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3.4.23.5: cathepsin D

This is an abbreviated version!
For detailed information about cathepsin D, go to the full flat file.

Word Map on EC 3.4.23.5

Reaction

Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His bond in B chain of insulin =

Synonyms

BmCatD, CAD 1, CAD 2, CAD 3, CapD, Cat D, CAT-D, CatD, Cath D, cath-D, cathD, cathepsin D, cathepsin D-like proteinase, cathepsin D1, cathepsin D2, CD1, CTSD, EC 3.4.4.23, matCTSD, PCD, Pep4p, preproCatD, pro-cathepsin, pro-cathepsin D, pro-CD, pro-CtsD, proCat, proCDrec, proCTSD, Proteinase A

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.5 cathepsin D

Expression

Expression on EC 3.4.23.5 - cathepsin D

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
15 days of starvation causes a 40% reduction in cathepsin D1 mRNA expression
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15 days of starvation does not cause significant changes in cathepsin D1 mRNA expression
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after 8 h Vibrio anguillarum challenge, the expression level of cathepsin D changes significantly in all examined tissues except mantle and hemocytes
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after challenge with Spiroplasma eriocheiris, the expression is significantly up-regulated from day 1 to 9
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cathepsin D decreases in chronic photodamaged skin
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cathepsin D expression and activity increases during epidermal differentiation
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cathepsin D expression in the buccal gland is increased 6.5-8.5fold after challenge with Escherichia coli or Staphylococcus aureus
cathepsin D expression shows an upward trend during embryonic development
cathepsin D is elevated in the frontal cortex, in pyramidal and granule cells of the hippocampus, and in cerebellar neurons of autistic subjects
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cathepsin D is not upregulated during apoptosis induced by 300 nM taxol or 0.01 mg doxorubicin or autophagy induced by 0.01 mM tamoxifen
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cathepsin D is overexpressed and hyper-secreted by epithelial breast cancer cells
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enzyme expression is upregulated in damaged tubular cells in nephrotoxic and ischemia reperfusion induced acute kidney injury. Enzyme expression is increased during acute tubular necrosis in transplanted kidneys
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enzyme expression levels are significantly increased in autolytic tissues
epidermal growth factor rapidly induces enzyme mRNA by 2-4fold. Cathepsin D is overexpressed in breast cancer
expression in mesenchymal stem cells is increased following co-culture with breast and colon cancer cells
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feeding after 15 days of starvation causes a 2.5fold increase in cathepsin D1 mRNA expression
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feeding after 15 days of starvation has no effect on cathepsin D1 mRNA expression
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manganese treatment causes significant increase of lysosomal enzyme cathepsin D
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senescence induced by ionizing radiation (6 Gy), 0.3 mM hydrogen peroxide or anticancer drugs (40 nM camptothecin, 0.03 mM etoposide, or 50 ng doxorubicin) is associated with up-regulation of cathepsin D
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Streptomyces pneumonia (strain D39) triggers activation of cathepsin D in macrophages about 2fold
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the enzyme expression is not influenced by the lysosomotropic agent Leu-Leu-OMe
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the enzyme expression is significantly upregulated in response to oxygen-glucose deprivation/reperfusion exposure
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the expression levels of cathepsin D in liver and head kidney increase gradually after 8 h and exceeded the background level after 24 h after challenge with Vibrio harveyi
there is a positive relationship between the expression and presence of cathepsin D at the extracellular compartment of the maternal-fetal interface and the invasiveness of the trophoblast during the postimplantation period
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