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Literature summary for 4.6.1.2 extracted from

  • Cortese-Krott, M.M.; Mergia, E.; Kramer, C.M.; Lueckstaedt, W.; Yang, J.; Wolff, G.; Panknin, C.; Bracht, T.; Sitek, B.; Pernow, J.; Stasch, J.P.; Feelisch, M.; Koesling, D.; Kelm, M.
    Identification of a soluble guanylate cyclase in RBCs preserved activity in patients with coronary artery disease (2018), Redox Biol., 14, 328-337 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine in red blood cells, an intact soluble guanylate cyclaseC/PDE5/PKG-dependent signaling pathway exists, which remains fully responsive to NO and guanylate cyclase stimulators/activators in patients with endothelial dysfunction Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
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General Information

General Information Comment Organism
physiological function red blood cells carry a catalytically active alpha1beta1-guanylate cyclase isoform 1, as well as phopshodiesterase PDE5 and protein kinase PKG. Specific cyclase stimulation by NO + BAY 41-2272 increases intracellular cGMP-levels up to 1000fold with concomitant activation of the canonical PKG/VASP-signaling pathway. This response to NO is blunted in subunit alpha1-cyclase knockout red blood cells, but fully preserved in alpha2-guanylate cyclase KO cells Homo sapiens