3.4.23.5: cathepsin D
This is an abbreviated version!
For detailed information about cathepsin D, go to the full flat file.
Word Map on EC 3.4.23.5
-
3.4.23.5
-
lysosomal
-
pepstatin
-
estrogen
-
metastasis
-
alzheimer
-
proteinases
-
aspartyl
-
node
-
vacuole
-
lymph
-
renin
-
pepsin
-
endosomes
-
progesterone
-
hydrolases
-
endocytic
-
phagosomes
-
amyloid
-
beta-glucuronidase
-
plasminogen
-
mannose
-
6-phosphate
-
axillary
-
autophagosomes
-
saposins
-
lysosomal-associated
-
leupeptin
-
plasmepsins
-
beta-hexosaminidase
-
missorting
-
mannose-6-phosphate
-
chymosin
-
lysotracker
-
lipofuscinosis
-
lc3-ii
-
autophagy-lysosomal
-
rab7
-
ceroid
-
estrogen-regulated
-
immunoradiometric
-
medicine
-
lc3
-
lamp-1
-
node-negative
-
trans-golgi
-
upa
-
endocytosed
-
node-positive
-
c-erbb-2
-
autolysosomes
-
cation-independent
-
molecular biology
- 3.4.23.5
- lysosomal
- pepstatin
- estrogen
- metastasis
- alzheimer
- proteinases
-
aspartyl
- node
- vacuole
- lymph
- renin
- pepsin
- endosomes
- progesterone
- hydrolases
-
endocytic
-
phagosomes
-
amyloid
- beta-glucuronidase
- plasminogen
- mannose
- 6-phosphate
-
axillary
-
autophagosomes
-
saposins
-
lysosomal-associated
- leupeptin
-
plasmepsins
- beta-hexosaminidase
-
missorting
- mannose-6-phosphate
- chymosin
-
lysotracker
- lipofuscinosis
-
lc3-ii
-
autophagy-lysosomal
- rab7
-
ceroid
-
estrogen-regulated
-
immunoradiometric
- medicine
- lc3
- lamp-1
-
node-negative
-
trans-golgi
- upa
-
endocytosed
-
node-positive
-
c-erbb-2
-
autolysosomes
-
cation-independent
- molecular biology
Reaction
Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His bond in B chain of insulin =
Synonyms
BmCatD, CAD 1, CAD 2, CAD 3, CapD, Cat D, CAT-D, CatD, Cath D, cath-D, cathD, cathepsin D, cathepsin D-like proteinase, cathepsin D1, cathepsin D2, CD1, CTSD, EC 3.4.4.23, matCTSD, PCD, Pep4p, preproCatD, pro-cathepsin, pro-cathepsin D, pro-CD, pro-CtsD, proCat, proCDrec, proCTSD, Proteinase A
ECTree
3.4.23.5 cathepsin DAdvanced search results
results (
results (Turnover Number
Turnover Number on EC 3.4.23.5 - cathepsin D
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TURNOVER NUMBER [1/s] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
59.6
(7-methoxycoumarin-4-yl)acetyl-Gly-Lys-Pro-Ile-Ile-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2
-
40°C, pH 4.0, gastric cathepsin D
0.75
(7-methoxycoumarin-4-yl)acetyl-Gly-Ser-Ser-Ala-Phe-Leu-Ala-Phe-Lys(Dnp)-D-Arg-NH2
-
40°C, pH 4.0, gastric cathepsin D
6.18
2-aminobenzoyl-AEKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
16.3
2-aminobenzoyl-AIAFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.47
2-aminobenzoyl-AIIFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.65
2-aminobenzoyl-AIKFFIRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.65
2-aminobenzoyl-AIKFFKRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
1.95
2-aminobenzoyl-AIKFFRRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.99
2-aminobenzoyl-AIKFFSAQTNRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
3.25
2-aminobenzoyl-AIKFFSNQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.52
2-aminobenzoyl-AIKMFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
8.45
2-aminobenzoyl-AINFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.081
2-aminobenzoyl-AIPFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.41
2-aminobenzoyl-AIQFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
5.53
2-aminobenzoyl-AITFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.97
2-aminobenzoyl-ALKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
5.85
2-aminobenzoyl-ANKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.65
2-aminobenzoyl-ASKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.17
2-aminobenzoyl-KITLLSALVETRIVRFNRQ-(N-(2,4-dinitrophenyl)ethylenediamine)
-
37°C, pH 4.0
2.8
2-aminobenzoyl-KITLLSALVETRQ-(N-(2,4-dinitrophenyl)ethylenediamine)
-
37°C, pH 4.0
2.2
(7-methoxycoumarin-4-yl)acetyl-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(Dnp)-D-Arg-NH2
-
40°C, pH 4.0, spleen cathepsin D
2.5
(7-methoxycoumarin-4-yl)acetyl-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(Dnp)-D-Arg-NH2
-
40°C, pH 4.0, gastric cathepsin D
0.03 - 0.55
2-aminobenzoyl-AIEFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
7.48
2-aminobenzoyl-AIEFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
2.28
2-aminobenzoyl-AIKFFERQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
2.94
2-aminobenzoyl-AIKFFERQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
1.63
2-aminobenzoyl-AIKFFLRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
2.94
2-aminobenzoyl-AIKFFLRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.98
2-aminobenzoyl-AIKFFNRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
6.08
2-aminobenzoyl-AIKFFNRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
3.13
2-aminobenzoyl-AIKFFSA-(N-(2,4-dinitrophenyl)ethylenediamine)
-
37°C, pH 4.0
-
4.16
2-aminobenzoyl-AIKFFSA-(N-(2,4-dinitrophenyl)ethylenediamine)
-
37°C, pH 4.0
-
6.18
2-aminobenzoyl-AIKFFSAQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
6.34
2-aminobenzoyl-AIKFFSAQ-N-(2,4-dinitrophenyl)ethylenediamine
-
37°C, pH 4.0
6.34
2-aminobenzoyl-AIKFFSAQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.99
2-aminobenzoyl-AIKFFSAQTNRHILRFNR-(N-(2,4-dinitrophenyl)ethylenediamine)
-
37°C, pH 4.0
-
2.44
2-aminobenzoyl-AIKFFSAQTNRHILRFNR-(N-(2,4-dinitrophenyl)ethylenediamine)
-
37°C, pH 4.0
-
2.94
2-aminobenzoyl-AIKFFSAQTNRHILRFNR-(N-(2,4-dinitrophenyl)ethylenediamine)
-
37°C, pH 4.0
-
2.44
2-aminobenzoyl-AIKFFSAQTNRHILRFNRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
2.94
2-aminobenzoyl-AIKFFSAQTNRHILRFNRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
3.13
2-aminobenzoyl-AIKFFSEQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
3.58
2-aminobenzoyl-AIKFFSEQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
1.63
2-aminobenzoyl-AIKFFSIQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
2.94
2-aminobenzoyl-AIKFFSIQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
4.88
2-aminobenzoyl-AIKFFSOQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
4.88
2-aminobenzoyl-AIKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.98
2-aminobenzoyl-AIKFFSSQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
6.08
2-aminobenzoyl-AIKFFSSQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
2.28
2-aminobenzoyl-AIKFFSVQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
2.94
2-aminobenzoyl-AIKFFSVQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
1.63
2-aminobenzoyl-AIKFFTRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
2.94
2-aminobenzoyl-AIKFFTRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
1.63
2-aminobenzoyl-AIKFFVRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
2.94
2-aminobenzoyl-AIKFFVRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.03 - 0.55
2-aminobenzoyl-AIKLFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
7.15
2-aminobenzoyl-AIKLFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.98
2-aminobenzoyl-AIKLLSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
6.08
2-aminobenzoyl-AIKLLSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
2.28
2-aminobenzoyl-AIKLMSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
2.94
2-aminobenzoyl-AIKLMSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
2.47
2-aminobenzoyl-AIMFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
2.94
2-aminobenzoyl-AIMFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.04 - 1.97
2-aminobenzoyl-AISFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
8.78
2-aminobenzoyl-AISFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.84
2-aminobenzoyl-AIVFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
6.08
2-aminobenzoyl-AIVFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
2.93
2-aminobenzoyl-APKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
3 - 6
2-aminobenzoyl-APKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
2.28
2-aminobenzoyl-AQKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
2.94
2-aminobenzoyl-AQKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
3.13
2-aminobenzoyl-ATKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
3.58
2-aminobenzoyl-ATKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
0.04 - 1.97
2-aminobenzoyl-AVKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
8.78
2-aminobenzoyl-AVKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
2.3
2-aminobenzoyl-KITLLSAQ-(N-(2,4-dinitrophenyl)ethylenediamine)
-
37°C, pH 4.0
3.6
2-aminobenzoyl-KITLLSAQ-(N-(2,4-dinitrophenyl)ethylenediamine)
-
37°C, pH 4.0
50
Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu
-
enzyme from liver of AH-130 hepatoma-bearing rats
65
Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu
-
enzyme from AH-130 hepatoma cells
25
Pro-Pro-Thr-Ile-Phe-(4-nitro)Phe-Arg-Leu
-
enzyme from liver of AH-130 hepatoma-bearing rats
95
Pro-Pro-Thr-Ile-Phe-(4-nitro)Phe-Arg-Leu
-
enzyme from AH-130 hepatoma cells
additional information
2-aminobenzoyl-AEKFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
additional information
2-aminobenzoyl-AIKFFSAQ-N-(2,4-dinitrophenyl)ethylenediamine
-
37°C, pH 4.0
additional information
2-aminobenzoyl-AIKFFSAQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
additional information
2-aminobenzoyl-AITFFSRQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 4.0, 37°C
