1.1.1.21: aldehyde reductase

This is an abbreviated version, for detailed information about aldehyde reductase, go to the full flat file.

Reaction

alditol
+
NAD(P)+
=
aldose
+
NAD(P)H
+
H+

Synonyms

17betaHSD5, 20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, AdhA, AKR1B, AKR1B1, AKR1B10, AKR1B13, AKR1B14, AKR1B3, AKR1C3, AKR4C7, aldehyde reductase, alditol/NADP+ oxidoreductase, alditol: NADP+ 1-oxidoreductase, alditol:NAD(P)+1oxidoreductase, alditol:NADP 1-oxidoreductase, alditol:NADP oxidoreductase, aldo-keto reductase, aldo-keto reductase family 1 member B7, aldoketo reductase 1C3, aldose reductase, aldose reductase 2, aldose reductase-like, aldose reductase-like protein, aldose xylose reductase, ALDRXV4, ALR, ALR1, ALR2, AR, ARI, BAR, Fibroblast growth factor regulated protein, FR-1 protein, GRE3, HAR, HRAR, isobutyraldehyde reductase, More, MVDP, NADPH-aldopentose reductase, NADPH-aldose reductase, polyol dehydrogenase (NADP2), RLAR, small intestine reductase, TPN-polyol dehydrogenase, VAS deferens androgen-dependent protein, YqhD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.21 aldehyde reductase

IC50 Value

IC50 Value on EC 1.1.1.21 - aldehyde reductase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.01
(1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazol-2-yl)acetic acid
Rattus norvegicus
P07943
IC50: 0.010 mM
0.02
(1-(2H-tetrazole-5-yl)-1H-pyrrol-2-yl)(phenyl)-methanone
Rattus norvegicus
-
pH 7.2, temperature not specified in the publication
-
0.018
(1-(2H-tetrazole-5-yl)-1H-pyrrol-3-yl)(phenyl)-methanone
Rattus norvegicus
-
pH 7.2, temperature not specified in the publication
-
0.0033
(17alpha)-17-hydroxyandrost-4-en-3-one
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
7.3
(1H-indol-1-yl)acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
2.87
(2,3-dihydrocyclopenta[b]indol-4(1H)-yl)acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000678
(2,4-dioxo-5-[(6,8-dimethyl-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl) acetic acid
Rattus norvegicus
-
pH 6.2, 37C
0.000522
(2,4-dioxo-5-[(6-isopropyl-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl) acetic acid
Rattus norvegicus
-
pH 6.2, 37C
0.000805
(2,4-dioxo-5-[(6-methyl-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 37C
0.000261
(2,4-dioxo-5-[(6-nitro-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 37C
0.0182
(2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0963 - 0.2572
(2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
0.04141
(2R)-1-[(benzyloxy)carbonyl]-2,3-dihydro-1H-indole-2-carboxylic acid
Homo sapiens
-
-
0.00057
(2R,4S)-6-fluoro-2',5'-dioxospiro-[chroman-4,4'-imidazoline]-2-carboxamide
Sus scrofa
-
IC50: 570 nM, mechanism, active site binding modeling, the stereochemistry of the exocyclic amide group influences the affinity for the enzyme
0.00377
(2S)-2'-methoxykurarinone
Rattus norvegicus
-
-
0.00363
(2S)-3beta,7,4'-trihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone
Rattus norvegicus
-
-
0.00037
(2S)-7,4'-dihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone
Homo sapiens
-
-
0.00049
(2Z)-3-(3,4-dihydroxyphenyl)-2-[(4-methylphenyl)carbonyl]prop-2-enoic acid
Rattus norvegicus
-
37C, pH 7.0
0.00795
(2Z)-3-(3-methoxyphenyl)-2-[(4-methylphenyl)carbonyl]prop-2-enoic acid
Rattus norvegicus
-
37C, pH 7.0
0.00111
(3-benzyl-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.097
(3-sulfanyl-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
2.24
(3-[[(2-fluorophenyl)methyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
4.06
(3-[[2-oxo-2-(2,4,6-trimethylanilino)ethyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0244
(4-hydroxy-3-methoxyphenyl)acetonitrile
Homo sapiens
-
IC50: 0.0244 mM
0.0634
(4-hydroxy-3-methoxyphenyl)methamine
Homo sapiens
-
IC50: 0.0634 mM
0.0414
(4-hydroxyphenyl)(6-hydroxypyrazin-2-yl)methanone
Homo sapiens
-
isolated from red ascidian Botryllus leachi, pyrazine derivative, IC50: 0.0414 mM
0.0214
(4-hydroxyphenyl)[4-(4-hydroxyphenyl)-1H-imidazol-2-yl]methanone
Homo sapiens
-
isolated from red ascidian Botryllus leachi, imidazole derivative, IC50: 0.0214 mM
11.46
(4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indol-5-yl)acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.00003
(4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrophthalazin-1-yl)acetic acid
Rattus norvegicus
-
in 0.1 M potassium phosphate, pH 7.4
0.0017
(5-biphenyl-4-ylmethyl-2,4-dioxothiazolidin-3-yl)acetic acid
Bos taurus
-
IC50: 0.0017 mM
0.00026
(5-biphenyl-4-ylmethylene-2,4-dioxothiazolidin-3-yl)-acetic acid
Bos taurus
-
IC50: 0.00026 mM
0.00017
(5-naphthalen-1-ylmethylene-2,4-dioxothiazolidin-3-yl)acetic acid
Bos taurus
-
IC50: 0.00017 mM
0.000432
(5E)-5-[4-(4-oxo-4H-chromen-2-yl)benzylidene]-1,3-thiazolidine-2,4-dione
Rattus norvegicus
-
pH 6.2, 37C
0.019
(5Z)-3-chloro-4-(3,5-dibromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one
Homo sapiens
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.019 mM
0.0008
(5Z)-3-chloro-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(4-hydroxyphenyl)furan-2(5H)-one
Homo sapiens
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.0008 mM
0.02
(5Z)-4-(3,5-dibromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one
Homo sapiens
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.020 mM
0.013
(5Z)-4-(3-bromo-4-hydroxyphenyl)-3-chloro-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one
Homo sapiens
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.013 mM
0.048
(5Z)-4-(3-bromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one
Homo sapiens
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.048 mM
0.017
(5Z)-4-(3-bromo-4-hydroxyphenyl)-5-[(3-bromo-4-hydroxyphenyl)methylidene]-3-chlorofuran-2(5H)-one
Homo sapiens
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.017 mM
0.057
(5Z)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(4-hydroxyphenyl)furan-2(5H)-one
Homo sapiens
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.057 mM
0.046
(5Z)-5-[(3-bromo-4-hydroxyphenyl)methylidene]-3-chloro-4-(4-hydroxyphenyl)furan-2(5H)-one
Homo sapiens
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.046 mM
0.000683
(5Z)-5-[(4-oxo-2-phenyl-4H-chromen-6-yl)methylidene]-1,3-thiazolidine-2,4-dione
Rattus norvegicus
-
pH 6.2, 37C
0.1
(6-amino-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazol-2-yl)acetic acid
Rattus norvegicus
P07943
IC50: 0.10 mM
0.18
(6-nitro-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazol-2-yl)acetic acid
Rattus norvegicus
P07943
IC50: 0.180 mM
2.75
(6H-indolo[2,3-b]quinoxalin-6-yl)acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
9.95
(7H-indolo[2',3':5,6][1,2,4]triazino[2,3-a]benzimidazol-7-yl)acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.33
(8-methyl-3-[[2-oxo-2-(propylamino)ethyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.1
(9-amino-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazol-2-yl)acetic acid
Rattus norvegicus
P07943
IC50: 0.10 mM
0.19
(9-nitro-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazol-2-yl)acetic acid
Rattus norvegicus
P07943
IC50: 0.190 mM
0.019
(E)-3-(5-(3-nitrophenyl)furan-2-yl)acrylic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0203
(Z)-2-(5-biphenyl-4-ylmethylene-2,4-dioxothiazolidin-3-yl)-N-hydroxyacetamide
Homo sapiens
-
in 0.25 M potassium phosphate buffer pH 6.8, at 37C
0.00734
(Z)-2-[5-(4-benzyloxybenzylidene)-2,4-dioxothiazolidin-3-yl]-N-hydroxyacetamide
Homo sapiens
-
in 0.25 M potassium phosphate buffer pH 6.8, at 37C
0.00652
(Z)-2-[5-(4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetamide
Homo sapiens
-
in 0.25 M potassium phosphate buffer pH 6.8, at 37C
0.0123
(Z)-5-[(3-hydroxyphenyl)methylidene]-3-(3,3,3-trifluoro-2-oxopropyl)-2,4-thiazolidinedione
Bos taurus
-
pH 6.8, 37C
-
0.0233
(Z)-5-[(3-methoxyphenyl)methylidene]-3-(3,3,3-trifluoro-2-oxopropyl)-2,4-thiazolidinedione
Bos taurus
-
pH 6.8, 37C
-
0.003
(Z)-5-[(4-hydroxyphenyl)methylidene]-3-(3,3,3-trifluoro-2-oxopropyl)-2,4-thiazolidinedione
Bos taurus
-
pH 6.8, 37C
-
0.0174
(Z)-5-[(4-methoxyphenyl)methylidene]-3-(3,3,3-trifluoro-2-oxopropyl)-2,4-thiazolidinedione
Bos taurus
-
pH 6.8, 37C
-
0.0083
(Z)-5-[(4-phenoxyphenyl)methylidene]-3-(3,3,3-trifluoro-2-oxopropyl)-2,4-thiazolidinedione
Bos taurus
-
pH 6.8, 37C
-
0.0042
(Z)-N-hydroxy-2-(5-naphthalen-1-ylmethylene-2,4-dioxothiazolidin-3-yl)acetamide
Homo sapiens
-
in 0.25 M potassium phosphate buffer pH 6.8, at 37C
0.0127
(Z)-N-hydroxy-2-[2,4-dioxo-5-(3-phenoxybenzylidene)-thiazolidin-3-yl]acetamide
Homo sapiens
-
in 0.25 M potassium phosphate buffer pH 6.8, at 37C
0.00367
(Z)-N-hydroxy-2-[2,4-dioxo-5-(4-phenoxybenzylidene)-thiazolidin-3-yl]acetamide
Homo sapiens
-
in 0.25 M potassium phosphate buffer pH 6.8, at 37C
0.00179
(Z)-N-hydroxy-2-[5-(4-hydroxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetamide
Homo sapiens
-
in 0.25 M potassium phosphate buffer pH 6.8, at 37C
0.07764
([2-[(4-methoxy-1-methyl-1H-indazol-3-yl)amino]-2-oxoethyl]sulfanyl)acetic acid
Homo sapiens
-
-
0.0034
1,5-bis(3,4-dihydroxyphenyl)-1,4-pentadiene-3-one
Bos taurus
-
IC50: 0.0034 mM
0.0253
1,5-bis(4-hydroxy-3,5-dimethoxyphenyl)-1,4-pentadiene-3-one
Bos taurus
-
IC50: 0.0253 mM
0.0359
1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadiene-3-one
Bos taurus
-
IC50: 0.0359 mM
0.0331
1,5-bis(4-hydroxyphenyl)-1,4-pentadiene-3-one
Bos taurus
-
IC50: 0.0331 mM
0.00029
1-butyl-2-[[(4-oxo-3,4-dihydroquinazolin-2-yl)methyl]sulfanyl]-1H-benzimidazole-5-sulfonamide
Homo sapiens
P42330
pH 6.6, temperature not specified in the publication
0.008
1-O-Galloyl-beta-D-glucose
Homo sapiens
-
pH and temperature not specified in the publication
0.012
17alpha-estradiol
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.003
17beta-estradiol
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.03561
2,1,3-benzoxadiazol-5-yl 5-chlorothiophene-2-sulfonate
Homo sapiens
-
-
0.5271
2,2'-[sulfonylbis(benzene-4,1-diyliminomethylylidene)]dipropanedinitrile
Homo sapiens
-
-
0.0026
2,5-bis(3,4-dihydroxybenzylidene)cyclopentanone
Bos taurus
-
IC50: 0.0026 mM
0.0208
2,5-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)cyclopentanone
Bos taurus
-
IC50: 0.0208 mM
0.0234
2,5-bis(4-hydroxy-3,5-dimethoxybenzylidene)cyclopentanone
Bos taurus
-
IC50: 0.0234 mM
0.0258
2,5-bis(4-hydroxy-3-methoxybenzylidene)cyclopentanone
Bos taurus
-
IC50: 0.0258 mM
0.0274
2,5-bis(4-hydroxybenzylidene)cyclopentanone
Bos taurus
-
IC50: 0.0274 mM
4.41
2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione
Homo sapiens
-
pH and temperature not specified in the publication
0.0029
2,6-bis(3,4-dihydroxybenzylidene)cyclohexanone
Bos taurus
-
IC50: 0.0029 mM
0.021
2,6-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)cyclohexanone
Bos taurus
-
IC50: 0.021 mM
0.0249
2,6-bis(4-hydroxy-3,5-dimethoxybenzylidene)cyclohexanone
Bos taurus
-
IC50: 0.0249 mM
0.0264
2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone
Bos taurus
-
IC50: 0.0264 mM
0.0275
2,6-bis(4-hydroxybenzylidene)cyclohexanone
Bos taurus
-
IC50: 0.0275 mM
0.000987
2-(2-oxo-3-((3,4,5-trifluorophenyl)amino)quinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.0303
2-(3,4-dimethoxyphenyl)-ethanoic acid
Homo sapiens
-
IC50: 0.0303 mM
0.00213
2-(3,7-bis(4-fluorophenyl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.001204
2-(3-((2,4-difluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.000124
2-(3-((4-bromo-2-fluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.00015
2-(3-((4-bromophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.000494
2-(3-((4-fluorophenyl)amino)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.0004
2-(3-(2,4-dihydroxyphenyl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.000639
2-(3-(3-indolyl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.000045
2-(3-(4-bromo-2-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.0000463
2-(3-(4-bromo-2-fluorophenoxy)-6-chloro-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.0000748
2-(3-(4-bromo-2-fluorophenoxy)-6-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.0000356
2-(3-(4-bromo-2-fluorophenoxy)-7-chloro-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.0000226
2-(3-(4-bromo-2-fluorophenoxy)-7-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.0000273
2-(3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.00000243
2-(3-(4-bromophenoxy)-6-chloro-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.0000493
2-(3-(4-bromophenoxy)-6-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.000033
2-(3-(4-bromophenoxy)-7-chloro-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.0000114
2-(3-(4-bromophenoxy)-7-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.000296
2-(3-(4-bromothiophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.00027
2-(3-(4-chlorothiophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.0000328
2-(3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.00338
2-(3-(4-fluorophenyl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C
259
2-(3-(4-hydroxyphenyl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.002
2-(3-benzoyl-1H-pyrrol-1-yl)acetic acid
Rattus norvegicus
-
pH 7.2, temperature not specified in the publication
-
0.000468
2-(3-phenoxy-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.00598
2-(3-phenyl-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.00042
2-(3-thiophenoxy-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.0185
2-(4-hydroxy-3-methoxyphenyl)ethanoic acid
Homo sapiens
-
derived from ginger rhizom, Zingiber officinale, IC50: 0.0185 mM, suppresses nt only sorbitol accumulation in human erythrocytes
0.0192
2-(4-hydroxy-3-methoxyphenyl)ethanol
Homo sapiens
-
derived from ginger rhizom, Zingiber officinale, IC50: 0.0192 mM, suppresses sorbitol accumulation in human erythrocytes
0.000139
2-(6-bromo-3-(2,4-dihydroxyphenyl)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.0000382
2-(6-bromo-3-(4-bromo-2-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.00000163
2-(6-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.000319
2-(6-bromo-3-(4-bromothiophenoxy)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.00000431
2-(6-bromo-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.000095
2-(6-chloro-3-(2,4-dihydroxyphenyl)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.00000504
2-(6-chloro-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.00006
2-(6-fluoro-3-(2,4-dihydroxyphenyl)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.00007
2-(6-fluoro-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.00334
2-(7-(4-fluorobenzyl)-3-(2,4-dihydroxyphenyl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.000091
2-(7-bromo-3-(2,4-dihydroxyphenyl)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.000368
2-(7-bromo-3-(3-indolyl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.0000047
2-(7-bromo-3-(4-bromo-2-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.0000435
2-(7-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.000467
2-(7-bromo-3-(4-bromothiophenoxy)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.000395
2-(7-bromo-3-(4-chlorothiophenoxy)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.0000063
2-(7-bromo-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.000069
2-(7-chloro-3-(2,4-dihydroxyphenyl)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.000238
2-(7-chloro-3-(2-benzothiophene)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.000326
2-(7-chloro-3-(4-bromothiophenoxy)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.000158
2-(7-chloro-3-(4-chlorothiophenoxy)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.0000423
2-(7-chloro-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.00152
2-(7-chloro-3-(4-fluorophenyl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.000032
2-(7-fluoro-3-(2,4-dihydroxyphenyl)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.00019
2-(7-fluoro-3-(4-bromothiophenoxy)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.000056
2-(7-fluoro-3-(4-chlorothiophenoxy)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.0000191
2-(7-fluoro-3-(4-fluorophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.00087
2-(7-fluoro-3-(4-fluorophenyl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.0265
2-amino-4-oxo-3,4-dihydropteridine-7-carboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.068 - 0.1
2-benzyl-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazole-4-carboxylic acid
0.00014
2-carboxymethyl-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazole-4-carboxylic acid
Rattus norvegicus
P07943
IC50: 140 nM, binding structure analysis
0.00055
2-carboxymethyl-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazole-4-carboxylic acid carboxymethyl ester
Rattus norvegicus
P07943
IC50: 550 nM, binding structure analysis
0.088
2-methyl-1,3,3-trioxo-1,2-dihydronaphtho[1,2-d]isothiazole-4-carboxylic acid
Rattus norvegicus
P07943
IC50: 0.088 mM
0.0251
2-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]-4-phenylbutanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0012
2-[(4-fluorobenzyl)[(2-fluorophenyl)sulfonyl]amino]-N-[2-(3-fluorophenyl)ethyl]acetamide
Homo sapiens
P42330
pH 6.6, temperature not specified in the publication
0.0318
3,3-Tetramethyleneglutaric acid
Rattus norvegicus
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37C
0.4812
3,4-dinitro-2,5-bis(phenylsulfanyl)thiophene
Homo sapiens
-
-
0.0049
3,5-bis(3,4-dihydroxybenzylidene)-4-piperidone
Bos taurus
-
IC50: 0.0049 mM
0.0208
3,5-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)-4-piperidone
Bos taurus
-
IC50: 0.0208 mM
0.0223
3,5-bis(4-hydroxy-3,5-dimethoxybenzylidene)-4-piperidone
Bos taurus
-
IC50: 0.0223 mM
0.0299
3,5-bis(4-hydroxy-3-methoxybenzylidene)-4-piperidone
Bos taurus
-
IC50: 0.0299 mM
0.0311
3,5-bis(4-hydroxyphenyl)-4-piperidone
Bos taurus
-
IC50: 0.0311 mM
0.127
3,5-dichlorosalicylic acid
Homo sapiens
-
ALR2 in 50 mM potassium phosphate (pH 6.2)
53.54
3-(1H-indol-1-yl)propanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0285 - 0.0765
3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
0.022
3-(2-phenylthiazole-4-yl)propanoic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0097
3-(3-benzoyl-1H-pyrrol-1-yl)propanoic acid
Rattus norvegicus
-
pH 7.2, temperature not specified in the publication
-
0.283
3-(4-hydroxy-3-methoxyphenyl)propanol
Homo sapiens
-
IC50: 0.283 mM
0.1073
3-(4-nitrophenyl)-2-[(phenylsulfonyl)amino]propanoic acid
Homo sapiens
-
-
0.0019 - 0.014
3-(5-(3-(trifluormethyl)phenyl)thiophene-2-yl)propanoic acid
0.003
3-(5-(3-acetylphenyl)furan-2-yl)propanoic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.016
3-(5-(3-aminophenyl)furan-2-yl)propanoic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0068
3-(5-(3-methoxyphenyl)furan-2-yl)propanoic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0054
3-(5-(3-methoxyphenyl)thiophene-2-yl)propanoic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0057
3-(5-(3-methylphenyl)furan-2-yl)propanoic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0049
3-(5-(3-methylphenyl)thiophene-2-yl)propanoic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.004
3-(5-(3-methylsulfonyl)phenylfuran-2-yl)propanoic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.00026
3-(5-(3-nitrophenyl)furan-2-yl)propanoic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.00017
3-(5-(3-nitrophenyl)thiophene-2-yl)propanoic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.002
3-(5-(3-trifluormethyl)phenylfuran-2-yl)propanoic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.016
3-(5-phenylfuran-2-yl)propanoic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0053
3-(5-phenylthiophene-2-yl)propanoic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.031
3-(5-pyridine-2-yl-furan-2-yl)propanoic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.019
3-(5-pyridine-3-yl-furan-2-yl)propanoic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.03108
3-benzyl-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl 4-methylbenzenesulfonate
Homo sapiens
-
-
0.062 - 0.172
3-hydroxycoumarin
0.0995 - 0.2808
3-[3,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl]-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
19.85
3-[3-[(diethylamino)methyl]-1H-indol-1-yl]propanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0288
30-norhederagenin
Rattus norvegicus
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37C
0.006
4-(3-benzoyl-1H-pyrrol-1-yl)butanoic acid
Rattus norvegicus
-
pH 7.2, temperature not specified in the publication
-
0.197
4-(4-hydroxy-3-methoxyphenyl)-2-butanone
Homo sapiens
-
IC50: 0.197 mM
0.642
4-(4-hydroxy-3-methoxyphenyl)butanol
Homo sapiens
-
IC50: 0.642 mM
0.0031
4-(5-(3-methylphenyl)thiophene-2-yl)butanoic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0064
4-(5-phenylthiophene-2-yl)butanoic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0016
4-androsten-17beta-ol-3-one
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0005
4-androstene-3,17-dione
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.273
4-hydroxy-3-methoxyphenol
Homo sapiens
-
IC50: 0.273 mM
0.0244
4-hydroxy-3-methoxyphenyl methanol
Homo sapiens
-
IC50: 0.0244 mM
0.045 - 0.4
4-Hydroxycoumarin
0.0362
4-O-butylpaeoniflorin
Rattus norvegicus
-
in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37C
0.0041
4-oxo-4-(5-(3-methylphenyl)thiophene-2-yl)butanoic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0065
4-oxo-4-(5-phenylthiophen-2-yl)butanoic acid
Homo sapiens
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0025
4-pregenene-21-ol-3,20-dione
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.017
4-pregnene-11beta,17alpha,21-triol-3,20-dione
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.005
4-pregnene-11beta,21-diol-3,20-dione
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0022
4-pregnene-17alpha,21-diol-3,11,20-trione
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.022
4-pregnene-18-al-11beta,21-diol-3,20-dione
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0255
4-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]butanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.00119 - 0.00392
4-[3-(5-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidin-6-yl)-1,2,4-oxadiazol-5-yl]butanoic acid
0.0624 - 0.1762
4-[5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol
0.0042
4-[5-(4-hydroxybenzylidene)-2,4-dioxothiazolidin-3-yl]-2-butenoic acid
Bos taurus
-
IC50: 0.0042 mM
0.0427 - 0.1306
4-[7-hydroxy-5-methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol
0.0202
5-(3-aminobenzylidene)-2,4-thiazolidinedione
Bos taurus
-
IC50: 0.0202 mM
0.0107
5-(3-hydroxybenzylidene)-2,4-thiazolidinedione
Bos taurus
-
IC50: 0.0107 mM
0.0789
5-(3-phenoxybenzyl)-2,4-thiazolidinedione
Bos taurus
-
IC50: 0.0789 mM
0.0314
5-(4-benzyloxybenzyl)-2,4-thiazolidinedione
Bos taurus
-
IC50: 0.0314 mM
0.009
5-(4-hydroxybenzylidene)-2,4-thiazolidinedione
Bos taurus
-
IC50: 0.009 mM
0.0404
5-(4-phenoxybenzyl)-2,4-thiazolidinedione
Bos taurus
-
IC50: 0.0404 mM
0.0011
5-androsten-3beta-ol-17-one
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0658
5-biphenyl-4-ylmethyl-2,4-thiazolidinedione
Bos taurus
-
IC50: 0.0658 mM
0.00023
5-cholenic acid-3beta-ol
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.05
5-hydroxy-3S-hydroxymethyl-6-methyl-2,3-dihydrobenzofuran
Rattus norvegicus
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37C
0.0107
5-naphthalen-1-ylmethylene-2,4-thiazolidinedione
Bos taurus
-
IC50: 0.0107 mM
0.0853
5-oxo-3-phenyl-5-(quinolin-2-ylamino)pentanoic acid
Homo sapiens
-
-
0.0117
5-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]pentanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000643
5-[(4-oxo-2-phenyl-4H-chromen-6-yl)methyl]-1,3-thiazolidine-2,4-dione
Rattus norvegicus
-
pH 6.2, 37C
0.000955
5-[(6-isopropyl-4-oxo-4H-chromen-3-yl)methylene]thiazolidine-2,4-dione
Rattus norvegicus
-
pH 6.2, 37C
0.000944
5-[(6-methyl-4-oxo-4H-chromen-3-yl)methylene]thiazolidine-2,4-dione
Rattus norvegicus
-
pH 6.2, 37C
0.000687
5-[3-(4-oxo-4H-chromen-2-yl)benzyl]-1,3-thiazolidine-2,4-dione
Rattus norvegicus
-
pH 6.2, 37C
0.000432
5-[4-(4-oxo-4H-chromen-2-yl)benzyl]-1,3-thiazolidine-2,4-dione
Rattus norvegicus
-
pH 6.2, 37C
0.0057
5alpha-Androstan-17alpha-ol-3-one
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00051
5alpha-androstan-17beta-ol-3-one
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0027
5alpha-Androstan-3alpha-ol-17-one
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00032
5alpha-Androstan-3beta-ol-17-one
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00039
5alpha-androstane-3,17-dione
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0046
5alpha-androstane-3alpha,17beta-diol
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00052
5alpha-Androstane-3beta,17beta-diol
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.000064
5alpha-cholanic acid-3beta-ol
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0005
5alpha-pregnan-3beta-ol-20-one
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00037
5alpha-pregnane-21-ol-3,20-dione
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00044
5alpha-pregnane-3,20-dione
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0042
5beta-androstan-17beta-ol-3-one
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0048
5beta-Androstan-3alpha-ol-17-one
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00033
5beta-androstan-3beta-ol-17-one
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0021
5beta-androstane-3,17-dione
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0016
5beta-androstane-3beta,17beta-diol
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.04
5beta-cholan-24-ol
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.000052
5beta-cholanic acid
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.018
5beta-cholanic acid methyl ester
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00011
5beta-cholanic acid-3-one
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00021
5beta-cholanic acid-3alpha,12alpha-diol
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00026
5beta-cholanic acid-3alpha,6alpha-diol
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0022
5beta-cholanic acid-3alpha,7alpha,12alpha-triol
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0011
5beta-cholanic acid-3alpha,7alpha-diol
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00078
5beta-cholanic acid-3alpha,7beta-diol
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00012
5beta-cholanic acid-3alpha-ol
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.000027
5beta-cholanic acid-3beta-ol
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00055
5beta-Pregnan-3alpha-ol-20-one
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00044
5beta-Pregnan-3beta-ol-20-one
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00078
5beta-pregnane-3,20-dione
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.038 - 0.064
6,7-dihydroxy-4-methylcoumarin
0.0096 - 0.066
6,7-dihydroxy-4-phenylcoumarin
0.0365 - 0.067
6,7-dihydroxycoumarin
0.000055
6-(2,3-dichlorobenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 55 nM
0.000035
6-(2,3-dichlorophenylmethanesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 35 nM
0.00039
6-(2,3-difluorobenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 390 nM
0.000257
6-(2,3-difluorophenylmethanesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 257 nM
0.00019
6-(2,4-dichlorobenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 190 nM
0.00087
6-(2,4-difluorobenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 870 nM
0.000073
6-(2,5-dichlorobenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 73 nM
0.00005
6-(2,6-dichlorobenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 50 nM
0.000052
6-(2,6-dichlorophenylmethanesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 52 nM
0.00021
6-(2-bromobenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 210 nM
0.00028
6-(2-chloro-4-fluorobenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 280 nM
0.000026
6-(2-chloro-6-fluorophenylmethanesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 26 nM
0.00017
6-(2-chlorobenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 170 nM
0.000118
6-(2-chlorophenylmethanesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 118 nM
0.000054
6-(2-fluoro-3-chlorophenylmethanesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 54 nM
0.000044
6-(2-fluoro-3-trifluoromethylphenylmethanesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 44 nM
0.000667
6-(2-fluoro-4-bromophenylmethanesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 667 nM
0.00054
6-(2-fluorobenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 540 nM
0.000422
6-(2-fluorophenylmethanesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 422 nM
0.0005
6-(2-trifluoromethylphenylmethanesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 500 nM
0.000013
6-(3,5-dimethylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 13 nM
0.00024
6-(3-chlorobenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 240 nM
0.00014
6-(3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 140 nM
0.000023
6-(3-phenylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 23 nM
0.000175
6-(3-trifluoromethylbenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 175 nM
0.000072
6-(3-trifluoromethylphenylmethanesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 72 nM
0.000049
6-(3-[4-fluorophenyl]benzofuran-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 49 nM
0.00014
6-(4-bromo-2-fluorobenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 140 nM
0.00035
6-(4-bromobenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 350 nM
0.00038
6-(4-chlorobenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 380 nM
0.000474
6-(4-fluorobenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 474 nM
0.002
6-(4-methoxybenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 0.002 mM
0.00036
6-(4-trifluoromethylbenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 360 nM
0.0038
6-(5,6-methylenedioxyindole-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 0.0038 mM
0.000087
6-(5,7-dichlorobenzofuran-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 87 nM
0.0002
6-(5,7-dichloroindole-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 200 nM
0.000006
6-(5-chloro-3-ethylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 6 nM
0.000092
6-(5-chloro-3-isopropylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 92 nM
0.001
6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 0.001 mM
0.000055
6-(5-chloro-3-methylbenzothiophene-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 55 nM
0.000034
6-(5-chloro-3-phenylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 34 nM
0.000025
6-(5-chlorobenzofuran-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 25 nM
0.0011
6-(5-chloroindole-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 0.0011 mM
0.000003
6-(5-fluoro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 3 nM
0.00023
6-(5-methoxybenzofuran-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 230 nM
0.00016
6-(5-methylbenzothiophene-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 160 nM
0.000005
6-(5-trifluoromethyl-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 5 nM
0.00019
6-(6-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 190 nM
0.000645
6-(6-chloroindole-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 645 nM
0.0014
6-(6-fluoroindole-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 0.0014 mM
0.00045
6-(7-chloroindole-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 450 nM
0.00015
6-(alpha-naphthylmethylbenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 150 nM
0.00015
6-(benzofuran-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 150 nM
0.00045
6-(benzothiazole-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 450 nM
0.00018
6-(benzothiophene-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 180 nM
0.00036
6-(beta-naphthylmethylbenzenesulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 360 nM
0.0022
6-(biphenyl-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 0.0022 mM
0.00059
6-(indole-2-sulfonyl)-2H-pyridazin-3-one
Rattus norvegicus
-
IC50: 590 nM
0.056 - 0.101
6-hydroxy-7-methoxycoumarin
0.156 - 0.171
6-hydroxycoumarin
0.05
6-methoxypaeoniflorigenone
Rattus norvegicus
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37C
0.00402
6-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]hexanoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0245 - 0.09
7-hydroxy-4-methylcoumarin
0.0024 - 0.037
7-hydroxy-4-phenylcoumarin
0.046 - 0.074
7-hydroxy-6-methoxycoumarin
0.023 - 0.086
7-hydroxycoumarin
0.053 - 0.063
7-hydroxylcoumarin-4-acetic acid
0.021 - 0.142
7-hydroxylcoumarinyl-4-acetic acid
0.0675 - 0.131
7-methoxycoumarin
0.00079 - 0.0038
8-lavandulylkaempferol
0.001
8-methoxy-N-[(1S)-2-methyl-1-(5-phenyl-1H-imidazol-2-yl)propyl]-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.000731
8-methoxy-N-[(5-phenyl-1H-imidazol-2-yl)methyl]-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.000899
8-methoxy-N-[[5-(4-methoxyphenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.05
8-O-benzoylpaeonidanin
Rattus norvegicus
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37C
0.000055
8-phenylsulfonylphthalazin-2H-3-one
Rattus norvegicus
-
IC50: 55 nM
0.05
alpha-benzoyloxypaeoniflorin
Rattus norvegicus
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37C
0.05
apiopaeonoside
Rattus norvegicus
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37C
0.0008
benzbromarone
Rattus norvegicus
-
in 0.1 M potassium phosphate, pH 7.4
0.05
benzoylpaeoniflorin
Rattus norvegicus
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37C
0.05
beta-benzoyloxypaeoniflorin
Rattus norvegicus
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37C
0.003
bezafibrate
Homo sapiens
-
noncompetitive, IC50: 0.003 mM, recombinant enzyme
0.0137
bisdemethoxycurcumin
Bos taurus
-
i.e. 1,7-bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione, extracted from Curcuma longa roots, IC50: 0.0137 mM
0.0007
butein
Homo sapiens
-
in 0.1 M sodium phosphate buffer (pH 6.2)
0.00086
ciprofibrate
Homo sapiens
-
competitive, IC50: 0.00086 mM, recombinant enzyme
0.0012
Clofibric acid
Homo sapiens
-
noncompetitive, IC50: 0.0012 mM, recombinant enzyme
0.1184 - 0.1873
coptisine
0.4 - 0.5
coumarin
0.0068 - 0.03
curcumin
0.01
daidzein
Rattus norvegicus
-
in 0.1 M potassium phosphate, pH 7.4
0.0159
demethoxycurcumin
Bos taurus
-
i.e. 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione, extracted from Curcuma longa roots, IC50: 0.0159 mM
0.00045 - 0.00095
desmethylanhydroicaritin
0.00000143 - 0.094
epalrestat
0.1 - 0.1681
epiberberine
0.025
estriol
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0016
estrone
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00056
fenofibrate
Homo sapiens
-
competitive, IC50: 0.00056 mM, recombinant enzyme
0.000026 - 0.033
fidarestat
0.0525
folic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0446
galloylpaeoniflorin
Rattus norvegicus
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37C
0.0065
gemfibrozil
Homo sapiens
-
noncompetitive, IC50: 0.0065 mM, recombinant enzyme
0.0071
glycochenodeoxycholic acid
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00071
glycolithocholic acid
Homo sapiens
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.1401 - 0.1542
groenlandicine
0.0032
Hexestrol
Rattus norvegicus
-
in 0.1 M potassium phosphate, pH 7.4
0.00928
indomethacin
Homo sapiens
-
pH 6.2, temperature not specified in the publication, ALR2
0.0034 - 0.0275
isoliquiritigenin
0.00027
kuraridin
Homo sapiens
-
-
0.00213
kurarinol
Rattus norvegicus
-
-
0.00299
kurarinone
Rattus norvegicus
-
-
0.00085 - 0.00774
kushenol E
0.000005 - 0.027
lidorestat
0.002 - 0.0219
liquiritigenin
0.0006
lukianol B
Homo sapiens
-
IC50: 0.0006 mM
0.00126
methyl 3-methyl-2-([2-nitro-4-(trifluoromethyl)phenyl]amino)butanoate
Homo sapiens
P42330
pH 6.6, temperature not specified in the publication
0.00028 - 0.0006
minalrestat
0.0068
myricetin
Rattus norvegicus
-
in 0.1 M potassium phosphate, pH 7.4
0.0175
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-beta-alanine
Homo sapiens
-
pH and temperature not specified in the publication
0.0124
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-alanine
Homo sapiens
-
pH and temperature not specified in the publication
0.069
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-isoleucine
Homo sapiens
-
pH and temperature not specified in the publication
0.0617
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-leucine
Homo sapiens
-
pH and temperature not specified in the publication
0.046
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-phenylalanine
Homo sapiens
-
pH and temperature not specified in the publication
0.0292
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-serine
Homo sapiens
-
pH and temperature not specified in the publication
0.216
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-tyrosine
Homo sapiens
-
pH and temperature not specified in the publication
0.0834
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-valine
Homo sapiens
-
pH and temperature not specified in the publication
0.00197
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycine
Homo sapiens
-
pH and temperature not specified in the publication
0.0055 - 0.0659
N-(2-phenylethyl)-N-[(2-fluoro-4-bromophenyl)sulfonyl]glycine
0.0011 - 0.0104
N-(2-phenylethyl)-N-[(3-nitrophenyl)sulfonyl]glycine
0.0036
N-(2-phenylethyl)-N-[(4-bromophenyl)sulfonyl]glycine
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.0454
N-(2-phenylethyl)-N-[(4-chlorophenyl)sulfonyl]glycine
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.0471 - 0.0745
N-(2-phenylethyl)-N-[(4-fluorophenyl)sulfonyl]glycine
0.0847
N-(2-phenylethyl)-N-[(4-methylphenyl)sulfonyl]glycine
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.021
N-(2-phenylethyl)-N-[(4-nitrophenyl)sulfonyl]glycine
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.0683
N-(2-phenylethyl)-N-[(4-trifluoromethylphenyl)sulfonyl]glycine
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.018 - 0.0804
N-benzyl-N-[(2-fluoro-4-bromophenyl)sulfonyl]glycine
0.0065 - 0.0083
N-benzyl-N-[(2-napthalenyl)sulfonyl]glycine
0.0055 - 0.0881
N-benzyl-N-[(3-nitrophenyl)sulfonyl]glycine
0.0704
N-benzyl-N-[(4-bromophenyl)sulfonyl]glycine
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.0234
N-benzyl-N-[(4-chlorophenyl)sulfonyl]glycine
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.029 - 0.0339
N-benzyl-N-[(4-fluorophenyl)sulfonyl]glycine
0.0248
N-benzyl-N-[(4-methylphenyl)sulfonyl]glycine
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.0173
N-benzyl-N-[(4-nitrophenyl)sulfonyl]glycine
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.0747
N-benzyl-N-[(4-trifluoromethylphenyl)sulfonyl]glycine
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.00367
N-cyclopropyl-N-[cyclopropyl(5-phenyl-1H-imidazol-2-yl)methyl]-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.003072
N-cyclopropyl-N-[cyclopropyl(5-phenyl-1H-imidazol-2-yl)methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.000222
N-cyclopropyl-N-[cyclopropyl[5-(pyridin-3-yl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.000146
N-cyclopropyl-N-[cyclopropyl[5-(pyridin-3-yl)-1H-imidazol-2-yl]methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.009
N-galloyl beta-D-glucopyranosylamine
Homo sapiens
-
pH and temperature not specified in the publication
0.001
N-tert-butyl-2-(2-chloro-6-methoxy-4-([(3-methyl-5-sulfanyl-4H-1,2,4-triazol-4-yl)amino]methyl)phenoxy)acetamide
Homo sapiens
P42330
pH 6.6, temperature not specified in the publication
0.00022
N-[(1S)-1-[5-(4-bromophenyl)-1H-imidazol-2-yl]-2-methylpropyl]-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.000771
N-[(1S)-1-[5-(4-bromophenyl)-1H-imidazol-2-yl]-2-methylpropyl]-8-methoxy-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.00429
N-[(1S)-2-methyl-1-(5-phenyl-1H-imidazol-2-yl)propyl]-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.002122
N-[(5-phenyl-1H-imidazol-2-yl)methyl]-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.0012 - 0.0265
N-[2-(2-thienyl)ethyl]-N-[(1,10-biphenyl)-4-sulfonyl]glycine
0.0124 - 0.0147
N-[2-(2-thienyl)ethyl]-N-[(1-naphthalenyl)sulfonyl]glycine
0.0022 - 0.0576
N-[2-(2-thienyl)ethyl]-N-[(2-fluoro-4-bromophenyl)sulfonyl]glycine
0.00427 - 0.0059
N-[2-(2-thienyl)ethyl]-N-[(2-naphthalenyl)sulfonyl]glycine
0.000431 - 0.0076
N-[2-(2-thienyl)ethyl]-N-[(3-nitrophenyl)sulfonyl]glycine
0.0046 - 0.0578
N-[2-(2-thienyl)ethyl]-N-[(4-bromophenyl)sulfonyl]glycine
0.0224
N-[2-(2-thienyl)ethyl]-N-[(4-chlorophenyl)sulfonyl]glycine
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.0108 - 0.0612
N-[2-(2-thienyl)ethyl]-N-[(4-fluorophenyl)sulfonyl]glycine
0.0119 - 0.0847
N-[2-(2-thienyl)ethyl]-N-[(4-nitrophenyl)sulfonyl]glycine
0.0525 - 0.0732
N-[2-(2-thienyl)ethyl]-N-[(4-trifluoromethylphenyl)sulfonyl]glycine
0.0133
N-[2-(2-thienyl)ethyl]-N-[(5-dimethylamino-1 naphthalenyl)sulfonyl]glycine
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.016
N-[2-(2-thienyl)ethyl]-N-[(5-dimethylamino-1-naphthalenyl)sulfonyl]glycine
Rattus norvegicus
-
pH 7.2, 37C, ALR1
0.000732
N-[[5-(4-bromophenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.000091
N-[[5-(4-bromophenyl)-1H-imidazol-2-yl]methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.000337
N-[[5-(4-chlorophenyl)-1H-imidazol-2-yl](cyclopropyl)methyl]-N-cyclopropyl-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.000031
N-[[5-(4-chlorophenyl)-1H-imidazol-2-yl](cyclopropyl)methyl]-N-cyclopropyl-8-methoxy-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.000114
N-[[5-(4-chlorophenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.000065
N-[[5-(4-chlorophenyl)-1H-imidazol-2-yl]methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.00042
N-[[5-(4-fluorophenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.000071
N-[[5-(4-fluorophenyl)-1H-imidazol-2-yl]methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.000275
N-[[5-(4-methoxyphenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide
Homo sapiens
-
pH 6.2, 30C
0.0241
N2-(2-methylaminobenzoyl)tetrahydro-1H-pyrido[3,4-b]indol-1-one
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00822
nitazoxanide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.05
nudanpinoside H
Rattus norvegicus
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37C
0.05
oxypaeoniflorin
Rattus norvegicus
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37C
0.05
paeoniflorigenone
Rattus norvegicus
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37C
0.05
paeoniflorin
Rattus norvegicus
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37C
0.05
paeonol
Rattus norvegicus
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37C
0.05
paeonolide
Rattus norvegicus
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37C
0.05
paeonoside
Rattus norvegicus
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37C
0.0114
palbinone
Rattus norvegicus
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37C
0.16
piplartine
Homo sapiens
-
pH 7.4, 37C
0.00008
ponalrestat
Bos taurus
-
IC50: 80 nM
0.0223
puerariafuran
Rattus norvegicus
-
pH 7.0, 37C
0.0387
pyrazolo[5,1-c][1,2,4]benzotriazin-8-yl dimethylcarbamate
Homo sapiens
-
-
0.0025 - 0.0376
quercetin
0.0188
S12728
Rattus norvegicus
-
pH 6.2, 30C, ALR2
0.0018 - 0.0106
semilicoisoflavone B
0.00014 - 0.03
sorbinil
0.0013
sulfuretin
Homo sapiens
-
in 0.1 M sodium phosphate buffer (pH 6.2)
0.000374
sulindac
Homo sapiens
-
pH 6.2, temperature not specified in the publication, ALR2
0.000279
sulindac sulfide
Homo sapiens
-
pH 6.2, temperature not specified in the publication, ALR2
0.000367
sulindac sulfone
Homo sapiens
-
pH 6.2, temperature not specified in the publication, ALR2
0.0314
thienocinnolinone alkanoic acid derivatives
Bos taurus
-
i.e. 8-halogen-4,4a-5,6-tetrahydrothieno[2,3-h]cinnolinone-N2-alkanoic acid derivatives, synthesis and inhibitory potency, IC50 as low as 0.0314 mM, the length of the N2 alkanoic chain strongly influences the inhibitory activity, overview
-
0.00535
tizoxanide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00239
Tolmetin
Homo sapiens
-
pH 6.2, temperature not specified in the publication, ALR2
0.00026 - 0.0008
Tolrestat
0.0501
Valproic acid
Rattus norvegicus
-
pH 7.2, temperature not specified in the publication
0.025
zearalenone
Rattus norvegicus
-
in 0.1 M potassium phosphate, pH 7.4
0.000004 - 0.00006
zopolrestat
0.0426
[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino](phenyl)acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
3.46
[(5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.001
[2,4-dioxo-5-(3-phenoxybenzyl)thiazolidin-3-yl]acetic acid
Bos taurus
-
IC50: 0.0010 mM
0.0028
[2,4-dioxo-5-(4-phenoxybenzyl)thiazolidin-3-yl]acetic acid
Bos taurus
-
IC50: 0.0028 mM
0.00082
[2,4-dioxo-5-(4-phenoxybenzylidene)thiazolidin-3-yl]acetic acid
Bos taurus
-
IC50: 0.00082 mM
0.00014
[2-oxo-3-(2-phenylethyl)quinoxalin-1(2H)-yl]acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.00082
[2-oxo-3-[(Z)-2-phenylethenyl]quinoxalin-1(2H)-yl]acetic acid
Rattus norvegicus
-
pH 6.2, 30C
-
13.76
[3-(2,2-dimethylpropanoyl)-1H-indol-1-yl]acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000007 - 0.1
[3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acid
30.14
[3-[(diethylamino)methyl]-1H-indol-1-yl]acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
42.16
[3-[(dimethylamino)methyl]-2-methyl-1H-indol-1-yl]acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000419
[3-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-2-oxoquinoxalin-1(2H)-yl]acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.00018
[3-[(E)-2-(4-hydroxyphenyl)ethenyl]-2-oxoquinoxalin-1(2H)-yl]acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.00418
[3-[(E)-2-(4-methoxyphenyl)ethenyl]-2-oxoquinoxalin-1(2H)-yl]acetic acid
Rattus norvegicus
-
pH 6.2, 30C
34.52
[3-[(morpholin-4-yl)methyl]-1H-indol-1-yl]acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
2.05
[3-[(propan-2-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl]acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
46.48
[3-[(pyrrolidin-1-yl)methyl]-1H-indol-1-yl]acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0008
[3-[2-(4-hydroxyphenyl)ethyl]-2-oxoquinoxalin-1(2H)-yl]acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.039
[5-(3-aminobenzylidene)-2,4-dioxothiazolidin-3-yl]-acetic acid methyl ester
Bos taurus
-
IC50: 0.039 mM
0.0002
[5-(3-carboxymethoxy-4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetic acid
Homo sapiens
-
ALR2, pH 6.7, temperature not specified in the publication
0.00066
[5-(3-hydroxy-4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetic acid
Homo sapiens
-
ALR2, pH 6.7, temperature not specified in the publication
0.00066
[5-(3-hydroxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetic acid
Bos taurus
-
IC50: 0.00066 mM
0.003
[5-(3-methoxybenzyl)-2,4-dioxothiazolidin-3-yl]acetic acid
Bos taurus
-
IC50: 0.0030 mM
0.0211
[5-(3-methoxybenzyl)-2,4-dioxothiazolidin-3-yl]acetic acid methyl ester
Bos taurus
-
IC50: 0.0211 mM
0.00049
[5-(3-nitrobenzylidene)-2,4-dioxothiazolidin-3-yl]-acetic acid
Bos taurus
-
IC50: 0.00049 mM
0.00028
[5-(4-benzyloxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetic acid
Bos taurus
-
IC50: 0.00028 mM
0.0021
[5-(4-hydroxybenzyl)-2,4-dioxothiazolidin-3-yl]acetic acid
Bos taurus
-
IC50: 0.0021 mM
0.00015
[5-(4-hydroxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetic acid
Bos taurus
-
IC50: 0.00015 mM
0.0062
[5-(4-hydroxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetic acid methyl ester
Bos taurus
-
IC50: 0.0062 mM
0.0011
[5-(4-methoxybenzyl)-2,4-dioxothiazolidin-3-yl]acetic acid
Bos taurus
-
IC50: 0.0011 mM
0.0012
[5-(4-nitrobenzylidene)-2,4-dioxothiazolidin-3-yl]-acetic acid
Bos taurus
-
IC50: 0.0012 mM
0.000012 - 0.1012
[6-ethyl-3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acid
0.0194
[6-hydroxy-3-(4-hydroxyphenoxy)pyrazin-2-yl](4-hydroxyphenyl)methanone
Homo sapiens
-
isolated from red ascidian Botryllus leachi, pyrazine derivative, IC50: 0.0194 mM
0.000008 - 0.1
[6-methyl-3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acid
0.000153
[7-fluoro-3-[(E)-2-(4-hydroxyphenyl)ethenyl]-2-oxoquinoxalin-1(2H)-yl]acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.00065
[7-fluoro-3-[2-(4-hydroxyphenyl)ethyl]-2-oxoquinoxalin-1(2H)-yl]acetic acid
Rattus norvegicus
-
pH 6.2, 30C
0.05887
[[(4-methylphenyl)sulfonyl](2-thiophen-2-ylethyl)amino]acetic acid
Homo sapiens
-
-
additional information
additional information
-