3.2.2.16: methylthioadenosine nucleosidase
This is an abbreviated version!
For detailed information about methylthioadenosine nucleosidase, go to the full flat file.
Word Map on EC 3.2.2.16
-
3.2.2.16
-
mtans
-
quorum
-
5'-deoxyadenosine
-
autoinducer-2
-
femtomolar
-
3.2.2.9
-
5-methylthioribose
-
adomet-dependent
-
ribooxacarbenium
-
s-ribosylhomocysteine
-
n-ribosidic
-
futalosine
-
slow-onset
-
dadme-immucillins
-
drug development
-
medicine
- 3.2.2.16
-
mtans
-
quorum
- 5'-deoxyadenosine
- autoinducer-2
-
femtomolar
-
3.2.2.9
- 5-methylthioribose
-
adomet-dependent
-
ribooxacarbenium
- s-ribosylhomocysteine
-
n-ribosidic
- futalosine
-
slow-onset
-
dadme-immucillins
- drug development
- medicine
Reaction
Synonyms
5'-deoxy-5'-methylthioadenosine nucleosidase, 5'-methylthioadenosine nucleosidase, 5'-methylthioadenosine/S-adenosyl-L-homocysteine nucleosidase, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, 5-methylthioadenosine nucleosidase, 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase, 50-methylthioadenosine/S-adenosylhomocysteine nucleosidase, adoHcy/MTA nucleosidase, Bgp protein, glycosaminoglycan-binding protein, HpyMqnB, lupin MeSAdo nucleosidase, MeSAdo nucleosidase, methylthioadenosine nucleosidase, methylthioadenosine/S-adenosylhomocysteine nucleosidase, MqnB, MTA nucleosidase, MTA ribohydrolase, MTA/SAH nucleosidase, MTAN, MTAN1, MTAN2, MTN, Pfs, Pfs protein, plant specific MTA nucleosidase, S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase
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Reference on EC 3.2.2.16 - methylthioadenosine nucleosidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kushad, M.M.; Yelenosky, G.; Knight, R.
Interrelationship of polyamine and ethylene biosynthesis during avocado fruit development and ripening
Plant Physiol.
87
463-467
1988
Persea americana
Kushad, M.M.; Richardson, D.G.; Ferro, A.J.
5'-Methylthioadenosine nucleosidase and 5-methylthioribose kinase activities and ethylene production during tomato fruit development and ripening
Plant Physiol.
79
525-529
1985
Solanum lycopersicum
Guranowski, A.B.; Chiang, P.K.; Cantoni, G.L.
5'-Methylthioadenosine nucleosidase(Lupinus luteus seeds)
Methods Enzymol.
94
365-369
1983
Escherichia coli, Lupinus luteus
-
Guranowski, A.B.; Chiang, P.K.; Cantoni, G.L.
5'-Methylthioadenosine nucleosidase. Purification and characterization of the enzyme from Lupinus luteus seeds
Eur. J. Biochem.
114
293-299
1981
Escherichia coli, Lupinus luteus
Yamakawa, M.; Schweiger, H.G.
5'-Methylthioadenosine nucleosidase, some characteristics of an enzyme from Acetabularia
Dev. Cell Biol.
3
241-254
1979
Acetabularia acetabulum, Escherichia coli
-
Cacciapuoti, G.; Oliva, A.; Zappia, V.
Studies on phosphate-activated 5'-methylthioadenosine nucleosidase from human placenta
Int. J. Biochem.
9
35-41
1978
Homo sapiens
Sugimoto, Y.; Toraya, T.; Fukui, S.
Studies on metabolic role of 5'-methylthioadenosine in Ochromonas malhamensis and other microorganisms
Arch. Microbiol.
108
175-182
1976
Ochromonas malhamensis
Baxter, C.; Coscia, C.J.
In vitro synthesis of spermidine in the higher plant, Vinca rosea
Biochem. Biophys. Res. Commun.
54
147-154
1973
Catharanthus roseus
Kushad, M.M.; Orvos, A.; Ferro, A.J.
5'-Methylthioadenosine nucleosidase and 5'-methylthioribose kinase activities in relation to stress-induced ethylene biosynthesis
Physiol. Plant.
86
532-538
1992
Persea americana, Cucumis sativus, Solanum lycopersicum
-
Dunn, S.M.; Bryant, J.A.; Kerr, M.W.
A simple spectrophotometric assay for plant 5'-deoxy-5'-methylthioadenosine nucleosidase using xanthine oxidase a coupling enzyme
Phytochem. Anal.
5
286-290
1994
Pisum sativum
-
Gatel, M.; Muzard, M.; Guillerm, D.; Guillerm, G.
Kinetic properties of fluorinated substrate analogues on 5'-methylthioadenosine nucleosidase from Escherichia coli
Eur. J. Med. Chem.
31
37-41
1996
Escherichia coli, Escherichia coli B / ATCC 11303
-
Sekowska, A.; Danchin, A.
Identification of yrrU as the methylthioadenosine nucleosidase gene in Bacillus subtilis
DNA Res.
6
255-264
1999
Bacillus subtilis
Della Ragione, F.; Porcelli, M.; Carteni-Farina, M.; Zappia, V.
Escherichia coli S-adenosylhomocysteine/5'-methylthioadenosine nucleosidasepurification, substrate specificity and mechanisms of action
Biochem. J.
232
335-341
1985
Escherichia coli
Lee, J.E.; Cornell, K.A.; Riscoe, M.K.; Howell, P.L.
Expression, purification, crystallization and preliminary X-ray analysis of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Acta Crystallogr. Sect. D
57
150-152
2001
Escherichia coli
Lee, J.E.; Cornell, K.A.; Riscoe, M.K.; Howell, P.L.
Structure of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysis
J. Biol. Chem.
278
8761-8770
2003
Escherichia coli
Gutierrez, J.A.; Luo, M.; Singh, V.; Li, L.; Brown, R.L.; Norris, G.E.; Evans, G.B.; Furneaux, R.H.; Tyler, P.C.; Painter, G.F.; Lenz, D.H.; Schramm, V.L.
Picomolar inhibitors as transition-state probes of 5-methylthioadenosine nucleosidases
ACS Chem. Biol.
2
725-734
2007
Streptococcus pneumoniae, Escherichia coli, Helicobacter pylori, Staphylococcus aureus, Neisseria meningitidis
Singh, V.; Shi, W.; Almo, S.C.; Evans, G.B.; Furneaux, R.H.; Tyler, P.C.; Painter, G.F.; Lenz, D.H.; Mee, S.; Zheng, R.; Schramm, V.L.
Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae
Biochemistry
45
12929-12941
2006
Escherichia coli, Streptococcus pneumoniae (Q8DQ16)
Singh, V.; Luo, M.; Brown, R.L.; Norris, G.E.; Schramm, V.L.
Transition-state structure of Neisseria meningitides 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase
J. Am. Chem. Soc.
129
13831-13833
2007
Neisseria meningitidis
Singh, V.; Schramm, V.L.
Transition-state analysis of S. pneumoniae 5-methylthioadenosine nucleosidase
J. Am. Chem. Soc.
129
2783-2795
2007
Streptococcus pneumoniae
Rzewuski, G.; Cornell, K.A.; Rooney, L.; Buerstenbinder, K.; Wirtz, M.; Hell, R.; Sauter, M.
OsMTN encodes a 5-methylthioadenosine nucleosidase that is up-regulated during submergence-induced ethylene synthesis in rice (Oryza sativa L.)
J. Exp. Bot.
58
1505-1514
2007
Oryza sativa (Q8W162), Oryza sativa
Evans, G.B.; Furneaux, R.H.; Greatrex, B.; Murkin, A.S.; Schramm, V.L.; Tyler, P.C.
Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases
J. Med. Chem.
51
948-956
2008
Streptococcus pneumoniae, Escherichia coli
Siu, K.K.; Lee, J.E.; Sufrin, J.R.; Moffatt, B.A.; McMillan, M.; Cornell, K.A.; Isom, C.; Howell, P.L.
Molecular determinants of substrate specificity in plant 5-methylthioadenosine nucleosidases
J. Mol. Biol.
378
112-128
2008
Arabidopsis thaliana
Park, E.Y.; Oh, S.; Nam, M.J.; Shin, J.S.; Kim, K.; Song, H.K.
Crystal structure of 5-methylthioadenosine nucleosidase from Arabidopsis thaliana at 1.5 A resolution
Proteins Struct. Funct. Bioinform.
65
519-523
2006
Arabidopsis thaliana
Siu, K.K.; Lee, J.E.; Smith, G.D.; Horvatin-Mrakovcic, C.; Howell, P.L.
Structure of Staphylococcus aureus 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Acta Crystallogr. Sect. F
64
343-350
2008
Escherichia coli (P0AF14), Escherichia coli, Staphylococcus aureus (Q99TQ0), Staphylococcus aureus
Luo, M.; Schramm, V.L.
Ribosyl geometry in the transition state of Streptococcus pneumoniae methylthioadenosine nucleosidase from the 3'-2H kinetic isotope effect
J. Am. Chem. Soc.
130
11617-11619
2008
Streptococcus pneumoniae
Cornell, K.A.; Primus, S.; Martinez, J.A.; Parveen, N.
Assessment of methylthioadenosine/S-adenosylhomocysteine nucleosidases of Borrelia burgdorferi as targets for novel antimicrobials using a novel high-throughput method
J. Antimicrob. Chemother.
63
1163-1172
2009
Borreliella burgdorferi
Gutierrez, J.A.; Crowder, T.; Rinaldo-Matthis, A.; Ho, M.C.; Almo, S.C.; Schramm, V.L.
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing
Nat. Chem. Biol.
5
251-257
2009
Vibrio cholerae serotype O1, Vibrio cholerae serotype O1 N16961
Oh, S.I.; Park, J.; Yoon, S.; Kim, Y.; Park, S.; Ryu, M.; Nam, M.J.; Ok, S.H.; Kim, J.K.; Shin, J.S.; Kim, K.N.
The Arabidopsis calcium sensor calcineurin B-like 3 inhibits the 5'-methylthioadenosine nucleosidase in a calcium-dependent manner
Plant Physiol.
148
1883-1896
2008
Arabidopsis thaliana
Park, E.Y.; Choi, W.S.; Oh, S.I.; Kim, K.N.; Shin, J.S.; Song, H.K.
Biochemical and structural characterization of 5-methylthioadenosine nucleosidases from Arabidopsis thaliana
Biochem. Biophys. Res. Commun.
381
619-624
2009
Arabidopsis thaliana
Challand, M.R.; Ziegert, T.; Douglas, P.; Wood, R.J.; Kriek, M.; Shaw, N.M.; Roach, P.L.
Product inhibition in the radical S-adenosylmethionine family
FEBS Lett.
583
1358-1362
2009
Escherichia coli
Siu, K.K.; Asmus, K.; Zhang, A.N.; Horvatin, C.; Li, S.; Liu, T.; Moffatt, B.; Woods, V.L.; Howell, P.L.
Mechanism of substrate specificity in 5-methylthioadenosine/S-adenosylhomocysteine nucleosidases
J. Struct. Biol.
173
86-98
2011
Arabidopsis thaliana, Escherichia coli
Bretes, E.; Guranowski, A.; Nuc, K.
5'-methylthioadenosine nucleosidase from yellow lupine (Lupinus luteus): molecular characterization and mutational analysis
Protein Pept. Lett.
18
817-824
2011
Lupinus luteus
Kim, R.Q.; Offen, W.A.; Davies, G.J.; Stubbs, K.A.
Structural enzymology of Helicobacter pylori methylthioadenosine nucleosidase in the futalosine pathway
Acta Crystallogr. Sect. D
70
177-185
2014
Helicobacter pylori (O24915), Helicobacter pylori
Kang, X.; Zhao, Y.; Jiang, D.; Li, X.; Wang, X.; Wu, Y.; Chen, Z.; Zhang, X.C.
Crystal structure and biochemical studies of Brucella melitensis 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Biochem. Biophys. Res. Commun.
446
965-970
2014
Brucella melitensis (Q8YBL1), Brucella melitensis
Mishra, V.; Ronning, D.R.
Crystal structures of the Helicobacter pylori MTAN enzyme reveal specific interactions between S-adenosylhomocysteine and the 5-alkylthio binding subsite
Biochemistry
51
9763-9772
2012
Helicobacter pylori (Q9ZMY2), Helicobacter pylori
Wang, S.; Thomas, K.; Schramm, V.L.
Catalytic site cooperativity in dimeric methylthioadenosine nucleosidase
Biochemistry
53
1527-1535
2014
Escherichia coli (P0AF12), Staphylococcus aureus (Q99TQ0), Staphylococcus aureus, Vibrio cholerae (A5F5R2)
Clinch, K.; Evans, G.B.; Froehlich, R.F.; Gulab, S.A.; Gutierrez, J.A.; Mason, J.M.; Schramm, V.L.; Tyler, P.C.; Woolhouse, A.D.
Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics
Bioorg. Med. Chem.
20
5181-5187
2012
Escherichia coli, Neisseria meningitidis
Gao, Q.; Zheng, D.; Yuan, Z.
Substrate preference of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase in Burkholderia thailandensis
FEMS Microbiol. Lett.
339
110-116
2013
Burkholderia thailandensis
Bao, Y.; Li, Y.; Jiang, Q.; Zhao, L.; Xue, T.; Hu, B.; Sun, B.
Methylthioadenosine/S-adenosylhomocysteine nucleosidase (Pfs) of Staphylococcus aureus is essential for the virulence independent of LuxS/AI-2 system
Int. J. Med. Microbiol.
303
190-200
2013
Staphylococcus aureus, Staphylococcus aureus NCTC 8325, Staphylococcus aureus RN4220
Wang, S.; Lim, J.; Thomas, K.; Yan, F.; Angeletti, R.H.; Schramm, V.L.
A complex of methylthioadenosine/S-adenosylhomocysteine nucleosidase, transition state analogue, and nucleophilic water identified by mass spectrometry
J. Am. Chem. Soc.
134
1468-1470
2012
Escherichia coli
Cho, Y.; Kim, J.; Kim, D.
Cobalt-requiring 5'-deoxy-5'-methylthioadenosine nucleosidase from soybean (Glycine max) cotyledon
J. Plant Biochem. Biotechnol.
21
113-116
2012
Glycine max
-
Thomas, K.; Haapalainen, A.M.; Burgos, E.S.; Evans, G.B.; Tyler, P.C.; Gulab, S.; Guan, R.; Schramm, V.L.
Femtomolar inhibitors bind to 5'-methylthioadenosine nucleosidases with favorable enthalpy and entropy
Biochemistry
51
7541-7550
2012
Escherichia coli, Salmonella enterica, Vibrio cholerae serotype O1
Chen, H.; Yang, H.; Hu, Z.; Yang, H.; Ma, H.; Gao, S.; Guo, Q.; Bai, W.; Qin, L.; Li, L.
Prokaryotic expression and activity analysis of 5'-methylthioadenosine nucleosidase in Mycobacterium tuberculosis
Chin. J. Microbiol. Immunol.
32
589-594
2012
Mycobacterium tuberculosis, Mycobacterium tuberculosis (P9WJN3)
-
Bao, Y.; Zhang, X.; Jiang, Q.; Xue, T.; Sun, B.
Pfs promotes autolysis-dependent release of eDNA and biofilm formation in Staphylococcus aureus
Med. Microbiol. Immunol.
204
215-226
2015
Staphylococcus aureus, Staphylococcus aureus NCTC 8325
Waduwara-Jayabahu, I.; Oppermann, Y.; Wirtz, M.; Hull, Z.T.; Schoor, S.; Plotnikov, A.N.; Hell, R.; Sauter, M.; Moffatt, B.A.
Recycling of methylthioadenosine is essential for normal vascular development and reproduction in Arabidopsis
Plant Physiol.
158
1728-1744
2012
Arabidopsis thaliana
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