Application | Comment | Organism |
---|---|---|
medicine | the lipid metabolic activity of enzyme plays a central role in the control of polymorphonuclear leukocyte function and in the development of inflammation, the regulation of enzyme presents a novel potential target for anti-inflammatory therapy | Homo sapiens |
medicine | the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
wild-type and mutant enzymes expressed in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S415D | significantly reduced epoxide hydrolase activity, little effect on aminopeptidase activity | Homo sapiens |
S415E | significantly reduced epoxide hydrolase activity, little effect on aminopeptidase activity | Homo sapiens |
S415Q | no effect on enzyme activity | Homo sapiens |
S415T | little effect on enzyme activity | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
69000 | - |
x * 69000, SDS-PAGE, mutant enzymes | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + H2O | Homo sapiens | biosynthesis of leukotriene B4 | leukotriene B4 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
leukotriene A4 + H2O = leukotriene B4 | enzyme contains two partly overlapping active sites which influence each other | Homo sapiens | |
leukotriene A4 + H2O = leukotriene B4 | Ser415 plays a key role in regulating epoxid hydrolase activity | Homo sapiens | |
leukotriene A4 + H2O = leukotriene B4 | bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | inactive form of enzyme | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + H2O | - |
Homo sapiens | leukotriene B4 | - |
? | |
leukotriene A4 + H2O | biosynthesis of leukotriene B4 | Homo sapiens | leukotriene B4 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 69000, SDS-PAGE, mutant enzymes | Homo sapiens |