3.4.23.5: cathepsin D

This is an abbreviated version!
For detailed information about cathepsin D, go to the full flat file.

Word Map on EC 3.4.23.5

3.4.23.5

lysosomal

pepstatin

estrogen

metastasis

alzheimer

proteinases

aspartyl

node

vacuole

lymph

renin

pepsin

endosomes

progesterone

hydrolases

endocytic

phagosomes

amyloid

beta-glucuronidase

plasminogen

mannose

6-phosphate

axillary

autophagosomes

saposins

lysosomal-associated

leupeptin

plasmepsins

beta-hexosaminidase

missorting

mannose-6-phosphate

chymosin

lysotracker

lipofuscinosis

lc3-ii

autophagy-lysosomal

rab7

ceroid

estrogen-regulated

immunoradiometric

medicine

lc3

lamp-1

node-negative

trans-golgi

upa

endocytosed

node-positive

c-erbb-2

autolysosomes

cation-independent

molecular biology

Reaction

Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His bond in B chain of insulin =

Synonyms

BmCatD, CAD 1, CAD 2, CAD 3, CapD, Cat D, CAT-D, CatD, Cath D, cath-D, cathD, cathepsin D, cathepsin D-like proteinase, cathepsin D1, cathepsin D2, CD1, CTSD, EC 3.4.4.23, matCTSD, PCD, Pep4p, preproCatD, pro-cathepsin, pro-cathepsin D, pro-CD, pro-CtsD, proCat, proCDrec, proCTSD, Proteinase A

ECTree

3.4 Acting on peptide bonds (peptidases)

3.4.23 Aspartic endopeptidases

3.4.23.5 cathepsin D

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Results	in table
9	Activating Compound
1050	AA Sequence
25	Application
1	CAS Registry Number
16	Cloned(Commentary)
6	Crystallization (Commentary)
7459	Disease/ Diagnostics
24	Expression
38	General Information
7	General Stability
75	IC50 Value
293	Inhibitors
51	Ki Value [mM]
97	KM Value [mM]
82	Localization
15	Metals/Ions
122	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
225	Organism
34	PDB ID
74	pH Optimum
18	pH Range
17	pH Stability
14	pI Value
34	Posttranslational Modification
12	Protein Variants
58	Purification (Commentary)
1	Reaction
2	Reaction Type
208	Reference
307	Source Tissue
35	Specific Activity [micromol/min/mg]
11	Storage Stability
364	Substrates and Products (Substrate)
70	Subunits
117	Synonyms
21	Temperature Optimum [°C]
8	Temperature Range [°C]
38	Temperature Stability [°C]
111	Turnover Number [1/s]

Molecular Weight

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of the Enzyme Summary Page.

Molecular Weight on EC 3.4.23.5 - cathepsin D

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100000

-

isoenzyme VI, probable precursor of isoenzyme V, gel filtration

12000

-

1 * 12000 + 1 * 34000, the enzyme also exists as a single chain enzyme form

13000

-

double chain form

13800

-

1 * 27400, subunit A, + 1 * 24600, subunit B, + 1 * 13800, subunit C, SDS-PAGE

14000

show

15000

show

18000

-

1 * 18000 + 1 * 33000, SDS-PAGE

20000

Oryctolagus cuniculus

-

x * 20000, SDS-PAGE

22000

Tribolium castaneum

-

x * 22000, SDS-PAGE

24600

-

1 * 27400, subunit A, + 1 * 24600, subunit B, + 1 * 13800, subunit C, SDS-PAGE

26229

x * 26229

27000

x * 27000, x * 35000, SDS-PAGE

27400

-

1 * 27400, subunit A, + 1 * 24600, subunit B, + 1 * 13800, subunit C, SDS-PAGE

29000

show

29000 - 30000

Oryctolagus cuniculus

-

equilibrium sedimentation

29100

Struthio camelus

-

1 * 29100 + 1 * 14000

30000

show

31000

show

33000

-

1 * 18000 + 1 * 33000, SDS-PAGE

34000

show

35000

show

36000

show

36400

show

36412

Ctenopharyngodon idella

x * 36412, mature cathepsin D, calculated from amino acid sequence

36500

Todarodes pacificus

-

x * 36500, SDS-PAGE

36510

Musca domestica

A1YZ22, A2ICG5, A2ICG6

CAD 3, calculated from amino acid sequence

36700

Spisula solidissima

-

gel filtration

37000

-

x * 37000, SDS-PAGE

37500

Sepia officinalis

-

x * 37500, purified enzyme, estimated from SDS-PAGE

38000

Clupea harengus

-

1 * 38000, SDS-PAGE

39000

Clupea harengus

-

gel filtration

40000

show

40000 - 50000

Rattus norvegicus

-

by cathepsin D-immunoblotting, major bands of 40000 to 50000 Da molecular weight are observed

40740

Rattus norvegicus

-

Cath D-I and Cath D-III, gel filtration

41000

x * 41000, mature enzyme, SDS-PAGE

42000

-

gel filtration

42600

Homarus americanus

-

x * 42600, calculated from amino acid sequence

42660

Rattus norvegicus

-

Cath D-II, gel filtration

42700

show

42772

Lethenteron camtschaticum

x * 42772, calculated from amino acid sequence

42800

-

gel filtration

43000

show

43106

Ctenopharyngodon idella

x * 43106, pre-pro-cathepsin D, calculated from amino acid sequence

44000

show

45000

show

45000 - 55000

-

two enzyme forms exist: a single 47000 Da polypeptide and a complex of 30000 Da subunit plus a 16500 Da subunit, gel filtration

46000

show

48000

show

49000

-

gel filtration

50000

show

50000 - 52000

Oryctolagus cuniculus

-

gel filtration

52000

show

53000

show

54000

Rattus norvegicus

-

prepro-cathepsin D

55000

show

56000

-

proform of CatD

95000

-

and a second molecular weight form of 45000 Da, gel filtration

additional information

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Release 2023.1 (January 2023)