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5'-(4-fluorosulfonylbenzoyl)adenosine + H2O
5-fluorosulfonylbenzoyl-D-ribose + adenine
-
-
-
?
5'-adenosylcysteine + H2O
adenine + S-ribosylcysteine
-
-
-
?
5'-butylthioadenosine + H2O
5-butylthio-D-ribose + adenine
5'-butylthioadenosine + H2O
adenine + 5-butylthio-D-ribose
-
25% activity compared to 5'-methylthioadenosine
-
-
?
5'-chloroadenosine + H2O
5-chloro-D-ribose + adenine
-
-
-
-
?
5'-chloroadenosine + H2O
adenine + 5-chloro-D-ribose
-
4% activity compared to 5'-methylthioadenosine
-
-
?
5'-deoxy-5'-(difluoromethylthio)adenosine + H2O
5-deoxy-5-(difluoromethylthio)-D-ribose + adenine
5'-deoxy-5'-(monofluoromethylthio)adenosine + H2O
5-deoxy-5-(monofluoromethylthio)-D-ribose + adenine
5'-deoxy-5'-(trifluoromethylthio)adenosine + H2O
5-deoxy-5-(trifluoromethylthio)-D-ribose + adenine
5'-deoxy-5'-isobutylthio-adenosine + H2O
5-isobutylthio-D-ribose + adenine
-
1-butanol buffer/propan-2-ol buffer
-
-
?
5'-deoxy-5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
5'-deoxy-5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-deoxy-5'-propylthioadenosine + H2O
5-propylthio-D-ribose + adenine
5'-deoxy-5'-S-adenosyl-L-cysteine + H2O
S-(5-deoxy-5-D-ribosyl)-L-cysteine + adenine
-
relative activity 95.2%
-
-
?
5'-deoxy-5'-S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-5-D-ribosyl)-L-homoscysteine + adenine
-
substrate analogue, relative activity 95.8%
-
-
?
5'-deoxy-5'-thioethanoladenosine + H2O
?
-
relative activity 98%
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
5'-ethylthio-2-aminoadenosine + H2O
5-ethylthio-D-ribose + 2-aminoadenosine
-
1-butanol buffer/propan-2-ol buffer
-
-
?
5'-ethylthioadenosine + H2O
5-ethylthio-D-ribose + adenine
5'-ethylthioadenosine + H2O
adenine + 5-ethylthio-D-ribose
-
40% activity compared to 5'-methylthioadenosine
-
-
?
5'-ethylthioinosine + H2O
5-ethylthio-D-ribose + hypoxanthine
-
1-butanol buffer
-
-
?
5'-iodoadenosine + H2O
adenine + 5-iodo-D-ribose
-
28% activity compared to 5'-methylthioadenosine
-
-
?
5'-iodothioadenosine + H2O
5-iodothio-D-ribose + adenine
5'-isobutylthio-3-deaza-adenosine + H2O
5-isobutylthio-D-ribose + 3-deazadenosine
-
1-butanol buffer/propan-2-ol buffer
-
-
?
5'-isobutylthioadenosine + H2O
5-isobutylthioribose + adenine
-
-
-
-
?
5'-isobutylthioadenosine + H2O
?
-
52% activity compared to 5'-methylthioadenosine
-
-
?
5'-isobutylthioadenosine + H2O
adenine + 5-isobutylthio-D-ribose
-
17% activity compared to 5'-methylthioadenosine
-
-
?
5'-isobutylthioinosine + H2O
5-isobutylthio-D-ribose + hypoxanthine
-
1-butanol buffer
-
-
?
5'-isopropylthioadenosine + H2O
5-isopropylthio-D-ribose + adenine
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
5'-methylthioadenosine + H2O
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
5'-methylthioarabinosyladenine + H2O
5-methylthioarabinose + adenine
-
1-butanol buffer/propan-2-ol buffer
-
-
?
5'-methylthioinosine + H2O
5-methylthio-D-ribose + hypoxanthine
5'-n-butylthioadenosine + H2O
5-n-butylthio-D-ribose + adenine
-
1-butanol buffer
-
-
?
5'-n-butylthioadenosine + H2O
?
-
40% activity compared to 5'-methylthioadenosine
-
-
?
5'-n-butylthioinosine + H2O
5-n-butylthio-D-ribose + hypoxanthine
-
1-butanol buffer
-
-
?
5'-phenylthioadenosine + H2O
5-phenylthio-D-ribose + adenine
5'-phenylthioadenosine + H2O
adenine + 5-phenylthio-D-ribose
-
12% activity compared to 5'-methylthioadenosine
-
-
?
5'-propylthioadenosine + H2O
5-propylthio-D-ribose + adenine
-
-
-
?
6-amino-6-deoxyfutalosine + H2O
3-{3-[(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]propanoyl}benzoic acid + 9H-purine-6-amine
6-amino-6-deoxyfutalosine + H2O
adenine + dehypoxanthinyl futalosine
-
-
-
?
adenosine + H2O
adenine + D-ribose
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
S-adenosyl-L-homocysteine + H2O
S-D-ribosyl-L-homocysteine + adenine
S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
S-adenosylhomocysteine + H2O
adenine + S-ribosylhomocysteine
S-adenosylmercaptoethanol + H2O
?
-
1-butanol buffer/propan-2-ol buffer
-
-
?
S-inosylmercaptoethanol + H2O
?
-
propan-2-ol buffer
-
-
?
S-isobutyl-5'-thioadenosine + H2O
5-S-(2-methylpropyl)-5-thio-beta-D-ribofuranose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
additional information
?
-
5'-butylthioadenosine + H2O
5-butylthio-D-ribose + adenine
-
-
-
-
?
5'-butylthioadenosine + H2O
5-butylthio-D-ribose + adenine
-
-
-
?
5'-deoxy-5'-(difluoromethylthio)adenosine + H2O
5-deoxy-5-(difluoromethylthio)-D-ribose + adenine
-
DFMTA, fluorinated substrate analogue
-
-
?
5'-deoxy-5'-(difluoromethylthio)adenosine + H2O
5-deoxy-5-(difluoromethylthio)-D-ribose + adenine
-
DFMTA, fluorinated substrate analogue
-
-
?
5'-deoxy-5'-(monofluoromethylthio)adenosine + H2O
5-deoxy-5-(monofluoromethylthio)-D-ribose + adenine
-
MFMTA , fluorinated analogue of MTA
-
-
?
5'-deoxy-5'-(monofluoromethylthio)adenosine + H2O
5-deoxy-5-(monofluoromethylthio)-D-ribose + adenine
-
MFMTA , fluorinated analogue of MTA
-
-
?
5'-deoxy-5'-(trifluoromethylthio)adenosine + H2O
5-deoxy-5-(trifluoromethylthio)-D-ribose + adenine
-
TFMTA, fluorinated substrate analogue
-
-
?
5'-deoxy-5'-(trifluoromethylthio)adenosine + H2O
5-deoxy-5-(trifluoromethylthio)-D-ribose + adenine
-
TFMTA, fluorinated substrate analogue
-
-
?
5'-deoxy-5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-deoxy-5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-deoxy-5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-deoxy-5'-propylthioadenosine + H2O
5-propylthio-D-ribose + adenine
-
-
-
-
?
5'-deoxy-5'-propylthioadenosine + H2O
5-propylthio-D-ribose + adenine
-
1-butanol buffer/propan-2-ol buffer
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
i.e. DOA, MTAN can rapidly hydrolyse DOA
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
1-butanol buffer
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
-
?
5'-ethylthioadenosine + H2O
5-ethylthio-D-ribose + adenine
-
-
-
-
?
5'-ethylthioadenosine + H2O
5-ethylthio-D-ribose + adenine
-
1-butanol buffer
-
-
?
5'-ethylthioadenosine + H2O
5-ethylthio-D-ribose + adenine
-
-
-
?
5'-iodothioadenosine + H2O
5-iodothio-D-ribose + adenine
-
-
-
-
?
5'-iodothioadenosine + H2O
5-iodothio-D-ribose + adenine
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
100% activity
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
Pfs protein and Bgp protein display 100% activity towards 5'-methylthioadenosine
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
ir
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
100% activity
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
Ochromonas malhamensis
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
enzyme activity increases parallel to ethylene biosynthesis during ripening or in wounded tissue, basal activity level of the enzyme in intact tissue reflects the synthesis of polyamines
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
enzyme activity increases parallel to ethylene biosynthesis during ripening or in wounded tissue, basal activity level of the enzyme in intact tissue reflects the synthesis of polyamines
-
-
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
5'-methylthioinosine + H2O
5-methylthio-D-ribose + hypoxanthine
-
-
-
-
?
5'-methylthioinosine + H2O
5-methylthio-D-ribose + hypoxanthine
-
maximal velocity about 50-times lower than for 5'-methylthioadenosine
-
?
5'-phenylthioadenosine + H2O
5-phenylthio-D-ribose + adenine
-
-
-
-
?
5'-phenylthioadenosine + H2O
5-phenylthio-D-ribose + adenine
-
-
-
?
6-amino-6-deoxyfutalosine + H2O
3-{3-[(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]propanoyl}benzoic acid + 9H-purine-6-amine
-
-
-
?
6-amino-6-deoxyfutalosine + H2O
3-{3-[(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]propanoyl}benzoic acid + 9H-purine-6-amine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
14% activity compared to 5'-methylthioadenosine
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-D-ribosyl-L-homocysteine + adenine
-
-
-
ir
S-adenosyl-L-homocysteine + H2O
S-D-ribosyl-L-homocysteine + adenine
-
-
-
ir
S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
-
-
-
-
?
S-adenosylhomocysteine + H2O
adenine + S-ribosylhomocysteine
-
-
-
-
?
S-adenosylhomocysteine + H2O
adenine + S-ribosylhomocysteine
-
-
-
-
?
S-adenosylhomocysteine + H2O
adenine + S-ribosylhomocysteine
-
-
-
-
ir
S-adenosylhomocysteine + H2O
adenine + S-ribosylhomocysteine
15.9% of the rate with 5'-methylthioadenosine
-
-
?
S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
almost completely preferred substrate
-
-
?
S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
ir
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
preferred substrate
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
ir
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
preferred substrate
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
additional information
?
-
-
no substrate: S-adenosylhomocysteine, adenosine
-
-
?
additional information
?
-
-
no activity towards S-adenosyl-L-homocysteine and adenosine
-
-
?
additional information
?
-
-
AtMTAN2 is dual-substrate specific and is responsible for the hydrolysis of 5'-methylthioadenosine and S-adenosylhomocysteine to adenine and their corresponding thioriboses, overview
-
-
?
additional information
?
-
-
dynamics are an important factor in substrate selection in MTAN, overview. Substrate binding induces a favourable entropic change in AtMTAN1
-
-
?
additional information
?
-
-
substrate specificities of isozymes, isozyme AtMTAN2 is also active with S-adenosyl-L-homocysteine, EC 3.2.2.9, overview. Isozyme AtMTAN2 shows markedly broad substrate specificity for hydrolysis of S-adenosyl-L-homocysteine, while isozyme AtMTAN1 does not
-
-
?
additional information
?
-
-
the enzyme also shows weak hydrolytic activity with S-adenosylhomocysteine
-
-
?
additional information
?
-
-
enzyme is involved in two catabolic reactions: irreversible cleavage of the glycosidic bond of 5'-methylthioadenoside and cleavago of the glcyosidic bond of S-adenosylhomocysteine
-
-
?
additional information
?
-
-
key role in biological methylation, polyamine biosynthesis, methionine recycling and bacterial quorum sensing
-
-
?
additional information
?
-
-
MTAN is dual-substrate specific and is responsible for the hydrolysis of 5'-methylthioadenosine and S-adenosylhomocysteine to adenine and their corresponding thioriboses, overview
-
-
?
additional information
?
-
-
MTAN restores the activity of three S-adenosyl-L-methionine utilizing enzymes, biotin synthase, lipoyl synthase and tyrosine lyase, that are inhibited by the highly reactive 5'-deoxyadenosyl radical, overview
-
-
?
additional information
?
-
-
substrate binding, specificity and dynamics, overview. Substrate binding induces a unfavourable entropic change
-
-
?
additional information
?
-
-
no activity toward 5'-methylthioinosine, 5'-isobutylthioinosine, 5'-isobutylthio-3-deaza-adenosine, 5'-methylthio-3-deaza-adenosine, 5'-chloroformycin, 5'-methylthioformycin, 5'-ethylthiotubercidin, S-tubercidinylhomocysteine, S-inosyl-L-homocysteine, S-guanosyl-L-homocysteine, S-cytidylhomocysteine, S-8-aza adenosyl-L-homocysteine, S-n-methyl-3-deaza-adenosyl-L-homocysteine, S-n6-dimethyl-3-deaza-adenosyl-L-homocysteine, sinefungin, S-adenosyl-L-homocysteine dialdehyde, and acyclic adenosyl-L-homocysteine
-
-
?
additional information
?
-
-
the enzyme catalyzes the hydrolytic cleavage of adenine from methylthioadenosine
-
-
?
additional information
?
-
broad substrate specificity
-
-
?
additional information
?
-
-
broad substrate specificity
-
-
?
additional information
?
-
-
the enzyme catalyzes the hydrolytic cleavage of adenine from methylthioadenosine
-
-
?
additional information
?
-
-
the enzyme catalyzes the hydrolytic cleavage of adenine from methylthioadenosine
-
-
?