3.4.23.5: cathepsin D
This is an abbreviated version!
For detailed information about cathepsin D, go to the full flat file.
Word Map on EC 3.4.23.5
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3.4.23.5
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lysosomal
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pepstatin
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estrogen
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metastasis
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alzheimer
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proteinases
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aspartyl
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node
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vacuole
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lymph
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renin
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pepsin
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endosomes
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progesterone
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hydrolases
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endocytic
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phagosomes
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amyloid
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beta-glucuronidase
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plasminogen
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mannose
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6-phosphate
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axillary
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autophagosomes
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saposins
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lysosomal-associated
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leupeptin
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plasmepsins
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beta-hexosaminidase
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missorting
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mannose-6-phosphate
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chymosin
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lysotracker
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lipofuscinosis
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lc3-ii
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autophagy-lysosomal
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rab7
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ceroid
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estrogen-regulated
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immunoradiometric
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medicine
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lc3
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lamp-1
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node-negative
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trans-golgi
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upa
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endocytosed
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node-positive
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c-erbb-2
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autolysosomes
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cation-independent
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molecular biology
- 3.4.23.5
- lysosomal
- pepstatin
- estrogen
- metastasis
- alzheimer
- proteinases
-
aspartyl
- node
- vacuole
- lymph
- renin
- pepsin
- endosomes
- progesterone
- hydrolases
-
endocytic
-
phagosomes
-
amyloid
- beta-glucuronidase
- plasminogen
- mannose
- 6-phosphate
-
axillary
-
autophagosomes
-
saposins
-
lysosomal-associated
- leupeptin
-
plasmepsins
- beta-hexosaminidase
-
missorting
- mannose-6-phosphate
- chymosin
-
lysotracker
- lipofuscinosis
-
lc3-ii
-
autophagy-lysosomal
- rab7
-
ceroid
-
estrogen-regulated
-
immunoradiometric
- medicine
- lc3
- lamp-1
-
node-negative
-
trans-golgi
- upa
-
endocytosed
-
node-positive
-
c-erbb-2
-
autolysosomes
-
cation-independent
- molecular biology
Reaction
Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His bond in B chain of insulin =
Synonyms
BmCatD, CAD 1, CAD 2, CAD 3, CapD, Cat D, CAT-D, CatD, Cath D, cath-D, cathD, cathepsin D, cathepsin D-like proteinase, cathepsin D1, cathepsin D2, CD1, CTSD, EC 3.4.4.23, matCTSD, PCD, Pep4p, preproCatD, pro-cathepsin, pro-cathepsin D, pro-CD, pro-CtsD, proCat, proCDrec, proCTSD, Proteinase A
ECTree
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Source Tissue
Source Tissue on EC 3.4.23.5 - cathepsin D
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cathepsin D is overexpressed and hyper-secreted by epithelial breast cancer cells
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in M-BE, a SV40T-transformed human bronchial epithelial cell line with phenotypic features of early tumorigenesis, it is shown by 2-DE/MALDI-TOF that cathepsin D among 23 other proteins is up-regulated
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human colorectal cancer cell line DLD1 and HT29 are used
cathepsin D of the silkworm Bombyx mori (BmCatD) is ecdysone-induced, differentially and spatially expressed in the larval fat body of the final instar and in the larval gut of pupal stage, and its expression leads to programmed cell death. Furthermore, BmCatD is highly induced in the fat body of baculovirus-infected Bombyx mori larvae
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studies are carried out using peripheral blood neutrophils which are purified from healthy normal individuals and patients suffering from septic shock by Ficoll-Hypaque centrifugation
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cathepsin D protein is over-expressed in plasma of 36 (out of 104) patients with lung squamous cell carcinoma
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CatD is expressed in human eccrine sweat. Both forms, the active beta-chain of CatD (31 kDa) as well as the proform (56 kDa) can be detected in eccrine sweat, the latter in lower amounts
additional information
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by Western blot analysis it is shown that cathepsin is approximately 280fold more abundant in human brain than BACE-1
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comparative transcriptome analysis is carried out in cholesterol-loaded monocyte-derived macrophages from low high density lipoprotein cholesterol (HDL-C) patients and control group: expression of CTSD is reduced by 50% in monocyte-derived macrophages of low HDL subjects, most significantly those with cholesterol efflux defects but without mutation in ABCA1 groups as compared with controls
CAD 3 is localized inside secretory vesicles and around microvilli in anterior and middle midgut cells
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using a tissue microarray it is shown that the cathepsin D expression levels in squamous cell carcinoma tissues is significantly higher than those in normal donors