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BRENDA support

3.4.23.5: cathepsin D

This is an abbreviated version!
For detailed information about cathepsin D, go to the full flat file.

Word Map on EC 3.4.23.5

Reaction

Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His bond in B chain of insulin =

Synonyms

BmCatD, CAD 1, CAD 2, CAD 3, CapD, Cat D, CAT-D, CatD, Cath D, cath-D, cathD, cathepsin D, cathepsin D-like proteinase, cathepsin D1, cathepsin D2, CD1, CTSD, EC 3.4.4.23, matCTSD, PCD, Pep4p, preproCatD, pro-cathepsin, pro-cathepsin D, pro-CD, pro-CtsD, proCat, proCDrec, proCTSD, Proteinase A

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.5 cathepsin D

Source Tissue

Source Tissue on EC 3.4.23.5 - cathepsin D

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
derived from human neuroblastoma cell line BE2-M17D
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
CP-A hTRT, CP-C hTRT, CP-D hTRT
Manually annotated by BRENDA team
lowest expression
Manually annotated by BRENDA team
-
cathepsin D is overexpressed and hyper-secreted by epithelial breast cancer cells
Manually annotated by BRENDA team
-
in M-BE, a SV40T-transformed human bronchial epithelial cell line with phenotypic features of early tumorigenesis, it is shown by 2-DE/MALDI-TOF that cathepsin D among 23 other proteins is up-regulated
Manually annotated by BRENDA team
-
prostate carcinoma, breast carcinoma
Manually annotated by BRENDA team
-
human colorectal cancer cell line DLD1 and HT29 are used
Manually annotated by BRENDA team
-
intraoocytic
Manually annotated by BRENDA team
lowest expression
Manually annotated by BRENDA team
-
fetal hepatocyte
Manually annotated by BRENDA team
-
T-cell hybridoma
Manually annotated by BRENDA team
-
Kupffer cells exhibit highest liver cathepsin D activity
Manually annotated by BRENDA team
cathepsin D of the silkworm Bombyx mori (BmCatD) is ecdysone-induced, differentially and spatially expressed in the larval fat body of the final instar and in the larval gut of pupal stage, and its expression leads to programmed cell death. Furthermore, BmCatD is highly induced in the fat body of baculovirus-infected Bombyx mori larvae
Manually annotated by BRENDA team
-
cell line J774 is used
Manually annotated by BRENDA team
-
inactive proform of enzyme
Manually annotated by BRENDA team
-
high expression
Manually annotated by BRENDA team
-
studies are carried out using peripheral blood neutrophils which are purified from healthy normal individuals and patients suffering from septic shock by Ficoll-Hypaque centrifugation
Manually annotated by BRENDA team
-
cathepsin D protein is over-expressed in plasma of 36 (out of 104) patients with lung squamous cell carcinoma
Manually annotated by BRENDA team
-
highly expressed in cultured Sertoli cells
Manually annotated by BRENDA team
-
surface
Manually annotated by BRENDA team
-
CatD is expressed in human eccrine sweat. Both forms, the active beta-chain of CatD (31 kDa) as well as the proform (56 kDa) can be detected in eccrine sweat, the latter in lower amounts
Manually annotated by BRENDA team
additional information