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3.3.2.6: leukotriene-A4 hydrolase

This is an abbreviated version!
For detailed information about leukotriene-A4 hydrolase, go to the full flat file.

Word Map on EC 3.3.2.6

Reaction

leukotriene A4
+
H2O
=
leukotriene B4

Synonyms

EH, epoxide hydrolase, hydrolase, leukotriene A4, leukotriene A(4) hydrolase, leukotriene A4 hydrolase, leukotriene A4 hydrolase/aminopeptidase, leukotriene hydrolase A4, leukotriene-A4 hydrolase, leukotriene-A4-hydrolase, LT A4 hydrolase, LTA-4 hydrolase, LTA4 hydrolase, LTA4-h, LTA4H, More

ECTree

     3 Hydrolases
         3.3 Acting on ether bonds
             3.3.2 Ether hydrolases
                3.3.2.6 leukotriene-A4 hydrolase

KCat KM Value

KCat KM Value on EC 3.3.2.6 - leukotriene-A4 hydrolase

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.002 - 0.321
L-alanine 2-naphthylamide
1.7 - 3.96
L-alanine-4-nitroanilide
1.497
L-alanine-7-amido-4-methylcoumarin
-
in 250 mM Tris buffer, pH 7.5, containing 500 mM KCl and 0.1% (w/v) of bovine serum albumin, at 37°C
0.001 - 0.141
L-arginine 2-naphthylamide
0.4706
L-arginine-7-amido-4-methylcoumarin
-
in 250 mM Tris buffer, pH 7.5, containing 500 mM KCl and 0.1% (w/v) of bovine serum albumin, at 37°C
0.012 - 0.055
L-isoleucine 2-naphthylamide
0.005 - 0.292
L-leucine 2-naphthylamide
0.343
L-leucine-7-amido-4-methylcoumarin
-
in 250 mM Tris buffer, pH 7.5, containing 500 mM KCl and 0.1% (w/v) of bovine serum albumin, at 37°C
0.617
L-lysine-7-amido-4-methylcoumarin
-
in 250 mM Tris buffer, pH 7.5, containing 500 mM KCl and 0.1% (w/v) of bovine serum albumin, at 37°C
0.025 - 0.453
L-methionine 2-naphthylamide
0.298
L-methionine-7-amido-4-methylcoumarin
-
in 250 mM Tris buffer, pH 7.5, containing 500 mM KCl and 0.1% of bovine serum albumin, at 37°C
0.747
L-phenylalanine-7-amido-4-methylcoumarin
-
in 250 mM Tris buffer, pH 7.5, containing 500 mM KCl and 0.1% (w/v) of bovine serum albumin, at 37°C
0.449
L-proline-7-amido-4-methylcoumarin
-
in 250 mM Tris buffer, pH 7.5, containing 500 mM KCl and 0.1% (w/v) of bovine serum albumin, at 37°C
0.016 - 0.05
L-valine 2-naphthylamide
0.45 - 0.8
leukotriene A4