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Literature summary for 3.2.2.16 extracted from

  • Bao, Y.; Li, Y.; Jiang, Q.; Zhao, L.; Xue, T.; Hu, B.; Sun, B.
    Methylthioadenosine/S-adenosylhomocysteine nucleosidase (Pfs) of Staphylococcus aureus is essential for the virulence independent of LuxS/AI-2 system (2013), Int. J. Med. Microbiol., 303, 190-200.
    View publication on PubMed
Search for more literature for 3.2.2.16

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5'-deoxyadenosine + H2O Staphylococcus aureus
-
 5-deoxy-D-ribose + adenine
-
 ?
5'-deoxyadenosine + H2O Staphylococcus aureus NCTC 8325
-
 5-deoxy-D-ribose + adenine
-
 ?
5'-deoxyadenosine + H2O Staphylococcus aureus RN4220
-
 5-deoxy-D-ribose + adenine
-
 ?
S-adenosyl-L-homocysteine + H2O Staphylococcus aureus
-
 S-ribosyl-L-homocysteine + adenine
-
 ?
S-adenosyl-L-homocysteine + H2O Staphylococcus aureus NCTC 8325
-
 S-ribosyl-L-homocysteine + adenine
-
 ?
S-adenosyl-L-homocysteine + H2O Staphylococcus aureus RN4220
-
 S-ribosyl-L-homocysteine + adenine
-
 ?
S-methyl-5'-thioadenosine + H2O Staphylococcus aureus
-
 S-methyl-5-thio-D-ribose + adenine
-
 ?
S-methyl-5'-thioadenosine + H2O Staphylococcus aureus
-
 adenine + S-methyl-5-thio-D-ribose
-
 ?
S-methyl-5'-thioadenosine + H2O Staphylococcus aureus NCTC 8325
-
 S-methyl-5-thio-D-ribose + adenine
-
 ?
S-methyl-5'-thioadenosine + H2O Staphylococcus aureus NCTC 8325
-
 adenine + S-methyl-5-thio-D-ribose
-
 ?
S-methyl-5'-thioadenosine + H2O Staphylococcus aureus RN4220
-
 S-methyl-5-thio-D-ribose + adenine
-
 ?
S-methyl-5'-thioadenosine + H2O Staphylococcus aureus RN4220
-
 adenine + S-methyl-5-thio-D-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus NCTC 8325
-
-
-
Staphylococcus aureus RN4220
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-deoxyadenosine + H2O
-
 Staphylococcus aureus 5-deoxy-D-ribose + adenine
-
 ?
5'-deoxyadenosine + H2O
-
 Staphylococcus aureus NCTC 8325 5-deoxy-D-ribose + adenine
-
 ?
5'-deoxyadenosine + H2O
-
 Staphylococcus aureus RN4220 5-deoxy-D-ribose + adenine
-
 ?
S-adenosyl-L-homocysteine + H2O
-
 Staphylococcus aureus S-ribosyl-L-homocysteine + adenine
-
 ?
S-adenosyl-L-homocysteine + H2O
-
 Staphylococcus aureus NCTC 8325 S-ribosyl-L-homocysteine + adenine
-
 ?
S-adenosyl-L-homocysteine + H2O
-
 Staphylococcus aureus RN4220 S-ribosyl-L-homocysteine + adenine
-
 ?
S-methyl-5'-thioadenosine + H2O
-
 Staphylococcus aureus S-methyl-5-thio-D-ribose + adenine
-
 ?
S-methyl-5'-thioadenosine + H2O
-
 Staphylococcus aureus NCTC 8325 S-methyl-5-thio-D-ribose + adenine
-
 ?
S-methyl-5'-thioadenosine + H2O
-
 Staphylococcus aureus RN4220 S-methyl-5-thio-D-ribose + adenine
-
 ?
S-methyl-5'-thioadenosine + H2O
-
 Staphylococcus aureus adenine + S-methyl-5-thio-D-ribose
-
 ?
S-methyl-5'-thioadenosine + H2O
-
 Staphylococcus aureus NCTC 8325 adenine + S-methyl-5-thio-D-ribose
-
 ?
S-methyl-5'-thioadenosine + H2O
-
 Staphylococcus aureus RN4220 adenine + S-methyl-5-thio-D-ribose
-
 ?

Synonyms

Synonyms Comment Organism
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
-
 Staphylococcus aureus
methylthioadenosine/S-adenosylhomocysteine nucleosidase
-
 Staphylococcus aureus
Pfs
-
 Staphylococcus aureus

General Information

General Information Comment Organism
physiological function the enzyme is essential for the virulence of Staphylococcus aureus. The enzyme is not essential for growth under nutrient-rich conditions, but is essential for AI-2 production Staphylococcus aureus
physiological function the enzyme is not essential for growth under nutrient-rich conditions, but is essential for AI-2 production. The enzyme is associated with Staphylococcus aureus subcutaneous abscess infection of mice Staphylococcus aureus