3.3.2.6: leukotriene-A4 hydrolase

This is an abbreviated version!
For detailed information about leukotriene-A4 hydrolase, go to the full flat file.

Word Map on EC 3.3.2.6

3.3.2.6

5-lipoxygenase

arachidonic

epoxide

medicine

leukocyte

asthma

bestatin

chemoattractant

eicosanoids

metalloenzyme

flap

ionophore

alox5ap

tuberculous

transcellular

5-lipoxygenase-activating

aminopeptidases

captopril

lipoxins

pro-gly-pro

montelukast

proline-glycine-proline

5-hete

zileuton

diagnostics

pharmacology

drug development

Reaction

leukotriene A4

+

H2O

=

leukotriene B4

Synonyms

EH, epoxide hydrolase, hydrolase, leukotriene A4, leukotriene A(4) hydrolase, leukotriene A4 hydrolase, leukotriene A4 hydrolase/aminopeptidase, leukotriene hydrolase A4, leukotriene-A4 hydrolase, leukotriene-A4-hydrolase, LT A4 hydrolase, LTA-4 hydrolase, LTA4 hydrolase, LTA4-h, LTA4H, More

ECTree

3.3 Acting on ether bonds

3.3.2 Ether hydrolases

3.3.2.6 leukotriene-A4 hydrolase

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Results	in table
21	Activating Compound
984	AA Sequence
71	Application
1	CAS Registry Number
28	Cloned(Commentary)
17	Crystallization (Commentary)
458	Disease/ Diagnostics
8	Expression
56	General Information
370	IC50 Value
645	Inhibitors
43	kcat/KM [mM/s]
46	Ki Value [mM]
84	KM Value [mM]
36	Localization
71	Metals/Ions
20	Molecular Weight [Da]
97	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
339	Organism
6	Pathway
83	PDB ID
15	pH Optimum
1	pH Range
2	pH Stability
13	pI Value
1	Posttranslational Modification
70	Protein Variants
27	Purification (Commentary)
49	Reaction
10	Reaction Type
145	Reference
189	Source Tissue
15	Specific Activity [micromol/min/mg]
6	Storage Stability
252	Substrates and Products (Substrate)
20	Subunits
155	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
66	Turnover Number [1/s]

KI Value

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KI Value on EC 3.3.2.6 - leukotriene-A4 hydrolase

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0.0003

1,10-phenanthroline

-

pH 8.0, 22°C

0.046

2-oxo-3-amino carboxylic ester

-

-

-

0.006

3-amino-3,4-dihydro-1H-naphthalen-2-one O-(3-phenylpropyl)oxime

-

-

0.008

3-amino-3,4-dihydro-1H-naphthalen-2-one O-(4-phenylbutyl)oxime

-

-

0.03

3-amino-3,4-dihydro-1H-naphthalen-2-one O-(5-phenylpentyl)oxime

-

-

0.0023

4-(4-benzylphenyl)thiazol-2-amine

at pH 7.8 and 37°C

0.00036

ARM1

pH and temperature not specified in the publication

0.0002 - 0.0765

bestatin

show

0.0037

captopril

pH and temperature not specified in the publication

0.0005

HgCl2

-

pH 7.8, 37°C

0.005

leukotriene A4

-

pH 8.0, 37°C

3

NEM

-

pH 7.8, 37°C

0.0007

PCMB

-

pH 7.8, 37°C

1.33 - 5.6

puromycin

show

0.000087 - 0.0037

RB-3014

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0.00016

RB202

pH and temperature not specified in the publication

0.000003

SC57461A

pH and temperature not specified in the publication

additional information

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Release 2023.1 (January 2023)