Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + H2O | Canis lupus familiaris | - |
leukotriene B4 | i.e. LTB4, a potent inflammatory mediator originating from membrane-derived arachidonic acid | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
healthy and atopic dogs | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skin | enzyme expression analysis in healthy and atopic dogs, overview | Canis lupus familiaris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + H2O | - |
Canis lupus familiaris | leukotriene B4 | - |
? | |
leukotriene A4 + H2O | - |
Canis lupus familiaris | leukotriene B4 | i.e. LTB4, a potent inflammatory mediator originating from membrane-derived arachidonic acid | ? |
Synonyms | Comment | Organism |
---|---|---|
leukotriene A4 hydrolase | - |
Canis lupus familiaris |
LTA4H | - |
Canis lupus familiaris |
Organism | Comment | Expression |
---|---|---|
Canis lupus familiaris | significantly higher mRNA expression of the key enzymes 5-lipoxygenase, 5-LO activating protein, leukotriene A4 hydrolase, and prostaglandin E synthase 1 and their PGE receptors 2 and 3, occur in canine atopic dermatitis, a chronic inflammatory skin disease, overview | up |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme takes part in the pathway for the conversion of arachidonic acid to eicosanoids, overview | Canis lupus familiaris |