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Literature summary for 4.6.1.2 extracted from

  • Lee, H.G.; Kim, S.Y.; Kim, d.u..S.; Seo, S.R.; Lee, S.I.; Shin, D.M.; De Smet, P.; Seo, J.T.
    1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one inhibits neurite outgrowth and causes neurite retraction in PC12 cells independently of soluble guanylyl cyclase (2009), J. Neurosci. Res., 87, 269-277.
    View publication on PubMed
Search for more literature for 4.6.1.2

Protein Variants

Protein Variants Comment Organism
additional information the depletion of sGC by RNA interference fails to prevent Y-27632- and staurosporine-induced neurite outgrowth Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one i.e. ODQ, inhibits the enzyme, and also inhibits Y-27632- and staurosporine-induced neurite outgrowth and triggered neurite retraction, but in an sGC-independent manner. The NO/sGC/cGMP signaling cascade is not, but the the ERK signaling pathway is critically involved in ODQ-induced neurite remodeling Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
neurite
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens
-
 3',5'-cyclic GMP + diphosphate
-
 ?
additional information Homo sapiens the NO/sGC/cGMP signaling cascade is not critically involved in ODQ-induced neurite remodeling, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuroblastoma cell
-
 Homo sapiens
-
neuron
-
 Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?
additional information the NO/sGC/cGMP signaling cascade is not critically involved in ODQ-induced neurite remodeling, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
sGC
-
 Homo sapiens
soluble guanylyl cyclase
-
 Homo sapiens