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3.4.23.5: cathepsin D

This is an abbreviated version!
For detailed information about cathepsin D, go to the full flat file.

Word Map on EC 3.4.23.5

Reaction

Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His bond in B chain of insulin =

Synonyms

BmCatD, CAD 1, CAD 2, CAD 3, CapD, Cat D, CAT-D, CatD, Cath D, cath-D, cathD, cathepsin D, cathepsin D-like proteinase, cathepsin D1, cathepsin D2, CD1, CTSD, EC 3.4.4.23, matCTSD, PCD, Pep4p, preproCatD, pro-cathepsin, pro-cathepsin D, pro-CD, pro-CtsD, proCat, proCDrec, proCTSD, Proteinase A

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.5 cathepsin D

Activating Compound

Activating Compound on EC 3.4.23.5 - cathepsin D

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ATP
-
385.5% activity at 1 mM
DELTA9-tetrahydrocannabinol
-
at 10 nM, almost doubles enzyme activity in cell culture
ethanol
-
in 10% (v/v) ethanol, the enzyme significantly increases its activity by 50%
H2O2
-
slight activation
Isopropanol
-
the presence of 15% (v/v) isopropanol generates a significant increase of 80% on enzyme activity
methanol
-
exposure of the enzyme to 5-15% (v/v) methanol produces 50% increase in enzyme activity
multi-granulin domain peptide
-
-
-
progranulin
-