Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of Hpa-tg mice in which transgenic heparanase is driven by a constitutive beta-actin promoter in a BALB/c genetic background. The skin of Hpa-tg mice has normal appearance and is characterized by an enhanced hair re-growth, no differences in proliferation of interfollicular keratinocytes between healthy Hpa-tg and wild-type mice. Heparanase overexpression preserves psoriasislike phenotype in mouse skin following multiple 12-O-tetradecanoyl phorbol 12-myristate 13-acetate application | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
8000 | - |
1 * 50000 + 1 * 8000, SDS-PAGE | Homo sapiens |
50000 | - |
1 * 50000 + 1 * 8000, SDS-PAGE | Homo sapiens |
65000 | - |
1 * 65000, precursor polypeptide, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Mus musculus BALB/c | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | - |
Mus musculus | - |
epidermis | - |
Homo sapiens | - |
epithelium | - |
Mus musculus | - |
epithelium | - |
Homo sapiens | - |
macrophage | - |
Mus musculus | - |
macrophage | - |
Homo sapiens | - |
skin | - |
Mus musculus | - |
skin | heparanase is preferentially expressed by epidermal keratinocytes in human psoriatic lesions | Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
heterodimer | 1 * 50000 + 1 * 8000, SDS-PAGE | Homo sapiens |
monomer | 1 * 65000, precursor polypeptide, SDS-PAGE | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | heparanase overexpressing transgenic mice in a model of 12-O-tetradecanoyl phorbol 12-myristate 13-acetate-induced cutaneous inflammation promotes development of mouse skin lesions that strongly recapitulate the human disease in terms of histomorphological appearance and molecularcellular characteristics | Mus musculus |
physiological function | heparanase is the sole mammalian endoglycosidase that cleaves heparan sulfate, the key polysaccharide of the ECM and basement membranes. Heparan sulfate is a ubiquitous macromolecule associated with the cell surface and extracellular matrix of a wide range of tissues and organs. Heparanase is preferentially expressed in human psoriatic lesions. The enzyme has the capacity to promote cancer progression. Enzyme involvement of heparanase in the pathogenesis of psoriasis and a role for the enzyme in facilitating abnormal interactions between immune and epithelial cell subsets of the affected skin | Homo sapiens |
physiological function | the enzyme induces development of psoriasiform skin inflammation in mice. Enzymatic cleavage of heparan sulfate by heparanase profoundly affects a variety of pathophysiological processes, including inflammation, where heparanase activity is often associated with extracellular matrix remodeling, immunocyte activation,and release of chemokines anchored within the extracellular matrix network and cell surface. Heparanase of epidermal origin appears to facilitate abnormal activation of skin-infiltrating macrophages, thus generating psoriasis-like inflammation conditions, characterized by induction of STAT 3, enhanced NF-kappaB signaling, elevated expression of TNF-alpha and increased vascularization. Enzyme involvement of heparanase in the pathogenesis of psoriasis and a role for the enzyme in facilitating abnormal interactions between immune and epithelial cell subsets of the affected skin | Mus musculus |