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Literature summary for 4.6.1.2 extracted from

  • Morbidelli, L.; Pyriochou, A.; Filippi, S.; Vasileiadis, I.; Roussos, C.; Zhou, Z.; Loutrari, H.; Waltenberger, J.; Stoessel, A.; Giannis, A.; Ziche, M.; Papapetropoulos, A.
    The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability (2010), Am. J. Physiol. Regul. Integr. Comp. Physiol., 298, R824-R832.
    View publication on PubMed
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
BAY 41-2272
-
 Homo sapiens
nitric oxide
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4H-8-bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one NS-2028, a soluble guanylyl cyclase inhibitor, complete inhibition at 0.01 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens
-
 3',5'-cyclic-GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell
-
 Homo sapiens
-
umbilical vein endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Homo sapiens 3',5'-cyclic-GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
sGC
-
 Homo sapiens
soluble guanylyl cyclase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction inhibition of soluble guanylyl cyclase reduces vascular endothelial growth factor-induced angiogenesis and permeability Homo sapiens
physiological function soluble guanylyl cyclase mediates the angiogenic and permeability-promoting activities of vascular endothelial growth factor. Soluble guanylyl cyclase is a downstream effector of vascular endothelial growth factor-triggered responses Homo sapiens