Protein Variants | Comment | Organism |
---|---|---|
additional information | reduced enzyme expression in enzyme-silenced cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
low molecular weight heparin | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | - |
Homo sapiens | - |
HK-2 cell | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
mesenchyme | - |
Homo sapiens | - |
renal tubule | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
HPSE | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | no effect by TGF-beta on the enzyme expression in enzyme-silenced cells | additional information |
General Information | Comment | Organism |
---|---|---|
malfunction | the lack of heparanase or its inhibition prevents the increased synthesis of TGF-beta by tubular cells in response to pro-fibrotic stimuli such as FGF-2, advanced glycosylation end products and albumin overload. TGF-beta induces an autocrine loop to sustain its signal, whereas the lack of the enzyme partially interferes with this autocrine loop | Homo sapiens |
physiological function | heparanase is a key player in renal fibrosis by regulating TGF-beta expression and activity, overview. Heparanase is an endo-beta-D-glucuronidase that cleaves heparan-sulfate thus regulating the bioavailability of growth factors (FGF-2, TGF-beta). The enzyme controls FGF-2-induced epithelial-mesenchymal transition in tubular cells and is necessary for the development of diabetic nephropathy in mice. | Homo sapiens |