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Literature summary for 3.2.1.166 extracted from
- Human heparanase. Purification, characterization, cloning, and expression (1999), J. Biol. Chem., 274, 24153-24160.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| NIH3T3 and COS-7 cells stably transfected with pBK-CMV expression vectors | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9Y251 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| heparan sulfate proteoglycan + H2O | the average molecular mass of the degradation products is determined to be 2000030000 Da | Homo sapiens | heparan sulfate fragment + truncated heparan sulfate proteoglycan | - |
? |  |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4.2 | - |
- |
Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4.2 | 6 | pH 4.2: maximal activity, pH 6.0: about 50% of maximal activity. No significant activity is observed below pH 3.5 and above pH 7.0 | Homo sapiens |
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