3.3.2.6: leukotriene-A4 hydrolase
This is an abbreviated version!
For detailed information about leukotriene-A4 hydrolase, go to the full flat file.
Word Map on EC 3.3.2.6
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3.3.2.6
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5-lipoxygenase
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arachidonic
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epoxide
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medicine
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leukocyte
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asthma
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bestatin
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chemoattractant
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eicosanoids
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metalloenzyme
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flap
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ionophore
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alox5ap
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tuberculous
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transcellular
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5-lipoxygenase-activating
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aminopeptidases
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captopril
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lipoxins
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pro-gly-pro
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montelukast
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proline-glycine-proline
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5-hete
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zileuton
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diagnostics
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pharmacology
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drug development
- 3.3.2.6
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5-lipoxygenase
-
arachidonic
- epoxide
- medicine
- leukocyte
- asthma
- bestatin
-
chemoattractant
-
eicosanoids
-
metalloenzyme
- flap
-
ionophore
-
alox5ap
-
tuberculous
-
transcellular
-
5-lipoxygenase-activating
- aminopeptidases
- captopril
-
lipoxins
- pro-gly-pro
- montelukast
- proline-glycine-proline
-
5-hete
- zileuton
- diagnostics
- pharmacology
- drug development
Reaction
Synonyms
EH, epoxide hydrolase, hydrolase, leukotriene A4, leukotriene A(4) hydrolase, leukotriene A4 hydrolase, leukotriene A4 hydrolase/aminopeptidase, leukotriene hydrolase A4, leukotriene-A4 hydrolase, leukotriene-A4-hydrolase, LT A4 hydrolase, LTA-4 hydrolase, LTA4 hydrolase, LTA4-h, LTA4H, More
ECTree
3.3.2.6 leukotriene-A4 hydrolaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.3.2.6 - leukotriene-A4 hydrolase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
leukotriene A4 + H2O
leukotriene B4 + 5(S),12R-dihydroxy-6,10-trans-8,14-ciseicosatetraenoic acid
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product ratio 9:1
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?
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
-
-
-
-
?
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
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-
-
-
?
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
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-
-
?
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
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substrate for the epoxide hydrolase reaction, in addition LTA4H shows a peptidase activity
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-
?
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
-
-
-
-
?
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
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substrate for epoxide hydrolase activity
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-
?
leukotriene A4 + H2O
leukotriene B4
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i.e. LTB4, a potent inflammatory mediator originating from membrane-derived arachidonic acid
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?
leukotriene A4 + H2O
leukotriene B4
biosynthesis of leukotriene B4
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?
leukotriene A4 + H2O
leukotriene B4
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leukotriene A4 hydrolase catalyzes the final step in the synthesis of leukotriene B4, a potent chemoattractant and proinflammatory eicosanoid. LTB4 functions as a macrophage chemoattractant in the zebrafish, injection into the hindbrain ventricle of wild-type arvae induces rapid recruitment of macrophages
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?
leukotriene A4 + H2O
leukotriene B4
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?
leukotriene A4 + H2O
leukotriene B4
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i.e. LTB4, a powerful proinflammatory agent
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?
leukotriene A4 + H2O
leukotriene B4
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one of the physiologically important processes in the arachidonic acid biosynthetic pathway, leukotriene B4 is a proinflammatory mediator which stimulates adhesion of circulating neutrophils to vascular endothelium and directs their migration towards sites of inflammation
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?
leukotriene A4 + H2O
leukotriene B4
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central enzyme in leukotriene B4 formation, it is likely to be involved in transcellular leukotriene formation
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?
leukotriene A4 + H2O
leukotriene B4
biosynthesis of leukotriene B4
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?
leukotriene A4 + H2O
leukotriene B4
biosynthesis of leukotriene B4
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?
leukotriene A4 + H2O
leukotriene B4
biosynthesis of leukotriene B4
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?
leukotriene A4 + H2O
leukotriene B4
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leukotriene A4 hydrolase catalyzes the final step in the synthesis of leukotriene B4, a potent chemoattractant and proinflammatory eicosanoid
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?
leukotriene A4 + H2O
leukotriene B4
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LTB4 is an endogenous itch mediator in the skin and is involved in the pruritus response in allergic reactions
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?
leukotriene A4 + H2O
leukotriene B4
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biosynthesis of leukotriene B4
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?
leukotriene A4 + H2O
leukotriene B4
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biosynthesis of leukotriene B4
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?
leukotriene A4 + H2O
leukotriene B4
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biosynthesis of leukotriene B4
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?
leukotriene A4 + H2O
leukotriene B4
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biosynthesis of leukotriene B4
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?
leukotriene A4 + H2O
leukotriene B4
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biosynthesis of leukotriene B4
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?
leukotriene A4 + H2O
leukotriene B4
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biosynthesis of leukotriene B4
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?
leukotriene A4 + H2O
leukotriene B4
biosynthesis of leukotriene B4
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?
additional information
?
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possible proteolytic function of the enzyme may be limited to the extracellular space
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?
