Application | Comment | Organism |
---|---|---|
medicine | specific inhibitors for heparanase are important for suppression of tumor progression and metastasis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sodium octyl 2-deoxy-2-(sulfonatoamino)-alpha-D-glucopyranoside | - |
Homo sapiens | |
sodium octyl 4-O-[2-deoxy-2-(sulfoamino)-alpha-D-glucopyranosyl]-beta-D-glucopyranosiduronate | specific inhibition | Homo sapiens | |
sodium octyl beta-D-glucopyranosiduronate | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted in invasive cells such as inflammatory cells and highly migratory tumor cells | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
inflammatory cell | - |
Homo sapiens | - |
additional information | the enzyme is secreted in invasive cells such as inflammatory cells and highly migratory tumor cells | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
heparanase-1 | - |
Homo sapiens |
Hpa1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
1.4 | - |
pH and temperature not specified in the publication | Homo sapiens | sodium octyl 4-O-[2-deoxy-2-(sulfoamino)-alpha-D-glucopyranosyl]-beta-D-glucopyranosiduronate | |
6 | - |
pH and temperature not specified in the publication | Homo sapiens | sodium octyl 2-deoxy-2-(sulfonatoamino)-alpha-D-glucopyranoside |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to the glycoside hydrolase family 79, GH79 | Homo sapiens |
physiological function | the enzyme is involved in the process of tumor metastasis | Homo sapiens |