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Literature summary for 3.2.1.166 extracted from

  • Lerner, I.; Hermano, E.; Zcharia, E.; Rodkin, D.; Bulvik, R.; Doviner, V.; Rubinstein, A.M.; Ishai-Michaeli, R.; Atzmon, R.; Sherman, Y.; Meirovitz, A.; Peretz, T.; Vlodavsky, I.; Elkin, M.
    Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice (2011), J. Clin. Invest., 121, 1709-1721.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mus musculus Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 x * 50000, N-terminally processed heparanase, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heparan sulfate proteoglycan + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 50000, N-terminally processed heparanase, SDS-PAGE Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression of the enzyme heparanase is clearly linked to colon carcinoma progression up

General Information

General Information Comment Organism
physiological function heparanase is constantly overexpressed and activated throughout ulcerative colitis. Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis. Heparanase overexpression markedly increases the incidence and severity of colitis-associated colonic tumors. Heparanase overexpression directly affects macrophage recruitment and activation Homo sapiens