3.3.2.6: leukotriene-A4 hydrolase

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For detailed information about leukotriene-A4 hydrolase, go to the full flat file.

Word Map on EC 3.3.2.6

3.3.2.6

5-lipoxygenase

arachidonic

epoxide

medicine

leukocyte

asthma

bestatin

chemoattractant

eicosanoids

metalloenzyme

flap

ionophore

alox5ap

tuberculous

transcellular

5-lipoxygenase-activating

aminopeptidases

captopril

lipoxins

pro-gly-pro

montelukast

proline-glycine-proline

5-hete

zileuton

diagnostics

pharmacology

drug development

Reaction

Synonyms

EH, epoxide hydrolase, hydrolase, leukotriene A4, leukotriene A(4) hydrolase, leukotriene A4 hydrolase, leukotriene A4 hydrolase/aminopeptidase, leukotriene hydrolase A4, leukotriene-A4 hydrolase, leukotriene-A4-hydrolase, LT A4 hydrolase, LTA-4 hydrolase, LTA4 hydrolase, LTA4-h, LTA4H, More

ECTree

3 Hydrolases

3.3 Acting on ether bonds

3.3.2 Ether hydrolases

3.3.2.6 leukotriene-A4 hydrolase

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Results	in table
21	Activating Compound
984	AA Sequence
71	Application
1	CAS Registry Number
28	Cloned(Commentary)
17	Crystallization (Commentary)
458	Disease/ Diagnostics
8	Expression
56	General Information
370	IC50 Value
645	Inhibitors
43	kcat/KM [mM/s]
46	Ki Value [mM]
84	KM Value [mM]
36	Localization
71	Metals/Ions
20	Molecular Weight [Da]
97	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
339	Organism
6	Pathway
83	PDB ID
15	pH Optimum
1	pH Range
2	pH Stability
13	pI Value
1	Posttranslational Modification
70	Protein Variants
27	Purification (Commentary)
49	Reaction
10	Reaction Type
145	Reference
189	Source Tissue
15	Specific Activity [micromol/min/mg]
6	Storage Stability
252	Substrates and Products (Substrate)
20	Subunits
155	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
66	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 3.3.2.6 - leukotriene-A4 hydrolase

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(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase

This is a bifunctional zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities [4,6]. It preferentially cleaves tripeptides at an arginyl bond, with dipeptides and tetrapeptides being poorer substrates [6] (see EC 3.4.11.6, aminopeptidase B). It also converts leukotriene A4 into leukotriene B4, unlike EC 3.3.2.10, soluble epoxide hydrolase, which converts leukotriene A4 into 5,6-dihydroxy-7,9,11,14-icosatetraenoic acid [3,4]. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol-5,6-oxide hydrolase) [5].