3.3.2.6: leukotriene-A4 hydrolase
This is an abbreviated version!
For detailed information about leukotriene-A4 hydrolase, go to the full flat file.
Word Map on EC 3.3.2.6
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3.3.2.6
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5-lipoxygenase
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arachidonic
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epoxide
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medicine
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leukocyte
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asthma
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bestatin
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chemoattractant
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eicosanoids
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metalloenzyme
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flap
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ionophore
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alox5ap
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tuberculous
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transcellular
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5-lipoxygenase-activating
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aminopeptidases
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captopril
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lipoxins
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pro-gly-pro
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montelukast
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proline-glycine-proline
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5-hete
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zileuton
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diagnostics
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pharmacology
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drug development
- 3.3.2.6
-
5-lipoxygenase
-
arachidonic
- epoxide
- medicine
- leukocyte
- asthma
- bestatin
-
chemoattractant
-
eicosanoids
-
metalloenzyme
- flap
-
ionophore
-
alox5ap
-
tuberculous
-
transcellular
-
5-lipoxygenase-activating
- aminopeptidases
- captopril
-
lipoxins
- pro-gly-pro
- montelukast
- proline-glycine-proline
-
5-hete
- zileuton
- diagnostics
- pharmacology
- drug development
Reaction
Synonyms
EH, epoxide hydrolase, hydrolase, leukotriene A4, leukotriene A(4) hydrolase, leukotriene A4 hydrolase, leukotriene A4 hydrolase/aminopeptidase, leukotriene hydrolase A4, leukotriene-A4 hydrolase, leukotriene-A4-hydrolase, LT A4 hydrolase, LTA-4 hydrolase, LTA4 hydrolase, LTA4-h, LTA4H, More
ECTree
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KM Value
KM Value on EC 3.3.2.6 - leukotriene-A4 hydrolase
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1.3
Arg-Ser-Arg
wild type enzyme, 500 mM KCl in 250 mM Tris buffer (pH 7.5)
0.301
L-arginine-7-amido-4-methylcoumarin
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in 250 mM Tris buffer, pH 7.5, containing 500 mM KCl and 0.1% (w/v) of bovine serum albumin, at 37°C
1.9
mutant enzyme E296Q, 500 mM KCl in 250 mM Tris buffer (pH 7.5)
1.9
L-Ala-p-nitroanilide
wild type enzyme, 500 mM KCl in 250 mM Tris buffer (pH 7.5)
3
L-Ala-p-nitroanilide
mutant enzyme D375A, 500 mM KCl in 250 mM Tris buffer (pH 7.5)
0.31
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mutant N362L, 25°C, pH not specified in the publication
0.339
L-alanine 2-naphthylamide
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mutant W365L, 25°C, pH not specified in the publication
0.4
L-alanine 2-naphthylamide
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mutant N362Q, 25°C, pH not specified in the publication
0.618
L-alanine 2-naphthylamide
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mutant N362E, 25°C, pH not specified in the publication
0.885
L-alanine 2-naphthylamide
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mutant D399A, 25°C, pH not specified in the publication
1.78
L-alanine 2-naphthylamide
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wild-type, 25°C, pH not specified in the publication
0.00087
mutant enzyme F375Y, at pH 7.8 and 22°C
1.5
wild type enzyme, 500 mM KCl in 250 mM Tris buffer (pH 7.5)
2.2
L-Arg-p-nitroanilide
mutant enzyme E296Q, 500 mM KCl in 250 mM Tris buffer (pH 7.5)
0.137
-
mutant N362Q, 25°C, pH not specified in the publication
0.199
L-arginine 2-naphthylamide
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mutant D399A, 25°C, pH not specified in the publication
0.275
L-arginine 2-naphthylamide
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mutant W365L, 25°C, pH not specified in the publication
0.366
L-arginine 2-naphthylamide
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wild-type, 25°C, pH not specified in the publication
0.49
L-arginine 2-naphthylamide
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mutant N362L, 25°C, pH not specified in the publication
0.587
L-arginine 2-naphthylamide
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mutant N362E, 25°C, pH not specified in the publication
0.488
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mutant W365L, 25°C, pH not specified in the publication
0.566
L-isoleucine 2-naphthylamide
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wild-type, 25°C, pH not specified in the publication
0.657
L-isoleucine 2-naphthylamide
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mutant D399A, 25°C, pH not specified in the publication
0.698
L-isoleucine 2-naphthylamide
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mutant N362Q, 25°C, pH not specified in the publication
0.105
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mutant N362Q, 25°C, pH not specified in the publication
0.29
L-leucine 2-naphthylamide
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mutant N362L, 25°C, pH not specified in the publication
0.365
L-leucine 2-naphthylamide
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mutant N362E, 25°C, pH not specified in the publication
0.693
L-leucine 2-naphthylamide
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mutant D399A, 25°C, pH not specified in the publication
0.745
L-leucine 2-naphthylamide
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wild-type, 25°C, pH not specified in the publication
0.771
L-leucine 2-naphthylamide
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mutant W365L, 25°C, pH not specified in the publication
2
L-leucine-4-nitroanilide
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pH 7.5, 22°C, enzyme stimulated by leukotriene A4
2.1
L-leucine-4-nitroanilide
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pH 7.5, 22°C, enzyme stimulated by leukotriene A4
0.128
-
mutant N362L, 25°C, pH not specified in the publication
0.15
L-methionine 2-naphthylamide
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mutant N362Q, 25°C, pH not specified in the publication
0.166
L-methionine 2-naphthylamide
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mutant N362E, 25°C, pH not specified in the publication
0.351
L-methionine 2-naphthylamide
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mutant W365L, 25°C, pH not specified in the publication
0.374
L-methionine 2-naphthylamide
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mutant D399A, 25°C, pH not specified in the publication
0.7
L-methionine 2-naphthylamide
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wild-type, 25°C, pH not specified in the publication
0.235
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mutant N362Q, 25°C, pH not specified in the publication
0.384
L-valine 2-naphthylamide
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wild-type, 25°C, pH not specified in the publication
0.803
L-valine 2-naphthylamide
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mutant D399A, 25°C, pH not specified in the publication
0.808
L-valine 2-naphthylamide
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mutant W365L, 25°C, pH not specified in the publication
0.006 - 0.028
leukotriene A4
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pH 8.0, wild-type enzyme in comparison to mutant enzymes
0.006 - 0.028
leukotriene A4
pH 8.0, wild-type enzyme in comparison to mutant enzymes
0.06
leukotriene A4
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pH 7.5, 22°C, 5S,6S-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic acid production
additional information
additional information
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influence of NaCl and NaSCN on KM
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