Activating Compound | Comment | Organism | Structure |
---|---|---|---|
BAY 41-2272 | riociguat, allosteric stimulator | Homo sapiens | |
nitric oxide | - |
Homo sapiens | |
YC-1 | allosteric stimulator | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | the enzyme is inhibited by high intracellular Ca2+ concentration | Homo sapiens | |
additional information | inhibition of soluble guanylyl cyclase requires binding to cell-surface receptor CD47. A thrombospondin-1 C-terminal fragment (E3CaG1) readily inhibits sGC in Jurkat T cells. This inhibition requires an increase in intracellular Ca+ concentration. Addition of angiotensin II also strongly inhibits soluble guanylyl cyclase activity by increasing intracellular Ca+ concentration | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.069 | - |
GTP | in the absence of Ca2+ and in the presence of 0.05 mM nitric oxide, in 50 mM HEPES, pH 7.5, at 37°C | Homo sapiens | |
0.234 | - |
GTP | in the absence of Ca2+ and nitric oxide, in 50 mM HEPES, pH 7.5, at 37°C | Homo sapiens | |
0.857 | - |
GTP | in the presence of 2 mM Ca2+ and in the absence of nitric oxide, in 50 mM HEPES, pH 7.5, at 37°C | Homo sapiens | |
0.887 | - |
GTP | in the presence of 2 mM Ca2+ and 0.05 mM nitric oxide, in 50 mM HEPES, pH 7.5, at 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JURKAT cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Homo sapiens | 3',5'-cyclic-GMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sGC | - |
Homo sapiens |
soluble guanylate cyclase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | the enzyme possesses a heme-containing beta subunit | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | soluble guanylate cyclase lowers intracellular Ca2+ concentration in response to nitric oxide, inducing vasodilationand is inhibited by high intracellular Ca2+ concentration, providing a fine balance between signals for vasodilation and vasoconstriction | Homo sapiens |