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Literature summary for 3.3.2.6 extracted from

  • Zarini, S.; Gijon, M.A.; Ransome, A.E.; Murphy, R.C.; Sala, A.
    Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation (2009), Proc. Natl. Acad. Sci. USA, 106, 8296-8301.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.6

Protein Variants

Protein Variants Comment Organism
additional information bone marrow cells from LTA4H-/- mice injected into 5LO-/- mice, defective for 5-lipoxygenase, restores the ability to synthesize LTB4, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + H2O Mus musculus
-
 leukotriene B4
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow cell
-
 Mus musculus
-
peritoneal fluid from lavage Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + H2O
-
 Mus musculus leukotriene B4
-
 ?

Synonyms

Synonyms Comment Organism
LTA4 hydrolase
-
 Mus musculus
LTA4H
-
 Mus musculus

General Information

General Information Comment Organism
metabolism the enzyme is involved in the leukotriene metabolism. In the leukotriene biosynthesis, cells expressing 5-lipoxygenase form LTA4 and transfer it to cells expressing LTA4 hydrolase or LTC4 synthase to produce LTB4 or LTC4 Mus musculus
physiological function the enzyme is involved in the leukotriene metabolism, leukotrienes are lipid mediators of inflammation formed by enzymatic oxidation of arachidonic acid Mus musculus