Literature summary for 4.6.1.2 extracted from

Pitari, G.M.; Li, T.; Baksh, R.I.; Waldman, S.A.
Exisulind and guanylyl cyclase C induce distinct antineoplastic signaling mechanisms in human colon cancer cells (2006), Mol. Cancer Ther., 5, 1190-1196.

Search for more literature for 4.6.1.2

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	GCC is activated by diarrheagenic bacterial heat-stable enterotoxins, which suppress proliferation of Caco-2 human colon carcinoma cells. Exisulind inhibits the ability of diarrheagenic bacterial heat-stable enterotoxin to induce maximal intracellular cGMP accumulation	Homo sapiens

Application

Application	Comment	Organism
medicine	antiproliferative mechanisms induced by GCC ligands and exisulind negatively interact in colon cancer cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Caco-2 cell	-	Homo sapiens	-
colonic cancer cell	-	Homo sapiens	-
additional information	T84 cell and SW480 cell	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP	-	Homo sapiens	3',5'-cyclic GMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
GCC	-	Homo sapiens
guanylyl cyclase C	-	Homo sapiens

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Release 2023.1 (January 2023)