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5'-(4-fluorosulfonylbenzoyl)adenosine + H2O
5-fluorosulfonylbenzoyl-D-ribose + adenine
-
-
-
?
5'-adenosylcysteine + H2O
adenine + S-ribosylcysteine
-
-
-
?
5'-butylthioadenosine + H2O
5-butylthio-D-ribose + adenine
5'-butylthioadenosine + H2O
adenine + 5-butylthio-D-ribose
-
25% activity compared to 5'-methylthioadenosine
-
-
?
5'-chloroadenosine + H2O
5-chloro-D-ribose + adenine
-
-
-
-
?
5'-chloroadenosine + H2O
adenine + 5-chloro-D-ribose
-
4% activity compared to 5'-methylthioadenosine
-
-
?
5'-deoxy-5'-(difluoromethylthio)adenosine + H2O
5-deoxy-5-(difluoromethylthio)-D-ribose + adenine
5'-deoxy-5'-(monofluoromethylthio)adenosine + H2O
5-deoxy-5-(monofluoromethylthio)-D-ribose + adenine
5'-deoxy-5'-(trifluoromethylthio)adenosine + H2O
5-deoxy-5-(trifluoromethylthio)-D-ribose + adenine
5'-deoxy-5'-isobutylthio-adenosine + H2O
5-isobutylthio-D-ribose + adenine
-
1-butanol buffer/propan-2-ol buffer
-
-
?
5'-deoxy-5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
5'-deoxy-5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-deoxy-5'-propylthioadenosine + H2O
5-propylthio-D-ribose + adenine
5'-deoxy-5'-S-adenosyl-L-cysteine + H2O
S-(5-deoxy-5-D-ribosyl)-L-cysteine + adenine
-
relative activity 95.2%
-
-
?
5'-deoxy-5'-S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-5-D-ribosyl)-L-homoscysteine + adenine
-
substrate analogue, relative activity 95.8%
-
-
?
5'-deoxy-5'-thioethanoladenosine + H2O
?
-
relative activity 98%
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
5'-ethylthio-2-aminoadenosine + H2O
5-ethylthio-D-ribose + 2-aminoadenosine
-
1-butanol buffer/propan-2-ol buffer
-
-
?
5'-ethylthioadenosine + H2O
5-ethylthio-D-ribose + adenine
5'-ethylthioadenosine + H2O
adenine + 5-ethylthio-D-ribose
-
40% activity compared to 5'-methylthioadenosine
-
-
?
5'-ethylthioinosine + H2O
5-ethylthio-D-ribose + hypoxanthine
-
1-butanol buffer
-
-
?
5'-iodoadenosine + H2O
adenine + 5-iodo-D-ribose
-
28% activity compared to 5'-methylthioadenosine
-
-
?
5'-iodothioadenosine + H2O
5-iodothio-D-ribose + adenine
5'-isobutylthio-3-deaza-adenosine + H2O
5-isobutylthio-D-ribose + 3-deazadenosine
-
1-butanol buffer/propan-2-ol buffer
-
-
?
5'-isobutylthioadenosine + H2O
5-isobutylthioribose + adenine
-
-
-
-
?
5'-isobutylthioadenosine + H2O
?
-
52% activity compared to 5'-methylthioadenosine
-
-
?
5'-isobutylthioadenosine + H2O
adenine + 5-isobutylthio-D-ribose
-
17% activity compared to 5'-methylthioadenosine
-
-
?
5'-isobutylthioinosine + H2O
5-isobutylthio-D-ribose + hypoxanthine
-
1-butanol buffer
-
-
?
5'-isopropylthioadenosine + H2O
5-isopropylthio-D-ribose + adenine
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
5'-methylthioadenosine + H2O
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
5'-methylthioarabinosyladenine + H2O
5-methylthioarabinose + adenine
-
1-butanol buffer/propan-2-ol buffer
-
-
?
5'-methylthioinosine + H2O
5-methylthio-D-ribose + hypoxanthine
5'-n-butylthioadenosine + H2O
5-n-butylthio-D-ribose + adenine
-
1-butanol buffer
-
-
?
5'-n-butylthioadenosine + H2O
?
-
40% activity compared to 5'-methylthioadenosine
-
-
?
5'-n-butylthioinosine + H2O
5-n-butylthio-D-ribose + hypoxanthine
-
1-butanol buffer
-
-
?
5'-phenylthioadenosine + H2O
5-phenylthio-D-ribose + adenine
5'-phenylthioadenosine + H2O
adenine + 5-phenylthio-D-ribose
-
12% activity compared to 5'-methylthioadenosine
-
-
?
5'-propylthioadenosine + H2O
5-propylthio-D-ribose + adenine
-
-
-
?
6-amino-6-deoxyfutalosine + H2O
3-{3-[(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]propanoyl}benzoic acid + 9H-purine-6-amine
6-amino-6-deoxyfutalosine + H2O
adenine + dehypoxanthinyl futalosine
-
-
-
?
adenosine + H2O
adenine + D-ribose
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
S-adenosyl-L-homocysteine + H2O
S-D-ribosyl-L-homocysteine + adenine
S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
S-adenosylhomocysteine + H2O
adenine + S-ribosylhomocysteine
S-adenosylmercaptoethanol + H2O
?
-
1-butanol buffer/propan-2-ol buffer
-
-
?
S-inosylmercaptoethanol + H2O
?
-
propan-2-ol buffer
-
-
?
S-isobutyl-5'-thioadenosine + H2O
5-S-(2-methylpropyl)-5-thio-beta-D-ribofuranose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
additional information
?
-
5'-butylthioadenosine + H2O
5-butylthio-D-ribose + adenine
-
-
-
-
?
5'-butylthioadenosine + H2O
5-butylthio-D-ribose + adenine
-
-
-
?
5'-deoxy-5'-(difluoromethylthio)adenosine + H2O
5-deoxy-5-(difluoromethylthio)-D-ribose + adenine
-
DFMTA, fluorinated substrate analogue
-
-
?
5'-deoxy-5'-(difluoromethylthio)adenosine + H2O
5-deoxy-5-(difluoromethylthio)-D-ribose + adenine
-
DFMTA, fluorinated substrate analogue
-
-
?
5'-deoxy-5'-(monofluoromethylthio)adenosine + H2O
5-deoxy-5-(monofluoromethylthio)-D-ribose + adenine
-
MFMTA , fluorinated analogue of MTA
-
-
?
5'-deoxy-5'-(monofluoromethylthio)adenosine + H2O
5-deoxy-5-(monofluoromethylthio)-D-ribose + adenine
-
MFMTA , fluorinated analogue of MTA
-
-
?
5'-deoxy-5'-(trifluoromethylthio)adenosine + H2O
5-deoxy-5-(trifluoromethylthio)-D-ribose + adenine
-
TFMTA, fluorinated substrate analogue
-
-
?
5'-deoxy-5'-(trifluoromethylthio)adenosine + H2O
5-deoxy-5-(trifluoromethylthio)-D-ribose + adenine
-
TFMTA, fluorinated substrate analogue
-
-
?
5'-deoxy-5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-deoxy-5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-deoxy-5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-deoxy-5'-propylthioadenosine + H2O
5-propylthio-D-ribose + adenine
-
-
-
-
?
5'-deoxy-5'-propylthioadenosine + H2O
5-propylthio-D-ribose + adenine
-
1-butanol buffer/propan-2-ol buffer
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
i.e. DOA, MTAN can rapidly hydrolyse DOA
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
1-butanol buffer
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
-
?
5'-ethylthioadenosine + H2O
5-ethylthio-D-ribose + adenine
-
-
-
-
?
5'-ethylthioadenosine + H2O
5-ethylthio-D-ribose + adenine
-
1-butanol buffer
-
-
?
5'-ethylthioadenosine + H2O
5-ethylthio-D-ribose + adenine
-
-
-
?
5'-iodothioadenosine + H2O
5-iodothio-D-ribose + adenine
-
-
-
-
?
5'-iodothioadenosine + H2O
5-iodothio-D-ribose + adenine
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
100% activity
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
Pfs protein and Bgp protein display 100% activity towards 5'-methylthioadenosine
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
ir
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
100% activity
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
Ochromonas malhamensis
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
enzyme activity increases parallel to ethylene biosynthesis during ripening or in wounded tissue, basal activity level of the enzyme in intact tissue reflects the synthesis of polyamines
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
enzyme activity increases parallel to ethylene biosynthesis during ripening or in wounded tissue, basal activity level of the enzyme in intact tissue reflects the synthesis of polyamines
-
-
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
5'-methylthioinosine + H2O
5-methylthio-D-ribose + hypoxanthine
-
-
-
-
?
5'-methylthioinosine + H2O
5-methylthio-D-ribose + hypoxanthine
-
maximal velocity about 50-times lower than for 5'-methylthioadenosine
-
?
5'-phenylthioadenosine + H2O
5-phenylthio-D-ribose + adenine
-
-
-
-
?
5'-phenylthioadenosine + H2O
5-phenylthio-D-ribose + adenine
-
-
-
?
6-amino-6-deoxyfutalosine + H2O
3-{3-[(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]propanoyl}benzoic acid + 9H-purine-6-amine
-
-
-
?
6-amino-6-deoxyfutalosine + H2O
3-{3-[(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]propanoyl}benzoic acid + 9H-purine-6-amine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
14% activity compared to 5'-methylthioadenosine
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-D-ribosyl-L-homocysteine + adenine
-
-
-
ir
S-adenosyl-L-homocysteine + H2O
S-D-ribosyl-L-homocysteine + adenine
-
-
-
ir
S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
-
-
-
-
?
S-adenosylhomocysteine + H2O
adenine + S-ribosylhomocysteine
-
-
-
-
?
S-adenosylhomocysteine + H2O
adenine + S-ribosylhomocysteine
-
-
-
-
?
S-adenosylhomocysteine + H2O
adenine + S-ribosylhomocysteine
-
-
-
-
ir
S-adenosylhomocysteine + H2O
adenine + S-ribosylhomocysteine
15.9% of the rate with 5'-methylthioadenosine
-
-
?
S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
almost completely preferred substrate
-
-
?
S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
ir
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
preferred substrate
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
ir
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
preferred substrate
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
additional information
?
-
-
no substrate: S-adenosylhomocysteine, adenosine
-
-
?
additional information
?
-
-
no activity towards S-adenosyl-L-homocysteine and adenosine
-
-
?
additional information
?
-
-
AtMTAN2 is dual-substrate specific and is responsible for the hydrolysis of 5'-methylthioadenosine and S-adenosylhomocysteine to adenine and their corresponding thioriboses, overview
-
-
?
additional information
?
-
-
dynamics are an important factor in substrate selection in MTAN, overview. Substrate binding induces a favourable entropic change in AtMTAN1
-
-
?
additional information
?
-
-
substrate specificities of isozymes, isozyme AtMTAN2 is also active with S-adenosyl-L-homocysteine, EC 3.2.2.9, overview. Isozyme AtMTAN2 shows markedly broad substrate specificity for hydrolysis of S-adenosyl-L-homocysteine, while isozyme AtMTAN1 does not
-
-
?
additional information
?
-
-
the enzyme also shows weak hydrolytic activity with S-adenosylhomocysteine
-
-
?
additional information
?
-
-
enzyme is involved in two catabolic reactions: irreversible cleavage of the glycosidic bond of 5'-methylthioadenoside and cleavago of the glcyosidic bond of S-adenosylhomocysteine
-
-
?
additional information
?
-
-
key role in biological methylation, polyamine biosynthesis, methionine recycling and bacterial quorum sensing
-
-
?
additional information
?
-
-
MTAN is dual-substrate specific and is responsible for the hydrolysis of 5'-methylthioadenosine and S-adenosylhomocysteine to adenine and their corresponding thioriboses, overview
-
-
?
additional information
?
-
-
MTAN restores the activity of three S-adenosyl-L-methionine utilizing enzymes, biotin synthase, lipoyl synthase and tyrosine lyase, that are inhibited by the highly reactive 5'-deoxyadenosyl radical, overview
-
-
?
additional information
?
-
-
substrate binding, specificity and dynamics, overview. Substrate binding induces a unfavourable entropic change
-
-
?
additional information
?
-
-
no activity toward 5'-methylthioinosine, 5'-isobutylthioinosine, 5'-isobutylthio-3-deaza-adenosine, 5'-methylthio-3-deaza-adenosine, 5'-chloroformycin, 5'-methylthioformycin, 5'-ethylthiotubercidin, S-tubercidinylhomocysteine, S-inosyl-L-homocysteine, S-guanosyl-L-homocysteine, S-cytidylhomocysteine, S-8-aza adenosyl-L-homocysteine, S-n-methyl-3-deaza-adenosyl-L-homocysteine, S-n6-dimethyl-3-deaza-adenosyl-L-homocysteine, sinefungin, S-adenosyl-L-homocysteine dialdehyde, and acyclic adenosyl-L-homocysteine
-
-
?
additional information
?
-
-
the enzyme catalyzes the hydrolytic cleavage of adenine from methylthioadenosine
-
-
?
additional information
?
-
broad substrate specificity
-
-
?
additional information
?
-
-
broad substrate specificity
-
-
?
additional information
?
-
-
the enzyme catalyzes the hydrolytic cleavage of adenine from methylthioadenosine
-
-
?
additional information
?
-
-
the enzyme catalyzes the hydrolytic cleavage of adenine from methylthioadenosine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
5'-deoxy-5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
ir
5'-methylthioadenosine + H2O
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
6-amino-6-deoxyfutalosine + H2O
3-{3-[(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]propanoyl}benzoic acid + 9H-purine-6-amine
S-adenosyl-L-homocysteine + H2O
S-D-ribosyl-L-homocysteine + adenine
S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
S-adenosylhomocysteine + H2O
adenine + S-ribosylhomocysteine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
additional information
?
-
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
Ochromonas malhamensis
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
enzyme activity increases parallel to ethylene biosynthesis during ripening or in wounded tissue, basal activity level of the enzyme in intact tissue reflects the synthesis of polyamines
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
enzyme activity increases parallel to ethylene biosynthesis during ripening or in wounded tissue, basal activity level of the enzyme in intact tissue reflects the synthesis of polyamines
-
-
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
5'-methylthioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
6-amino-6-deoxyfutalosine + H2O
3-{3-[(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]propanoyl}benzoic acid + 9H-purine-6-amine
-
-
-
?
6-amino-6-deoxyfutalosine + H2O
3-{3-[(2R,3S,4R,5R)-3,4,5-trihydroxytetrahydrofuran-2-yl]propanoyl}benzoic acid + 9H-purine-6-amine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-D-ribosyl-L-homocysteine + adenine
-
-
-
ir
S-adenosyl-L-homocysteine + H2O
S-D-ribosyl-L-homocysteine + adenine
-
-
-
ir
S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-ribosyl-L-homocysteine + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
almost completely preferred substrate
-
-
?
S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
adenine + S-methyl-5-thio-D-ribose
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
ir
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
ir
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
preferred substrate
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
?
S-methyl-5'-thioadenosine + H2O
S-methyl-5-thio-D-ribose + adenine
-
-
-
-
?
additional information
?
-
-
AtMTAN2 is dual-substrate specific and is responsible for the hydrolysis of 5'-methylthioadenosine and S-adenosylhomocysteine to adenine and their corresponding thioriboses, overview
-
-
?
additional information
?
-
-
the enzyme also shows weak hydrolytic activity with S-adenosylhomocysteine
-
-
?
additional information
?
-
-
enzyme is involved in two catabolic reactions: irreversible cleavage of the glycosidic bond of 5'-methylthioadenoside and cleavago of the glcyosidic bond of S-adenosylhomocysteine
-
-
?
additional information
?
-
-
key role in biological methylation, polyamine biosynthesis, methionine recycling and bacterial quorum sensing
-
-
?
additional information
?
-
-
MTAN is dual-substrate specific and is responsible for the hydrolysis of 5'-methylthioadenosine and S-adenosylhomocysteine to adenine and their corresponding thioriboses, overview
-
-
?
additional information
?
-
-
the enzyme catalyzes the hydrolytic cleavage of adenine from methylthioadenosine
-
-
?
additional information
?
-
-
the enzyme catalyzes the hydrolytic cleavage of adenine from methylthioadenosine
-
-
?
additional information
?
-
-
the enzyme catalyzes the hydrolytic cleavage of adenine from methylthioadenosine
-
-
?
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(1R,2S)-2-(((4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)amino)-1-(methylthio)propane-1,3-diol
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-methylthio-D-ribitol
(1S,2R)-2-(((4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)amino)-1-(methylthio)propane-1,3-diol
(2R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol
(2R,3R)-2-([[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]methyl)-4-(methylsulfanyl)butane-1,3-diol
(2R,3R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
(2R,3S)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
(2R,3S)-4-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-3-[(methylsulfanyl)methyl]butane-1,2-diol
(2S)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-2-ol
(2S)-2-[[(1S)-1-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2-hydroxyethyl]amino]-3-(methylsulfanyl)propan-1-ol
(2S,3R)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-4-(methylsulfanyl)butane-2,3-diol
(2S,3R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
-
(2S,3R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol - methane (1:1)
-
-
(2S,3R)-N-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-3,4-dihydroxy-2-[(methylsulfanyl)methyl]butan-1-aminium trifluoroacetate
(2S,3S)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine
(3R,4S)-1-[9-deazaadenin-(9-yl)methyl]-3-hydroxy-4-(methylthiomethyl)pyrrolidine
-
(3R,4S)-4-(benzylthiomethyl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
complete inhibition at 0.1 mM
(4S,5S)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(methylsulfanyl)methyl]-1,2-thiazolidin-4-ol
(S)-9-(2,3-dihydroxy-propyl)adenine
-
-
1'-aza-4'-deaza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
-
1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine
1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine-3-methanol
2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propane-1,3-diol
3-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propan-1-ol
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
5'-4-chloro-phenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
5'-4-chloro-phenylthio-immucillin-A
5'-Chloroadenosine
-
exhibits a 35-47% inhibition of enzyme activity
5'-isobutylthio-3-deaza-adenosine
-
poor inhibitor
5'-isobutylthioadenosine
-
inhibits the reaction with methylthioadenosine by about 40%
5'-Isobutylthioinosine
-
-
5'-Isopropylthioadenosine
-
inhibits the reaction with methylthioadenosine by about 40%
5'-methylthio-3-deaza-adenosine
-
poor inhibitor
5'-Methylthioformycin
-
powerful inhibitor
5'-n-butylthioinosine
-
-
5'-p-aminophenylthioadenosine
-
Pfs protein shows 45% relative activity in the presence of 0.1 mM 5'-p-aminophenylthioadenosine, Bgp protein shows 20% relative activity in the presence of 0.1 mM 5'-p-aminophenylthioadenosine
5'-p-nitrophenylthioadenosine
-
-
5'-p-nitrophenythioadenosine
-
Pfs protein shows 0.6% relative activity in the presence of 0.1 mM 5'-p-aminophenylthioadenosine, Bgp protein shows 5% relative activity in the presence of 0.1 mM 5'-p-aminophenylthioadenosine
5,5'-dithio-bis(2-nitrobenzoic acid)
-
-
9-erythro-(2-hydroxyl 3-nonyl)adenine
-
-
aminoethoxyvinylglycine
-
34% inhibition
benzylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
benzylthio-immucillin A
-
-
butylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
picomolar inhibitor of MTAN
calcineurin B-like 3 protein
-
calcineurin B-like 3 protein and MTAN physically associate only in the presence of Ca2+
-
ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
ethylthio-immucillin A
-
-
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene) -immucillin-A
-
-
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
methylthio-immucillin A
-
-
p-chloromercuribenzoic acid
-
mM PCMB causes quantitative inhibition
p-chlorophenylthio-immucillin A
-
-
S-8-aza-adenosyl-L-homocysteine
-
powerful inhibitor
S-adenosyl-L-homocysteine sulfoxide
-
poor inhibitor
S-adenosylhomocysteine
-
competitive inhibition
S-adenosylmethionine
-
competitive inhibition
S-formycinylhomocysteine
-
powerful inhibitor
S-N6-dimethyl-3-deaza-adenosyl-L-homocysteine
-
poor inhibitor
S-Tubercidinylhomocysteine
-
powerful inhibitor
Tris
-
Tris buffer severely inhibits
(1R,2S)-2-(((4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)amino)-1-(methylthio)propane-1,3-diol
-
-
(1R,2S)-2-(((4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)amino)-1-(methylthio)propane-1,3-diol
-
-
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-methylthio-D-ribitol
-
MT-immucillin-A
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-methylthio-D-ribitol
-
MT-immucillin-A
(1S,2R)-2-(((4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)amino)-1-(methylthio)propane-1,3-diol
-
-
(1S,2R)-2-(((4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)amino)-1-(methylthio)propane-1,3-diol
-
-
(2R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol
-
-
(2R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol
-
-
(2R,3R)-2-([[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]methyl)-4-(methylsulfanyl)butane-1,3-diol
-
-
(2R,3R)-2-([[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]methyl)-4-(methylsulfanyl)butane-1,3-diol
-
-
(2R,3R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
-
(2R,3R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
-
(2R,3S)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
-
(2R,3S)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
-
(2R,3S)-4-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-3-[(methylsulfanyl)methyl]butane-1,2-diol
-
-
(2R,3S)-4-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-3-[(methylsulfanyl)methyl]butane-1,2-diol
-
-
(2S)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-2-ol
-
-
(2S)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-2-ol
-
-
(2S)-2-[[(1S)-1-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2-hydroxyethyl]amino]-3-(methylsulfanyl)propan-1-ol
-
-
(2S)-2-[[(1S)-1-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2-hydroxyethyl]amino]-3-(methylsulfanyl)propan-1-ol
-
-
(2S,3R)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-4-(methylsulfanyl)butane-2,3-diol
-
-
(2S,3R)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-4-(methylsulfanyl)butane-2,3-diol
-
-
(2S,3R)-N-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-3,4-dihydroxy-2-[(methylsulfanyl)methyl]butan-1-aminium trifluoroacetate
-
-
(2S,3R)-N-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-3,4-dihydroxy-2-[(methylsulfanyl)methyl]butan-1-aminium trifluoroacetate
-
-
(2S,3S)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
-
-
(2S,3S)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
-
-
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine
-
MT-DADMe-immucillin-A
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine
-
MT-DADMe-immucillin-A
(4S,5S)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(methylsulfanyl)methyl]-1,2-thiazolidin-4-ol
-
-
(4S,5S)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(methylsulfanyl)methyl]-1,2-thiazolidin-4-ol
-
-
1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine
-
transition state analogue inhibitor, comparison with inhibition of Streptococcus pneumoniae enzyme and several methylthioadenosine phosphorylases
1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine
-
transition state analogue inhibitor, comparison with inhibition of Escherichia coli enzyme and several methylthioadenosine phosphorylases
1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine-3-methanol
-
transition state analogue inhibitor, comparison with inhibition of Streptococcus pneumoniae enzyme and several methylthioadenosine phosphorylases
1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine-3-methanol
-
transition state analogue inhibitor, comparison with inhibition of Escherichia coli enzyme and several methylthioadenosine phosphorylases
2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propane-1,3-diol
-
-
2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propane-1,3-diol
-
-
3-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propan-1-ol
-
-
3-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propan-1-ol
-
-
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Streptococcus pneumoniae and human enzyme
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
-
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Neisseria meningitides, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Helicobacter pylori, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Escherichia coli, Streptococcus pneumoniae and human enzyme
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Escherichia coli and human enzyme
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
5'-4-chloro-phenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
-
5'-4-chloro-phenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
-
5'-4-chloro-phenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
-
5'-4-chloro-phenylthio-immucillin-A
-
-
5'-4-chloro-phenylthio-immucillin-A
-
-
5'-4-chloro-phenylthio-immucillin-A
-
-
5'-Chloroformycin
-
reduces activity by 86%
5'-Chloroformycin
-
powerful inhibitor
5'-Chloroformycin
-
substrate analogue, reduces enzyme activity by 89%
5'-ethylthioadenosine
-
reduces activity by 25%
5'-ethylthioadenosine
-
inhibits the reaction with methylthioadenosine by about 40%
5'-ethylthioadenosine
-
-
5'-methylthiotubercidin
-
transition state analogue
5'-methylthiotubercidin
-
powerful inhibitor
5'-methylthiotubercidin
-
competitive inhibition
adenine
-
70% inhibition
adenine
-
potent competitive inhibitor, feedback inhibition by one of its products
adenosine
-
85% inhibition
adenosine
-
inhibits 30% of the total activity of the enzyme
Adenosine 5'-carboxamide
-
-
Adenosine 5'-carboxamide
-
-
benzylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Streptococcus pneumoniae and human enzyme
benzylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Neisseria meningitides, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme
benzylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Helicobacter pylori, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme
benzylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Escherichia coli, Streptococcus pneumoniae and human enzyme
benzylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Escherichia coli and human enzyme
ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Streptococcus pneumoniae and human enzyme
ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Neisseria meningitides, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme
ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Helicobacter pylori, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme
ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Escherichia coli, Streptococcus pneumoniae and human enzyme
ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Escherichia coli and human enzyme
ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
picomolar inhibitor of MTAN
ethylthio-immucillin-A
-
-
Formycin A
-
transition state analogue
Formycin A
-
complete inhibition at 0.1 mM
immucillin-A
-
-
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Streptococcus pneumoniae and human enzyme
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
-
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
i.e. MT-DADMe-ImmA, transition state analogue inhibitor, comparison with inhibition of Streptococcus pneumoniae enzyme and several methylthioadenosine phosphorylases
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
-
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Neisseria meningitides, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Helicobacter pylori, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Escherichia coli, Streptococcus pneumoniae and human enzyme
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Escherichia coli and human enzyme
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
i.e. MT-DADMe-ImmA, transition state analogue inhibitor, comparison with inhibition of Escherichia coli enzyme and several methylthioadenosine phosphorylases
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
picomolar inhibitor of MTAN
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
-
methylthio-immucillin-A
-
weak
methylthio-immucillin-A
-
-
methylthio-immucillin-A
-
-
methylthio-immucillin-A
weak
methylthio-immucillin-A
-
-
p-tolylthio-immucillin-A
-
-
p-tolylthio-immucillin-A
-
phenylthio-immucillin-A
-
-
phenylthio-immucillin-A
-
sinefungin
-
poor inhibitor
additional information
-
MTAN does not interact with calcineurin B-like 1 protein and calcineurin B-like 4 protein
-
additional information
-
not inhibited by 5'-methylthioinosine, S-inosyl-L-homocysteine, S-guanosyl-L-homocysteine, S-N6-methyl-3-deaza-adenosyl-L-homocysteine, S-adenosyl-L-homocysteine dialdehyde, acyclic adenosyl-L-homocysteine, S-cytidylhomocysteine, hypoxanthine, guanine, and AMP
-
additional information
-
MTAN is not inhibited by the highly reactive 5'-deoxyadenosyl radical
-
additional information
-
inhibitor design and synthesis informed by transition state analysis have developed femtomolar inhibitors, thermodynamic analyses of transition state analogues, overview
-
additional information
-
inhibitor design and synthesis informed by transition state analysis have developed femtomolar inhibitors, thermodynamic analyses of transition state analogues, overview
-
additional information
-
inhibitor design and synthesis informed by transition state analysis have developed femtomolar inhibitors, thermodynamic analyses of transition state analogues, overview
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.00031 - 0.0435
5'-deoxy-5'-methylthioadenosine
0.00019 - 2.1
5'-methylthioadenosine
0.00055 - 0.055
5'-methylthioinosine
0.004 - 1.3
S-adenosyl-L-homocysteine
0.00000019 - 0.039
S-methyl-5'-thioadenosine
additional information
additional information
-
0.00031
5'-deoxy-5'-methylthioadenosine
-
-
0.00041
5'-deoxy-5'-methylthioadenosine
-
-
0.00725
5'-deoxy-5'-methylthioadenosine
-
-
0.0103
5'-deoxy-5'-methylthioadenosine
-
-
0.015
5'-deoxy-5'-methylthioadenosine
-
-
0.0435
5'-deoxy-5'-methylthioadenosine
-
-
0.00019
5'-methylthioadenosine
-
pH 7.5, 25°C, recombinant enzyme
0.00036
5'-methylthioadenosine
-
pH 7.5, 25°C, recombinant enzyme
0.0004
5'-methylthioadenosine
-
pH 7.5, 25°C, recombinant enzyme
0.0004
5'-methylthioadenosine
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.0005
5'-methylthioadenosine
-
-
0.0007
5'-methylthioadenosine
-
Pfs protein, at pH 5.0
0.00124
5'-methylthioadenosine
recombinant enzyme, in 50 mM potassium phosphate, pH 7.0
0.003
5'-methylthioadenosine
-
at 25°C, in 100 mM HEPES, pH 7.5, and 50 mM KCl
0.0034
5'-methylthioadenosine
-
22°C
0.005
5'-methylthioadenosine
-
Bgp protein, at pH 5.0
0.0071
5'-methylthioadenosine
-
22°C
0.0071
5'-methylthioadenosine
-
in 100 mM sodium phosphate buffer, pH 7.0
0.00738
5'-methylthioadenosine
recombinant enzyme, in 50 mM potassium phosphate, pH 7.0
0.023
5'-methylthioadenosine
pH 7.5, 25°C
0.43
5'-methylthioadenosine
-
pH 7.5, 25°C
2.1
5'-methylthioadenosine
pH 7.0, 22°C
0.00055
5'-methylthioinosine
-
-
0.055
5'-methylthioinosine
-
-
0.004
S-adenosyl-L-homocysteine
wild type enzyme, in 100 mM HEPES (pH 7.5), at 25°C
0.0041
S-adenosyl-L-homocysteine
mutant enzyme A15M, in 100 mM HEPES (pH 7.5), at 25°C
0.0056
S-adenosyl-L-homocysteine
mutant enzyme S167A, in 100 mM HEPES (pH 7.5), at 25°C
0.0058
S-adenosyl-L-homocysteine
mutant enzyme V34I, in 100 mM HEPES (pH 7.5), at 25°C
0.0061
S-adenosyl-L-homocysteine
mutant enzyme R85H, in 100 mM HEPES (pH 7.5), at 25°C
0.0062
S-adenosyl-L-homocysteine
mutant enzyme V34A, in 100 mM HEPES (pH 7.5), at 25°C
0.0068
S-adenosyl-L-homocysteine
mutant enzyme R85A, in 100 mM HEPES (pH 7.5), at 25°C
0.0076
S-adenosyl-L-homocysteine
mutant enzyme W179A, in 100 mM HEPES (pH 7.5), at 25°C
0.0098
S-adenosyl-L-homocysteine
mutant enzyme W179F, in 100 mM HEPES (pH 7.5), at 25°C
0.01
S-adenosyl-L-homocysteine
wild type enzyme, at pH 7.2 and 25°C
0.013
S-adenosyl-L-homocysteine
pH 7.5, 25°C
0.0133
S-adenosyl-L-homocysteine
mutant enzyme R164A, in 100 mM HEPES (pH 7.5), at 25°C
0.014
S-adenosyl-L-homocysteine
mutant enzyme H109A, at pH 7.2 and 25°C
0.019
S-adenosyl-L-homocysteine
mutant enzyme F107A, at pH 7.2 and 25°C
0.0381
S-adenosyl-L-homocysteine
mutant enzyme Y134A, in 100 mM HEPES (pH 7.5), at 25°C
0.0452
S-adenosyl-L-homocysteine
mutant enzyme Y134F, in 100 mM HEPES (pH 7.5), at 25°C
0.0951
S-adenosyl-L-homocysteine
mutant enzyme M144A, in 100 mM HEPES (pH 7.5), at 25°C
1.3
S-adenosyl-L-homocysteine
-
pH 7.5, 25°C
0.00000019
S-methyl-5'-thioadenosine
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
0.00000036
S-methyl-5'-thioadenosine
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
0.0000004
S-methyl-5'-thioadenosine
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
0.000061
S-methyl-5'-thioadenosine
wild type enzyme, at pH 7.7 and 25°C
0.000139
S-methyl-5'-thioadenosine
wild type enzyme, at pH 7.7 and 25°C
0.000202
S-methyl-5'-thioadenosine
mutant enzyme A113P/V153I/R158G, at pH 7.7 and 25°C
0.000262
S-methyl-5'-thioadenosine
mutant enzyme A113P, at pH 7.7 and 25°C
0.000262
S-methyl-5'-thioadenosine
mutant enzyme A113P/V153I, at pH 7.7 and 25°C
0.00043
S-methyl-5'-thioadenosine
mutant enzyme V153I, at pH 7.7 and 25°C
0.0009
S-methyl-5'-thioadenosine
wild type enzyme, at pH 7.2 and 25°C
0.0022
S-methyl-5'-thioadenosine
wild type enzyme, in 100 mM HEPES (pH 7.5), at 25°C
0.0029
S-methyl-5'-thioadenosine
mutant enzyme F104C/C186S, at pH 7.2 and 25°C
0.0031
S-methyl-5'-thioadenosine
mutant enzyme A15M, in 100 mM HEPES (pH 7.5), at 25°C
0.0044
S-methyl-5'-thioadenosine
mutant enzyme S167A, in 100 mM HEPES (pH 7.5), at 25°C
0.0045
S-methyl-5'-thioadenosine
mutant enzyme V34I, in 100 mM HEPES (pH 7.5), at 25°C
0.0048
S-methyl-5'-thioadenosine
mutant enzyme R85H, in 100 mM HEPES (pH 7.5), at 25°C
0.0053
S-methyl-5'-thioadenosine
mutant enzyme V34A, in 100 mM HEPES (pH 7.5), at 25°C
0.0054
S-methyl-5'-thioadenosine
mutant enzyme R85A, in 100 mM HEPES (pH 7.5), at 25°C
0.0054
S-methyl-5'-thioadenosine
mutant enzyme W179A, in 100 mM HEPES (pH 7.5), at 25°C
0.0074
S-methyl-5'-thioadenosine
mutant enzyme W179F, in 100 mM HEPES (pH 7.5), at 25°C
0.008
S-methyl-5'-thioadenosine
mutant enzyme R164A, in 100 mM HEPES (pH 7.5), at 25°C
0.019
S-methyl-5'-thioadenosine
-
at pH 7.5 and 25°C
0.028
S-methyl-5'-thioadenosine
mutant enzyme Y134A, in 100 mM HEPES (pH 7.5), at 25°C
0.0301
S-methyl-5'-thioadenosine
mutant enzyme Y134F, in 100 mM HEPES (pH 7.5), at 25°C
0.033
S-methyl-5'-thioadenosine
mutant enzyme H109A, at pH 7.2 and 25°C
0.0351
S-methyl-5'-thioadenosine
mutant enzyme M144A, in 100 mM HEPES (pH 7.5), at 25°C
0.037
S-methyl-5'-thioadenosine
mutant enzyme F107A, at pH 7.2 and 25°C
0.039
S-methyl-5'-thioadenosine
wild type enzyme, at pH 7.2 and 25°C
additional information
additional information
-
Michaelis-Menten kinetics
-
additional information
additional information
-
kinetics and thermodynamics, overview
-
additional information
additional information
-
kinetics and thermodynamics, overview
-
additional information
additional information
-
Michelis-Menten kinetics, substrate 5'-deoxyadenosine
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.00973 - 20
5'-methylthioadenosine
0.15 - 7.1
S-adenosyl-L-homocysteine
0.0079 - 20
S-methyl-5'-thioadenosine
0.00973
5'-methylthioadenosine
recombinant enzyme, in 50 mM potassium phosphate, pH 7.0
0.25
5'-methylthioadenosine
pH 7.5, 25°C
0.49
5'-methylthioadenosine
recombinant enzyme, in 50 mM potassium phosphate, pH 7.0
2
5'-methylthioadenosine
-
22°C
2
5'-methylthioadenosine
-
at 25°C, in 100 mM HEPES, pH 7.5, and 50 mM KCl
2.3
5'-methylthioadenosine
-
pH 7.5, 25°C, recombinant enzyme
4
5'-methylthioadenosine
-
pH 7.5, 25°C
4.2
5'-methylthioadenosine
-
pH 7.5, 25°C, recombinant enzyme
18.7
5'-methylthioadenosine
-
22°C
18.7
5'-methylthioadenosine
-
in 100 mM sodium phosphate buffer, pH 7.0
20
5'-methylthioadenosine
-
pH 7.5, 25°C, recombinant enzyme
0.15
S-adenosyl-L-homocysteine
mutant enzyme M144A, in 100 mM HEPES (pH 7.5), at 25°C
0.35
S-adenosyl-L-homocysteine
mutant enzyme Y134F, in 100 mM HEPES (pH 7.5), at 25°C
0.37
S-adenosyl-L-homocysteine
pH 7.5, 25°C
0.37
S-adenosyl-L-homocysteine
mutant enzyme W179F, in 100 mM HEPES (pH 7.5), at 25°C
0.39
S-adenosyl-L-homocysteine
mutant enzyme Y134A, in 100 mM HEPES (pH 7.5), at 25°C
0.44
S-adenosyl-L-homocysteine
mutant enzyme F107A, at pH 7.2 and 25°C
0.55
S-adenosyl-L-homocysteine
mutant enzyme S167A, in 100 mM HEPES (pH 7.5), at 25°C
0.74
S-adenosyl-L-homocysteine
mutant enzyme H109A, at pH 7.2 and 25°C
0.86
S-adenosyl-L-homocysteine
mutant enzyme W179A, in 100 mM HEPES (pH 7.5), at 25°C
0.92
S-adenosyl-L-homocysteine
mutant enzyme R85H, in 100 mM HEPES (pH 7.5), at 25°C
0.93
S-adenosyl-L-homocysteine
mutant enzyme R85A, in 100 mM HEPES (pH 7.5), at 25°C
1.1
S-adenosyl-L-homocysteine
mutant enzyme A15M, in 100 mM HEPES (pH 7.5), at 25°C
1.8
S-adenosyl-L-homocysteine
wild type enzyme, at pH 7.2 and 25°C
2.1
S-adenosyl-L-homocysteine
-
pH 7.5, 25°C
2.1
S-adenosyl-L-homocysteine
mutant enzyme V34A, in 100 mM HEPES (pH 7.5), at 25°C
2.3
S-adenosyl-L-homocysteine
mutant enzyme V34I, in 100 mM HEPES (pH 7.5), at 25°C
4.7
S-adenosyl-L-homocysteine
mutant enzyme R164A, in 100 mM HEPES (pH 7.5), at 25°C
7.1
S-adenosyl-L-homocysteine
wild type enzyme, in 100 mM HEPES (pH 7.5), at 25°C
0.0079
S-methyl-5'-thioadenosine
mutant enzyme V153I, at pH 7.7 and 25°C
0.074
S-methyl-5'-thioadenosine
mutant enzyme A113P/V153I, at pH 7.7 and 25°C
0.11
S-methyl-5'-thioadenosine
mutant enzyme A113P/V153I/R158G, at pH 7.7 and 25°C
0.17
S-methyl-5'-thioadenosine
mutant enzyme A113P, at pH 7.7 and 25°C
0.18
S-methyl-5'-thioadenosine
wild type enzyme, at pH 7.7 and 25°C
0.32
S-methyl-5'-thioadenosine
wild type enzyme, at pH 7.7 and 25°C
0.51
S-methyl-5'-thioadenosine
mutant enzyme M144A, in 100 mM HEPES (pH 7.5), at 25°C
0.58
S-methyl-5'-thioadenosine
mutant enzyme S167A, in 100 mM HEPES (pH 7.5), at 25°C
0.58
S-methyl-5'-thioadenosine
mutant enzyme W179F, in 100 mM HEPES (pH 7.5), at 25°C
0.69
S-methyl-5'-thioadenosine
mutant enzyme W179A, in 100 mM HEPES (pH 7.5), at 25°C
0.71
S-methyl-5'-thioadenosine
mutant enzyme Y134F, in 100 mM HEPES (pH 7.5), at 25°C
0.78
S-methyl-5'-thioadenosine
mutant enzyme Y134A, in 100 mM HEPES (pH 7.5), at 25°C
1
S-methyl-5'-thioadenosine
mutant enzyme F107A, at pH 7.2 and 25°C
1.2
S-methyl-5'-thioadenosine
mutant enzyme H109A, at pH 7.2 and 25°C
1.3
S-methyl-5'-thioadenosine
mutant enzyme R85H, in 100 mM HEPES (pH 7.5), at 25°C
1.4
S-methyl-5'-thioadenosine
mutant enzyme R85A, in 100 mM HEPES (pH 7.5), at 25°C
1.8
S-methyl-5'-thioadenosine
-
at pH 7.5 and 25°C
1.8
S-methyl-5'-thioadenosine
mutant enzyme A15M, in 100 mM HEPES (pH 7.5), at 25°C
2.3
S-methyl-5'-thioadenosine
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
2.5
S-methyl-5'-thioadenosine
mutant enzyme V34I, in 100 mM HEPES (pH 7.5), at 25°C
2.7
S-methyl-5'-thioadenosine
mutant enzyme V34A, in 100 mM HEPES (pH 7.5), at 25°C
3.8
S-methyl-5'-thioadenosine
wild type enzyme, at pH 7.2 and 25°C
4.2
S-methyl-5'-thioadenosine
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
7.2
S-methyl-5'-thioadenosine
mutant enzyme F104C/C186S, at pH 7.2 and 25°C
8
S-methyl-5'-thioadenosine
mutant enzyme R164A, in 100 mM HEPES (pH 7.5), at 25°C
8.8
S-methyl-5'-thioadenosine
wild type enzyme, in 100 mM HEPES (pH 7.5), at 25°C
10.2
S-methyl-5'-thioadenosine
wild type enzyme, at pH 7.2 and 25°C
20
S-methyl-5'-thioadenosine
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.5 - 1200
5'-methylthioadenosine
1.6 - 1800
S-adenosyl-L-homocysteine
0.00012 - 50000
S-methyl-5'-thioadenosine
0.5
5'-methylthioadenosine
-
pH 7.5, 25°C, recombinant enzyme
1.2
5'-methylthioadenosine
-
pH 7.5, 25°C, recombinant enzyme
1200
5'-methylthioadenosine
-
pH 7.5, 25°C, recombinant enzyme
1.6
S-adenosyl-L-homocysteine
mutant enzyme M144A, in 100 mM HEPES (pH 7.5), at 25°C
7.8
S-adenosyl-L-homocysteine
mutant enzyme Y134F, in 100 mM HEPES (pH 7.5), at 25°C
10
S-adenosyl-L-homocysteine
mutant enzyme Y134A, in 100 mM HEPES (pH 7.5), at 25°C
23
S-adenosyl-L-homocysteine
mutant enzyme F107A, at pH 7.2 and 25°C
38
S-adenosyl-L-homocysteine
mutant enzyme W179F, in 100 mM HEPES (pH 7.5), at 25°C
51
S-adenosyl-L-homocysteine
mutant enzyme H109A, at pH 7.2 and 25°C
100
S-adenosyl-L-homocysteine
mutant enzyme S167A, in 100 mM HEPES (pH 7.5), at 25°C
110
S-adenosyl-L-homocysteine
mutant enzyme W179A, in 100 mM HEPES (pH 7.5), at 25°C
140
S-adenosyl-L-homocysteine
mutant enzyme R85A, in 100 mM HEPES (pH 7.5), at 25°C
150
S-adenosyl-L-homocysteine
mutant enzyme R85H, in 100 mM HEPES (pH 7.5), at 25°C
170
S-adenosyl-L-homocysteine
wild type enzyme, at pH 7.2 and 25°C
270
S-adenosyl-L-homocysteine
mutant enzyme A15M, in 100 mM HEPES (pH 7.5), at 25°C
330
S-adenosyl-L-homocysteine
mutant enzyme V34A, in 100 mM HEPES (pH 7.5), at 25°C
350
S-adenosyl-L-homocysteine
mutant enzyme R164A, in 100 mM HEPES (pH 7.5), at 25°C
390
S-adenosyl-L-homocysteine
mutant enzyme V34I, in 100 mM HEPES (pH 7.5), at 25°C
1800
S-adenosyl-L-homocysteine
wild type enzyme, in 100 mM HEPES (pH 7.5), at 25°C
0.00012
S-methyl-5'-thioadenosine
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
0.00012
S-methyl-5'-thioadenosine
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
15
S-methyl-5'-thioadenosine
mutant enzyme M144A, in 100 mM HEPES (pH 7.5), at 25°C
18
S-methyl-5'-thioadenosine
mutant enzyme V153I, at pH 7.7 and 25°C
24
S-methyl-5'-thioadenosine
mutant enzyme Y134F, in 100 mM HEPES (pH 7.5), at 25°C
27
S-methyl-5'-thioadenosine
mutant enzyme F107A, at pH 7.2 and 25°C
28
S-methyl-5'-thioadenosine
mutant enzyme Y134A, in 100 mM HEPES (pH 7.5), at 25°C
37
S-methyl-5'-thioadenosine
mutant enzyme H109A, at pH 7.2 and 25°C
79
S-methyl-5'-thioadenosine
mutant enzyme W179F, in 100 mM HEPES (pH 7.5), at 25°C
95
S-methyl-5'-thioadenosine
-
at pH 7.5 and 25°C
97
S-methyl-5'-thioadenosine
wild type enzyme, at pH 7.2 and 25°C
130
S-methyl-5'-thioadenosine
mutant enzyme S167A, in 100 mM HEPES (pH 7.5), at 25°C
130
S-methyl-5'-thioadenosine
mutant enzyme W179A, in 100 mM HEPES (pH 7.5), at 25°C
200
S-methyl-5'-thioadenosine
mutant enzyme A113P/V153I/R158G, at pH 7.7 and 25°C
250
S-methyl-5'-thioadenosine
mutant enzyme R85A, in 100 mM HEPES (pH 7.5), at 25°C
280
S-methyl-5'-thioadenosine
mutant enzyme R85H, in 100 mM HEPES (pH 7.5), at 25°C
400
S-methyl-5'-thioadenosine
mutant enzyme A113P/V153I, at pH 7.7 and 25°C
510
S-methyl-5'-thioadenosine
mutant enzyme V34A, in 100 mM HEPES (pH 7.5), at 25°C
560
S-methyl-5'-thioadenosine
mutant enzyme V34I, in 100 mM HEPES (pH 7.5), at 25°C
580
S-methyl-5'-thioadenosine
mutant enzyme A15M, in 100 mM HEPES (pH 7.5), at 25°C
600
S-methyl-5'-thioadenosine
mutant enzyme R164A, in 100 mM HEPES (pH 7.5), at 25°C
700
S-methyl-5'-thioadenosine
mutant enzyme A113P, at pH 7.7 and 25°C
2300
S-methyl-5'-thioadenosine
wild type enzyme, at pH 7.7 and 25°C
2480
S-methyl-5'-thioadenosine
mutant enzyme F104C/C186S, at pH 7.2 and 25°C
3000
S-methyl-5'-thioadenosine
wild type enzyme, at pH 7.7 and 25°C
4000
S-methyl-5'-thioadenosine
wild type enzyme, in 100 mM HEPES (pH 7.5), at 25°C
11300
S-methyl-5'-thioadenosine
wild type enzyme, at pH 7.2 and 25°C
50000
S-methyl-5'-thioadenosine
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0000011
(1R,2S)-2-(((4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)amino)-1-(methylthio)propane-1,3-diol
-
pH and temperature not specified in the publication
0.00000008 - 0.00000036
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-methylthio-D-ribitol
0.00000023
(1S,2R)-2-(((4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)amino)-1-(methylthio)propane-1,3-diol
-
pH and temperature not specified in the publication
0.0000008 - 0.0000017
(2R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol
0.000132 - 0.000401
(2R,3R)-2-([[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]methyl)-4-(methylsulfanyl)butane-1,3-diol
0.00001
(2R,3R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
0.0000008 - 0.0000009
(2R,3S)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
0.000061 - 0.0023
(2R,3S)-4-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-3-[(methylsulfanyl)methyl]butane-1,2-diol
0.000036 - 0.00004
(2S)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-2-ol
0.000047 - 0.00172
(2S)-2-[[(1S)-1-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2-hydroxyethyl]amino]-3-(methylsulfanyl)propan-1-ol
0.000085 - 0.000202
(2S,3R)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-4-(methylsulfanyl)butane-2,3-diol
0.0000039
(2S,3R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
pH and temperature not specified in the publication
0.000006
(2S,3R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol - methane (1:1)
-
pH and temperature not specified in the publication
0.000005 - 0.000009
(2S,3R)-N-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-3,4-dihydroxy-2-[(methylsulfanyl)methyl]butan-1-aminium trifluoroacetate
0.0000018 - 0.0000021
(2S,3S)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
0.000000002 - 0.00000014
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine
0.0000023 - 0.0000034
(3R,4S)-4-(benzylthiomethyl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
0.00000045 - 0.000084
1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine
0.00000084 - 0.00015
1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine-3-methanol
0.000004 - 0.0000058
2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propane-1,3-diol
0.00000036 - 0.0000012
3-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propan-1-ol
0.00000036
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
0.00000000004 - 0.0000000093
5'-4-chloro-phenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
0.0000000055 - 0.000000059
5'-4-chloro-phenylthio-immucillin-A
0.000322
5'-Chloroformycin
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.000027
5'-Methylthioformycin
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.0041 - 0.01
5'-methylthiotubercidin
0.000077 - 0.000116
5'-p-aminophenylthioadenosine
0.000587 - 0.000698
5'-p-nitrophenylthioadenosine
0.0000000003
BuT-DADMe-ImmA
-
pH and temperature not specified in the publication
0.000000208
butylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
at 25°C, in 50 mM phosphate buffer, pH 7.9, and 10 mM KCl
0.00000007
ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
at 25°C, in 50 mM phosphate buffer, pH 7.9, and 10 mM KCl
0.00004
ethylthio-immucillin-A
0.00105 - 0.00269
Formycin A
0.000000005
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene) -immucillin-A
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
0.00000000011 - 0.000024
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
0.000000089 - 0.001
methylthio-immucillin-A
0.00006
p-tolylthio-immucillin-A
0.000335
phenylthio-immucillin-A
0.000928
S-8-aza-adenosyl-L-homocysteine
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.0000097
S-formycinylhomocysteine
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.0019
S-Tubercidinylhomocysteine
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.00000008
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-methylthio-D-ribitol
-
pH and temperature not specified in the publication
0.00000036
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-methylthio-D-ribitol
-
pH and temperature not specified in the publication
0.0000008
(2R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol
-
pH and temperature not specified in the publication
0.0000017
(2R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol
-
pH and temperature not specified in the publication
0.000132
(2R,3R)-2-([[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]methyl)-4-(methylsulfanyl)butane-1,3-diol
-
pH and temperature not specified in the publication
0.000401
(2R,3R)-2-([[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]methyl)-4-(methylsulfanyl)butane-1,3-diol
-
pH and temperature not specified in the publication
0.00001
(2R,3R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
pH and temperature not specified in the publication
0.00001
(2R,3R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
pH and temperature not specified in the publication
0.0000008
(2R,3S)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
pH and temperature not specified in the publication
0.0000009
(2R,3S)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
pH and temperature not specified in the publication
0.000061
(2R,3S)-4-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-3-[(methylsulfanyl)methyl]butane-1,2-diol
-
pH and temperature not specified in the publication
0.0023
(2R,3S)-4-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-3-[(methylsulfanyl)methyl]butane-1,2-diol
-
pH and temperature not specified in the publication
0.000036
(2S)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-2-ol
-
pH and temperature not specified in the publication
0.00004
(2S)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-2-ol
-
pH and temperature not specified in the publication
0.000047
(2S)-2-[[(1S)-1-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2-hydroxyethyl]amino]-3-(methylsulfanyl)propan-1-ol
-
pH and temperature not specified in the publication
0.00172
(2S)-2-[[(1S)-1-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2-hydroxyethyl]amino]-3-(methylsulfanyl)propan-1-ol
-
pH and temperature not specified in the publication
0.000085
(2S,3R)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-4-(methylsulfanyl)butane-2,3-diol
-
pH and temperature not specified in the publication
0.000202
(2S,3R)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-4-(methylsulfanyl)butane-2,3-diol
-
pH and temperature not specified in the publication
0.000005
(2S,3R)-N-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-3,4-dihydroxy-2-[(methylsulfanyl)methyl]butan-1-aminium trifluoroacetate
-
pH and temperature not specified in the publication
0.000009
(2S,3R)-N-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-3,4-dihydroxy-2-[(methylsulfanyl)methyl]butan-1-aminium trifluoroacetate
-
pH and temperature not specified in the publication
0.0000018
(2S,3S)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
pH and temperature not specified in the publication
-
0.0000021
(2S,3S)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
pH and temperature not specified in the publication
-
0.000000002
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine
-
pH and temperature not specified in the publication
0.00000014
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine
-
pH and temperature not specified in the publication
0.0000023
(3R,4S)-4-(benzylthiomethyl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
Bgp protein, at pH 5.0
0.0000034
(3R,4S)-4-(benzylthiomethyl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
Pfs protein, at pH 5.0
0.00000045
1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine
-
-
0.000084
1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine
-
-
0.00000084
1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine-3-methanol
-
-
0.00015
1-[(9-deazaadenin-9-yl)methyl]-3-methylthiomethylazetidine-3-methanol
-
-
0.000004
2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propane-1,3-diol
-
pH and temperature not specified in the publication
0.0000058
2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propane-1,3-diol
-
pH and temperature not specified in the publication
0.00000036
3-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propan-1-ol
-
pH and temperature not specified in the publication
0.0000012
3-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propan-1-ol
-
pH and temperature not specified in the publication
0.00000036
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
pH 7.5, 25°C
0.00000036
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
pH 7.5, 25°C
0.00000000004
5'-4-chloro-phenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
0.0000000027
5'-4-chloro-phenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
0.0000000093
5'-4-chloro-phenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
0.0000000055
5'-4-chloro-phenylthio-immucillin-A
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
0.000000038
5'-4-chloro-phenylthio-immucillin-A
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
0.000000059
5'-4-chloro-phenylthio-immucillin-A
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
0.0041
5'-methylthiotubercidin
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.01
5'-methylthiotubercidin
-
-
0.000077
5'-p-aminophenylthioadenosine
-
Pfs protein, at pH 5.0
0.000116
5'-p-aminophenylthioadenosine
-
Bgp protein, at pH 5.0
0.000587
5'-p-nitrophenylthioadenosine
-
Pfs protein, at pH 5.0
0.000698
5'-p-nitrophenylthioadenosine
-
Bgp protein, at pH 5.0
0.00004
ethylthio-immucillin-A
-
pH 7.5, 25°C
0.00004
ethylthio-immucillin-A
pH 7.5, 25°C
0.00105
Formycin A
-
Pfs protein, at pH 5.0
0.00269
Formycin A
-
Bgp protein, at pH 5.0
0.00000000011
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
0.0000000125
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
0.000000048
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
-
0.000000073
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
at 25°C, in 50 mM phosphate buffer, pH 7.9, and 10 mM KCl
0.000024
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
pH 7.5, 25°C
0.000024
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
pH 7.5, 25°C
0.000000089
methylthio-immucillin-A
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
0.000000274
methylthio-immucillin-A
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
0.0000003
methylthio-immucillin-A
-
in 100 mM HEPES, 50 mM KCl (pH 7.5), at 25°C
0.001
methylthio-immucillin-A
-
pH 7.5, 25°C
0.001
methylthio-immucillin-A
pH 7.5, 25°C
0.00006
p-tolylthio-immucillin-A
-
pH 7.5, 25°C
0.00006
p-tolylthio-immucillin-A
pH 7.5, 25°C
0.000335
phenylthio-immucillin-A
-
pH 7.5, 25°C
0.000335
phenylthio-immucillin-A
pH 7.5, 25°C
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Kushad, M.M.; Yelenosky, G.; Knight, R.
Interrelationship of polyamine and ethylene biosynthesis during avocado fruit development and ripening
Plant Physiol.
87
463-467
1988
Persea americana
brenda
Kushad, M.M.; Richardson, D.G.; Ferro, A.J.
5'-Methylthioadenosine nucleosidase and 5-methylthioribose kinase activities and ethylene production during tomato fruit development and ripening
Plant Physiol.
79
525-529
1985
Solanum lycopersicum
brenda
Guranowski, A.B.; Chiang, P.K.; Cantoni, G.L.
5'-Methylthioadenosine nucleosidase(Lupinus luteus seeds)
Methods Enzymol.
94
365-369
1983
Escherichia coli, Lupinus luteus
-
brenda
Guranowski, A.B.; Chiang, P.K.; Cantoni, G.L.
5'-Methylthioadenosine nucleosidase. Purification and characterization of the enzyme from Lupinus luteus seeds
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