Cloned (Comment) | Organism |
---|---|
transient expression in COS-7 cells | Mus musculus |
transient expression in COS-7 cells | Bos taurus |
transient expression in COS-7 cells as GST-tagged enzyme, reconstitution of the Galphat-retGC interaction in COS-7 cells, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mouse line lacking retGC-1, GCE null, light-induced transducin redistribution occurs faster in mice lacking ret-GC1, phenotype, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | retGC is a transmembrane protein localized in the outer segment | Mus musculus | 16020 | - |
membrane | retGC is a transmembrane protein localized in the outer segment | Bos taurus | 16020 | - |
membrane | retGC is a transmembrane protein localized in the outer segment | Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Bos taurus | |
Mg2+ | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
115000 | - |
x * 115000, SDS-PAGE | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Mus musculus | the retinal isozyme retGC-1 influences transducin movement, not through its cyclase activity, but through direct interaction with Galphat protein, overview | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | Bos taurus | the retinal isozyme retGC-1 influences transducin movement, not through its cyclase activity, but through direct interaction with Galphat protein, overview | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | Homo sapiens | the retinal isozyme retGC-1 influences transducin movement, not through its cyclase activity, but through direct interaction with Galphat protein, overview | 3',5'-cyclic GMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | Q02846 | - |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant GST-tagged retGC from COS-7 cells by glutathione affinity chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eye | retina and rod segements, retGC is a transmembrane protein localized in the outer segment | Mus musculus | - |
eye | retina and rod segements, retGC is a transmembrane protein localized in the outer segment | Bos taurus | - |
eye | retina and rod segements, retGC is a transmembrane protein localized in the outer segment | Homo sapiens | - |
retina | - |
Mus musculus | - |
retina | - |
Bos taurus | - |
retina | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | - |
Bos taurus | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | - |
Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | the retinal isozyme retGC-1 influences transducin movement, not through its cyclase activity, but through direct interaction with Galphat protein, overview | Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | the retinal isozyme retGC-1 influences transducin movement, not through its cyclase activity, but through direct interaction with Galphat protein, overview | Bos taurus | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | the retinal isozyme retGC-1 influences transducin movement, not through its cyclase activity, but through direct interaction with Galphat protein, overview | Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? | |
additional information | the enzyme binds the human rod Galphat protein without altering cyclase activity, interactions with ligands, overview | Bos taurus | ? | - |
? | |
additional information | the enzyme binds the human rod Galphat protein without altering cyclase activity, overview | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 115000, SDS-PAGE | Bos taurus |
Synonyms | Comment | Organism |
---|---|---|
retGC | - |
Mus musculus |
retGC | - |
Bos taurus |
retGC | - |
Homo sapiens |
retinal guanylate cyclase | - |
Mus musculus |
retinal guanylate cyclase | - |
Bos taurus |
retinal guanylate cyclase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
30 | - |
assay at | Bos taurus |
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Mus musculus |
7.2 | - |
assay at | Bos taurus |
7.2 | - |
assay at | Homo sapiens |