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Literature summary for 3.4.23.5 extracted from
- Purification of cathepsin D from cartilage and uterus and its action on the protein-polysaccharide complex of cartilage (1973), J. Biol. Chem., 248, 1634-1642.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-indolepyruvate | - |
Gallus gallus |  |
| 6-aminohexanoate | - |
Gallus gallus | |
| 6-aminohexanoate | - |
Oryctolagus cuniculus | |
| Chloroquine | - |
Gallus gallus | |
| pepstatin | - |
Bos taurus | |
| pepstatin | - |
Gallus gallus | |
| pepstatin | - |
Oryctolagus cuniculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 40000 | - |
gel filtration | Gallus gallus |
| 43000 | - |
gel filtration | Bos taurus |
| 43000 | - |
gel filtration | Oryctolagus cuniculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Gallus gallus | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Gallus gallus |
- |
Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cartilage | from ear | Oryctolagus cuniculus | - |
| cartilage | from limb | Gallus gallus | - |
| uterus | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Gallus gallus |
| additional information | - |
- |
Bos taurus |
| additional information | - |
- |
Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Hemoglobin + H2O | - |
Gallus gallus | ? | - |
? | |
| Hemoglobin + H2O | - |
Bos taurus | ? | - |
? | |
| Hemoglobin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
| insulin + H2O | - |
Bos taurus | ? | - |
? | |
| insulin + H2O | beta-chain of oxidized insulin | Gallus gallus | ? | - |
? | |
| insulin + H2O | beta-chain of oxidized insulin | Oryctolagus cuniculus | ? | - |
? | |
| protein-polysaccharide complex of bovine nasal cartilage + H2O | - |
Gallus gallus | fragments of bovine nasal cartilage | fragments are larger than single chains of chondroitin sulfate | ? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4 | - |
- |
Bos taurus |
| 4 | - |
protein-polysaccharide complex of bovine nasal cartilage | Gallus gallus |
| 4 | - |
protein-polysaccharide complex of bovine nasal cartilage | Oryctolagus cuniculus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 2.3 | 5 | pH 2.3: about 35% of maximal activity, pH 5.0: about 45% of maximal activity, digestion of denatured hemoglobin | Oryctolagus cuniculus |
| 2.5 | 5 | pH 2.5: about 95% of maximal activity, pH 5.0: about 20% of maximal activity, digestion of denatured hemoglobin | Gallus gallus |
| 3.5 | 4.5 | pH 3.5: about 55% of maximal activity, pH 4.5: about 60% of maximal activity | Oryctolagus cuniculus |
| 3.5 | 4.5 | pH 3.5: about 55% of maximal activity, pH 4.5: about 80% of maximal activity | Bos taurus |
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