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Literature summary for 3.3.2.6 extracted from

  • Tsuji, F.; Aono, H.; Tsuboi, T.; Murakami, T.; Enomoto, H.; Mizutani, K.; Inagaki, N.
    Role of leukotriene B4 in 5-lipoxygenase metabolite- and allergy-induced itch-associated responses in mice (2010), Biol. Pharm. Bull., 33, 1050-1053.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
S-[4-(dimethylamino)benzyl]-N-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-cysteine i.e. SA6541, a specific inhibiter of LTA4 hydrolase, that attenuates 5-lipoxygenase metabolite-induced scratching behavior, but does not affect the increase in vascular permeability caused by 5-hydroperoxyeicosatetraenoic acid, 5-HPETE, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + H2O Mus musculus
-
leukotriene B4 LTB4 is an endogenous itch mediator in the skin and is involved in the pruritus response in allergic reactions ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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male ICR mice
-

Source Tissue

Source Tissue Comment Organism Textmining
skin
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + H2O
-
Mus musculus leukotriene B4
-
?
leukotriene A4 + H2O
-
Mus musculus leukotriene B4 LTB4 is an endogenous itch mediator in the skin and is involved in the pruritus response in allergic reactions ?

Synonyms

Synonyms Comment Organism
LTA4 hydrolase
-
Mus musculus