Reference on EC 3.2.1.166 - heparanase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bame, K.J.; Hassall, A.; Sanderson, C.; Venkatesan, I.; Sun, C.
Partial purification of heparanase activities in Chinese hamster ovary cells: evidence for multiple intracellular heparanases
Biochem. J.
336
191-200
1998
Cricetulus griseus
McKenzie, E.; Young, K.; Hircock, M.; Bennett, J.; Bhaman, M.; Felix, R.; Turner, P.; Stamps, A.; McMillan, D.; Saville, G.; Ng, S.; Mason, S.; Snell, D.; Schofield, D.; Gong, H.; Townsend, R.; Gallagher, J.; Page, M.; Parekh, R.; Stubberfield, C.
Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells
Biochem. J.
373
423-435
2003
Homo sapiens (Q9Y251), Homo sapiens
Hulett, M.D.; Hornby, J.R.; Ohms, S.J.; Zuegg, J.; Freeman, C.; Gready, J.E.; Parish, C.R.
Identification of active-site residues of the pro-metastatic endoglycosidase heparanase
Biochemistry
39
15659-15667
2000
Homo sapiens (Q9Y251), Homo sapiens
Zhao, H.; Liu, H.; Chen, Y.; Xin, X.; Li, J.; Hou, Y.; Zhang, Z.; Zhang, X.; Xie, C.; Geng, M.; Ding, J.
Oligomannurarate sulfate, a novel heparanase inhibitor simultaneously targeting basic fibroblast growth factor, combats tumor angiogenesis and metastasis
Cancer Res.
66
8779-8787
2006
Homo sapiens (Q9Y251)
Klipper, E.; Tatz, E.; Kisliouk, T.; Vlodavsky, I.; Moallem, U.; Schams, D.; Lavon, Y.; Wolfenson, D.; Meidan, R.
Induction of heparanase in bovine granulosa cells by luteinizing hormone: possible role during the ovulatory process
Endocrinology
150
413-421
2009
Bos taurus
Bame, K.J.
Heparanases: endoglycosidases that degrade heparan sulfate proteoglycans
Glycobiology
11
91R-98R
2001
Cricetulus griseus, Homo sapiens (Q9Y251)
Dredge, K.; Hammond, E.; Davis, K.; Li, C.P.; Liu, L.; Johnstone, K.; Handley, P.; Wimmer, N.; Gonda, T.J.; Gautam, A.; Ferro, V.; Bytheway, I.
The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy
Invest. New Drugs
28
276-283
2010
Homo sapiens (Q9Y251)
Pikas, D.S.; Li, J.P.; Vlodavsky, I.; Lindahl, U.
Substrate specificity of heparanases from human hepatoma and platelets
J. Biol. Chem.
273
18770-18777
1998
Homo sapiens (Q9Y251), Homo sapiens
Toyoshima, M.; Nakajima, M.
Human heparanase. Purification, characterization, cloning, and expression
J. Biol. Chem.
274
24153-24160
1999
Homo sapiens (Q9Y251), Homo sapiens
Fairbanks, M.B.; Mildner, A.M.; Leone, J.W.; Cavey, G.S.; Mathews, W.R.; Drong, R.F.; Slightom, J.L.; Bienkowski, M.J.; Smith, C.W.; Bannow, C.A.; Heinrikson, R.L.
Processing of the human heparanase precursor and evidence that the active enzyme is a heterodimer
J. Biol. Chem.
274
29587-29590
1999
Homo sapiens (Q9Y251), Homo sapiens
Goldshmidt, O.; Zcharia, E.; Aingorn, H.; Guatta-Rangini, Z.; Atzmon, R.; Michal, I.; Pecker, I.; Mitrani, E.; Vlodavsky, I.
Expression pattern and secretion of human and chicken heparanase are determined by their signal peptide sequence
J. Biol. Chem.
276
29178-29187
2001
Gallus gallus
Okada, Y.; Yamada, S.; Toyoshima, M.; Dong, J.; Nakajima, M.; Sugahara, K.
Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence
J. Biol. Chem.
277
42488-42495
2002
Homo sapiens (Q9Y251), Homo sapiens
Gong, F.; Jemth, P.; Escobar Galvis, M.L.; Vlodavsky, I.; Horner, A.; Lindahl, U.; Li, J.P.
Processing of macromolecular heparin by heparanase
J. Biol. Chem.
278
35152-35158
2003
Homo sapiens (Q9Y251), Homo sapiens
Levy-Adam, F.; Abboud-Jarrous, G.; Guerrini, M.; Beccati, D.; Vlodavsky, I.; Ilan, N.
Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase
J. Biol. Chem.
280
20457-20466
2005
Homo sapiens (Q9Y251), Homo sapiens
Vreys, V.; David G.
Mammalian heparanase: what is the message?
J. Cell. Mol. Med.
11
427-452
2007
Homo sapiens (Q9Y251)
Bernard, D.; Mehul, B.; Delattre, C.; Simonetti, L.; Thomas-Collignon, A.; Schmidt, R.
Purification and characterization of the endoglycosidase heparanase 1 from human plantar stratum corneum: a key enzyme in epidermal physiology?
J. Invest. Dermatol.
117
1266-1273
2001
Homo sapiens
Navarro, F.P.; Fares, R.P.; Sanchez, P.E.; Nadam, J.; Georges, B.; Moulin, C.; Morales, A.; Pequignot, J.M.; Bezin, L.
Brain heparanase expression is up-regulated during postnatal development and hypoxia-induced neovascularization in adult rats
J. Neurochem.
105
34-45
2008
Rattus norvegicus
Schubert, S.Y.; Ilan, N.; Shushy, M.; Ben-Izhak, O.; Vlodavsky, I.; Goldshmidt, O.
Human heparanase nuclear localization and enzymatic activity
Lab. Invest.
84
535-544
2004
Rattus norvegicus, Homo sapiens (Q9Y251), Homo sapiens
Vlodavsky, I.; Friedmann, Y.; Elkin, M.; Aingorn, H.; Atzmon, R.; Ishai-Michaeli, R.; Bitan, M.; Pappo, O.; Peretz, T.; Michal, I.; Spector, L.; Pecker, I.
Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis
Nat. Med.
5
793-802
1999
Homo sapiens
Nasser, N.J.; Nevo, E.; Shafat, I.; Ilan, N.; Vlodavsky, I.; Avivi, A.
Adaptive evolution of heparanase in hypoxia-tolerant Spalax: gene cloning and identification of a unique splice variant
Proc. Natl. Acad. Sci. USA
102
15161-15166
2005
Nannospalax galili, Nannospalax judaei (Q333X5)
Miao, H.Q.; Navarro, E.; Patel, S.; Sargent, D.; Koo, H.; Wan, H.; Plata, A.; Zhou, Q.; Ludwig, D.; Bohlen, P.; Kussie, P.
Cloning, expression, and purification of mouse heparanase
Protein Expr. Purif.
26
425-431
2002
Mus musculus
Miles, J.R.; Vallet, J.L.; Freking, B.A.; Nonneman, D.J.
Molecular cloning and characterisation of heparanase mRNA in the porcine placenta throughout gestation
Reprod. Fertil. Dev.
21
757-772
2009
Sus scrofa
Hammond, E.; Li, C.P.; Ferro, V.
Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening
Anal. Biochem.
396
112-116
2009
Homo sapiens (Q9Y251)
Poon, I.K.; Yee, D.Y.; Jones, A.L.; Wood, R.J.; Davis, D.S.; Freeman, C.; Parish, C.R.; Hulett, M.D.
Histidine-rich glycoprotein binds heparanase and regulates its enzymatic activity and cell surface interactions
Int. J. Biochem. Cell Biol.
42
1507-1516
2010
Homo sapiens (Q9Y251)
Peterson, S.B.; Liu, J.
Unraveling the specificity of heparanase utilizing synthetic substrates
J. Biol. Chem.
285
14504-14513
2010
Homo sapiens (Q9Y251)
Smith, P.N.; Freeman, C.; Yu, D.; Chen, M.; Gatenby, P.A.; Parish, C.R.; Li, R.W.
Heparanase in primary human osteoblast
J. Orthop. Res.
28
1315-1322
2010
Homo sapiens (Q9Y251), Homo sapiens
Zheng, L.D.; Jiang, G.S.; Pu, J.R.; Mei, H.; Dong, J.H.; Hou, X.H.; Tong, Q.S.
Stable knockdown of heparanase expression in gastric cancer cells in vitro
World J. Gastroenterol.
15
5442-5448
2009
Homo sapiens (Q9Y251), Homo sapiens
Cui, H.; Shao, C.; Liu, Q.; Yu, W.; Fang, J.; Yu, W.; Ali, A.; Ding, K.
Heparanase enhances nerve growth factor induced PC12 cell neuritogenesis via the p38 MAPK pathway
Biochem. J.
440
273-282
2011
Rattus norvegicus
Masola, V.; Gambaro, G.; Tibaldi, E.; Onisto, M.; Abaterusso, C.; Lupo, A.
Regulation of heparanase by albumin and advanced glycation end products in proximal tubular cells
Biochim. Biophys. Acta
1813
1475-1482
2011
Homo sapiens
Zhang, Y.; Ryan, D.; Bower, K.; Ilan, N.; Vlodavsky, I.; Laurie, G.
Focus on molecules: Heparanase
Exp. Eye Res.
91
476-477
2010
Homo sapiens (Q9Y251)
Barash, U.; Cohen-Kaplan, V.; Arvatz, G.; Gingis-Velitski, S.; Levy-Adam, F.; Nativ, O.; Shemesh, R.; Ayalon-Sofer, M.; Ilan, N.; Vlodavsky, I.
A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics
FASEB J.
24
1239-1248
2010
Homo sapiens
Barash, U.; Cohen-Kaplan, V.; Dowek, I.; Sanderson, R.D.; Ilan, N.; Vlodavsky, I.
Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis
FEBS J.
277
3890-3903
2010
Homo sapiens
Miller, J.D.; Clabaugh, S.E.; Smith, D.R.; Stevens, R.B.; Wrenshall, L.E.
Interleukin-2 is present in human blood vessels and released in biologically active form by heparanase
Immunol. Cell Biol.
90
159-167
2012
Homo sapiens
Levy-Adam, F.; Feld, S.; Cohen-Kaplan, V.; Shteingauz, A.; Gross, M.; Arvatz, G.; Naroditsky, I.; Ilan, N.; Doweck, I.; Vlodavsky, I.
Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity
J. Biol. Chem.
285
28010-28019
2010
Homo sapiens
Ramani, V.C.; Yang, Y.; Ren, Y.; Nan, L.; Sanderson, R.D.
Heparanase plays a dual role in driving hepatocyte growth factor (HGF) signaling by enhancing HGF expression and activity
J. Biol. Chem.
286
6490-6499
2011
Homo sapiens
Lerner, I.; Hermano, E.; Zcharia, E.; Rodkin, D.; Bulvik, R.; Doviner, V.; Rubinstein, A.M.; Ishai-Michaeli, R.; Atzmon, R.; Sherman, Y.; Meirovitz, A.; Peretz, T.; Vlodavsky, I.; Elkin, M.
Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice
J. Clin. Invest.
121
1709-1721
2011
Homo sapiens
Bitan, M.; Weiss, L.; Reibstein, I.; Zeira, M.; Fellig, Y.; Slavin, S.; Zcharia, E.; Nagler, A.; Vlodavsky, I.
Heparanase upregulates Th2 cytokines, ameliorating experimental autoimmune encephalitis
Mol. Immunol.
47
1890-1898
2010
Mus musculus
Planer, D.; Metzger, S.; Zcharia, E.; Wexler, I.D.; Vlodavsky, I.; Chajek-Shaul, T.
Role of heparanase on hepatic uptake of intestinal derived lipoprotein and fatty streak formation in mice
PLoS ONE
6
e18370
2011
Homo sapiens
Wilson, J.C.; Laloo, A.E.; Singh, S.; Ferro, V.
1H NMR spectroscopic studies establish that heparanase is a retaining glycosidase
Biochem. Biophys. Res. Commun.
443
185-188
2014
Homo sapiens
Fernandes dos Santos, T.C.; Gomes, A.M.; Paschoal, M.E.; Stelling, M.P.; Rumjanek, V.M.; Junior, A.d.o.R.; Valiante, P.M.; Madi, K.; Pereira de Souza, H.S.; Pavao, M.S.; Castelo-Branco, M.T.
Heparanase expression and localization in different types of human lung cancer
Biochim. Biophys. Acta
1840
2599-2608
2014
Homo sapiens
Masola, V.; Zaza, G.; Secchi, M.F.; Gambaro, G.; Lupo, A.; Onisto, M.
Heparanase is a key player in renal fibrosis by regulating TGF-beta expression and activity
Biochim. Biophys. Acta
1843
2122-2128
2014
Homo sapiens
Mosulen, S.; Pineda-Lucena, A.; Carbajo, R.J.
Chemical shift assignments and secondary structure of the surrogate domain for drug discovery studies of human heparanase
Biomol. NMR Assign.
9
15-19
2014
Homo sapiens
Gozalbes, R.; Mosulen, S.; Orti, L.; Rodriguez-Diaz, J.; Carbajo, R.J.; Melnyk, P.; Pineda-Lucena, A.
Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches
Bioorg. Med. Chem.
21
1944-1951
2013
Homo sapiens
Winkler, S.; Schweiger, D.; Wei, Z.; Rajkovic, E.; Kungl, A.J.
Bacterial expression and functional reconstitution of human heparanase
Carbohydr. Res.
389
72-77
2014
Homo sapiens
Lerner, I.; Zcharia, E.; Neuman, T.; Hermano, E.; Rubinstein, A.M.; Vlodavsky, I.; Elkin, M.
Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice
Cell. Mol. Life Sci.
71
2347-2357
2014
Homo sapiens, Mus musculus, Mus musculus BALB/c
Ohmae, M.; Fujita, Y.; Takada, J.; Kimura, S.
Development of novel inhibitors specific for human heparanase-1
Chem. Lett.
42
797-798
2013
Homo sapiens
-
Hammond, E.; Handley, P.; Dredge, K.; Bytheway, I.
Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues
FEBS Open Bio
3
346-351
2013
Homo sapiens
Hammond, E.; Khurana, A.; Shridhar, V.; Dredge, K.
The role of heparanase and sulfatases in the modification of heparan sulfate proteoglycans within the tumour microenvironment and opportunities for novel cancer therapeutics
Front. Oncol.
4
195
2014
Homo sapiens
Gandhi, N.; Freeman, C.; Parish, C.; Mancera, R.
Computational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-D-glucuronidase (heparanase)
Glycobiology
22
35-55
2012
Homo sapiens (Q9Y251), Homo sapiens
Thompson, C.A.; Purushothaman, A.; Ramani, V.C.; Vlodavsky, I.; Sanderson, R.D.
Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes
J. Biol. Chem.
288
10093-10099
2013
Homo sapiens
Peterson, S.B.; Liu, J.
Multi-faceted substrate specificity of heparanase
Matrix Biol.
32
223-227
2013
Mammalia
Goldberg, R.; Meirovitz, A.; Hirshoren, N.; Bulvik, R.; Binder, A.; Rubinstein, A.M.; Elkin, M.
Versatile role of heparanase in inflammation
Matrix Biol.
32
234-240
2013
Mammalia
Vlodavsky, I.; Blich, M.; Li, J.P.; Sanderson, R.D.; Ilan, N.
Involvement of heparanase in atherosclerosis and other vessel wall pathologies
Matrix Biol.
32
241-251
2013
Homo sapiens
Qin, Q.; Niu, J.; Wang, Z.; Xu, W.; Qiao, Z.; Gu, Y.
Astragalus embranaceus extract activates immune response in macrophages via heparanase
Molecules
17
7232-7240
2012
Mus musculus
He, Y.Q.; Sutcliffe, E.L.; Bunting, K.L.; Li, J.; Goodall, K.J.; Poon, I.K.; Hulett, M.D.; Freeman, C.; Zafar, A.; McInnes, R.L.; Taya, T.; Parish, C.R.; Rao, S.
The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes
Transcription
3
130-145
2012
Homo sapiens
Melo, C.M.; Tersariol, I.L.; Nader, H.B.; Pinhal, M.A.; Lima, M.A.
Development of new methods for determining the heparanase enzymatic activity
Carbohydr. Res.
412
66-70
2015
Homo sapiens (Q9Y251)
Loka, R.S.; Yu, F.; Sletten, E.T.; Nguyen, H.M.
Design, synthesis, and evaluation of heparan sulfate mimicking glycopolymers for inhibiting heparanase activity
Chem. Commun. (Camb.)
53
9163-9166
2017
Homo sapiens (Q9Y251)
Vlodavsky, I.; Singh, P.; Boyango, I.; Gutter-Kapon, L.; Elkin, M.; Sanderson, R.D.; Ilan, N.
Heparanase from basic research to therapeutic applications in cancer and inflammation
Drug Resist. Updat.
29
54-75
2016
Homo sapiens (Q9Y251), Homo sapiens
Messore, A.; Madia, V.N.; Pescatori, L.; Saccoliti, F.; Tudino, V.; De Leo, A.; Bortolami, M.; De Vita, D.; Scipione, L.; Pepi, F.; Costi, R.; Rivara, S.; Scalvini, L.; Mor, M.; Ferrara, F.F.; Pavoni, E.; Roscilli, G.; Cassinelli, G.; Milazzo, F.M.; Battistuzzi, G.; Di Santo, R.; Giannini, G.
Novel symmetrical benzazolyl derivatives endowed with potent anti-heparanase activity
J. Med. Chem.
61
10834-10859
2018
Homo sapiens (Q9Y251)
Bohlmann, L.; Tredwell, G.D.; Yu, X.; Chang, C.W.; Haselhorst, T.; Winger, M.; Dyason, J.C.; Thomson, R.J.; Tiralongo, J.; Beacham, I.R.; Blanchard, H.; von Itzstein, M.
Functional and structural characterization of a heparanase
Nat. Chem. Biol.
11
955-957
2015
Burkholderia pseudomallei
Wu, L.; Viola, C.M.; Brzozowski, A.M.; Davies, G.J.
Structural characterization of human heparanase reveals insights into substrate recognition
Nat. Struct. Mol. Biol.
22
1016-1022
2015
Homo sapiens (Q9Y251), Homo sapiens
Bohdan, N.; Espin, S.; Aguila, S.; Teruel-Montoya, R.; Vicente, V.; Corral, J.; Martinez-Martinez, I.
Heparanase activates antithrombin through the binding to its heparin binding site
PLoS ONE
11
e0157834
2016
Homo sapiens (Q9Y251)
Gutter-Kapon, L.; Alishekevitz, D.; Shaked, Y.; Li, J.P.; Aronheim, A.; Ilan, N.; Vlodavsky, I.
Heparanase is required for activation and function of macrophages
Proc. Natl. Acad. Sci. USA
113
E7808-E7817
2016
Mus musculus (Q6YGZ1)
Ushakov, V.; Tsidulko, A.; De La Bourdonnaye, G.; Kazanskaya, G.; Volkov, A.; Kiselev, R.; Kobozev, V.; Kostromskaya, D.; Gaytan, A.; Krivoshapkin, A.; Aidagulova, S.; Grigorieva, E.
Heparan sulfate biosynthetic system is inhibited in human glioma due to EXT1/2 and HS6ST1/2 down-regulation
Int. J. Mol. Sci.
18
2301
2017
Homo sapiens (Q9Y251)
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