1.1.1.21: aldehyde reductase

This is an abbreviated version, for detailed information about aldehyde reductase, go to the full flat file.

Reaction

alditol
+
NAD(P)+
=
aldose
+
NAD(P)H
+
H+

Synonyms

17betaHSD5, 20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, AdhA, AKR1B, AKR1B1, AKR1B10, AKR1B13, AKR1B14, AKR1B3, AKR1C3, AKR4C7, aldehyde reductase, alditol/NADP+ oxidoreductase, alditol: NADP+ 1-oxidoreductase, alditol:NAD(P)+1oxidoreductase, alditol:NADP 1-oxidoreductase, alditol:NADP oxidoreductase, aldo-keto reductase, aldo-keto reductase family 1 member B7, aldoketo reductase 1C3, aldose reductase, aldose reductase 2, aldose reductase-like, aldose reductase-like protein, aldose xylose reductase, ALDRXV4, ALR, ALR1, ALR2, AR, ARI, BAR, Fibroblast growth factor regulated protein, FR-1 protein, GRE3, HAR, HRAR, isobutyraldehyde reductase, More, MVDP, NADPH-aldopentose reductase, NADPH-aldose reductase, polyol dehydrogenase (NADP2), RLAR, small intestine reductase, TPN-polyol dehydrogenase, VAS deferens androgen-dependent protein, YqhD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.21 aldehyde reductase

Cloned

Cloned on EC 1.1.1.21 - aldehyde reductase

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
cloning from human placenta RNA by reverse transcriptase PCR and recombinant expression in Escherichia coli strain BL21(DE3)pLysS. The recombinant protein presents an additional methionine at the N-terminus as the sole modification compared to the native enzyme
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DNA and amino acid sequence determination and analysis, phylogenetic analysis, RT-PCRexpression analysis, recombinant expressionin Escherichia coli strain BL21 (DE3)
expressed as a recombinant His-tag fusion protein in Escherichia coli BL21(DE3) cells
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expressed in Escherichia coli and in YPEN-1 and NRK cells
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expressed in Escherichia coli BL21 (DE3) cells
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expressed in Escherichia coli BL21 (DE3) pLysS cells
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expressed in Escherichia coli BL21 (DE3) pLysS cells and in HeLa cells
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expressed in Escherichia coli BL21 cells
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expressed in Escherichia coli cells
expression in AML12 cell
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expression in baculovirus system
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expression in Escherichia coli
expression in Escherichia coli, with His-tag
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expression in MCF-7 and HEK-293 cell
expression in rat renal mesangial cells
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expression of AKR1B10 in Escherichia coli strain BL21, and overexpression of ALR2 in Escherichia coli
expression of ALR2 in Escherichia coli
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expression of His6-tagged ALR2 in Escherichia coli
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expression of wild-type and mutant enzymes in Escherichia coli strain BL21
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expression of wild-type and mutant enzymes in Escherichia coli strain BL21(DE3)
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gene AKR1B1, quantitative real-time PCR enzyme expression analysis in wild-type and mutant mice
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gene AKR1B1, quantitative real-time PCR enzyme expression analysis, recombinant expression of FLAG-tagged enzyme in AML12 cells
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gene AKR1B1, recombinant cardiomyocyte-specific overexpression of human enzyme in transgenic mice, adenoviral transduction. Expression in mice hearts leads to a decrease in histone deacetylase 3, HDAC3, levels accompanied by an increase in PPARgamma activity thereby contributing to lipid-enriched environment, enzyme expression leads to lipid accumulation. Human enzyme expression leads to reduced histone deacetylase 3 corepressor complexes with consequent increases in RARB in the nucleus and derepression of its target gene expression
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gene AKR1B1, recombinant expression of His6-tagged enzyme in Escherichia coli strain BL21 gold (DE3)
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gene AKR1B10, recombinant expression of His-tagged wild-type and mutant enzymes in Escherichia coli strain BL21(DE3); gene AKR1B1, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)
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gene ALDRXV4, cDNA expression of His-tagged enzyme in Escherichia coli strain BL21(DE3) using pET28a expression vector. Overexpression of enzyme ALDRXV4 improves growth and tolerance against diverse abiotic stresses induced by high salt (500 mM NaCl), osmoticum (10% PEG 6000), heavy metal (20 mM CdCl2), and methylglyoxal (5 mM) in Escherichia coli cells. Recombinant expression of ALDRXV4-GFP fusion enzyme in onion epidermal peel via Agrobacterium tumefaciens transfection method
overexpression
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overexpression in Escherichia coli
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overexpression of His-tagged enzyme in Escherichia coli strain BL21
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overexpression of the enzyme in lens epithelial cells
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overexpression of the enzyme in mice
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recombinant expression of GFP-tagged enzyme in retina
transgenic C57BL6 background mice overexpressing human aldose reductase exhibit increased JAK2 and STAT5 activation
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