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3.3.2.6: leukotriene-A4 hydrolase

This is an abbreviated version!
For detailed information about leukotriene-A4 hydrolase, go to the full flat file.

Word Map on EC 3.3.2.6

Reaction

leukotriene A4
+
H2O
=
leukotriene B4

Synonyms

EH, epoxide hydrolase, hydrolase, leukotriene A4, leukotriene A(4) hydrolase, leukotriene A4 hydrolase, leukotriene A4 hydrolase/aminopeptidase, leukotriene hydrolase A4, leukotriene-A4 hydrolase, leukotriene-A4-hydrolase, LT A4 hydrolase, LTA-4 hydrolase, LTA4 hydrolase, LTA4-h, LTA4H, More

ECTree

     3 Hydrolases
         3.3 Acting on ether bonds
             3.3.2 Ether hydrolases
                3.3.2.6 leukotriene-A4 hydrolase

KM Value

KM Value on EC 3.3.2.6 - leukotriene-A4 hydrolase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.47 - 0.5
alanine-4-nitroanilide
1.3
Arg-Ser-Arg
wild type enzyme, 500 mM KCl in 250 mM Tris buffer (pH 7.5)
1.9 - 3
L-Ala-p-nitroanilide
0.31 - 1.78
L-alanine 2-naphthylamide
0.00087 - 10.8
L-alanine-4-nitroanilide
1.5 - 2.2
L-Arg-p-nitroanilide
0.137 - 0.587
L-arginine 2-naphthylamide
0.2
L-arginine-4-nitroanilide
-
pH 7.6, 22°C
0.301
L-arginine-7-amido-4-methylcoumarin
-
in 250 mM Tris buffer, pH 7.5, containing 500 mM KCl and 0.1% (w/v) of bovine serum albumin, at 37°C
0.488 - 0.698
L-isoleucine 2-naphthylamide
0.105 - 0.771
L-leucine 2-naphthylamide
0.15 - 2.1
L-leucine-4-nitroanilide
0.128 - 0.7
L-methionine 2-naphthylamide
0.235 - 0.808
L-valine 2-naphthylamide
0.001 - 0.06
leukotriene A4
0.1
lysine-4-nitroanilide
-
pH 7.6, 22°C
0.1
proline-4-nitroanilide
-
pH 7.6, 22°C
additional information
additional information
-