1.1.1.21: aldehyde reductase

This is an abbreviated version, for detailed information about aldehyde reductase, go to the full flat file.

Reaction

alditol
+
NAD(P)+
=
aldose
+
NAD(P)H
+
H+

Synonyms

17betaHSD5, 20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, AdhA, AKR1B, AKR1B1, AKR1B10, AKR1B13, AKR1B14, AKR1B3, AKR1C3, AKR4C7, aldehyde reductase, alditol/NADP+ oxidoreductase, alditol: NADP+ 1-oxidoreductase, alditol:NAD(P)+1oxidoreductase, alditol:NADP 1-oxidoreductase, alditol:NADP oxidoreductase, aldo-keto reductase, aldo-keto reductase family 1 member B7, aldoketo reductase 1C3, aldose reductase, aldose reductase 2, aldose reductase-like, aldose reductase-like protein, aldose xylose reductase, ALDRXV4, ALR, ALR1, ALR2, AR, ARI, BAR, Fibroblast growth factor regulated protein, FR-1 protein, GRE3, HAR, HRAR, isobutyraldehyde reductase, More, MVDP, NADPH-aldopentose reductase, NADPH-aldose reductase, polyol dehydrogenase (NADP2), RLAR, small intestine reductase, TPN-polyol dehydrogenase, VAS deferens androgen-dependent protein, YqhD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.21 aldehyde reductase

KI Value

KI Value on EC 1.1.1.21 - aldehyde reductase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0182 - 3.081
(2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-yl)-acetic acid
0.0167 - 0.328
(2-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-yl)-acetic acid
0.00004 - 0.0078
(5-chloro-2-[(4-cyanobenzyl)carbamoyl]phenoxy)acetic acid
0.0088
1,2,7-trihydroxy-3,8-dimethoxy-6-methylanthracene-9,10-dione 2-O-beta-D-glucoside
-
pH 7.0, 37°C
0.0136
1,3,7-trihydroxy-2,8-dimethoxy-6-methylanthracene-9,10-dione
-
pH 7.0, 37°C
0.0159
1,3,8-trihydroxy-6-methylanthracene-9,10-dione
-
pH 7.0, 37°C
0.0241
3,3-Tetramethyleneglutaric acid
-
pH 7.0, 37°C
0.0141
4-amino-N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamide
-
-
0.00297
6-[[(di(2,4-dimethoxyphenyl)methylidene)amino]oxy]hexanoic acid
-
pH 6.8, 37°C
0.00299
6-[[(di(3,5-dimethoxyphenyl)methylidene)amino]oxy]hexanoic acid
-
pH 6.8, 37°C
0.00292
6-[[(di(4-methoxy-3-methylphenyl)methylidene)amino]oxy]hexanoic acid
-
pH 6.8, 37°C
0.0011 - 0.0026
bezafibrate
-
pH 6.2, 25°C, recombinant enzyme
0.00088
ciprofibrate
-
pH 6.2, 25°C, recombinant enzyme
0.00124
Clofibric acid
-
pH 6.2, 25°C, recombinant enzyme
0.00033 - 0.00056
davallialactone
0.00063 - 0.00137
ellagic acid
0.00056
fenofibrat
-
pH 6.2, 25°C, recombinant enzyme
0.0012 - 0.0037
gemfibrozil
-
pH 6.2, 25°C, recombinant enzyme
0.00082 - 0.00128
hypholomine B
0.0155
N-(3,5-difluoro-4-hydroxyphenyl)-4-methoxybenzenesulfonamide
-
-
0.0444
N-(3,5-difluoro-4-hydroxyphenyl)-4-nitrobenzenesulfonamide
-
-
0.0329
N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamide
-
-
0.01355
nitazoxanide
-
pH and temperature not specified in the publication
0.00045
sorbinil
-
pH 6.2, 25°C, recombinant enzyme
0.000458
sulindac
-
pH 6.2, temperature not specified in the publication, ALR2
0.0003
sulindac sulfide
-
pH 6.2, temperature not specified in the publication, ALR2
0.000434
sulindac sulfone
-
pH 6.2, temperature not specified in the publication, ALR2
0.00935
tizoxanide
-
pH and temperature not specified in the publication
0.000005 - 0.000043
zopolrestat
additional information
additional information
-