Activating Compound | Comment | Organism | Structure |
---|---|---|---|
GCAP1 | activating protein. At near-saturating concentrations, GCAP1 and GCAP2 activate RetGC1 from HEK293 in a non-additive fashion. GCAP1 mutant M26R binds but does not activate RetGC1 and suppresses activation of recombinant and native RetGC1 by competing with both GCAP1 and GCAP2 | Homo sapiens | |
GCAP2 | activating protein. At near-saturating concentrations, GCAP1 and GCAP2 activate RetGC1 from HEK293 in a non-additive fashion. Deletion of a residues Tyr1016-Ser1103 fragment in RetGC1 does not block GCAP2 binding to the cyclase. Substitutions in the kinase homology domain, W708R and I734T, linked to Leber congenital amaurosis prevent binding of both GCAP1-GFP and GCAP2-GFP | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in HEK-293 cell | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
I734T | substitution in the kinase homology domain linked to Leber congenital amaurosis, prevents binding of both GCAP1-GFP and GCAP2-GFP | Homo sapiens |
additional information | deletion of a residues Tyr1016-Ser1103 fragment in RetGC1 does not block GCAP2 binding to the cyclase | Homo sapiens |
W708R | substitution in the kinase homology domain linked to Leber congenital amaurosis, prevents binding of both GCAP1-GFP and GCAP2-GFP | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q02846 | isoform RetGC1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
retina | - |
Homo sapiens | - |