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Literature summary for 4.6.1.2 extracted from

  • Newton, M.; Niewczas, I.; Clark, J.; Bellamy, T.C.
    A real-time fluorescent assay of the purified nitric oxide receptor, guanylyl cyclase (2010), Anal. Biochem., 402, 129-136.
    View publication on PubMed
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
BAY 41-2272 3-(4-amino-5-cyclopropylpyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine, synergistic activator of sGC Homo sapiens
nitric oxide
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0357
-
 2'-O-(N-methylanthraniloyl) guanosine 5'-triphosphate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens
-
 3',5'-cyclic-GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-O-(N-methylanthraniloyl) guanosine 5'-triphosphate
-
 Homo sapiens ?
-
 ?
GTP
-
 Homo sapiens 3',5'-cyclic-GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
alpha1beta1 sGC
-
 Homo sapiens
sGC
-
 Homo sapiens
soluble guanylyl cyclase
-
 Homo sapiens