chronic obstructive pulmonary disease after smoking cessation.
Impact of cathepsin D activity and C224T polymorphism (rs17571) on chronic obstructive pulmonary disease: correlations with oxidative and inflammatory markers.
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Pulmonary Fibrosis
Altered surfactant homeostasis and alveolar epithelial cell stress in amiodarone-induced lung fibrosis.
Immunolocalization of cathepsin D in pneumocytes of normal human lung and in pulmonary fibrosis.
Renal Insufficiency
The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach.
Renal Insufficiency, Chronic
Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease.
Morin hydrate attenuates adenine-induced renal fibrosis via targeting cathepsin D signaling.
Relation between serum cathepsin D levels and endothelial dysfunction in patients with chronic kidney disease.
Retinal Degeneration
Cathepsin proteases mediate photoreceptor cell degeneration in Drosophila.
Light induced retinal degeneration activates a caspase-independent pathway involving cathepsin D.
Practical considerations of recombinant adeno-associated virus-mediated gene transfer for treatment of retinal degenerations.
Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice-An Animal Model of CLN10 Disease.
Retinal Diseases
Loss of melanoregulin (MREG) enhances cathepsin-D secretion by the retinal pigment epithelium.
Retinal Dystrophies
Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice-An Animal Model of CLN10 Disease.
Retinitis Pigmentosa
Identification of proteins in retinas and IPM from eyes with retinitis pigmentosa.
Retinoblastoma
The pathological and biological nature of screen-detected breast carcinomas: a morphological and immunohistochemical study.
Rhabdomyolysis
Immunocytochemical studies of cathepsin D in human skeletal muscle.
Rheumatic Diseases
Cathepsin D agglutinators in rheumatoid arthritis. I. Increased CDA titers in serum and synovial fluid of patients with seropositive RA.
Proceedings: Incidence of cathepsin D agglutinators in sera, synovial fluids, and exudate cells and synovial tissue of patients with RA and other rheumatic diseases.
Sarcoma
Proteomic expression analysis of colorectal cancer by two-dimensional differential gel electrophoresis.
Schistosomiasis
Cathepsin D immobilized capillary reactors for on-flow screening assays.
Lipid core peptide targeting the cathepsin D hemoglobinase of Schistosoma mansoni as a component of a schistosomiasis vaccine.
Scrapie
Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes.
Ubiquitin immunocytochemistry in human spongiform encephalopathies.
Seizures
Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis.
Elevated cathepsin D expression in kainate-evoked rat brain neurodegeneration.
Picrotoxin-induced convulsions and lysosomal function in the rat brain.
Zinc and 4-hydroxy-2-nonenal mediate lysosomal membrane permeabilization induced by H2O2 in cultured hippocampal neurons.
Shock, Septic
Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation.
Divergent results induced by different types of septic shock in transglutaminase 2 knockout mice.
Plasma lysosomal enzymes in experimental and clinical endotoxemia.
Small Cell Lung Carcinoma
Activity and tissue localization of cathepsin D in non small cell lung cancer.
Secretion of a latent, acid activatable cathepsin L precursor by human non-small cell lung cancer cell lines.
Spermatic Cord Torsion
Immunohistochemical study of flotillin-1 in rat testis with ischemia/reperfusion injury.
Spinal Cord Injuries
Gene expression profiling of cathepsin D, metallothioneins-1 and -2, osteopontin, and tenascin-C in a mouse spinal cord injury model by cDNA microarray analysis.
Immunohistochemical study of cathepsin D in the spinal cords of rats with clip compression injury.
Squamous Cell Carcinoma of Head and Neck
Cathepsin D in laryngeal carcinoma. preliminary report.
Detection of oral squamous cell carcinoma metastasis with cathepsin D: An immunohistochemical approach.
Differential expression levels of urokinase-type plasminogen activator and cathepsin D in locally advanced laryngeal squamous cell carcinoma: clinical implications.
Immunohistochemical analysis and prognostic value of cathepsin D determination in laryngeal squamous cell carcinoma.
ST Elevation Myocardial Infarction
Correlation between electrocardiographic changes and coronary findings in patients with acute myocardial infarction and single-vessel disease.
Role of cathepsin D activation in major adverse cardiovascular events and new-onset heart failure after STEMI.
Starvation
Aspartic Cathepsin D Endopeptidase Contributes to Extracellular Digestion in Clawed Lobsters Homarus americanus and Homarus gammarus.
Autophagy maintains cardiac function in the starved adult.
Cancer with low cathepsin D levels is susceptible to V-ATPase inhibition.
Dietary control of cardiac lysosomal enzyme activities.
Effect of starvation on global gene expression and proteolysis in rainbow trout (Oncorhynchus mykiss).
Effects of brief starvation on brain protease activity.
Functional significance and morphological characterization of starvation-induced autophagy in the adult heart.
Hormonal and nutritional substrate control of cardiac lysosomal enzyme activities.
In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11.
Increased resistance of lipofuscin-loaded prematurely senescent fibroblasts to starvation-induced programmed cell death.
Influence of starvation on the activities and localization of cathepsin D and other lysosomal enzymes in hearts of rabbits and mice.
Metabolic priorities during starvation: enzyme sparing in liver and white muscle of Atlantic cod, Gadus morhua L.
Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes.
Rabbit cardiac immunoreactive cathepsin D content during starvation-induced atrophy.
Regulation of proteinase levels in the nematode Caenorhabditis elegans. Preferential depression by acute or chronic starvation.
Salmon spawning migration and muscle protein metabolism: the August Krogh principle at work.
Stomach Diseases
[Activity of cathepsin D in the blood in various stomach diseases]
Stomach Neoplasms
FOXM1 facilitates gastric cancer cell migration and invasion by inducing Cathepsin D.
Intracytoplasmic localization of cathepsin D reflects the invasive potential of gastric carcinoma.
Micro-lymph node metastasis and its correlation with cathepsin D expression in early gastric cancer.
Predictive value of cathepsin D and Ki-67 expression at the deepest penetration site for lymph node metastases in gastric cancer.
Prognostic value of cytosolyc cathepsin D content in resectable gastric cancer.
Proteomics-based Strategy to Delineate the Molecular Mechanisms of RhoGDI2-induced Metastasis and Drug Resistance in Gastric Cancer.
Relationship of tumoral hyaluronic acid and cathepsin D contents with histological type of gastric carcinoma.
Significance of Elevated Levels of Collagen Type IV and Hyaluronic Acid in Gastric Juice and Serum in Gastric Cancer and Precancerous Lesion.
Tumor-associated proteases and inhibitors in gastric cancer: analysis of prognostic impact and individual risk protease patterns.
VPS52 induces apoptosis via cathepsin D in gastric cancer.
[Activity of cathepsin D in some neoplasms of the gastrointestinal tract]
[Activity of cathepsin D in the blood serum and urine of patients with cancer of the stomach, pancreas and liver]
[Cathepsin D activity in gastric cancer]
Stroke
7A.10: METABOLIC SYNDROME PREDICTS INDEPENDENTLY FROM ITS COMPONENTS ADVERSE EVENTS IN ESSENTIAL HYPERTENSIVE SUBJECTS.
Multidisciplinary rounds (MDR): an implementation system for sustained improvement in the American Heart Association's Get With The Guidelines program.
Synovitis
Experimental arthritis of rabbits caused by intra-articular injection of autologous Fab2 produced by digestion of IgG with cathepsin D.
Ultrastructural studies of rabbit synovitis induced by autologous IgG fragments. II. Infiltrating cells in the sublining layer.
Synucleinopathies
Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species.
Lysosomal enzyme activities as possible CSF biomarkers of synucleinopathies.
Tauopathies
Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy.
Cathepsin D: A Candidate Link between Amyloid ?-protein and Tauopathy in Alzheimer Disease.
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
Teratocarcinoma
Protease activity associated with loss of adhesiveness in mouse teratocarcinoma.
Teratoma
Use of a novel system for defining a gene imprinting region.
Tetanus
Application of a novel highly sensitive activity-based probe for detection of cathepsin G.
Natural processing sites for human cathepsin E and cathepsin D in tetanus toxin: implications for T cell epitope generation.
Thrombocytosis
The prognostic significance of p53, mdm2, c-erbB-2, cathepsin D, and thrombocytosis in stage IB cervical cancer treated by primary radical hysterectomy.
Thrombosis
Anaphylactic cardiovascular collapse and Kounis syndrome: systemic vasodilation or coronary vasoconstriction?
Cathepsin D and cathepsin L activities in aortic aneurysm wall and parietal thrombus.
Hemorphin 7 reflects hemoglobin proteolysis in abdominal aortic aneurysm.
Thymoma
Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells.
Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB).
Thyroid Neoplasms
Cathepsin D in normal and neoplastic thyroid tissues.
Estrogen receptors and cathepsin D in human thyroid tissue.
Expression, localization, and thyrotropin regulation of cathepsin D in human thyroid tissues.
Lipid-rich residual bodies in the human thyroid gland: ultrastructural, histochemical, and morphometric study.
Thyrotoxicosis
Thyroid hormones and cathepsin D activity in the rat liver, kidney and brain.
Toxic Optic Neuropathy
Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of ?-secretase inhibitors.
Triple Negative Breast Neoplasms
A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment.
Cathepsin D inhibitors as potential therapeutics for breast cancer treatment: Molecular docking and bioevaluation against triple-negative and triple-positive breast cancers.
Co-Expression of Androgen Receptor and Cathepsin D Defines a Triple-Negative Breast Cancer Subgroup with Poorer Overall Survival.
Inhibition of Triple-Negative Breast Cancer Cell Aggressiveness by Cathepsin D Blockage: Role of Annexin A1.
Tuberculosis
Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited.
Differential trafficking of live and dead Mycobacterium marinum organisms in macrophages.
Lysophosphatidic acid enhances antimycobacterial activity both in vitro and ex vivo.
The role of cathepsin D in the pathogenesis of tuberculosis. A histochemical study employing unlabeled antibodies and the peroxidase-antiperoxidase complex.
Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block.
[Comparative characteristics of the activity of proteolytic enzymes and their inhibitors in the lung tissue of guinea pigs during development of generalized and destructive tuberculosis]
Tularemia
Sequential metabolic alterations in the myocardium during influenza and tularemia in mice.
Urinary Bladder Neoplasms
An immunohistochemical and prognostic evaluation of cathepsin D expression in 105 bladder carcinomas.
Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging.
Chromosomal and proteome analysis of a new T24-based cell line model for aggressive bladder cancer.
Expression of cathepsin D in bladder carcinoma: correlation with pathological features and serum cystatin C levels.
Expression of cathepsin D in transitional cell bladder tumours.
Expression of cathepsin D in urothelial carcinoma of the urinary bladder: an immunohistochemical study including correlations with extracellular matrix components, CD44, p53, Rb, c-erbB-2 and the proliferation indices.
Immunohistochemical studies of proliferating cell nuclear antigen and cathepsin D in transitional cell carcinoma of the urinary bladder.
Novel blood biomarkers of human urinary bladder cancer.
Prognostic significance of angiogenesis and immunoreactivity of cathepsin D and type IV collagen in high-grade stage T1 primary bladder cancer.
The value of the lysosomal protease cathepsin-d in egyptian bladder-cancer.
[Cancer procoagulant and cathepsin D activity in blood serum in patients with bladder cancer]
[Cathepsin D and B activity in the serum of patients with urothelial bladder cancer].
[Study of cathepsin D levels in invasive bladder cancer and its stroma. Correlation with tumor stage, cytological grade, lymph node metastasis and survival]
Uterine Cervical Neoplasms
Significance of cathepsin-D expression in uterine tumours.
Stable transfection of the estrogen receptor cDNA into Hela cells induces estrogen responsiveness of endogenous cathepsin D gene but not of cell growth.
The effect of combined therapy on activity of cathepsin D and alpha-1-antitrypsin in the blood serum of women with cervical cancer.
The prognostic significance of p53, mdm2, c-erbB-2, cathepsin D, and thrombocytosis in stage IB cervical cancer treated by primary radical hysterectomy.
Uterine Hemorrhage
Clinical prognostic factors and expression of cathepsin D in endometrioid adenocarcinoma.
Uterine Neoplasms
New cathepsin d inhibitors with hydroxyethylamine isosteres: preparation and characterization.
Vaccinia
High yield synthesis and characterization of phosphorylated recombinant human procathepsin D expressed in mammalian cells.
Varicose Veins
Cathepsin D activity and protein degradation products content in the walls of varicose veins of the lower limbs.
Vesicular Stomatitis
Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling.
Physical properties of a soluble form of the glycoprotein of vesicular stomatitis virus at neutral and acidic pH.
Virus Diseases
Astrocytosis and cathepsin D activity in experimental measles encephalomyelitis.
Peripartum cardiomyopathy. An update.
[Role of age-related serum factors in the mechanism of interferon production]
Wasting Syndrome
Muscle aspartyl protease (cathepsin D) activity: detection using a chromophoric substrate and relation to wasting in DBA/2 mice implanted with leukemic L1210 tumor cells.