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3.3.2.6: leukotriene-A4 hydrolase

This is an abbreviated version!
For detailed information about leukotriene-A4 hydrolase, go to the full flat file.

Word Map on EC 3.3.2.6

Reaction

leukotriene A4
+
H2O
=
leukotriene B4

Synonyms

EH, epoxide hydrolase, hydrolase, leukotriene A4, leukotriene A(4) hydrolase, leukotriene A4 hydrolase, leukotriene A4 hydrolase/aminopeptidase, leukotriene hydrolase A4, leukotriene-A4 hydrolase, leukotriene-A4-hydrolase, LT A4 hydrolase, LTA-4 hydrolase, LTA4 hydrolase, LTA4-h, LTA4H, More

ECTree

     3 Hydrolases
         3.3 Acting on ether bonds
             3.3.2 Ether hydrolases
                3.3.2.6 leukotriene-A4 hydrolase

Cloned

Cloned on EC 3.3.2.6 - leukotriene-A4 hydrolase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
-
expressed in Escherichia coli JM101 cells
expressed in Sf-9 cells
-
expression in Escherichia coli
expression in Escherichia coli and in Sf9 cells, using the baculovirus system
-
expression in Escherichia coli as a fusion protein with ten additional amino acids at the amino terminus
-
high-level expression enzyme in Spodoptera frugiperda cells infected with baculovirus vector
-
identification of two isoforms of the mRNA, short and long, by using a sequential reverse transcriptase (RT)-PCR mapping approach, both enzyme mRNAs are expressed in blood cells, endothelial cells, smooth muscle cells, fibroblasts and tumor cells
into the pYES2.1-Topo vector for expression of the recombinant proteins in Saccharomyces cerevisiae 1971
-
LTA4H gene, genotyping
-
mRNA is distributed in liver, brain, lung, heart, kidney, and highly expressed in the intestine and spleen
overexpressed in Escherichia coli YA21 using pEX85 vector
-
quantitative real-time PCR expression analysis
recombinant expression of human LTA4H with C-terminal hexahistidine tag and N-terminal T7 gene leader sequence
semiquantitative LTA4H expression analysis in peripheral nerves and spinal cord, overview
the enzyme is encoded in the lta4h locus, lta4h interacts with the TNF signaling pathway
-
the enzyme is encoded in the lta4h locus, lta4h interacts with the TNF signaling pathway. LthA4 genotyping in leprosy patients from Vietnam and Nepal, overview
-
wild-type and mutant enzymes expressed in Escherichia coli