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3.2.2.16: methylthioadenosine nucleosidase

This is an abbreviated version!
For detailed information about methylthioadenosine nucleosidase, go to the full flat file.

Word Map on EC 3.2.2.16

Reaction

S-methyl-5'-thioadenosine
+
H2O
=
S-methyl-5-thio-D-ribose
 +
adenine

Synonyms

5'-deoxy-5'-methylthioadenosine nucleosidase, 5'-methylthioadenosine nucleosidase, 5'-methylthioadenosine/S-adenosyl-L-homocysteine nucleosidase, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, 5-methylthioadenosine nucleosidase, 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase, 50-methylthioadenosine/S-adenosylhomocysteine nucleosidase, adoHcy/MTA nucleosidase, Bgp protein, glycosaminoglycan-binding protein, HpyMqnB, lupin MeSAdo nucleosidase, MeSAdo nucleosidase, methylthioadenosine nucleosidase, methylthioadenosine/S-adenosylhomocysteine nucleosidase, MqnB, MTA nucleosidase, MTA ribohydrolase, MTA/SAH nucleosidase, MTAN, MTAN1, MTAN2, MTN, Pfs, Pfs protein, plant specific MTA nucleosidase, S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.2 Hydrolysing N-glycosyl compounds
                3.2.2.16 methylthioadenosine nucleosidase

Inhibitors

Inhibitors on EC 3.2.2.16 - methylthioadenosine nucleosidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1R,2S)-2-(((4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)amino)-1-(methylthio)propane-1,3-diol
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-methylthio-D-ribitol
(1S,2R)-2-(((4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)amino)-1-(methylthio)propane-1,3-diol
(2R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol
(2R,3R)-2-([[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]methyl)-4-(methylsulfanyl)butane-1,3-diol
(2R,3R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
(2R,3S)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
(2R,3S)-4-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-3-[(methylsulfanyl)methyl]butane-1,2-diol
(2S)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-2-ol
(2S)-2-[[(1S)-1-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2-hydroxyethyl]amino]-3-(methylsulfanyl)propan-1-ol
(2S,3R)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-4-(methylsulfanyl)butane-2,3-diol
(2S,3R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
-
(2S,3R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol - methane (1:1)
-
-
(2S,3R)-N-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-3,4-dihydroxy-2-[(methylsulfanyl)methyl]butan-1-aminium trifluoroacetate
(2S,3S)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine
(3R,4S)-1-[9-deazaadenin-(9-yl)methyl]-3-hydroxy-4-(methylthiomethyl)pyrrolidine
-
(3R,4S)-4-(benzylthiomethyl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
complete inhibition at 0.1 mM
(4S,5S)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(methylsulfanyl)methyl]-1,2-thiazolidin-4-ol
(S)-9-(2,3-dihydroxy-propyl)adenine
-
-
1'-aza-4'-deaza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
-
1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine
1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine-3-methanol
2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propane-1,3-diol
3-Deazaadenine
-
-
3-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propan-1-ol
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
5'-4-chloro-phenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
5'-4-chloro-phenylthio-immucillin-A
5'-Chloroadenosine
-
exhibits a 35-47% inhibition of enzyme activity
5'-Chloroformycin
5'-ethylthioadenosine
5'-isobutylthio-3-deaza-adenosine
-
poor inhibitor
5'-isobutylthioadenosine
-
inhibits the reaction with methylthioadenosine by about 40%
5'-Isobutylthioinosine
-
-
5'-Isopropylthioadenosine
-
inhibits the reaction with methylthioadenosine by about 40%
5'-methylthio-3-deaza-adenosine
-
poor inhibitor
5'-Methylthioformycin
-
powerful inhibitor
5'-methylthiotubercidin
5'-n-butylthioinosine
-
-
5'-p-aminophenylthioadenosine
-
Pfs protein shows 45% relative activity in the presence of 0.1 mM 5'-p-aminophenylthioadenosine, Bgp protein shows 20% relative activity in the presence of 0.1 mM 5'-p-aminophenylthioadenosine
5'-p-nitrophenylthioadenosine
-
-
5'-p-nitrophenythioadenosine
-
Pfs protein shows 0.6% relative activity in the presence of 0.1 mM 5'-p-aminophenylthioadenosine, Bgp protein shows 5% relative activity in the presence of 0.1 mM 5'-p-aminophenylthioadenosine
5,5'-dithio-bis(2-nitrobenzoic acid)
-
-
9-erythro-(2-hydroxyl 3-nonyl)adenine
-
-
adenine
adenosine
Adenosine 5'-carboxamide
aminoethoxyvinylglycine
-
34% inhibition
benzylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
benzylthio-immucillin A
-
-
BuT-DADMe-ImmA
-
-
butylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
picomolar inhibitor of MTAN
calcineurin B-like 3 protein
-
calcineurin B-like 3 protein and MTAN physically associate only in the presence of Ca2+
-
Decoyinine
-
-
ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
ethylthio-immucillin A
-
-
ethylthio-immucillin-A
Formycin A
immucillin-A
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene) -immucillin-A
-
-
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
methylthio-immucillin A
-
-
methylthio-immucillin-A
p-chloromercuribenzoic acid
-
mM PCMB causes quantitative inhibition
p-chlorophenylthio-immucillin A
-
-
p-tolylthio-immucillin-A
phenylthio-immucillin-A
S-8-aza-adenosyl-L-homocysteine
-
powerful inhibitor
S-adenosyl-L-homocysteine sulfoxide
-
poor inhibitor
S-adenosylhomocysteine
-
competitive inhibition
S-adenosylmethionine
-
competitive inhibition
S-formycinylhomocysteine
-
powerful inhibitor
S-N6-dimethyl-3-deaza-adenosyl-L-homocysteine
-
poor inhibitor
S-Tubercidinylhomocysteine
-
powerful inhibitor
sinefungin
Tris
-
Tris buffer severely inhibits
additional information
-