1.1.1.21: aldehyde reductase

This is an abbreviated version, for detailed information about aldehyde reductase, go to the full flat file.

Reaction

alditol
+
NAD(P)+
=
aldose
+
NAD(P)H
+
H+

Synonyms

17betaHSD5, 20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, AdhA, AKR1B, AKR1B1, AKR1B10, AKR1B13, AKR1B14, AKR1B3, AKR1C3, AKR4C7, aldehyde reductase, alditol/NADP+ oxidoreductase, alditol: NADP+ 1-oxidoreductase, alditol:NAD(P)+1oxidoreductase, alditol:NADP 1-oxidoreductase, alditol:NADP oxidoreductase, aldo-keto reductase, aldo-keto reductase family 1 member B7, aldoketo reductase 1C3, aldose reductase, aldose reductase 2, aldose reductase-like, aldose reductase-like protein, aldose xylose reductase, ALDRXV4, ALR, ALR1, ALR2, AR, ARI, BAR, Fibroblast growth factor regulated protein, FR-1 protein, GRE3, HAR, HRAR, isobutyraldehyde reductase, More, MVDP, NADPH-aldopentose reductase, NADPH-aldose reductase, polyol dehydrogenase (NADP2), RLAR, small intestine reductase, TPN-polyol dehydrogenase, VAS deferens androgen-dependent protein, YqhD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.21 aldehyde reductase

KM Value

KM Value on EC 1.1.1.21 - aldehyde reductase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.2
(1S)-Camphorquinone
-
in 0.1 M potassium phosphate, pH 7.4
0.015 - 0.091
1-butanal
63
1-butanol
-
in 0.1 M potassium phosphate, pH 7.4
0.0055
1-decanal
-
in 0.1 M potassium phosphate, pH 7.4
0.0044 - 0.082
1-Decanol
0.0026
1-Dodecanal
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.0027
1-heptanal
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.023 - 0.112
1-hexanal
0.18 - 0.97
1-Hexanol
0.0007 - 0.005
1-nonanal
0.011 - 0.74
1-nonanol
0.0017 - 0.014
1-octanal
0.0096
1-palmitoyl-2-(5-oxovaleryl)sn-glycero-3-phosphocholine
-
pH 6.0, 30°C
0.3
1-propanal
-
in 0.1 M potassium phosphate, pH 7.4
0.0006
1-Tetradecanol
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.0057
16-ketoestrone
-
in 0.1 M potassium phosphate, pH 7.4
0.68
2,3-Butanedione
-
in 0.1 M potassium phosphate, pH 7.4
0.0065
2,3-heptanedione
-
in 0.1 M potassium phosphate, pH 7.4
0.014 - 0.051
2,3-Hexanedione
0.2
2,3-Pentanedione
-
in 0.1 M potassium phosphate, pH 7.4
0.048
2,4-decadienal
-
in 0.1 M potassium phosphate, pH 7.4
0.064
2,4-nonadienal
-
in 0.1 M potassium phosphate, pH 7.4
0.01
2-decenal
-
in 0.1 M potassium phosphate, pH 7.4
10.6
2-deoxygalactose
-
-
17.5
2-Deoxyribose
-
-
0.075
2-hexenal
-
in 0.1 M potassium phosphate, pH 7.4
0.017
2-nonenal
-
in 0.1 M potassium phosphate, pH 7.4
0.78
2-phenyl-1-propanol
-
in 0.1 M potassium phosphate, pH 7.4
0.052
2-phenyl-2-propenal
-
in 0.1 M potassium phosphate, pH 7.4
0.099
2-pyridinecarboxaldehyde
-
-
0.0009
20alpha-hydroxyprogesterone
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.001
20alpha-Isocorticosterone
-
and 20alpha-isocortisol, values below
0.0032 - 0.0095
21-Dehydrocortisol
0.31
3,4-hexanedione
-
in 0.1 M potassium phosphate, pH 7.4
0.07 - 0.129
3-deoxyglucosone
0.046
3-Pyridinecarboxaldehyde
-
-
0.03
4-hydroxynonenal
-
in 0.1 M potassium phosphate, pH 7.4
0.01
4-hydroxyphenylacetaldehyde
-
-
0.002 - 0.0035
4-Nitrobenzaldehyde
0.004
4-Pyridinecarboxaldehyde
-
-
0.0002
5-Pregnene-3beta,20alpha-diol
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.0004
5alpha-pregnan-20alpha-ol-3-one
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.0008
5alpha-pregnane-3beta,20alpha-diol
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C
1.1
acetaldehyde
-
in 50 mM MOPS buffer, pH 7.0, at 37°C
0.12 - 13
acrolein
0.0097 - 0.295
benzaldehyde
0.3 - 2.1
benzyl alcohol
0.444
Butyraldehyde
-
-
446.7 - 448.4
D-arabinose
0.4 - 28.1
D-erythrose
9.6
D-fructose
-
-
59.3
D-fucose
-
-
40 - 228
D-galactose
47.3 - 281
D-glucose
0.152 - 19.2
D-glucuronate
0.7
D-glucuronolactone
-
-
0.035
D-glyceraldehyde
-
-
0.073 - 0.74
D-lactoaldehyde
479.2 - 2740
D-Lyxose
53.4
D-mannose
-
-
7 - 370.9
D-ribose
29.1
D-ribose-5-phosphate
-
-
399.5
D-sorbitol
-
in 50 mM sodium phosphate at pH 7.0 and 30°C
24.8
D-tagatose
-
-
179.5
D-xylitol
-
in 50 mM sodium phosphate at pH 7.0 and 30°C
2 - 1340
D-xylose
24.9
D-xylose-5-phosphate
-
-
0.02 - 730.2
DL-glyceraldehyde
130.2 - 142
galactose
0.025
geraniol
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.0004 - 0.0009
geranylgeraniol
21.8 - 155
glucose
113
glucose-6-phosphate
-
-
0.51
glyceraldehyde
-
-
1.5 - 1.8
glycoaldehyde
21
glycolaldehyde
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C
1.28 - 18.9
Glyoxal
0.034 - 120.5
Hexanal
0.016
Indole-3-acetaldehyde
-
-
0.0022 - 0.069
isatin
0.02 - 1
Isobutyraldehyde
0.056
isocaproaldehyde
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C
287.2 - 416.8
L-arabinose
80.7
L-fucose
-
-
0.018
L-Glyceraldehyde
0.8 - 4
L-idose
312.3
L-Lyxose
-
-
52.3
L-rhamnose
-
-
245
L-ribose
-
-
22
L-sorbose
-
-
100 - 1190
L-Xylose
0.112 - 6.3
methylglyoxal
0.087
n-Pentanal
-
-
0.14
NAD(P)+
-
-
0.016
NAD(P)H
-
-
0.22 - 0.62
NADH
0.0032 - 85
NADPH
0.02
nerol
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.02
p-bromobenzaldehyde
-
-
0.005
p-Carboxybenzaldehyde
-
-
0.007
p-nitrobenzaldehyde
-
-
0.056
phenyl-1,2-propanedione
-
in 0.1 M potassium phosphate, pH 7.4
0.016 - 0.68
Phenylglyoxal
365
propanal
-
-
0.011
propionaldehyde
-
-
0.012 - 0.13
Pyridine-3-aldehyde
0.49
Pyridine-3-methanol
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.02
Pyridine-4-aldehyde
-
in 0.1 M potassium phosphate, pH 7.4
102
ribose
-
-
0.285
Succinic semialdehyde
-
-
0.0023 - 0.0033
trans,trans-farnesol
0.25
trans-2-buten-1-al
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.004
trans-2-decen-1-al
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.028
trans-2-hexen-1-al
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.0034
trans-2-nonen-1-al
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C
530
xylitol
-
-
1.67 - 29.77
xylose
additional information
additional information
-