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BRENDA support

Literature summary for 3.2.1.166 extracted from

  • Planer, D.; Metzger, S.; Zcharia, E.; Wexler, I.D.; Vlodavsky, I.; Chajek-Shaul, T.
    Role of heparanase on hepatic uptake of intestinal derived lipoprotein and fatty streak formation in mice (2011), PLoS ONE, 6, e18370.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mus musculus Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining

General Information

General Information Comment Organism
physiological function heparanase over-expression results in reduced hepatic clearance of postprandial lipoproteins and higher levels of fasting and postprandial serum triglycerides. Heparanase over-expression also induces formation of fatty streaks in the aorta Homo sapiens