1.1.1.21: aldehyde reductase

This is an abbreviated version, for detailed information about aldehyde reductase, go to the full flat file.

Reaction

alditol
+
NAD(P)+
=
aldose
+
NAD(P)H
+
H+

Synonyms

17betaHSD5, 20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, AdhA, AKR1B, AKR1B1, AKR1B10, AKR1B13, AKR1B14, AKR1B3, AKR1C3, AKR4C7, aldehyde reductase, alditol/NADP+ oxidoreductase, alditol: NADP+ 1-oxidoreductase, alditol:NAD(P)+1oxidoreductase, alditol:NADP 1-oxidoreductase, alditol:NADP oxidoreductase, aldo-keto reductase, aldo-keto reductase family 1 member B7, aldoketo reductase 1C3, aldose reductase, aldose reductase 2, aldose reductase-like, aldose reductase-like protein, aldose xylose reductase, ALDRXV4, ALR, ALR1, ALR2, AR, ARI, BAR, Fibroblast growth factor regulated protein, FR-1 protein, GRE3, HAR, HRAR, isobutyraldehyde reductase, More, MVDP, NADPH-aldopentose reductase, NADPH-aldose reductase, polyol dehydrogenase (NADP2), RLAR, small intestine reductase, TPN-polyol dehydrogenase, VAS deferens androgen-dependent protein, YqhD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.21 aldehyde reductase

Specific Activity

Specific Activity on EC 1.1.1.21 - aldehyde reductase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.2
-
purified enzyme
0.475
-
-
0.488
-
-
0.92
-
purified native enzyme from lens
0.93
-
purified enzyme, pH 6.8, 37C
1.32
-
purified enzyme, NADPH
1.68
-
-
5.3
-
purified enzyme, pH 6.8, 37C
7.333
-
purified enzyme
10.2
-
-
10.4
-
isozyme ALR 2
11.2
-
-
12.1
-
recombinant expressed in Escherichia coli
13.6
-
lens epithelial cell extract
17.1
-
purified enzyme
19.2
-
diabetic lens
26.8
-
isozyme ALR 1
28.64
-
purified enzyme
37
-
purified enzyme
333.3
-
purified enzyme, with NADH in sodium phosphate buffer 100 mM, pH 7.0
additional information