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Literature summary for 3.3.2.6 extracted from

  • Haeggström, J.Z.; Wetterholm, A.; Shapiro, R.; Vallee, B.L.; Samuelsson, B.
    Leukotriene A4 hydrolase: a zinc metalloenzyme (1990), Biochem. Biophys. Res. Commun., 172, 965-970.
    View publication on PubMed
Search for more literature for 3.3.2.6

Application

Application Comment Organism
medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Homo sapiens
8-Hydroxy-quinoline-5-sulfonic acid
-
 Homo sapiens
additional information not: EDTA, dipicolinic acid Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc zinc content: 1 mol of zinc per mol of enzyme Homo sapiens
Zinc zinc protein Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + H2O Homo sapiens biosynthesis of leukotriene B4 leukotriene B4
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Storage Stability

Storage Stability Organism
4°C, 25 mM HEPES, pH 8.0 the apoenzyme is stable for more than 5 weeks Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?
leukotriene A4 + H2O biosynthesis of leukotriene B4 Homo sapiens leukotriene B4
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0003
-
 1,10-phenanthroline pH 8.0, 22°C Homo sapiens