Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sulodexide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
HK-2 cell | - |
Homo sapiens | - |
renal proximal tubule | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
syndecan-1 + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heparan sulfate glycosidase | - |
Homo sapiens |
heparanase-1 | - |
Homo sapiens |
HPSE | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | bovine serum albumin and advanced glycation end-product, but not high glucose levels, increase heparanase expression in adult tubular cells via the AKT/PI3K signaling pathway 1.68 and 2.81times, respectively | up |
General Information | Comment | Organism |
---|---|---|
physiological function | over-expression of heparanase is responsible for heparan sulfate reduction via its endoglycosidase activity and its capacity to regulate the heparan sulfate-proteoglycans core protein. Heparanase regulates the gene expression of syndecan-1. The enzyme is relevant to the progression of diabetic nephropathytake and takes part in several processes, e.g. extracellular-matrix remodeling and cell-cell crosstalk, via its heparan sulfate endoglycosidase activity and capacity to regulate the expression of the heparan sulfate-proteoglycan syndecan-1 | Homo sapiens |