Reference on EC 4.6.1.2 - guanylate cyclase and Organism(s) Homo sapiens and UniProt Accession P51841
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Asano, T.; Hidaka, H.
Purification of guanylate cyclase from human platelets and effect of arachidonic acid peroxide
Biochem. Biophys. Res. Commun.
78
910-918
1977
Homo sapiens
Boehme, E.; Jung, R.; Mechler, I.
Guanylate cyclase in human platelets
Methods Enzymol.
38C
199-202
1974
Homo sapiens
-
Russwurm, M.; Behrends, S.; Harteneck, C.; Koesling, D.
Functional properties of a naturally occurring isoform of soluble guanylyl cyclase
Biochem. J.
335
125-130
1998
Homo sapiens (P33402), Homo sapiens
Bruene, B.; Schmidt, K.U.; Ullrich, V.
Activation of soluble guanylate cyclase by carbon monoxide and inhibition by superoxide anion
Eur. J. Biochem.
192
683-688
1990
Homo sapiens
Chhajlani, V.; Axelsson, K.; Ahlner, J.; Wikberg, J.E.S.
Purification of soluble guanylate cyclase enzyme from human platelets
Biochem. Int.
19
1039-1044
1989
Homo sapiens
Kosarikov, D.N.; Young, P.; Uversky, V.N.; Gerber, N.C.
Human soluble guanylate cyclase: functional expression, purification and structural characterization
Arch. Biochem. Biophys.
388
185-197
2001
Homo sapiens
Koglin, M.; Behrends, S.
Native human nitric oxide sensitive guanylyl cyclase: purification and characterization
Biochem. Pharmacol.
67
1579-1585
2004
Homo sapiens
Vijayachandra, K.; Guruprasad, M.; Bhandari, R.; Manjunath, U.H.; Somesh, B.P.; Srinivasan, N.; Suguna, K.; Visweswariah, S.S.
Biochemical characterization of the intracellular domain of the human guanylyl cyclase C receptor provides evidence for a catalytically active homotrimer
Biochemistry
39
16075-16083
2000
Homo sapiens
Schmidt, P.; Schramm, M.; Schroder, H.; Stasch, J.P.
Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase
Eur. J. Pharmacol.
468
167-174
2003
Homo sapiens
Koglin, M.; Behrends, S.
A Functional domain of the a1 subunit of soluble guanylyl cyclase is necessary for activation of the enzyme by nitric oxide and YC-1 but is not involved in heme binding
J. Biol. Chem.
278
12590-12597
2003
Homo sapiens
Rambotti, M.G.; Spreca, A.; Giambanco, I.; Sorci, G.; Donato, R.
Ultracytochemistry as a tool for the study of the cellular and subcellular localization of membrane-bound guanylate cyclase (GC) activity. Applicability to both receptor-activated and receptor-independent GC activity
Mol. Cell. Biochem.
230
85-96
2002
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Martin, E.; Sharina, I.; Kots, A.; Murad, F.
A constitutively activated mutant of human soluble guanylyl cyclase (sGC): Implication for the mechanism of sGC activation
Proc. Natl. Acad. Sci. USA
100
9208-9213
2003
Homo sapiens
Ruiz-Stewart, I.; Tiyyagura, S.R.; Lin, J.E.; Kazerounian, S.; Pitari, G.M.; Schulz, S.; Martin, E.; Murad, F.; Waldman, S.A.
Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism
Proc. Natl. Acad. Sci. USA
101
37-42
2004
Homo sapiens
Lee, Y.C.; Martin, E.; Murad, F.
Human recombinant soluble guanylyl cyclase: expression, purification, and regulation
Proc. Natl. Acad. Sci. USA
97
10763-10768
2000
Homo sapiens (Q02108), Homo sapiens
Zhou, Z.; Gross, S.; Roussos, C.; Meurer, S.; Muller-Esterl, W.; Papapetropoulos, A.
Structural and functional characterization of the dimerization region of soluble guanylyl cyclase
J. Biol. Chem.
279
24935-24943
2004
Homo sapiens
Madhani, M.; Okorie, M.; Hobbs, A.J.; MacAllister, R.J.
Reciprocal regulation of human soluble and particulate guanylate cyclases in vivo
Br. J. Pharmacol.
149
797-801
2006
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Poulos, T.L.
Soluble guanylate cyclase
Curr. Opin. Struct. Biol.
16
736-743
2006
Bos taurus, Clostridium botulinum, Homo sapiens, Rattus norvegicus, Caldanaerobacter subterraneus subsp. tengcongensis, Vibrio cholerae serotype O1
Isenberg, J.S.; Ridnour, L.A.; Thomas, D.D.; Wink, D.A.; Roberts, D.D.; Espey, M.G.
Guanylyl cyclase-dependent chemotaxis of endothelial cells in response to nitric oxide gradients
Free Radic. Biol. Med.
40
1028-1033
2006
Homo sapiens
Pitari, G.M.; Li, T.; Baksh, R.I.; Waldman, S.A.
Exisulind and guanylyl cyclase C induce distinct antineoplastic signaling mechanisms in human colon cancer cells
Mol. Cancer Ther.
5
1190-1196
2006
Homo sapiens
Singh, S.; Gray, T.; Wurster, R.D.
Nitric oxide and carbon monoxide synthesizing enzymes and soluble guanylyl cyclase within neurons of adult human cardiac ganglia
Auton. Neurosci.
145
93-98
2009
Homo sapiens
Rosenzweig, D.H.; Nair, K.S.; Levay, K.; Peshenko, I.V.; Crabb, J.W.; Dizhoor, A.M.; Slepak, V.Z.
Interaction of retinal guanylate cyclase with the alpha subunit of transducin: potential role in transducin localization
Biochem. J.
417
803-812
2009
Bos taurus, Mus musculus, Homo sapiens (Q02846)
Tian, X.; Michal, A.M.; Li, P.; Wolfe, H.R.; Waldman, S.A.; Wickstrom, E.
STa peptide analogs for probing guanylyl cyclase C
Biopolymers
90
713-723
2008
Homo sapiens, Mus musculus
Haramis, G.; Zhou, Z.; Pyriochou, A.; Koutsilieris, M.; Roussos, C.; Papapetropoulos, A.
cGMP-independent anti-tumour actions of the inhibitor of soluble guanylyl cyclase, ODQ, in prostate cancer cell lines
Br. J. Pharmacol.
155
804-813
2008
Homo sapiens
Hoenicka, M.; Schmid, C.
Cardiovascular effects of modulators of soluble guanylyl cyclase activity
Cardiovasc. Hematol. Agents Med. Chem.
6
287-301
2008
Bos taurus, Canis lupus familiaris, Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa, Ovis aries (Q8SPV3)
Brahmajothi, M.V.; Campbell, D.L.
Heterogeneous expression of NO-activated soluble guanylyl cyclase in mammalian heart: implications for NO- and redox-mediated indirect versus direct regulation of cardiac ion channel function
Channels
1
353-365
2008
Homo sapiens, Mustela putorius furo
Schermuly, R.T.; Stasch, J.P.; Pullamsetti, S.S.; Middendorff, R.; Mueller, D.; Schlueter, K.D.; Dingendorf, A.; Hackemack, S.; Kolosionek, E.; Kaulen, C.; Dumitrascu, R.; Weissmann, N.; Mittendorf, J.; Klepetko, W.; Seeger, W.; Ghofrani, H.A.; Grimminger, F.
Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension
Eur. Respir. J.
32
881-891
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Grimminger, F.; Weimann, G.; Frey, R.; Voswinckel, R.; Thamm, M.; Boelkow, D.; Weissmann, N.; Mueck, W.; Unger, S.; Wensing, G.; Schermuly, R.T.; Ghofrani, H.A.
First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension
Eur. Respir. J.
33
785-792
2009
Homo sapiens
Vazquez-Padron, R.I.; Pham, S.M.; Mateu, D.; Khan, S.; Aitouche, A.
An internal ribosome entry site mediates the initiation of soluble guanylyl cyclase beta2 mRNA translation
FEBS J.
275
3598-3607
2008
Homo sapiens (O75343), Homo sapiens
Jankowska, A.; Burczy?ska, B.; Duda, T.; Warchol, J.B.
Rod outer segment membrane guanylate cyclase type 1 (ROS-GC1) calcium-modulated transduction system in the sperm
Fertil. Steril.
93
904-912
2008
Homo sapiens
Stasch, J.P.; Hobbs, A.J.
NO-independent, haem-dependent soluble guanylate cyclase stimulators
Handb. Exp. Pharmacol.
191
277-308
2009
Homo sapiens
Schmidt, H.H.; Schmidt, P.M.; Stasch, J.P.
NO- and haem-independent soluble guanylate cyclase activators
Handb. Exp. Pharmacol.
191
309-339
2009
Homo sapiens
Kuhn, M.
Function and dysfunction of mammalian membrane guanylyl cyclase receptors: lessons from genetic mouse models and implications for human diseases
Handb. Exp. Pharmacol.
191
47-69
2009
Homo sapiens, Homo sapiens (P16066), Homo sapiens (P20594), Homo sapiens (P25092), Homo sapiens (P51841), Mus musculus
Usami, S.; Kishimoto, I.; Saito, Y.; Harada, M.; Kuwahara, K.; Nakagawa, Y.; Nakanishi, M.; Yasuno, S.; Kangawa, K.; Nakao, K.
Association of CT dinucleotide repeat polymorphism in the 5-flanking region of the guanylyl cyclase (GC)-A gene with essential hypertension in the Japanese
Hypertens. Res.
31
89-96
2008
Homo sapiens
Ellis, D.Z.; Dismuke, W.M.; Chokshi, B.M.
Characterization of soluble guanylate cyclase in NO-induced increases in aqueous humor outflow facility and in the trabecular meshwork
Invest. Ophthalmol. Vis. Sci.
50
1808-1813
2008
Homo sapiens, Sus scrofa
Sharina, I.G.; Jelen, F.; Bogatenkova, E.P.; Thomas, A.; Martin, E.; Murad, F.
Alpha1 soluble guanylyl cyclase (sGC) splice forms as potential regulators of human sGC activity
J. Biol. Chem.
283
15104-15113
2008
Homo sapiens (Q02108), Homo sapiens
Marro, M.L.; Peiro, C.; Panayiotou, C.M.; Baliga, R.S.; Meurer, S.; Schmidt, H.H.; Hobbs, A.J.
Characterization of the human alpha1 beta1 soluble guanylyl cyclase promoter: key role for NF-kappaB(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor
J. Biol. Chem.
283
20027-20036
2008
Homo sapiens
Peshenko, I.V.; Olshevskaya, E.V.; Dizhoor, A.M.
Binding of guanylyl cyclase activating protein 1 (GCAP1) to retinal guanylyl cyclase (RetGC1). The role of individual EF-hands
J. Biol. Chem.
283
21747-21757
2008
Homo sapiens
Frey, R.; Mueck, W.; Unger, S.; Artmeier-Brandt, U.; Weimann, G.; Wensing, G.
Pharmacokinetics, pharmacodynamics, tolerability, and safety of the soluble guanylate cyclase activator cinaciguat (BAY 58-2667) in healthy male volunteers
J. Clin. Pharmacol.
48
1400-1410
2008
Homo sapiens
Frey, R.; Mueck, W.; Unger, S.; Artmeier-Brandt, U.; Weimann, G.; Wensing, G.
Single-dose pharmacokinetics, pharmacodynamics, tolerability, and safety of the soluble guanylate cyclase stimulator BAY 63-2521: an ascending-dose study in healthy male volunteers
J. Clin. Pharmacol.
48
926-934
2008
Homo sapiens
Lee, H.G.; Kim, S.Y.; Kim, d.u..S.; Seo, S.R.; Lee, S.I.; Shin, D.M.; De Smet, P.; Seo, J.T.
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one inhibits neurite outgrowth and causes neurite retraction in PC12 cells independently of soluble guanylyl cyclase
J. Neurosci. Res.
87
269-277
2009
Homo sapiens
Gambaryan, S.; Kobsar, A.; Hartmann, S.; Birschmann, I.; Kuhlencordt, P.J.; Mueller-Esterl, W.; Lohmann, S.M.; Walter, U.
NO-synthase-/NO-independent regulation of human and murine platelet soluble guanylyl cyclase activity
J. Thromb. Haemost.
6
1376-1384
2008
Homo sapiens, Mus musculus
Punathil, T.; Katiyar, S.K.
Inhibition of non-small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and ERK1/2
Mol. Carcinog.
48
232-242
2008
Homo sapiens
Emmons, T.L.; Mathis, K.J.; Shuck, M.E.; Reitz, B.A.; Curran, D.F.; Walker, M.C.; Leone, J.W.; Day, J.E.; Bienkowski, M.J.; Fischer, H.D.; Tomasselli, A.G.
Purification and characterization of recombinant human soluble guanylate cyclase produced from baculovirus-infected insect cells
Protein Expr. Purif.
65
133-139
2009
Homo sapiens
Morbidelli, L.; Pyriochou, A.; Filippi, S.; Vasileiadis, I.; Roussos, C.; Zhou, Z.; Loutrari, H.; Waltenberger, J.; Stoessel, A.; Giannis, A.; Ziche, M.; Papapetropoulos, A.
The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability
Am. J. Physiol. Regul. Integr. Comp. Physiol.
298
R824-R832
2010
Homo sapiens
Newton, M.; Niewczas, I.; Clark, J.; Bellamy, T.C.
A real-time fluorescent assay of the purified nitric oxide receptor, guanylyl cyclase
Anal. Biochem.
402
129-136
2010
Homo sapiens
Sovershaev, M.A.; Egorina, E.M.; Hansen, J.B.; Osterud, B.; Pacher, P.; Stasch, J.P.; Evgenov, O.V.
Soluble guanylate cyclase agonists inhibit expression and procoagulant activity of tissue factor
Arterioscler. Thromb. Vasc. Biol.
29
1578-1586
2009
Homo sapiens
Miller, T.W.; Isenberg, J.S.; Roberts, D.D.
Thrombospondin-1 is an inhibitor of pharmacological activation of soluble guanylate cyclase
Br. J. Pharmacol.
159
1542-1547
2010
Homo sapiens
Mueck, W.; Frey, R.
Population pharmacokinetics and pharmacodynamics of cinaciguat, a soluble guanylate cyclase activator, in patients with acute decompensated heart failure
Clin. Pharmacokinet.
49
119-129
2010
Homo sapiens
Cardoso, M.H.; Morganti, R.P.; Lilla, S.; Murad, F.; De Nucci, G.; Antunes, E.; Marcondes, S.
The role of superoxide anion in the inhibitory effect of SIN-1 in thrombin-activated human platelet adhesion
Eur. J. Pharmacol.
627
229-234
2010
Homo sapiens
Riego, J.A.; Broniowska, K.A.; Kettenhofen, N.J.; Hogg, N.
Activation and inhibition of soluble guanylyl cyclase by S-nitrosocysteine: involvement of amino acid transport system L
Free Radic. Biol. Med.
47
269-274
2009
Homo sapiens
Suryanarayana, S.; Goettle, M.; Huebner, M.; Gille, A.; Mou, T.C.; Sprang, S.R.; Richter, M.; Seifert, R.
Differential inhibition of various adenylyl cyclase isoforms and soluble guanylyl cyclase by 2,3-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5-triphosphates
J. Pharmacol. Exp. Ther.
330
687-695
2009
Homo sapiens
Ramanathan, S.; Mazzalupo, S.; Boitano, S.; Montfort, W.R.
Thrombospondin-1 and angiotensin II inhibit soluble guanylyl cyclase through an increase in intracellular calcium concentration
Biochemistry
50
7787-7799
2011
Homo sapiens
Robinson, J.W.; Potter, L.R.
ATP potentiates competitive inhibition of guanylyl cyclase A and B by the staurosporine analog, Go6976: Reciprocal regulation of ATP and GTP binding
J. Biol. Chem.
286
33841-33844
2011
Homo sapiens
Baehre, H.; Danker, K.Y.; Stasch, J.P.; Kaever, V.; Seifert, R.
Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells
Biochem. Biophys. Res. Commun.
443
1195-1199
2014
Homo sapiens
Seeger, F.; Quintyn, R.; Tanimoto, A.; Williams, G.J.; Tainer, J.A.; Wysocki, V.H.; Garcin, E.D.
Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity
Biochemistry
53
2153-2165
2014
Homo sapiens (Q02108), Homo sapiens
Arshad, N.; Ballal, S.; Visweswariah, S.S.
Site-specific N-linked glycosylation of receptor guanylyl cyclase C regulates ligand binding, ligand-mediated activation and interaction with vesicular integral membrane protein 36, VIP36
J. Biol. Chem.
288
3907-3917
2013
Homo sapiens
Allerston, C.K.; von Delft, F.; Gileadi, O.
Crystal structures of the catalytic domain of human soluble guanylate cyclase
PLoS ONE
8
e57644
2013
Homo sapiens (Q02108), Homo sapiens
Robinson, J.W.; Potter, L.R.
Guanylyl cyclases A and B are asymmetric dimers that are allosterically activated by ATP binding to the catalytic domain
Sci. Signal.
5
ra65
2012
Homo sapiens
Soemmer, A.; Sandner, P.; Behrends, S.
BAY 60-2770 activates two isoforms of nitric oxide sensitive guanylyl cyclase Evidence for stable insertion of activator drugs
Biochem. Pharmacol.
147
10-20
2018
Homo sapiens
Peshenko, I.V.; Olshevskaya, E.V.; Dizhoor, A.M.
Evaluating the role of retinal membrane guanylyl cyclase 1 (RetGC1) domains in binding guanylyl cyclase-activating proteins (GCAPs)
J. Biol. Chem.
290
6913-6924
2015
Homo sapiens (Q02846)
Dickey, D.M.; Edmund, A.B.; Otto, N.M.; Chaffee, T.S.; Robinson, J.W.; Potter, L.R.
Catalytically active guanylyl cyclase B requires endoplasmic reticulum-mediated glycosylation, and mutations that inhibit this process cause dwarfism
J. Biol. Chem.
291
11385-11393
2016
Homo sapiens (P20594)
Otto, N.M.; McDowell, W.G.; Dickey, D.M.; Potter, L.R.
A glutamate-substituted mutant mimics the phosphorylated and active form of guanylyl cyclase-A
Mol. Pharmacol.
92
67-74
2017
Homo sapiens (P16066)
Agullo, L.; Buch, I.; Gutierrez-de-Teran, H.; Garcia-Dorado, D.; Villa-Freixa, J.
Computational exploration of the binding mode of heme-dependent stimulators into the active catalytic domain of soluble guanylate cyclase
Proteins
84
1534-1548
2016
Homo sapiens (Q02153)
Cortese-Krott, M.M.; Mergia, E.; Kramer, C.M.; Lueckstaedt, W.; Yang, J.; Wolff, G.; Panknin, C.; Bracht, T.; Sitek, B.; Pernow, J.; Stasch, J.P.; Feelisch, M.; Koesling, D.; Kelm, M.
Identification of a soluble guanylate cyclase in RBCs preserved activity in patients with coronary artery disease
Redox Biol.
14
328-337
2018
Homo sapiens
