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Literature summary for 3.3.2.6 extracted from

  • Menard, A.; Papini, E.; Mock, M.; Montecucco, C.
    The cytotoxic activity of Bacillus anthracis lethal factor is inhibited by leukotriene A4 hydrolase and metallopeptidase inhibitors (1996), Biochem. J., 320, 687-691.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information some enzyme inhibitors also affect the cytotoxicity of the anthrax lethal factor on macrophage cell lines Homo sapiens
omega-[(omega-arylalkyl)aryl]alkanoid acids
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + H2O Homo sapiens biosynthesis of leukotriene B4 leukotriene B4
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
leukotriene A4 + H2O = leukotriene B4 pathway Homo sapiens
leukotriene A4 + H2O = leukotriene B4 enzyme contains two partly overlapping active sites which influence each other Homo sapiens
leukotriene A4 + H2O = leukotriene B4 bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + H2O
-
Homo sapiens leukotriene B4
-
?
leukotriene A4 + H2O biosynthesis of leukotriene B4 Homo sapiens leukotriene B4
-
?