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Literature summary for 3.2.1.166 extracted from
- Purification and characterization of the endoglycosidase heparanase 1 from human plantar stratum corneum: a key enzyme in epidermal physiology? (2001), J. Invest. Dermatol., 117, 1266-1273.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| heparan sulfate proteoglycan + H2O | Homo sapiens | heparanase 1 has multiple physiologic functions in the epidermis. It plays an important role in epidermal differentiation, possibly by modulating the liberation of heparan sulfate bound (growth) factors. In the stratum corneum, the endoglycosidase activity of heparanase 1 might be indispensable and represent the first step in the desquamation process and in Langerhans cells, its catalytic activity is required for the trans-tissue migration of these cells | heparan sulfate fragment + truncated heparan sulfate proteoglycan | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epidermis | - |
Homo sapiens | - |
| stratum corneum | plantar stratum corneum | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| heparan sulfate proteoglycan + H2O | - |
Homo sapiens | heparan sulfate fragment + truncated heparan sulfate proteoglycan | - |
? | |
| heparan sulfate proteoglycan + H2O | heparanase 1 has multiple physiologic functions in the epidermis. It plays an important role in epidermal differentiation, possibly by modulating the liberation of heparan sulfate bound (growth) factors. In the stratum corneum, the endoglycosidase activity of heparanase 1 might be indispensable and represent the first step in the desquamation process and in Langerhans cells, its catalytic activity is required for the trans-tissue migration of these cells | Homo sapiens | heparan sulfate fragment + truncated heparan sulfate proteoglycan | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| heparanase 1 | - |
Homo sapiens |
| Hpa1 | - |
Homo sapiens |
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