Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.166 extracted from

  • Masola, V.; Gambaro, G.; Tibaldi, E.; Onisto, M.; Abaterusso, C.; Lupo, A.
    Regulation of heparanase by albumin and advanced glycation end products in proximal tubular cells (2011), Biochim. Biophys. Acta, 1813, 1475-1482.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
sulodexide
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-
HK-2 cell
-
Homo sapiens
-
renal proximal tubule
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
syndecan-1 + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
heparan sulfate glycosidase
-
Homo sapiens
heparanase-1
-
Homo sapiens
HPSE
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens bovine serum albumin and advanced glycation end-product, but not high glucose levels, increase heparanase expression in adult tubular cells via the AKT/PI3K signaling pathway 1.68 and 2.81times, respectively up

General Information

General Information Comment Organism
physiological function over-expression of heparanase is responsible for heparan sulfate reduction via its endoglycosidase activity and its capacity to regulate the heparan sulfate-proteoglycans core protein. Heparanase regulates the gene expression of syndecan-1. The enzyme is relevant to the progression of diabetic nephropathytake and takes part in several processes, e.g. extracellular-matrix remodeling and cell-cell crosstalk, via its heparan sulfate endoglycosidase activity and capacity to regulate the expression of the heparan sulfate-proteoglycan syndecan-1 Homo sapiens