Inhibitors | Comment | Organism | Structure |
---|---|---|---|
S-[4-(dimethylamino)benzyl]-N-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-cysteine | i.e. SA6541, a specific inhibiter of LTA4 hydrolase, that attenuates 5-lipoxygenase metabolite-induced scratching behavior, but does not affect the increase in vascular permeability caused by 5-hydroperoxyeicosatetraenoic acid, 5-HPETE, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + H2O | Mus musculus | - |
leukotriene B4 | LTB4 is an endogenous itch mediator in the skin and is involved in the pruritus response in allergic reactions | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
male ICR mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skin | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + H2O | - |
Mus musculus | leukotriene B4 | - |
? | |
leukotriene A4 + H2O | - |
Mus musculus | leukotriene B4 | LTB4 is an endogenous itch mediator in the skin and is involved in the pruritus response in allergic reactions | ? |
Synonyms | Comment | Organism |
---|---|---|
LTA4 hydrolase | - |
Mus musculus |