Reference on EC 1.1.1.21 - aldose reductase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Das, B.; Srivastava, S.K.
Purification and properties of aldose reductase and aldehyde reductase II from human erythrocyte
Arch. Biochem. Biophys.
238
670-679
1985
Homo sapiens
Tanimoto, T.; Ohta, M.; Tanaka, A.; Ikemoto, I.; Machida, T.
Purification and characterization of human testis aldose and aldehyde reductase
Int. J. Biochem.
23
421-428
1991
Homo sapiens
Negm, F.B.
Purification and properties of an NADPH-aldose reductase (aldehyde reductase) from Euonymus japonica leaves
Plant Physiol.
80
972-977
1986
Celastrus orbiculatus, Euonymus japonicus, Euonymus sp.
Srivastava, S.K.; Ansari, N.H.; Hair, G.A.; Das, B.
Aldose and aldehyde reductases in human tissues
Biochim. Biophys. Acta
800
220-227
1984
Homo sapiens
Wermuth, B.; von Wartburg, J.P.
Aldose reductase from human tissues
Methods Enzymol.
89
181-186
1982
Homo sapiens
Wermuth, B.; Burgisser, H.; Bohren, K.; von Wartburg, J.P.
Purification and characterization of human-brain aldose reductase
Eur. J. Biochem.
127
279-284
1982
Homo sapiens
O'Brien, M.M.; Schofield, P.J.
Polyol-pathway enzymes of human brain. Partial purification and properties of aldose reductase and hexonate dehydrogenase
Biochem. J.
187
21-30
1980
Homo sapiens
Sheaff, C.M.; Doughty, C.C.
Physical and kinetic properties of homogenous bovine lens aldose reductase
J. Biol. Chem.
251
2696-2702
1976
Bos taurus
Clements, R.S.; Winegrad, A.I.
Purification of alditol: NADP oxidoreductase from human placenta
Biochem. Biophys. Res. Commun.
47
1473-1479
1972
Homo sapiens
Cromlish, J.A.; Flynn, T.G.
Purification and characterization of two aldose reductase isoenzymes from rabbit muscle
J. Biol. Chem.
258
3416-3424
1983
Bos taurus, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
Dons, R.F.; Doughty, C.C.
Isolation and characterization of aldose reductase from calf brain
Biochim. Biophys. Acta
452
1-12
1976
Bos taurus
Hayman, S.; Kinoshita, J.H.
Isolation and properties of lens aldose reductase
J. Biol. Chem.
240
877-882
1965
Bos taurus
Attwood, M.A.; Doughty, C.C.
Purification and properties of calf liver aldose reductase
Biochim. Biophys. Acta
370
358-368
1974
Bos taurus
Scher, B.M.; Horecker, B.I.
Pentose metabolism in Candida utilis
Arch. Biochem. Biophys.
116
117-128
1966
Cyberlindnera jadinii
Halder, A.B.; Crabbe, M.J.C.
Bovine lens aldehyde reductase (aldose reductase)
Biochem. J.
219
33-39
1984
Bos taurus
Ryle, C.M.; Dowling, T.G.; Tipton, K.F.
Purification and properties of low-KM aldehyde reductase from ox brain
Biochim. Biophys. Acta
791
155-163
1984
Bos taurus
Ryle, C.M.; Tipton, K.F.
Kinetic studies with low-KM aldehyde reductase from ox brain
Biochem. J.
227
621-627
1985
Bos taurus
Ansari, N.H.; Bhatnagar, A.; Liu, S.; Srivastava, S.K.
Purification and characterization of aldose reductase and aldehyde reductase from human kidney
Biochem. Int.
25
755-765
1991
Homo sapiens
Bohren, K.M.; Grimshaw, C.E.; Lai, C.J.; Harrison, D.H.; Ringe, D.; Petsko, G.A.; Gabbay, K.H.
Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme
Biochemistry
33
2021-2032
1994
Homo sapiens
Gross, W.; Seipold, P.; Schnarrenberger, C.
Characterization and purification of an aldose from the acidophilic and thermophilic red algae Galdiera sulphuraria
Plant Physiol.
114
231-236
1997
Galdieria sulphuraria
Marini, I.; Bucchioni, L.; Voltarelli, M.; Del Corso, A.; Mura, U.
Alpha-crystallin-like molecular chaperone against the thermal denaturation of lens aldose reductase: the effect of divalent metal ions
Biochem. Biophys. Res. Commun.
212
413-420
1995
Bos taurus
Nidetzky, B.; Mayr, P.; Neuhauser, W.; Puchberger, M.
Structural and functional properties of alsode xylose reductase from the D-xylose-metabolizing Candida tenuis
Chem. Biol. Interact.
130-132
583-595
2001
Yamadazyma tenuis
Mayr, P.; Bruggler, K.; Kulbe, K.D.; Nidetzky, B.
D-Xylose metabolism by Candida intermedia: isolation and characterization of two forms of aldose reductase with different coenzyme specificities
J. Chromatogr.
737
195-202
2000
[Candida] intermedia
Neuhauser, W.; Haltrich, D.; Kulbe, K.D.; Nidetzky, B.
NAD(P)H-dependent aldose reductase from the xylose-assimilating yeast Candida tenuis
Biochem. J.
326
683-692
1997
Yamadazyma tenuis
Sato, S.; Old, S.; Carper, D.; Kador, P.F.
Purification and characterization of recombinant human placental and rat lens aldose reductases expressed in Escherichia coli
Adv. Exp. Med. Biol.
5
259-268
1995
Homo sapiens, Rattus norvegicus
Nishimura, C.; Yamaoka, T.; Mizutani, M.; Yamashita, K.; Akera, T.; Tanimoto, T.
Purification and characterization of the recombinant human aldose reductase expressed in baculovirus system
Biochim. Biophys. Acta
1078
171-178
1991
Homo sapiens
Inazu, N.; Nagashima, Y.; Satoh, T.; Fujii, T.
Purification and properties of six aldo-keto reductases from rat adrenal gland
J. Biochem.
115
991-999
1994
Rattus norvegicus
Petrash, J.M.; Tarle, I.; Wilson, D.K.; Quiocho, F.A.
Aldose reductase catalysis and crystallography
Diabetes
43
955-959
1994
Homo sapiens
Kinoshita, T.; Miyake, H.; Fujii, T.; Takakura, S.; Goto, T.
The structure of human recombinant aldose reductase complexed with the potent inhibitor zenarestat
Acta Crystallogr. Sect. D
58
622-626
2002
Homo sapiens (P15121), Homo sapiens
Ruiz, F.; Hazemann, I.; Mitschler, A.; Joachimiak, A.; Schneider, T.; Karplus, M.; Podjarny, A.
The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48
Acta Crystallogr. Sect. D
60
1347-1354
2004
Homo sapiens (P15121), Homo sapiens
Srivastava, S.; Chandrasekar, B.; Bhatnagar, A.; Prabhu, S.D.
Lipid peroxidation-derived aldehydes and oxidative stress in the failing heart: Role of aldose reductase
Am. J. Physiol.
283
H2612-H2619
2002
Canis lupus familiaris
Alves, L.A.; Vitolo, M.; Felipe, M.G.; de Almeida e Silva, J.B.
Xylose reductase and xylitol dehydrogenase activities of Candida guilliermondii as a function of different treatments of sugarcane bagasse hemicellulosic hydrolysate employing experimental design
Appl. Biochem. Biotechnol.
98-100
403-413
2002
Meyerozyma guilliermondii
Lima, L.H.; das Gracas de Almeida Felipe, M.; Vitolo, M.; Torres, F.A.
Effect of acetic acid present in bagasse hydrolysate on the activities of xylose reductase and xylitol dehydrogenase in Candida guilliermondii
Appl. Microbiol. Biotechnol.
65
734-738
2004
Meyerozyma guilliermondii
Da Settimo, F.; Primofiore, G.; La Motta, C.; Salerno, S.; Novellino, E.; Greco, G.; Lavecchia, A.; Laneri, S.; Boldrini, E.
Spirohydantoin derivatives of thiopyrano[2,3-b]pyridin-4(4H)-one as potent in vitro and in vivo aldose reductase inhibitors
Bioorg. Med. Chem.
13
491-499
2005
Rattus norvegicus
Yabe-Nishimura, C.; Nishinaka, T.; Iwata, K.; Seo, H.G.
Up-regulation of aldose reductase by the substrate, methylglyoxal
Chem. Biol. Interact.
143-144
317-323
2003
Rattus norvegicus
Srivastava, S.K.; Ramana, K.V.; Chandra, D.; Srivastava, S.; Bhatnagar, A.
Regulation of aldose reductase and the polyol pathway activity by nitric oxide
Chem. Biol. Interact.
143-144
333-340
2003
Homo sapiens, Rattus norvegicus
Doorn, J.A.; Srivastava, S.K.; Petersen, D.R.
Aldose reductase catalyzes reduction of the lipid peroxidation product 4-oxonon-2-enal
Chem. Res. Toxicol.
16
1418-1423
2003
Homo sapiens (P15121)
Hwang, Y.C.; Sato, S.; Tsai, J.Y.; Yan, S.; Bakr, S.; Zhang, H.; Oates, P.J.; Ramasamy, R.
Aldose reductase activation is a key component of myocardial response to ischemia
FASEB J.
16
243-245
2002
Rattus norvegicus
Ramana, K.V.; Friedrich, B.; Bhatnagar, A.; Srivastava, S.K.
Aldose reductase mediates cytotoxic signals of hyperglycemia and TNF-alpha in human lens epithelial cells
FASEB J.
17
315-317
2003
Homo sapiens
Hwang, Y.C.; Kaneko, M.; Bakr, S.; Liao, H.; Lu, Y.; Lewis, E.R.; Yan, S.; Ii, S.; Itakura, M.; Rui, L.; Skopicki, H.; Homma, S.; Schmidt, A.M.; Oates, P.J.; Szabolcs, M.; Ramasamy, R.
Central role for aldose reductase pathway in myocardial ischemic injury
FASEB J.
18
1192-1199
2004
Homo sapiens
Ramana, K.V.; Bhatnagar, A.; Srivastava, S.K.
Aldose reductase regulates TNF-alpha-induced cell signaling and apoptosis in vascular endothelial cells
FEBS Lett.
570
189-194
2004
Homo sapiens
Lee, H.S.
Rat lens aldose reductase inhibitory activities of Coptis japonica root-derived isoquinoline alkaloids
J. Agric. Food Chem.
50
7013-7016
2002
Rattus norvegicus
Ramana, K.V.; Chandra, D.; Srivastava, S.; Bhatnagar, A.; Aggarwal, B.B.; Srivastava, S.K.
Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells
J. Biol. Chem.
277
32063-32070
2002
Rattus norvegicus
Cecconi, I.; Scaloni, A.; Rastelli, G.; Moroni, M.; Vilardo, P.G.; Costantino, L.; Cappiello, M.; Garland, D.; Carper, D.; Petrash, J.M.; Del Corso, A.; Mura, U.
Oxidative modification of aldose reductase induced by copper ion. Definition of the metal-protein interaction mechanism
J. Biol. Chem.
277
42017-42027
2002
Bos taurus, Homo sapiens, Rattus norvegicus
Galvez, A.S.; Ulloa, J.A.; Chiong, M.; Criollo, A.; Eisner, V.; Barros, L.F.; Lavandero, S.
Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis: differential effects of sorbitol and mannitol
J. Biol. Chem.
278
38484-38494
2003
Rattus norvegicus
Srivastava, S.; Spite, M.; Trent, J.O.; West, M.B.; Ahmed, Y.; Bhatnagar, A.
Aldose reductase-catalyzed reduction of aldehyde phospholipids
J. Biol. Chem.
279
53395-53406
2004
Homo sapiens
Cortez, E.V.; Pessoa, A.Jr.; das Gracas de Almeida Felipe, M.; Roberto, I.C.; Vitolo, M.
Optimized extraction by cetyl trimethyl ammonium bromide reversed micelles of xylose reductase and xylitol dehydrogenase from Candida guilliermondii homogenate
J. Chromatogr. B
807
47-54
2004
Meyerozyma guilliermondii
Zaher, N.; Nicolaou, I.; Demopoulos, V.J.
Pyrrolylbenzothiazole derivatives as aldose reductase inhibitors
J. Enzyme Inhib.
17
131-135
2002
Homo sapiens
Yablochkova, E.N.; Bolotnikova, O.I.; Mikhailova, N.P.; Nemova, N.N.; Ginak, A.I.
The activity of xylose reductase and xylitol dehydrogenase in yeasts
Microbiology
72
414-417
2003
Candida parapsilosis, Candida tropicalis, Candida tropicalis Y-456, Kluyveromyces marxianus, Kluyveromyces marxianus Y-488, Meyerozyma guilliermondii, Meyerozyma guilliermondii Y-1017, Pachysolen tannophilus, Scheffersomyces shehatae, Scheffersomyces shehatae Y-1632, Scheffersomyces stipitis, Torulopsis molishiama, [Candida] diddensiae, [Candida] intermedia, [Candida] silvanorum, [Candida] silvanorum VGI-II
Chang, K.C.; Paek, K.S.; Kim, H.J.; Lee, Y.S.; Yabe-Nishimura, C.; Seo, H.G.
Substrate-induced up-regulation of aldose reductase by methylglyoxal, a reactive oxoaldehyde elevated in diabetes
Mol. Pharmacol.
61
1184-1191
2002
Rattus norvegicus
El-Kabbani, O.; Ramsland, P.; Darmanin, C.; Chung, R.P.; Podjarny, A.
Structure of human aldose reductase holoenzyme in complex with statil: an approach to structure-based inhibitor design of the enzyme
Proteins
50
230-238
2003
Homo sapiens (P15121), Homo sapiens
Sotriffer, C.A.; Kramer, O.; Klebe, G.
Probing flexibility and "induced-fit" phenomena in aldose reductase by comparative crystal structure analysis and molecular dynamics simulations
Proteins
56
52-66
2004
Homo sapiens, Sus scrofa
Kaneko, M.; Bucciarelli, L.; Hwang, Y.C.; Lee, L.; Yan, S.F.; Schmidt, A.M.; Ramasamy, R.
Aldose reductase and AGE-RAGE pathways: key players in myocardial ischemic injury
Ann. N. Y. Acad. Sci.
1043
702-709
2005
Homo sapiens, Mus musculus
Dal Monte, M.; Del Corso, A.; Moschini, R.; Cappiello, M.; Amodeo, P.; Mura, U.
Zofenoprilat-glutathione mixed disulfide as a specific S-thiolating agent of bovine lens aldose reductase
Antioxid. Redox Signal.
7
841-848
2005
Bos taurus
Moschini, R.; Marini, I.; Malerba, M.; Cappiello, M.; Del Corso, A.; Mura, U.
Chaperone-like activity of alpha-crystallin toward aldose reductase oxidatively stressed by copper ion
Arch. Biochem. Biophys.
453
13-17
2006
Bos taurus
Du, Z.Y.; Bao, Y.D.; Liu, Z.; Qiao, W.; Ma, L.; Huang, Z.S.; Gu, L.Q.; Chan, A.S.
Curcumin analogs as potent aldose reductase inhibitors
Arch. Pharm.
339
123-128
2006
Bos taurus
Jiang, H.; Wang, X.F.; Fang, L.; Tang, C.; Zhu, Y.; Wang, X.
Upregulation of aldose reductase by homocysteine in type II alveolar epithelial cells
Biochem. Biophys. Res. Commun.
337
1084-1091
2005
Homo sapiens (P15121), Homo sapiens
Balendiran, G.K.; Rajkumar, B.
Fibrates inhibit aldose reductase activity in the forward and reverse reactions
Biochem. Pharmacol.
70
1653-1663
2005
Homo sapiens
Bohren, K.M.; Brownlee, J.M.; Milne, A.C.; Gabbay, K.H.; Harrison, D.H.
The structure of Apo R268A human aldose reductase: Hinges and latches that control the kinetic mechanism
Biochim. Biophys. Acta
1748
201-212
2005
Homo sapiens
Brownlee, J.M.; Carlson, E.; Milne, A.C.; Pape, E.; Harrison, D.H.
Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes
Bioorg. Chem.
34
424-444
2006
Homo sapiens
Maccari, R.; Ottana, R.; Curinga, C.; Vigorita, M.G.; Rakowitz, D.; Steindl, T.; Langer, T.
Structure-activity relationships and molecular modelling of 5-arylidene-2,4-thiazolidinediones active as aldose reductase inhibitors
Bioorg. Med. Chem.
13
2809-2823
2005
Bos taurus
Rakowitz, D.; Maccari, R.; Ottana, R.; Vigorita, M.G.
In vitro aldose reductase inhibitory activity of 5-benzyl-2,4-thiazolidinediones
Bioorg. Med. Chem.
14
567-574
2006
Bos taurus
Tammali, R.; Ramana, K.V.; Singhal, S.S.; Awasthi, S.; Srivastava, S.K.
Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin e2 production in human colon cancer cells
Cancer Res.
66
9705-9713
2006
Homo sapiens
Kang, E.S.; Kim, H.J.; Paek, K.S.; Jang, H.S.; Chang, K.C.; Lee, J.H.; Nishinaka, T.; Yabe-Nishimura, C.; Seo, H.G.
Phorbol ester up-regulates aldose reductase expression in A549 cells: a potential role for aldose reductase in cell cycle modulation
Cell. Mol. Life Sci.
62
1146-1155
2005
Homo sapiens
Srivastava, S.; Ramana, K.V.; Tammali, R.; Srivastava, S.K.; Bhatnagar, A.
Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells
Diabetes
55
901-910
2006
Rattus norvegicus
Srivastava, S.; Tammali, R.; Chandra, D.; Greer, D.A.; Ramana, K.V.; Bhatnagar, A.; Srivastava, S.K.
Regulation of lens aldose reductase activity by nitric oxide
Exp. Eye Res.
81
664-672
2005
Homo sapiens, Rattus norvegicus
Pladzyk, A.; Ramana, K.V.; Ansari, N.H.; Srivastava, S.K.
Aldose reductase prevents aldehyde toxicity in cultured human lens epithelial cells
Exp. Eye Res.
83
408-416
2006
Homo sapiens
Hwang, Y.C.; Shaw, S.; Kaneko, M.; Redd, H.; Marrero, M.B.; Ramasamy, R.
Aldose reductase pathway mediates JAK-STAT signaling: a novel axis in myocardial ischemic injury
FASEB J.
19
795-797
2005
Homo sapiens, Rattus norvegicus
Drel, V.R.; Pacher, P.; Stevens, M.J.; Obrosova, I.G.
Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells
Free Radic. Biol. Med.
40
1454-1465
2006
Homo sapiens, Rattus norvegicus
Brown, K.E.; Broadhurst, K.A.; Mathahs, M.M.; Kladney, R.D.; Fimmel, C.J.; Srivastava, S.K.; Brunt, E.M.
Immunodetection of aldose reductase in normal and diseased human liver
Histol. Histopathol.
20
429-436
2005
Homo sapiens
Kato, A.; Higuchi, Y.; Goto, H.; Kizu, H.; Okamoto, T.; Asano, N.; Hollinshead, J.; Nash, R.J.; Adachi, I.
Inhibitory effects of Zingiber officinale Roscoe derived components on aldose reductase activity in vitro and in vivo
J. Agric. Food Chem.
54
6640-6644
2006
Homo sapiens
Kaiserova, K.; Srivastava, S.; Hoetker, J.D.; Awe, S.O.; Tang, X.L.; Cai, J.; Bhatnagar, A.
Redox activation of aldose reductase in the ischemic heart
J. Biol. Chem.
281
15110-15120
2006
Homo sapiens, Rattus norvegicus
Ramana, K.V.; Bhatnagar, A.; Srivastava, S.; Yadav, U.C.; Awasthi, S.; Awasthi, Y.C.; Srivastava, S.K.
Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth
J. Biol. Chem.
281
17652-17660
2006
Rattus norvegicus
Ramana, K.V.; Fadl, A.A.; Tammali, R.; Reddy, A.B.; Chopra, A.K.; Srivastava, S.K.
Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages
J. Biol. Chem.
281
33019-33029
2006
Mus musculus
El-Kabbani, O.; Carbone, V.; Darmanin, C.; Oka, M.; Mitschler, A.; Podjarny, A.; Schulze-Briese, C.; Chung, R.P.
Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity
J. Med. Chem.
48
5536-5542
2005
Sus scrofa
Mylari, B.L.; Armento, S.J.; Beebe, D.A.; Conn, E.L.; Coutcher, J.B.; Dina, M.S.; OGorman, M.T.; Linhares, M.C.; Martin, W.H.; Oates, P.J.; Tess, D.A.; Withbroe, G.J.; Zembrowski, W.J.
A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners
J. Med. Chem.
48
6326-6339
2005
Rattus norvegicus
Da Settimo, F.; Primofiore, G.; La Motta, C.; Sartini, S.; Taliani, S.; Simorini, F.; Marini, A.M.; Lavecchia, A.; Novellino, E.; Boldrini, E.
Naphtho[1,2-d]isothiazole acetic acid derivatives as a novel class of selective aldose reductase inhibitors
J. Med. Chem.
48
6897-6907
2005
Rattus norvegicus (P07943)
Steuber, H.; Zentgraf, M.; Podjarny, A.; Heine, A.; Klebe, G.
High-resolution crystal structure of aldose reductase complexed with the novel sulfonyl-pyridazinone inhibitor exhibiting an alternative active site anchoring group
J. Mol. Biol.
356
45-56
2006
Homo sapiens (P15121)
Manzanaro, S.; Salva, J.; de la Fuente, J.A.
Phenolic marine natural products as aldose reductase inhibitors
J. Nat. Prod.
69
1485-1487
2006
Homo sapiens
Pau, A.; Asproni, B.; Murineddu, G.; Boatto, G.; Grella, G.E.; Rakowitz, D.; Costantino, L.; Pinna, G.A.
Thienocinnolinone alkanoic acid derivatives as aldose reductase inhibitors
Med. Chem.
2
39-45
2006
Bos taurus
Jiang, T.; Che, Q.; Lin, Y.; Li, H.; Zhang, N.
Aldose reductase regulates TGF-beta1-induced production of fibronectin and type IV collagen in cultured rat mesangial cells
Nephrology
11
105-112
2006
Homo sapiens
Kayser, M.M.; Drolet, M.; Stewart, J.D.
Application of newly available bio-reducing agents to the synthesis of chiral hydroxy-beta-lactams: model for aldose reductase selectivity
Tetrahedron Asymmetry
16
4004-4009
2005
Saccharomyces cerevisiae
-
Biadene, M.; Hazemann, I.; Cousido, A.; Ginell, S.; Joachimiak, A.; Sheldrick, G.M.; Podjarny, A.; Schneider, T.R.
The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop
Acta Crystallogr. Sect. D
63
665-672
2007
Homo sapiens (P15121), Homo sapiens
Kiyota, E.; Morais de Sousa, S.; dos Santos, M.L.; Lima, A.d.; Menossi, M.; Yunes, J.A.; Aparicio, R.
Crystallization and preliminary x-ray diffraction analysis of maize aldose reductase
Acta Crystallogr. Sect. F
F63
990-992
2007
Zea mays (A2T1W7), Zea mays
Rakowitz, D.; Piccolruaz, G.; Pirker, C.; Matuszczak, B.
Novel aldose reductase inhibitors derived from 6-[[(diphenylmethylene)amino]oxy]hexanoic acid
Arch. Pharm.
340
202-208
2007
Homo sapiens
Webb, L.J.; Boxer, S.G.
Electrostatic fields near the active site of human aldose reductase: 1. New inhibitors and vibrational stark effect measurements
Biochemistry
47
1588-1598
2008
Homo sapiens
Jang, D.S.; Lee, G.Y.; Kim, Y.S.; Lee, Y.M.; Kim, C.S.; Yoo, J.L.; Kim, J.S.
Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase
Biol. Pharm. Bull.
30
2207-2210
2007
Rattus norvegicus
Lee, Y.S.; Kang, Y.H.; Jung, J.Y.; Kang, I.J.; Han, S.N.; Chung, J.S.; Shin, H.K.; Lim, S.S.
Inhibitory constituents of aldose reductase in the fruiting body of Phellinus linteus
Biol. Pharm. Bull.
31
765-768
2008
Homo sapiens, Rattus norvegicus
Alexiou, P.; Nicolaou, I.; Stefek, M.; Kristl, A.; Demopoulos, V.J.
Design and synthesis of N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides as aldose reductase inhibitors
Bioorg. Med. Chem.
16
3926-3932
2008
Rattus norvegicus
Stefek, M.; Snirc, V.; Djoubissie, P.O.; Majekova, M.; Demopoulos, V.; Rackova, L.; Bezakova, Z.; Karasu, C.; Carbone, V.; El-Kabbani, O.
Carboxymethylated pyridoindole antioxidants as aldose reductase inhibitors: Synthesis, activity, partitioning, and molecular modeling
Bioorg. Med. Chem.
16
4908-4920
2008
Rattus norvegicus
Tammali, R.; Ramana, K.V.; Srivastava, S.K.
Aldose reductase regulates TNF-alpha -induced PGE2 production in human colon cancer cells
Cancer Lett.
252
299-306
2007
Homo sapiens
Bozdag-Duendar, O.; Evranos, B.; Das-Evcimen, N.; Sarikaya, M.; Ertan, R.
Synthesis and aldose reductase inhibitory activity of some new chromonyl-2,4-thiazolidinediones
Eur. J. Med. Chem.
43
2412-2417
2008
Rattus norvegicus
Ramana, K.V.; Reddy, A.B.; Tammali, R.; Srivastava, S.K.
Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophages
Free Radic. Biol. Med.
42
1290-1302
2007
Mus musculus
Qiu, L.; Wu, X.; Chau, J.F.; Szeto, I.Y.; Tam, W.Y.; Guo, Z.; Chung, S.K.; Oates, P.J.; Chung, S.S.; Yang, J.Y.
Aldose reductase regulates hepatic peroxisome proliferator-activated receptor alpha phosphorylation and activity to impact lipid homeostasis
J. Biol. Chem.
283
17175-17183
2008
Mus musculus
Das-Evcimen, N.; Bozdag-Dundar, O.; Sarikaya, M.; Ertan, R.
In vitro aldose reductase inhibitory activity of some flavonyl-2,4-thiazolidinediones
J. Enzyme Inhib. Med. Chem.
23
297-301
2008
Rattus norvegicus
Steuber, H.; Heine, A.; Klebe, G.
Structural and thermodynamic study on aldose reductase: nitro-substituted inhibitors with strong enthalpic binding contribution
J. Mol. Biol.
368
618-638
2007
Homo sapiens (P15121)
Steuber, H.; Zentgraf, M.; La Motta, C.; Sartini, S.; Heine, A.; Klebe, G.
Evidence for a novel binding site conformer of aldose reductase in ligand-bound state
J. Mol. Biol.
369
186-197
2007
Homo sapiens (P15121), Homo sapiens
Steuber, H.; Heine, A.; Podjarny, A.; Klebe, G.
Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features
J. Mol. Biol.
379
991-1016
2008
Homo sapiens (P15121), Homo sapiens
Fu, J.; Tay, S.S.; Ling, E.A.; Dheen, S.T.
Aldose reductase is implicated in high glucose-induced oxidative stress in mouse embryonic neural stem cells
J. Neurochem.
103
1654-1665
2007
Mus musculus
Wang, S.; Yan, J.; Hao, D.; Niu, X.; Cheng, M.
Synthesis and activity of a new series of (Z)-3-phenyl-2-benzoylpropenoic acid derivatives as aldose reductase inhibitors
Molecules
12
885-895
2007
Rattus norvegicus, Homo sapiens (P15121), Homo sapiens
Blakeley, M.P.; Ruiz, F.; Cachau, R.; Hazemann, I.; Meilleur, F.; Mitschler, A.; Ginell, S.; Afonine, P.; Ventura, O.N.; Cousido-Siah, A.; Haertlein, M.; Joachimiak, A.; Myles, D.; Podjarny, A.
Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase
Proc. Natl. Acad. Sci. USA
105
1844-1848
2008
Homo sapiens (P15121), Homo sapiens
Chung, R.; Endo, S.; Hara, A.; El-Kabbani, O.
Crystallization and preliminary X-ray analysis of a rat aldose reductase-like protein (AKR1B14)
Acta Crystallogr. Sect. F
65
395-397
2009
Rattus norvegicus
Atsumi, S.; Wu, T.Y.; Eckl, E.M.; Hawkins, S.D.; Buelter, T.; Liao, J.C.
Engineering the isobutanol biosynthetic pathway in Escherichia coli by comparison of three aldehyde reductase/alcohol dehydrogenase genes
Appl. Microbiol. Biotechnol.
85
651-657
2010
Escherichia coli
Endo, S.; Matsunaga, T.; Mamiya, H.; Ohta, C.; Soda, M.; Kitade, Y.; Tajima, K.; Zhao, H.T.; El-Kabbani, O.; Hara, A.
Kinetic studies of AKR1B10, human aldose reductase-like protein: endogenous substrates and inhibition by steroids
Arch. Biochem. Biophys.
487
1-9
2009
Homo sapiens (O60218), Homo sapiens
Jung, H.A.; Yoon, N.Y.; Bae, H.J.; Min, B.S.; Choi, J.S.
Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase
Arch. Pharm. Res.
31
1405-1412
2008
Homo sapiens, Rattus norvegicus
Lee, E.H.; Song, D.G.; Lee, J.Y.; Pan, C.H.; Um, B.H.; Jung, S.H.
Inhibitory effect of the compounds isolated from Rhus verniciflua on aldose reductase and advanced glycation endproducts
Biol. Pharm. Bull.
31
1626-1630
2008
Homo sapiens
Chethan, S.; Dharmesh, S.M.; Malleshi, N.G.
Inhibition of aldose reductase from cataracted eye lenses by finger millet (Eleusine coracana) polyphenols
Bioorg. Med. Chem.
16
10085-10090
2008
Homo sapiens
Maccari, R.; Ottana, R.; Ciurleo, R.; Rakowitz, D.; Matuszczak, B.; Laggner, C.; Langer, T.
Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives
Bioorg. Med. Chem.
16
5840-5852
2008
Homo sapiens (P15121)
Carbone, V.; Zhao, H.T.; Chung, R.; Endo, S.; Hara, A.; El-Kabbani, O.
Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase
Bioorg. Med. Chem.
17
1244-1250
2009
Homo sapiens (P15121)
Endo, S.; Matsunaga, T.; Mamiya, H.; Hara, A.; Kitade, Y.; Tajima, K.; El-Kabbani, O.
Characterization of a rat NADPH-dependent aldo-keto reductase (AKR1B13) induced by oxidative stress
Chem. Biol. Interact.
178
151-157
2009
Rattus norvegicus
Baba, S.P.; Wetzelberger, K.; Hoetker, J.D.; Bhatnagar, A.
Posttranslational glutathiolation of aldose reductase (AKR1B1): a possible mechanism of protein recovery from S-nitrosylation
Chem. Biol. Interact.
178
250-258
2009
Homo sapiens
Eisenmann, M.; Steuber, H.; Zentgraf, M.; Altenkaemper, M.; Ortmann, R.; Perruchon, J.; Klebe, G.; Schlitzer, M.
Structure-based optimization of aldose reductase inhibitors originating from virtual screening
ChemMedChem
4
809-819
2009
Homo sapiens (P15121), Homo sapiens
Del Corso, A.; Cappiello, M.; Mura, U.
From a dull enzyme to something else: facts and perspectives regarding aldose reductase
Curr. Med. Chem.
15
1452-1461
2008
Homo sapiens
Reddy, A.B.; Ramana, K.V.; Srivastava, S.; Bhatnagar, A.; Srivastava, S.K.
Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-alpha via protein kinase C-delta and TNF-alpha converting enzyme in vascular smooth muscle cells
Endocrinology
150
63-74
2009
Rattus norvegicus
Masuda, C.A.; Previato, J.O.; Miranda, M.N.; Assis, L.J.; Penha, L.L.; Mendonca-Previato, L.; Montero-Lomeli, M.
Overexpression of the aldose reductase GRE3 suppresses lithium-induced galactose toxicity in Saccharomyces cerevisiae
FEMS Yeast Res.
8
1245-1253
2008
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Rath, J.; Gowri, V.S.; Chauhan, S.C.; Padmanabhan, P.K.; Srinivasan, N.; Madhubala, R.
A glutathione-specific aldose reductase of Leishmania donovani and its potential implications for methylglyoxal detoxification pathway
Gene
429
1-9
2009
Leishmania donovani
Lee, S.J.; Park, W.H.; Park, S.D.; Moon, H.I.
Aldose reductase inhibitors from Litchi chinensis Sonn
J. Enzyme Inhib. Med. Chem.
24
957-959
2009
Rattus norvegicus
Cosconati, S.; Marinelli, L.; La Motta, C.; Sartini, S.; Da Settimo, F.; Olson, A.J.; Novellino, E.
Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening
J. Med. Chem.
52
5578-5581
2009
Homo sapiens (P15121)
Wang, Z.; Ling, B.; Zhang, R.; Suo, Y.; Liu, Y.; Yu, Z.; Liu, C.
Docking and molecular dynamics studies toward the binding of new natural phenolic marine inhibitors and aldose reductase
J. Mol. Graph. Model.
28
162-169
2009
Homo sapiens (P15121), Homo sapiens
Ha, D.T.; Ngoc, T.M.; Lee, I.; Lee, Y.M.; Kim, J.S.; Jung, H.; Lee, S.; Na, M.; Bae, K.
Inhibitors of aldose reductase and formation of advanced glycation end-products in moutan cortex (Paeonia suffruticosa)
J. Nat. Prod.
72
1465-1470
2009
Rattus norvegicus
Jung, H.A.; Yoon, N.Y.; Kang, S.S.; Kim, Y.S.; Choi, J.S.
Inhibitory activities of prenylated flavonoids from Sophora flavescens against aldose reductase and generation of advanced glycation endproducts
J. Pharm. Pharmacol.
60
1227-1236
2008
Homo sapiens, Rattus norvegicus
Zhang, Y.; Huang, P.; Jiang, T.; Zhao, J.; Zhang, N.
Role of aldose reductase in TGF-beta1-induced fibronectin synthesis in human mesangial cells
Mol. Biol. Rep.
37
2735-2742
2010
Homo sapiens
Reddy, G.B.; Satyanarayana, A.; Balakrishna, N.; Ayyagari, R.; Padma, M.; Viswanath, K.; Petrash, J.M.
Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy
Mol. Vis.
14
593-601
2008
Homo sapiens
de Sousa, S.M.; Rosselli, L.K.; Kiyota, E.; da Silva, J.C.; Souza, G.H.; Peroni, L.A.; Stach-Machado, D.R.; Eberlin, M.N.; Souza, A.P.; Koch, K.E.; Arruda, P.; Torriani, I.L.; Yunes, J.A.
Structural and kinetic characterization of a maize aldose reductase
Plant Physiol. Biochem.
47
98-104
2009
Zea mays (A2T1W7), Zea mays
Olsen, J.; Pedersen, L.; Christensen, C.; Olsen, O.; Henriksen, A.
Barley aldose reductase: Structure, cofactor binding, and substrate recognition in the aldo/keto reductase 4C family
Proteins Struct. Funct. Genet.
71
1572-1581
2008
Hordeum vulgare
Hallam, K.M.; Li, Q.; Ananthakrishnan, R.; Kalea, A.; Zou, Y.S.; Vedantham, S.; Schmidt, A.M.; Yan, S.F.; Ramasamy, R.
Aldose reductase and AGE-RAGE pathways: central roles in the pathogenesis of vascular dysfunction in aging rats
Aging Cell
9
776-784
2010
Rattus norvegicus
Kim, N.H.; Kim, Y.S.; Lee, Y.M.; Jang, D.S.; Kim, J.S.
Inhibition of aldose reductase and xylose-induced lens opacity by puerariafuran from the roots of Pueraria lobata
Biol. Pharm. Bull.
33
1605-1609
2010
Rattus norvegicus
Lee, Y.S.; Kim, S.H.; Jung, S.H.; Kim, J.K.; Pan, C.H.; Lim, S.S.
Aldose reductase inhibitory compounds from Glycyrrhiza uralensis
Biol. Pharm. Bull.
33
917-921
2010
Homo sapiens, Rattus norvegicus
Van Zandt, M.C.; Doan, B.; Sawicki, D.R.; Sredy, J.; Podjarny, A.D.
Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications
Bioorg. Med. Chem. Lett.
19
2006-2008
2009
Homo sapiens
Kato, A.; Kobayashi, K.; Narukawa, K.; Minoshima, Y.; Adachi, I.; Hirono, S.; Nash, R.J.
6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2
Bioorg. Med. Chem. Lett.
20
5630-5633
2010
Rattus norvegicus
Pegklidou, K.; Koukoulitsa, C.; Nicolaou, I.; Demopoulos, V.J.
Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case of bioisosterism between a carboxylic acid moiety and that of a tetrazole
Bioorg. Med. Chem.
18
2107-2114
2010
Rattus norvegicus
Maccari, R.; Ciurleo, R.; Giglio, M.; Cappiello, M.; Moschini, R.; Corso, A.D.; Mura, U.; Ottana, R.
Identification of new non-carboxylic acid containing inhibitors of aldose reductase
Bioorg. Med. Chem.
18
4049-4055
2010
Bos taurus
Srivastava, S.; Vladykovskaya, E.; Barski, O.A.; Spite, M.; Kaiserova, K.; Petrash, J.M.; Chung, S.S.; Hunt, G.; Dawn, B.; Bhatnagar, A.
Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice
Circ. Res.
105
793-802
2009
Mus musculus
Tammali, R.; Saxena, A.; Srivastava, S.K.; Ramana, K.V.
Aldose reductase regulates vascular smooth muscle cell proliferation by modulating G1/S phase transition of cell cycle
Endocrinology
151
2140-2150
2010
Rattus norvegicus
Carbone, V.; Giglio, M.; Chung, R.; Huyton, T.; Adams, J.; Maccari, R.; Ottana, R.; Hara, A.; El-Kabbani, O.
Structure of aldehyde reductase in ternary complex with a 5-arylidene-2,4-thiazolidinedione aldose reductase inhibitor
Eur. J. Med. Chem.
45
1140-1145
2010
Homo sapiens (P15121)
Koukoulitsa, C.; Bailly, F.; Pegklidou, K.; Demopoulos, V.J.; Cotelle, P.
Evaluation of aldose reductase inhibition and docking studies of 6-nitro and 6,6-dinitrorosmarinic acids
Eur. J. Med. Chem.
45
1663-1666
2010
Homo sapiens (P15121)
Muthenna, P.; Suryanarayana, P.; Gunda, S.K.; Petrash, J.M.; Reddy, G.B.
Inhibition of aldose reductase by dietary antioxidant curcumin: mechanism of inhibition, specificity and significance
FEBS Lett.
583
3637-3642
2009
Homo sapiens (P15121), Homo sapiens
Obrosova, I.G.; Maksimchyk, Y.; Pacher, P.; Agardh, E.; Smith, M.L.; El-Remessy, A.B.; Agardh, C.D.
Evaluation of the aldose reductase inhibitor fidarestat on ischemia-reperfusion injury in rat retina
Int. J. Mol. Med.
26
135-142
2010
Rattus norvegicus
D'Souza, D.R.; Salib, M.M.; Bennett, J.; Mochin-Peters, M.; Asrani, K.; Goldblum, S.E.; Renoud, K.J.; Shapiro, P.; Passaniti, A.
Hyperglycemia regulates RUNX2 activation and cellular wound healing through the aldose reductase polyol pathway
J. Biol. Chem.
284
17947-17955
2009
Homo sapiens
Liu, H.Y.; Liu, S.S.; Qin, L.T.; Mo, L.Y.
CoMFA and CoMSIA analysis of 2,4-thiazolidinediones derivatives as aldose reductase inhibitors
J. Mol. Model.
15
837-845
2009
Homo sapiens
Ramana, K.V.; Tammali, R.; Srivastava, S.K.
Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells
Mol. Cancer Ther.
9
813-824
2010
Homo sapiens
Kato, A.; Yasuko, H.; Goto, H.; Hollinshead, J.; Nash, R.; Adachi, I.
Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity
Phytomedicine
16
258-261
2009
Homo sapiens
Xu, Z.; Yang, H.; Zhou, M.; Feng, Y.; Jia, W.
Inhibitory effect of total lignan from fructus Arctii on aldose reductase
Phytother. Res.
24
472-473
2010
Rattus norvegicus
Tammali, R.; Reddy, A.B.; Srivastava, S.K.; Ramana, K.V.
Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo
Angiogenesis
14
209-221
2011
Homo sapiens
Stefek, M.; Tsantili-Kakoulidou, A.; Milackova, I.; Juskova, M.; Snirc, V.; Triantos, N.
(2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid: an aldose reductase inhibitor and antioxidant of zwitterionic nature
Bioorg. Med. Chem.
19
7181-7185
2011
Rattus norvegicus, Rattus norvegicus Wistar
Yang, Y.; Zhang, S.; Wu, B.; Ma, M.; Chen, X.; Qin, X.; He, M.; Hussain, S.; Jing, C.; Ma, B.; Zhu, C.
An efficient synthesis of quinoxalinone derivatives as potent inhibitors of aldose reductase
ChemMedChem
7
823-835
2012
Rattus norvegicus, Rattus norvegicus Wistar
Zheng, X.; Zhang, L.; Chen, W.; Chen, Y.; Xie, W.; Hu, X.
Partial inhibition of aldose reductase by nitazoxanide and its molecular basis
ChemMedChem
7
1921-1923
2012
Rattus norvegicus
Ramunno, A.; Cosconati, S.; Sartini, S.; Maglio, V.; Angiuoli, S.; La Pietra, V.; Di Maro, S.; Giustiniano, M.; La Motta, C.; Da Settimo, F.; Marinelli, L.; Novellino, E.
Progresses in the pursuit of aldose reductase inhibitors: the structure-based lead optimization step
Eur. J. Med. Chem.
51
216-226
2012
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Rao, V.R.; Muthenna, P.; Shankaraiah, G.; Akileshwari, C.; Babu, K.H.; Suresh, G.; Babu, K.S.; Chandra Kumar, R.S.; Prasad, K.R.; Yadav, P.A.; Petrash, J.M.; Reddy, G.B.; Rao, J.M.
Synthesis and biological evaluation of new piplartine analogues as potent aldose reductase inhibitors (ARIs)
Eur. J. Med. Chem.
57
344-361
2012
Homo sapiens
Zheng, X.; Zhang, L.; Zhai, J.; Chen, Y.; Luo, H.; Hu, X.
The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase
FEBS Lett.
586
55-59
2012
Homo sapiens (P15121), Homo sapiens
Tammali, R.; Saxena, A.; Srivastava, S.K.; Ramana, K.V.
Aldose reductase inhibition prevents hypoxia-induced increase in hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) by regulating 26 S proteasome-mediated protein degradation in human colon cancer cells
J. Biol. Chem.
286
24089-24100
2011
Homo sapiens
Nakamura, S.; Fujimoto, K.; Matsumoto, T.; Ohta, T.; Ogawa, K.; Tamura, H.; Matsuda, H.; Yoshikawa, M.
Structures of acylated sucroses and an acylated flavonol glycoside and inhibitory effects of constituents on aldose reductase from the flower buds of Prunus mume
J. Nat. Med.
67
799-806
2013
Rattus norvegicus
Liu, J.; Wang, J.; Wang, S.; Xu, B.; Liu, X.; Wang, X.; Hu, W.
Molecular cloning and characterization of Schistosoma japonicum aldose reductase
Parasitol. Res.
112
549-558
2013
Schistosoma japonicum (Q5DD64), Schistosoma japonicum
Takashima, Y.; Hatanaka, S.; Mizohata, E.; Nagata, N.; Fukunishi, Y.; Matsumura, H.; Urade, Y.; Inoue, T.
Crystallization and preliminary X-ray diffraction analysis of mouse prostaglandin F2alpha synthase, AKR1B3
Acta Crystallogr. Sect. F
67
1630-1632
2011
Mus musculus (P45376), Mus musculus
Schuster, D.; Kowalik, D.; Kirchmair, J.; Laggner, C.; Markt, P.; Aebischer-Gumy, C.; Stroehle, F.; Moeller, G.; Wolber, G.; Wilckens, T.; Langer, T.; Odermatt, A.; Adamski, J.
Identification of chemically diverse, novel inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 and 5 by pharmacophore-based virtual screening
J. Steroid Biochem. Mol. Biol.
125
148-161
2011
Homo sapiens (P42330)
Balestri, F.; Cappiello, M.; Moschini, R.; Rotondo, R.; Buggiani, I.; Pelosi, P.; Mura, U.; Del-Corso, A.
L-Idose: an attractive substrate alternative to D-glucose for measuring aldose reductase activity
Biochem. Biophys. Res. Commun.
456
891-895
2015
Homo sapiens (P15121), Homo sapiens, Bos taurus (P16116), Bos taurus
Chang, K.C.; Shieh, B.; Petrash, J.M.
Aldose reductase mediates retinal microglia activation
Biochem. Biophys. Res. Commun.
473
565-571
2016
Mus musculus (P45376), Mus musculus, Mus musculus C57BL/6 (P45376)
Balestri, F.; Cappiello, M.; Moschini, R.; Rotondo, R.; Abate, M.; Del-Corso, A.; Mura, U.
Modulation of aldose reductase activity by aldose hemiacetals
Biochim. Biophys. Acta
1850
2329-2339
2015
Homo sapiens (P15121), Homo sapiens, Bos taurus (P16116), Bos taurus
Saito, R.; Suzuki, S.; Sasaki, K.
Pterin-7-carboxamides as a new class of aldose reductase inhibitors
Bioorg. Med. Chem. Lett.
26
4870-4874
2016
Homo sapiens (P15121), Homo sapiens
Thiagarajan, D.; Ananthakrishnan, R.; Zhang, J.; OShea, K.M.; Quadri, N.; Li, Q.; Sas, K.; Jing, X.; Rosario, R.; Pennathur, S.; Schmidt, A.M.; Ramasamy, R.
Aldose reductase acts as a selective derepressor of PPARgamma and the retinoic acid receptor
Cell Rep.
15
181-196
2016
Homo sapiens (P15121)
Ruiz, F.X.; Cousido-Siah, A.; Mitschler, A.; Farres, J.; Pares, X.; Podjarny, A.
X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP+ and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity
Chem. Biol. Interact.
202
178-185
2013
Homo sapiens (O60218), Homo sapiens (P15121)
Gopinath, G.; Sankeshi, V.; Perugu, S.; Alaparthi, M.D.; Bandaru, S.; Pasala, V.K.; Chittineni, P.R.; Krupadanam, G.L.; Sagurthi, S.R.
Design and synthesis of chiral 2H-chromene-N-imidazolo-amino acid conjugates as aldose reductase inhibitors
Eur. J. Med. Chem.
124
750-762
2016
Homo sapiens (P15121)
Hussain, S.; Parveen, S.; Hao, X.; Zhang, S.; Wang, W.; Qin, X.; Yang, Y.; Chen, X.; Zhu, S.; Zhu, C.; Ma, B.
Structure-activity relationships studies of quinoxalinone derivatives as aldose reductase inhibitors
Eur. J. Med. Chem.
80
383-392
2014
Rattus norvegicus (P07943), Rattus norvegicus Wistar (P07943)
Iqbal, Z.; Hameed, S.; Ali, S.; Tehseen, Y.; Shahid, M.; Iqbal, J.
Synthesis, characterization, hypoglycemic and aldose reductase inhibition activity of arylsulfonylspiro[fluorene-9,5-imidazolidine]-2,4-diones
Eur. J. Med. Chem.
98
127-138
2015
Bos taurus (P16116)
Yadav, U.C.; Ramana, K.V.; Srivastava, S.K.
Aldose reductase regulates acrolein-induced cytotoxicity in human small airway epithelial cells
Free Radic. Biol. Med.
65
15-25
2013
Homo sapiens (P15121), Homo sapiens
Zheng, T.; Olson, D.G.; Murphy, S.J.; Shao, X.; Tian, L.; Lynd, L.R.
Both adhE and a separate NADPH-dependent alcohol dehydrogenase (adhA) are necessary for high ethanol production in Thermoanaerobacterium saccharolyticum
J. Bacteriol.
199
e00542-16
2017
Thermoanaerobacterium saccharolyticum, Thermoanaerobacterium saccharolyticum LL1049
Baba, S.P.; Hoetker, J.D.; Merchant, M.; Klein, J.B.; Cai, J.; Barski, O.A.; Conklin, D.J.; Bhatnagar, A.
Role of aldose reductase in the metabolism and detoxification of carnosine-acrolein conjugates
J. Biol. Chem.
288
28163-28179
2013
Homo sapiens (P15121), Homo sapiens, Mus musculus (P45376), Mus musculus
Li, L.; Chang, K.C.; Zhou, Y.; Shieh, B.; Ponder, J.; Abraham, A.D.; Ali, H.; Snow, A.; Petrash, J.M.; LaBarbera, D.V.
Design of an amide N-glycoside derivative of beta-glucogallin: a stable, potent, and specific inhibitor of aldose reductase
J. Med. Chem.
57
71-77
2014
Homo sapiens (P15121), Mus musculus (P45376)
Qin, X.; Hao, X.; Han, H.; Zhu, S.; Yang, Y.; Wu, B.; Hussain, S.; Parveen, S.; Jing, C.; Ma, B.; Zhu, C.
Design and synthesis of potent and multifunctional aldose reductase inhibitors based on quinoxalinones
J. Med. Chem.
58
1254-1267
2015
Rattus norvegicus (P07943), Rattus norvegicus Wistar (P07943)
Stefek, M.; Soltesova Prnova, M.; Majekova, M.; Rechlin, C.; Heine, A.; Klebe, G.
Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold
J. Med. Chem.
58
2649-2657
2015
Homo sapiens (P15121)
Singh, P.; Sarin, N.B.
Structural characterization and functional validation of aldose reductase from the resurrection plant Xerophyta viscosa
Mol. Biotechnol.
56
971-978
2014
Xerophyta viscosa (Q9XF81), Xerophyta viscosa
Zhang, Q.; Bian, G.; Chen, P.; Liu, L.; Yu, C.; Liu, F.; Xue, Q.; Chung, S.K.; Song, B.; Ju, G.; Wang, J.
Aldose reductase regulates microglia/macrophages polarization through the cAMP response element-binding protein after spinal cord injury in mice
Mol. Neurobiol.
53
662-676
2016
Mus musculus (P45376), Mus musculus C57BL/6 (P45376)
Lee, I.S.; Kim, Y.J.; Jung, S.H.; Kim, J.H.; Kim, J.S.
Flavonoids from Litsea japonica inhibit AGEs formation and rat lense aldose reductase in vitro and vessel dilation in zebrafish
Planta Med.
83
318-325
2016
Rattus norvegicus (P07943)
Qiu, L.; Lin, J.; Ying, M.; Chen, W.; Yang, J.; Deng, T.; Chen, J.; Shi, D.; Yang, J.Y.
Aldose reductase is involved in the development of murine diet-induced nonalcoholic steatohepatitis
PLoS ONE
8
e73591
2013
Mus musculus
Del-Corso, A.; Balestri, F.; Di Bugno, E.; Moschini, R.; Cappiello, M.; Sartini, S.; La-Motta, C.; Da-Settimo, F.; Mura, U.
A new approach to control the enigmatic activity of aldose reductase
PLoS ONE
8
e74076
2013
Bos taurus (P16116)
Rechlin, C.; Scheer, F.; Terwesten, F.; Wulsdorf, T.; Pol, E.; Fridh, V.; Toth, P.; Diederich, W.E.; Heine, A.; Klebe, G.
Price for opening the transient specificity pocket in human aldose reductase upon ligand binding structural, thermodynamic, kinetic, and computational analysis
ACS Chem. Biol.
12
1397-1415
2017
Homo sapiens (P15121), Homo sapiens
Rivelli, J.F.; Ochoa, A.L.; Santander, V.S.; Nigra, A.; Previtali, G.; Casale, C.H.
Regulation of aldose reductase activity by tubulin and phenolic acid derivates
Arch. Biochem. Biophys.
654
19-26
2018
Homo sapiens (P15121)
Salem, M.G.; Abdel Aziz, Y.M.; Elewa, M.; Elshihawy, H.A.; Said, M.M.
Molecular modelling and synthesis of spiroimidazolidine-2,4-diones with dual activities as hypoglycemic agents and selective inhibitors of aldose reductase
Bioorg. Chem.
79
131-144
2018
Homo sapiens (P15121)
Celestina, S.; Sundaram, K.; Ravi, S.
In vitro studies of potent aldose reductase inhibitors Synthesis, characterization, biological evaluation and docking analysis of rhodanine-3-hippuric acid derivatives
Bioorg. Chem.
97
103640
2020
Rattus norvegicus
Chen, H.; Zhang, X.; Zhang, X.; Fan, Z.; Liu, W.; Lei, Y.; Zhu, C.; Ma, B.
Dihydrobenzoxazinone derivatives as aldose reductase inhibitors with antioxidant activity
Bioorg. Med. Chem.
28
115699
2020
Homo sapiens (P15121)
Hlavac, M.; Kovacikova, L.; Soltesova Prnova, M.; Addova, G.; Hanquet, G.; Stefek, M.; Bohac, A.
Novel substituted N-benzyl(oxotriazinoindole) inhibitors of aldose reductase exploiting ALR2 unoccupied interactive pocket
Bioorg. Med. Chem.
29
115885
2021
Rattus norvegicus
Hao, X.; Han, Z.; Li, Y.; Li, C.; Wang, X.; Zhang, X.; Yang, Q.; Ma, B.; Zhu, C.
Synthesis and structure-activity relationship studies of phenolic hydroxyl derivatives based on quinoxalinone as aldose reductase inhibitors with antioxidant activity
Bioorg. Med. Chem. Lett.
27
887-892
2017
Homo sapiens (P15121)
Cui, F.; Liu, L.; Tang, H.; Yang, K.; Li, Y.
Construction of explicit models to correlate the structure and the inhibitory activity of aldose reductase Flavonoids and sulfonyl-pyridazinones as inhibitors
Chem. Biol. Drug Des.
89
482-491
2017
Homo sapiens (P15121)
Hmimid, F.; Lahlou, F.; Guenaou, I.; Nait Irahal, I.; Errami, A.; Fahde, S.; Bourhim, N.
Purification and characterization of aldose reductase from jerboa (Jaculus orientalis) and evaluation of its inhibitory activity by Euphorbia regis-jubae (Webb & Berth) extracts
Comp. Biochem. Physiol. C Toxicol. Pharmacol.
244
109001
2021
Jaculus orientalis
Papastavrou, N.; Chatzopoulou, M.; Ballekova, J.; Cappiello, M.; Moschini, R.; Balestri, F.; Patsilinakos, A.; Ragno, R.; Stefek, M.; Nicolaou, I.
Enhancing activity and selectivity in a series of pyrrol-1-yl-1-hydroxypyrazole-based aldose reductase inhibitors The case of trifluoroacetylation
Eur. J. Med. Chem.
130
328-335
2017
Rattus norvegicus, Homo sapiens (P15121)
Crespo, I.; Gimenez-Dejoz, J.; Porte, S.; Cousido-Siah, A.; Mitschler, A.; Podjarny, A.; Pratsinis, H.; Kletsas, D.; Pares, X.; Ruiz, F.X.; Metwally, K.; Farres, J.
Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase
Eur. J. Med. Chem.
152
160-174
2018
Homo sapiens (P15121), Homo sapiens
Sonowal, H.; Saxena, A.; Qiu, S.; Srivastava, S.; Ramana, K.
Aldose reductase regulates doxorubicin-induced immune and inflammatory responses by activating mitochondrial biogenesis
Eur. J. Pharmacol.
895
173884
2021
Mus musculus
Yang, Y.; Yang, Q.; Yu, J.; Wan, W.; Wei, X.
Characterization of structural requirement for binding of gigantol and aldose reductase
Front. Biosci. (Landmark Ed.)
24
1024-1036
2019
Rattus norvegicus
Khan, M.S.; Qais, F.A.; Rehman, M.T.; Ismail, M.H.; Alokail, M.S.; Altwaijry, N.; Alafaleq, N.O.; AlAjmi, M.F.; Salem, N.; Alqhatani, R.
Mechanistic inhibition of non-enzymatic glycation and aldose reductase activity by naringenin Binding, enzyme kinetics and molecular docking analysis
Int. J. Biol. Macromol.
159
87-97
2020
Homo sapiens (P15121)
Patil, K.K.; Gacche, R.N.
Inhibition of glycation and aldose reductase activity using dietary flavonoids A lens organ culture studies
Int. J. Biol. Macromol.
98
730-738
2017
Capra hircus
Alim, Z.; Kilinc, N.; Sengul, B.; Beydemir, S.
Mechanism of capsaicin inhibition of aldose reductase activity
J. Biochem. Mol. Toxicol.
31
e21898
2017
Rattus norvegicus
Sekhon, G.; Singh, B.; Singh, R.
Role of Cys-298 in specific recognition of glutathione by aldose reductase
J. Biomol. Struct. Dyn.
FEHLT
1-9
2021
Homo sapiens
Hao, X.; Qi, G.; Ma, H.; Zhu, C.; Han, Z.
Novel 2-phenoxypyrido[3,2-b]pyrazin-3(4H)-one derivatives as potent and selective aldose reductase inhibitors with antioxidant activity
J. Enzyme Inhib. Med. Chem.
34
1368-1372
2019
Homo sapiens (P15121)
D'Andrea, F.; Sartini, S.; Piano, I.; Franceschi, M.; Quattrini, L.; Guazzelli, L.; Ciccone, L.; Orlandini, E.; Gargini, C.; La Motta, C.; Nencetti, S.
Oxy-imino saccharidic derivatives as a new structural class of aldose reductase inhibitors endowed with anti-oxidant activity
J. Enzyme Inhib. Med. Chem.
35
1194-1205
2020
Homo sapiens (P15121), Homo sapiens
Lee, H.E.; Kim, J.A.; Whang, W.K.
Chemical constituents of smilax China l. stems and their inhibitory activities against glycation, aldose reductase, alpha-glucosidase, and lipase
Molecules
22
451
2017
Rattus norvegicus
Thiagarajan, D.; O Shea, K.; Sreejit, G.; Ananthakrishnan, R.; Quadri, N.; Li, Q.; Schmidt, A.M.; Gabbay, K.; Ramasamy, R.
Aldose reductase modulates acute activation of mesenchymal markers via the beta-catenin pathway during cardiac ischemia-reperfusion
PLoS ONE
12
e0188981
2017
Mus musculus
Paidimuddala, B.; Krishna Aradhyam, G.; Gummadi, S.
A halotolerant aldose reductase from Debaryomyces nepalensis gene isolation, overexpression and biochemical characterization
RSC Adv.
7
20384-20393
2017
Debaryomyces nepalensis (A0A0M4HL56)
-
Celestina, S.K.; Sundaram, K.; Ravi, S.
Novel derivatives of rhodanine-3-hippuric acid as active inhibitors of aldose reductase synthesis, biological evaluation, and molecular docking analysis
Russ. J. Bioorg. Chem.
45
405-415
2019
Rattus norvegicus
-
Ahuja, V.; Sharma, V.; Rana, N.; Rathour, R.; Bhatia, R.; Bhatt, A.
Enhanced production of alkalo-tolerant NADPH dependent xylose reductase from Emericella sp. XLT-11 by statistical modeling
Trends Carbohydr. Res.
12
51-63
2020
Emericella sp. XLT-11
-
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