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3.3.2.6: leukotriene-A4 hydrolase

This is an abbreviated version!
For detailed information about leukotriene-A4 hydrolase, go to the full flat file.

Word Map on EC 3.3.2.6

Reaction

leukotriene A4
+
H2O
=
leukotriene B4

Synonyms

EH, epoxide hydrolase, hydrolase, leukotriene A4, leukotriene A(4) hydrolase, leukotriene A4 hydrolase, leukotriene A4 hydrolase/aminopeptidase, leukotriene hydrolase A4, leukotriene-A4 hydrolase, leukotriene-A4-hydrolase, LT A4 hydrolase, LTA-4 hydrolase, LTA4 hydrolase, LTA4-h, LTA4H, More

ECTree

     3 Hydrolases
         3.3 Acting on ether bonds
             3.3.2 Ether hydrolases
                3.3.2.6 leukotriene-A4 hydrolase

Expression

Expression on EC 3.3.2.6 - leukotriene-A4 hydrolase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
healthy smokers display elevated enzyme expression
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human esophageal adenocarcinoma cell (EAC) and adjacent nontumor esophageal tissues reveal overexpression of LTA4H in EAC tissues compared to that in nontumor samples. LTA4H is overexpressed in several other human cancers, particularly lung adenocarcinoma, adenosquamous carcinoma, bronchioalveolar carcinoma, large cell carcinoma, thyroid adenocarcinoma, and gall bladder adenocarcinoma. Upregulation of LTA4H expression in primary effusion lymphoma, which is a rare HIV-associated non-Hodgkin B cell lymphoma
knockdown of LTA4H inhibits anchorage-independent growth of HCT116 colon cancer cells
LTA4H is overexpressed in all rat esophageal adenocarcinoma (EAC) samples compared to that in the normal duodenal tissues in an esophagogastroduodenal anastomosis (EGDA) surgical model
LTA4H shows increased expression along with increased LTB4 in an azoxymethane-induced colorectal cancer (CRC) mouse model
significantly higher mRNA expression of the key enzymes 5-lipoxygenase, 5-LO activating protein, leukotriene A4 hydrolase, and prostaglandin E synthase 1 and their PGE receptors 2 and 3, occur in canine atopic dermatitis, a chronic inflammatory skin disease, overview
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the enzyme expression is upregulated in keratinocytes by 2-chloroethyl ethyl sulfide via p38MAP kinase signaling pathway, inhibition of p38 MAP kinase suppresses CEES-induced expression of LTA4 hydrolase, overview
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the enzyme is induced by HIV-1 infection, facilitating the protein transformation from the cytosol to the plasma membrane, which is linked to cathepsin B- and caspase 9, 3-dependent apoptosis, overview
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